The NMF (natural moisturizing factor) like active Temporary version 04-07-2013
The NMF-like moisturizing ingredient to recover a perfect moisturization of skin. Unimoist U-125 G is a complete combination of active substances which are very similar to the natural moisturizing factor (NMF): Restore moisture retaning capacity... for a natural hydration of the skin. Unimoist U-125 G contains, in addition to natural saccharides, an ideal combination of various high grade amino acids such as creatine, alanine, aspartic acid, glycocol, with supplementary components include urea and a polycarbinol to compensate the loss of NMF upon aging. NMF composition 1 : 40% Free amino acids 17% Ammonia, uric acid, glucosamine, creatine and other organic substances 7% Urea 1.5% Magnesium 34.5% Other substances such as pyrrolidone carboxylic acid (12%), lactates, chlorides, phosphates, citrates and formiates (12%),... Skin has a natural capacity to retain water thanks to the natural moisture factor (NMF) 1 Composition quoted from Eckstein, R.A. Kosmetologie - Aus Forschung, und Praxis, pp. 95. (1971)
The NMF-like moisturizing ingredient to recover a perfect moisturization of skin. Unimoist U-125 G is a complete combination of active substances which are very similar to the natural moisturizing factor (NMF): Restore moisture retaning capacity... for a natural hydration of the skin. Unimoist U-125 G contains, in addition to natural saccharides, an ideal combination of various high grade amino acids such as creatine, alanine, aspartic acid, glycocol, with supplementary components include urea and a polycarbinol to compensate the loss of NMF upon aging. NMF composition 1 : 40% Free amino acids 17% Ammonia, uric acid, glucosamine, creatine and other organic substances 7% Urea 1.5% Magnesium 34.5% Other substances such as pyrrolidone carboxylic acid (12%), lactates, chlorides, phosphates, citrates and formiates (12%),... Skin has a natural capacity to retain water thanks to the natural moisture factor (NMF) Environmental factors : extreme climatic conditions, sunlight, pollution,... 1 Composition quoted from Eckstein, R.A. Kosmetologie - Aus Forschung, und Praxis, pp. 95. (1971)
The NMF-like moisturizing ingredient to recover a perfect moisturization of skin. Unimoist U-125 G is a complete combination of active substances which are very similar to the natural moisturizing factor (NMF): Restore moisture retaning capacity... for a natural hydration of the skin. Unimoist U-125 G contains, in addition to natural saccharides, an ideal combination of various high grade amino acids such as creatine, alanine, aspartic acid, glycocol, with supplementary components include urea and a polycarbinol to compensate the loss of NMF upon aging. NMF composition 1 : 40% Free amino acids 17% Ammonia, uric acid, glucosamine, creatine and other organic substances 7% Urea 1.5% Magnesium 34.5% Other substances such as pyrrolidone carboxylic acid (12%), lactates, chlorides, phosphates, citrates and formiates (12%),... Skin has a natural capacity to retain water thanks to the natural moisture factor (NMF) Natural hydration Unimoist U-125 G > 65% of NMF components 1 Composition quoted from Eckstein, R.A. Kosmetologie - Aus Forschung, und Praxis, pp. 95. (1971)
Improvement of skin hydration (clinical efficacy) Protocol: Unimoist U-125 G was tested for its moisture retaining effect on live human skin. Creams containing a range fo concentration of the product (0 to 5%) were applied on the inside forearm of each test subject. Measurement were done every 30 min, for 6 hrs. Result: Unimoist U-125 G improves skin moisture content with an increasing lasting effect according to the concentration of product. Number of hours of hydration 5 4 3 2 1 0 Moisture content of the skin Measurement of the dielectric constant Placebo 1% 2% 3% 4% 5% Percentage of Unimoist U-125 G n% of Unimoist U-125 n hours of hydration
Improvement of skin hydration (clinical efficacy) Protocol: Unimoist U-125 G was tested for its moisture retaining effect on live human skin. Creams containing a range fo concentration of the product (0 to 5%) were applied on the inside forearm of each test subject. Measurement were done every 30 min, for 6 hrs. 80 Reading 70 60 Moisture content of the skin Measurement of the dielectric constant A B C D G F E n% of Unimoist U-125 n hours of hydration Result: Unimoist U-125 G improves skin moisture content with an increasing lasting effect according to the concentration of product. A = B = C = D = E = 0 1 2 3 4 5 6 untreated skin cream O/W cream with 0% witunimoist U-125 cream with 1% Unimoist U-125 cream with 2% Unimoist U-125 D = E = F = G = hours cream with 2% Unimoist U-125 cream with 3% Unimoist U-125 cream with 4% Unimoist U-125 cream with 5% Unimoist U-125
TECHNICAL INFORMATION INCI: Origin: Preservation: Appearance: Solubility: Dosage: Processing: Regulatory status: Claims: Glycerin (or Butylene Glycol for Unimoist BG-125 NP), Urea, Saccharide Hydrolysate, Magnesium Aspartate, Glycine, Alanine, Creatine Organic synthesis Preservative free (except Unimoist U-125 NP, Unimoist BG-125 NP) Clear, slightly yellow liquid Water-soluble, ethanol/water up to 60/40 1-3% Can be incorporated in any formula in liquid form at ph between 5.0 and 8.0 and temperature below 50 C CN, JP, KR, HK, AU, ASEAN, USA, CA, South-Am., Mid-East, EU Moisturizing SAFETY ASSESSMENT Ocular irritation: Skin irritation: Mutagenicity: Eye irritation test - OECD 405 - non irritant at 100% Closed epicutan patch test - non irritant at 20% Ames assay - OECD 471 - non mutagenic
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