Cosmetic ingredients found safe, with qualifications (987 total, through February, 2012)

Transcription

1 Cosmetic ingredients found safe, with qualifications (987 total, through February, 2012) Ingredient # Qualification Acetamide MEA 1 7.5% for leave-on; safe for use in rinse-off products; but should contain no nitrosamine, no free acetamide and should not be used in cosmetic formulations in which N-nitroso compounds can be formed Acid Orange % in hair dyes Acid Violet 43 1 safe for use in hair dye formulations when free of impurities except for the following: 18% volatile matter (at 135C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble matter; 0.2% 1- hydroxy-9,10-anthracenedione; 0.2% 1,4-dihydroxy-9,10-anthracenedione; 0.1% p-toluidine; 0.2% p- toluidine sulfonic acids, sodium salts; 1% subsidiary colors; 20 ppm lead (as Pb); 3 ppm arsenic (as As); 1 ppm mercury (as Hg); and 80% total color. Acrylates Copolymer group 1 34 safe for use in cosmetics, when formulated to avoid irritation Alkyl PEG Ethers safe in the present practices of use and concentration in cosmetics, when formulated to avoid irritation Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice, Aloe Barbadensis Polysaccharides, and Aloe Barbadensis Leaf Water 6 safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment, if anthraquinone levels in the ingredients do not exceed 50 ppm. Alpha Hydroxy Acids (e.g.- Glycolic Acid) 0 10%, at final formulation ph 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection; 30%, at final formulation ph 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Aluminum Starch Octenylsuccinate 1 safe as used provided that established limitations on heavy metal concentrations are not exceeded 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol HCl 2 up to 2% in hair dyes 6-Amino-m-Cresol and 4-Chloro-2-Aminophenol 2 safe as used in oxidative hairdyes, but the available data are insufficient to support the safety in nonoxidative hair dyes 2-amino-4-hydroxyethylaminoanisole 1 not in use at the time,* but should not be used in cosmetic products in which N-nitroso compounds may be formed 2-amino-4-hydroxyethylaminoanisole sulfate to 1.5% in hair dyes (max. 3% before dilution), but should not be used in cosmetic products in which N-nitroso compounds may be formed Ammonium Dodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Ammonium Cocoyl Sarcosinate and Ammonium Lauroyl Sarcosinate 2 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in products where N-nitroso compounds may be formed Ammonium Lauryl Sulfate 1 safe for use in rinse-off products; but 1% for leave-on Ammonium Persulfate 1 safe as used as oxidizing agents in hair colorants and lighteners designed for brief discontinuous use followed by thorough rinsing from the hair and skin. Ammonium Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Arachidyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Benzalkonium Chloride 1 0.1% free active ingredient Benzethonium Chloride 1 0.5% skin; 0.02% eye area Boric Acid 1 5%; but not safe for use on infant or injured skin 5-Bromo-5-Nitro-1,3-Dioxane 1 0.1%; but should not be used in cosmetic products in which in which N-nitroso compounds can be formed 2-Bromo-2-Nitropropane-1,3-Diol 1 0.1%; may contribute to endogenous nitrosamine formation; but should not be used in cosmetic products in which N-nitroso compounds can be formed Butoxyethanol 1 up to 10% Butyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating t-butyl Hydroquinone (aka TBHQ) 1 0.1% Butyl Methacrylate group 3 22 safe as used in nail enhancement products when skin contact is avoided; products containing these ingredients should be accompanied with direction to avoid skin contact because of the sensitizing potential of methacrylates Butyl Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair C10-16 Alkyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating C12-18 Alkyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating C12-20 Alkyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating C20-22 Alkyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating

