AURIGENE Micro-emulsion P Patented Formula.on Triple Ac.on for the treatment of wrinkles 1
AURIGENE Micro-emulsion P 1. Presenta.on of Aurigene 2. How it works: 1. Hyaluronic Acid 2. Acetyl hexapep.de 3 3. Effec.veness 2
AURIGENE Micro emulsion 3
PRODUCT PRESENTATION Indica8ons Smooths out expression wrinkles Fill wrinkles and small lines Prolongs the ac8on of medical injec8ons (Hyaluronic acid, Botox ) 4
PRODUCT PRESENTATION Composi.on Micro emulsion Nanosomes 3 ingredients for triple ac8on : Acetyl Hexapep8de Hyaluronic Acid 50kDA Hyaluronic Acid 10kDA 5
PRODUCT PRESENTATION Micro emulsion Specific vector to improve skin penetra8on 6
HOW IT WORKS Acétyl Hexapep.de 3 Fragments of the botulic toxine Hexapep8de (Ac Glu Glu Met Gln Arg NH2) Int J. of Cosm Sciences, 2002, 24, 303 310 7
HOW IT WORKS Botulic Toxine Produced by bacteria (Clostridum botulinum) Mul8ple types of botulic toxins exist (A, B, C, D, E, F) Clostridum botulinum A neurotoxin In very high doses, the botulic toxin is responsible for botulism In aesthe8c medicine, it is the botulic toxine type A or BTX A 8
HOW IT WORKS Muscular Contrac.on Acetylcholine = neuro transmission Acetylcholine is kept in the vesicles termina8ng the synapse 5 000 to 10 000 molecules per vesicle 9
HOW IT WORKS Toxine Botulique A neurotoxine Cleaves the protein SNAP 25 SNARE complex is destoyed Muscle paralyses 10
HOW IT WORKS Acétyl Hexapep.de 500 ppm Smooths out expression wrinkles Block Modulates the forma8on of SNARE complex (acetylcholine) Muscle is released 11
HOW IT WORKS Nanosomes Contains Hyaluronic Acids (50kDA & 10kDA) Improves skin penetra8on 160 nm 12
HOW IT WORKS Hyaluronic Acid Naturally present in mul8ple 8ssues of the body 50% of total AH total in the skin Hydrata8on and elas8city of the skin Reduces with age, causing wrinkles and fine lines 13
HOW IT WORKS Hyaluronic Acid: 50 kda Hyaluronic acid (2%) in nanosomes To reduce wrinkles and fine lines Hyaluronic acid reacts in the centre of the wrinkles to fill them 14
HOW IT WORKS Acide Hyaluronique : 10 kda Hyaluronic acid (2%) in nanosomes To inhibit the degrada8on of hyaluronic acid Inhibi8on of hyaluronidases 15
PRODUCT EFFECTIVENESS Evalua.on of an. wrinkle effect (Dermscan, Lyon, 2009) Clinical protocol : 20 women (between the age of 40 and 65) Twice a day during 28 days Goals: Evalua8on of the an. wrinkle effect Evalua8on of the tolerance Evalua8on of organolep.c proper.es 16
PRODUCT EFFECTIVENESS Evalua.on of an. wrinkle effect (Dermscan, Lyon, 2009) Methode used for evalua.ng an. wrinkle effect: Polymer silicone skin s prints (Siflo ) Skin Image Analyser (S.I.A ) Quan8Rides soaware Methode used for illustra.ng an. wrinkle effect: Polymer silicone skin s prints (Siflo ) Primos 3D Compact 17
PRODUCT EFFECTIVENESS Evalua.on of an. wrinkle effect (Dermscan, Lyon, 2009) -9% wrinkles after 28 days smoothing effect D0 D28 18
PRODUCT EFFECTIVENESS Evalua.on of an. wrinkle effect (Dermscan, Lyon, 2009) -9% wrinkles after 28 days smoothing effect D0 D28 19
PRODUCT EFFECTIVENESS Subjec.ve evalua.on by the pa.ents 91% global apprecia8on 100% skin looks younger 77% skin is smooth 91% an8 wrinkle effec8veness of the product 95% future usage of the product 20
TRIPLE ACTION FOR THE TREATMENT OF WRINKLES Conclusions Causes a significant an8 wrinkle effect Pa8ent sa8sfac8on its organolep8c characteris8cs its effec8veness on the skin s structure its effec8veness on crows feet 21
CONCLUSIONS Indica.ons Smooths out expression wrinkles Fills wrinkles and fine lines Prolongs ac8on of medical injec8ons ( Hyaluronic acid, Botox ) Usage Apply twice a day on the zones that need treatment 22