2 Ingredient # Qualification Calcium Dodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Calcium Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair ; safe for use in depilatories when formulated to be non-irritating under conditions of recommended use Caprylyl/Capryl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Caprylyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Capsicum Annuum Extract, Fruit Extract, Resin, and Fruit Powder; Capsicum Frutescens Fruit, Fruit Extract, and Resin; and Capsaicin 8 safe when formulated to avoid irritation Carvacrol 1 5% Cetearyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Chlorhexidine 1.14% Chlorhexidine Diacetate 1.19% Chlorhexidine Digluconate 1.20% Chlorhexidine Dihydrochloride 1.16% p-chloro-m-cresol 1 5% Chlorothymol 1 5% Cocamide MEA 1 safe as used in rinse-off products and safe at concentrations up to 10% in leave-on products; should not be used as an ingredient in cosmetic products in which N-nitroso compounds can be formed, or in product formulations intended to be aerosolized Cocamidopropylamine Oxide 1 safe for rinse-off uses (up to 4%); insufficient data for leave-on uses Cocamidopropyl Betaine and Related Amidopropyl Betaines 4 31 Safe in the present practices of use and concentration in cosmetics, as long as they are formulated to be nonsensitizing, which may be based on a quantitative risk assessment Coco-Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Cocoyl Sarcosine 1 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in products where N-nitroso compounds can be formed Cottonseed Glycerides, 1 safe as used, provided that established limitations imposed on gossypol, heavy metal and pesticide concentrations are not exceeded (Gossypol limited to a concentration < 450 ppm; heavy metal limitations are lead 0.1 mg/kg, arsenic 3 ppm (as As), and mercury 1 ppm (as Hg); PCB/pesticide contamination limited to not more than 3 ppm with not more 1 ppm for any specific residue) m-cresol 1 5% o-cresol 1 5% Crosslinked Alkyl Acrylates 8 23 safe in the present practices of use and concentration, when not polymerized in benzene o-cymen-5-ol 1 5% DEA Amides 9 33 safe in the present practices of use and concentration when formulated to be non-irritating and when the levels of DEA do not exceed those considered safe in the CIR safety assessment of DEA and its salts; should not be used in products where N-nitroso compounds can be formed DEA-Dodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Decyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating 2,4-Diaminophenol 2 0.2% as the free base and 2,4-Diaminophenol HCl Diazolidinyl Urea 1 0.5% Dicetyl Thiodipropionate 1 safe for use in cosmetic products when formulated to be non-irritating Diethanolamine (DEA) and DEA salts Safe in the present practices of use and concentration, when formulated to be non-irritating, except that these ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed Diisopropanolamine 1 safe for use in cosmetic products; but should not be used in products in which N-nitroso compounds can be formed Diisopropylamine 1 safe for use in cosmetic products; but should not be used in products in which N-nitroso compounds can be formed Dilauryl Thiodipropionate 1 safe for use in cosmetic products when formulated to be non-irritating Dimyristyl Thiodipropionate 1 safe for use in cosmetic products when formulated to be non-irritating Disperse Blue 1 1 up to 1% Distearyl Thiodipropionate 1 safe for use in cosmetic products when formulated to be non-irritating Ditridecyl Thiodipropionate 1 safe for use in cosmetic products when formulated to be non-irritating Ethanolamine (formerly Monoethanolamine) 1 safe for use in rinse-off products; but should not be used in leave-on products

3 Ingredient # Qualification Ethanolamine Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Ethyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Ethyl Methacrylate 1 safe as used in nail products when application is accompanied by directions to avoid skin contact because of the sensitizing potential Ethyl Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Formaldehyde and Methylene Glycol 2 safe for use in cosmetics when formulated to ensure use at the minimal effective concentration, but in no case should the formalin concentration exceed 0.2% (w/w), which would be 0.074% (w/w) calculated as formaldehyde or 0.118% (w/w) calculated as methylene glycol; safe in the present practices of use and concentration in nail hardening products Note: formaldehyde and methylene glycol are unsafe in the present practices of use and concentration in hair smoothing products Formic Acid 1 64 ppm of the free acid Glutaral 1 < 0.5% for rinse-off; but should not be used in products intended to be aerosolized (insufficient data to support safety in leave-on products) Glyceryl Dilaurate, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dierucate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Distearate, Glyceryl Palmitate Lactate, Glyceryl Stearate Citrate, Glyceryl Stearate Lactate, and Glyceryl Stearate Succinate 17 safe as cosmetic ingredients in the practices of use and concentration as described in the safety assessment, provided that the content of 1,2-diesters is not high enough to induce epidermal hyperplasia Glyceryl Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Glycolic Acid; Ammonium, Calcium, Potassium, and Sodium Glycolate; Methyl, Ethyl, Propyl, and Butyl Glycolate (e.g.- Alpha Hydroxy Acid) 9 10%, at final formulation ph 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection; 30%, at final formulation ph 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. Glyoxal % in products intended to be applied to the nail HC Orange No. 1 1 safe for use in hair dyes up to 3% HC Red No % HC Red No. 3 1 safe as used in hair dyes; but should not be used in products in which N-nitroso compounds can be formed HC Yellow No % Hexadecyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Hexamidine and Hexamidine Diisethionate 2 0.1% Hydrogenated Cottonseed Glyceride 1 safe as used, provided that established limitations imposed on gossypol, heavy metal and pesticide concentrations are not exceeded (Gossypol limited to a concentration < 450 ppm; heavy metal limitations are lead 0.1 mg/kg, arsenic 3 ppm (as As), and mercury 1 ppm (as Hg); total PCB/pesticide contamination limited to not more than 3 ppm with not more 1 ppm for any specific residue) Hydrogenated Lecithin 1 safe as used in rinse-off products and safe for use in leave-on products at concentrations 15%; the data are insufficient to determine safety where this ingredient is likely to be inhaled. This ingredient should not be used in cosmetic products in which N-nitroso compounds may be formed. Hydroquinone 1 safe at concentrations of 1% for cosmetic formulations designed for discontinuous, brief use followed by rinsing from the skin and hair; safe for use in nail glue products in the practices of use and concentration described in the safety assessment; should not be used in other leave-on cosmetic products. Iodopropynyl Butylcarbamate 1 safe for use at 0.1%; should not be used in products intended to be aerosolized Isooctyl Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Isoparaffins 5 24 Safe for use in cosmetics when formulated to be non-irritating Isopropanolamine 1 safe for use in cosmetic products; but should not be used in products in which N-nitroso compounds can be formed Isopropylamine Dodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Isopropyl Cresols 1 5%

4 Ingredient # Qualification Isopropyl Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Isostearamide MEA 1 safe for use in rinse-off products; for leave-on use, OK at conc. that limit release of ethanolamines to 5%, but max. conc. of 40%; should not be used in products in which N-nitroso compounds can be formed Isostearamidopropyl Morpholine Lactate 1 safe for use in rinse-off products; data are insufficient to support safety in leave-on formulations Isostearyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating Kojic Acid 1 safe for use in cosmetic formulations at concentrations up to 1% Lactic Acid; Ammonium, Calcium, Potassium, Sodium, and TEA- Lactate; Methyl, Ethyl, Isopropyl, and Butyl Lactate; and Lauryl, Myristyl, and Cetyl Lactate Lard Glyceride, Lard Glycerides, Lard, Hydrogenated Lard Glyceride, Hydrogenated Lard Glycerides, and Hydrogenated Lard 13 10%, at final formulation ph 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection; 30%, at final formulation ph 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection. 6 safe as used, provided that established limitations on heavy metals and pesticide concentrations are not exceeded (Lead is limited to not more than 0.1 mg/kg (0.1 ppm); arsenic (as As) limited to 3 ppm and mercury (as Hg) to 1 ppm. Total PCB/pesticide contamination limited to not more than 40 ppm with not more than 10 ppm for any specific residue) Lauramine Oxide 1 safe for use in rinse-off products; but 3.7% for leave-on products Lauroyl Sarcosine 1 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in products in which N-nitroso compounds can be formed Lauryl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Lecithin 1 safe as used in rinse-off products and safe for use in leave-on products at concentrations 15%; the data are insufficient to determine safety where this ingredient is likely to be inhaled. This ingredient should not be used in cosmetic products in which N-nitroso compounds can be formed Magnesium Isodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Magnesium Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair Malic Acid 1 safe for use as ph adjuster, insufficient for other uses Methacrylic Acid 1 safe as used as a nail primer by trained professionals, insufficient data to support the safety for retail use by consumers Methenamine %; but should not be used in products intended to be aerosolized Methyl Alcohol 1 safe as used to denature alcohol used in cosmetic products Methylbenzethonium Chloride 1 0.5% skin; 0.02% eye area Methylisothiazolinone (alone) 1 safe for use in cosmetic formulations up to 100 ppm (0.01%). Methylchloroisothiazolinone (with Methylisothiazolinone) 1 rinse-off 15 ppm; leave-on 7.5 ppm Methyldibromo Glutaronitrile 1 leave-on 0.025% Methylene Chloride 1 found safe for brief, discontinuous use only by CIR, but FDA has prohibited the use of Methylene Chloride in cosmetic products, which supercedes the CIR conclusion (21CFR ) Methyl Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair MIPA-Dodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Mixed Isopropanolamines 1 safe for use in cosmetic products; but should not be used in products in which N-nitroso compounds can be formed Monoethanolamine (aka- Ethanolamine) 0 safe for use in rinse-off products; but should not be used in leave-on products Myristamide MEA 1 safe for use in rinse-off products; for leave-on use, OK at conc. that limit release of ethanolamines to 5%, but max. conc. of 40%; should not be used in products in which N-nitroso compounds can be formed Myristoyl Sarcosine 1 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in which N-nitroso compounds can be formed Myristyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Nonoxynol-1, -2-3, -4, -5, -6, -7, -8 8 safe as used in rinse-offs; safe at 5% in leave-ons Octadecyl Glucoside 1 safe in the present practices of use and concentration, when formulated to be non-irritating Octoxynol-1, -3, -5, -6, -7, -8 6 safe as used in rinse-offs; safe at 5% in leave-ons Octyldodecyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating Oleoyl Sarcosine 1 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in products in which N-nitroso compounds can be formed

5 Ingredient # Qualification Oxyquinoline and Oxyquinoline Sulfate 2 safe as used as stabilizers for hydrogen peroxide in rinse-off hair care products, but insufficient to support the safety of these ingredients in leave-on products PCA 1 should not be used in products containing N-nitrosating agents PEG-30, -33, -35, -36, -40 Castor Oil 5 up to 50% PEG-2, -4, -6, -8, -12, -20, -32, -75, up to 25% Dilaurate PEG-7, -30, -40, -78, -80 Glyceryl Cocoate 5 Safe as used in rinse-off products and safe up to 10% in leave-on products PEG-30, -40 Hydrogenated Castor Oil 2 up to 100% PEG-2, -4, -6, -8, -9, -10, -12, -14, 13 up to 25% -20, -32, -75, -150, -200 Laurate PEG-2 Laurate SE 1 up to 25% Peppermint (Mentha Piperita) Extract, Peppermint (Mentha Piperita) Leaves, Peppermint (Mentha Piperita) Oil, and Peppermint (Mentha Piperita) Water 4 safe as used if the concentration of pulegone in this ingredient does not exceed 1%. Phenethyl Alcohol 1 1% m-phenylenediamine and 2 10% in hair dyes m-phenylenediamine Sulfate N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine HCl, and N-Phenyl-p-Phenylenediamine Sulfate 3 1.7% as the free base Picramic Acid 1 not to exceed 0.1% Polyacrylamide 1 acrylamide monomer should not exceed 5 ppm in formulation Polyoxymethylene Urea 1 concentration of free formaldehyde should be 0.2%; unsafe for aerosols Polypropylene Glycol (aka PPG 3) 0 safe when formulated to be non-irritating Potassium Bromate % (calculated as Sodium Bromate) Potassium Dodecylbenzenesulfonate 1 safe in the present practices of use and concentration when formulated to be non-irritating Potassium Persulfate 1 safe as used as oxidizing agents in hair colorants and lighteners designed for brief discontinuous use followed by thorough rinsing from the hair and skin. Potassium Silicate 1 safe when formulated to avoid irritation Potassium Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair ; safe for use in depilatories when formulated to be non-irritating under conditions of recommended use PPG 3 (aka- Polypropylene Glycol) 1 Because PPGs of various chain lengths are likely to be added to the International Cosmetic Ingredient Dictionary and Handbook in the future, the CIR Expert Panel concluded that any PPG 3 would be safe for use in cosmetics when formulated to be non-irritating PPG-3, -7, -9, -12,-13, -15,-16, -17,-20, 16 safe when formulated to be non-irritating -26,-30, -33, -34, -51, 52, -69 PPG-2, -4, -5, -9, -12, -14, -15, -16, -17, -18, -20, -22, -24, -26, -30, -33, -40, -52, and -53 Butyl Ether 19 safe when formulated to avoid irritation Propylene Glycol 1 safe when formulated to be non-irritating Propyl Gallate 1 0.1% Quaternium-15 1 safe up to 0.2% Quaternium-26 1 should not be used in products in which N-nitroso compounds can be formed Salicylic Acid group 6 17 safe as used when formulated to avoid irritation and when formulated to avoid increasing sun sensitivity, or, when increased sun sensitivity would be expected, directions for use include the daily use of sun protection Shellac 1 6% silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate Sodium Alpha-Olefin (C12-14 Olefin) Sulfonates 4 safe in the present practices of use and concentration when formulated and delivered in the final product to be non-irritating and non-sensitizing to the respiratory tract 0 safe as used in rinse off products; safe up to 2% in leave ons; the gamma sultone impurities should not exceed 10 ppm for unsubstituted alkane sultones, 1 ppm for chlorosultones, and 0.1 ppm for unsaturated sultones Sodium Borate 1 5%; but not for use on infant or injured skin Sodium Bromate % Sodium p-chloro-m-cresol 1 5% Sodium Cocoyl Isethionate 1 50% rinse-off; 17% leave-on

6 Ingredient # Qualification Sodium Decylbenzenesulfonate, Sodium Dodecylbenzenesulfonate, Sodium Tridecylbenzenesulfonate Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, and Sodium Myristoyl Sarcosinate Sodium C12-14 Olefin Sulfonate Sodium C14-16 Olefin Sulfonate Sodium C14-18 Olefin Sulfonate Sodium C16-18 Olefin Sulfonate 3 safe as cosmetic ingredients in the present practices of use and concentration when formulated to be nonirritating 3 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in products in which N-nitroso compounds can be formed 4 safe as used in rinse off products; safe up to 2% in leave ons; the gamma sultone impurities should not exceed 10 ppm for unsubstituted alkane sultones, 1 ppm for chlorosultones, and 0.1 ppm for unsaturated sultones Sodium Hexametaphosphate 1 safe when formulated to avoid skin irritation Sodium Lauryl Sulfate 1 safe for use in rinse-off products; but 1% for leave-on products Sodium Malate 1 safe for use as ph adjuster, insufficient for other uses Sodium Metaphosphate 1 safe when formulated to avoid skin irritation Sodium Metasilicate 1 safe when formulated to avoid skin irritation Sodium Naphthalenesulfonate and 2 safe as used, except insufficient data to support safety where ingested or contacts mucous membranes Polynaphthalenesulfonate Sodium Octoxynol-2 Ethane Sulfonate, Sodium Octoxynol-2 Sulfate, and Sodium Octoxynol-6 Sulfate 3 safe as used in rinse-off products; but 5% for leave-on products Sodium PCA 1 should not be used in cosmetic products in which N-nitroso compounds can be formed Sodium Persulfate 1 safe as used as oxidizing agents in hair colorants and lighteners designed for brief discontinuous use followed by thorough rinsing from the hair and skin. Sodium Picramate 1 not to exceed 0.1% Sodium Silicate 1 safe when formulated to avoid skin irritation Sodium Sulfate 1 up to 1% in leave-on formulations Sodium Thioglycolate 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair ; safe for use in depilatories when formulated to be non-irritating under conditions of recommended use Sodium Trimetaphosphate 1 safe when formulated to avoid skin irritation Stearamide MEA 1 safe for use in rinse-off products; for leave-on use, OK at conc. that limit release of ethanolamines to 5%, but max. conc. of 40%; should not be used in products in which N-nitroso compounds can be formed Stearamine Oxide 1 safe for use in rinse-off products; but 5% for leave-on products Stearoyl Sarcosine 1 safe as used in rinse-off products; but 5% for leave-on products, and the data are insufficient to determine safety for use in products where inhalation is likely; should not be used in which N-nitroso compounds can be formed TEA-Dodecylbenzenesulfonate and TEA- Tridecylbenzenesulfonate 2 safe as cosmetic ingredients in the present practices of use and concentration when formulated to be nonirritating TBHQ (aka- t-butyl Hydroquinone) 0 0.1% Thiodipropionic Acid 1 safe for use in cosmetic products when formulated to be non-irritating Thioglycolic Acid 1 safe for use in hair straighteners, permanent waves, tonic, dressings, etc., wave sets, other non-coloring hair ; safe for use in depilatories when formulated to be non-irritating under conditions of recommended use Thymol 1 5% Triethanolamine (TEA) and TEA-containing ingredients Safe in the present practices of use and concentration, when formulated to be non-irritating and should not be used in products in which N-nitroso compounds can be formed Triisopropanolamine 1 safe for use in cosmetic products; but should not be used in products in which N-nitroso compounds can be formed Trimoniums 7 52 Safe in the present practices of use and concentration, when formulated to be non-irritating Tripropylene Glycol 1 Safe for use in cosmetics when formulated to be non-irritating Undecyl Glucoside 1 not in use at the time*, but safe when formulated to be non-irritating Total includes Acrylates Copolymer, Ammonium Acrylates Copolymer, Ammonium VA/Acrylates Copolymer, Sodium Acrylates Copolymer, Ethylene/Acrylic Acid Copolymer, Ethylene/Calcium Acrylate Copolymer, Ethylene/ Magnesium Acrylate Copolymer, Ethylene/Sodium Acrylate Copolymer, Ethylene/Zinc Acrylate Copolymer, Ethylene/Acrylic Acid/VA Copolymer, Acrylates/PVP Copolymer, Acrylates/VA Copolymer, Steareth-10 Allyl Ether/Acrylates Copolymer, Acrylates/Steareth-50 Acrylate Copolymer, Acrylates/Steareth-20 Methacrylate Copolymer, Acrylates/Ammonium Methacrylate Copolymer, Styrene/Acrylates

7 Copolymer, Styrene/ Acrylates/ Ammonium Methacrylate Copolymer, Ammonium Styrene/Acrylates Copolymer, Sodium Styrene/Acrylates Copolymer, Acrylates/Hydroxyesters Acrylates Copolymer, Methacryloyl Ethyl Betaine/Acrylates Copolymer, Lauryl Acrylate/VA Copolymer, VA/Butyl Maleate/Isobornyl Acrylate Copolymer, Ethylene/Methacrylate Copolymer, Vinyl Caprolactam/PVP/ Dimethylaminoethyl Methacrylate Copolymer, Sodium Acrylates/Acrolein Copolymer, PVP/Dimethylaminoethyl Methacrylate Copolymer, AMP-Acrylates Copolymer, Polyacrylic Acid, Ammonium Polyacrylate, Potassium Aluminum Polyacrylate, Potassium Polyacrylate, and Sodium Polyacrylate 2 This assessment is also intended to address future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units. Those ingredients not in current use are indicated with an asterisk (*). The 369 ingredients included in this safety assessment are:

8 Arachideth-20* Beheneth-2* Beheneth-5* Beheneth-10 Beheneth-15* Beheneth-20 Beheneth-25 Beheneth-30 C9-11 Pareth-3* C9-11 Pareth-4 * C9-11 Pareth-6 C9-11-Pareth-8 C9-15 Pareth-8* C10-16 Pareth-1* C10-16 Pareth-2 * C11-13 Pareth-6* C11-13 Pareth-9* C11-13 Pareth-10* C11-15 Pareth-3 C11-15 Pareth-5 C11-15 Pareth-7 C11-15 Pareth-9 C11-15 Pareth-12* C11-15 Pareth-15* C11-15 Pareth-20* C11-15 Pareth-30* C11-15 Pareth-40 C11-21-Pareth-3* C11-21-Pareth-10* C12-13 Pareth-1* C12-13 Pareth-2* C12-13 Pareth-3 C12-13 Pareth-4* C12-13 Pareth-5* C12-13 Pareth-6* C12-13 Pareth-7 C12-13 Pareth-9* C12-13 Pareth-10* C12-13 Pareth-15* C12-13 Pareth-23 C12-14 Pareth-3 C12-14 Pareth-5* C12-14 Pareth-7* C12-14 Pareth-9* C12-14 Pareth-12 C12-15 Pareth-2* C12-15 Pareth-3 C12-15 Pareth-4* C12-15 Pareth-5* C12-15 Pareth-7 C12-15 Pareth-9 C12-15 Pareth-10* C12-15 Pareth-11* C12-15 Pareth-12 C12-16 Pareth-5* C12-16 Pareth-7 C12-16 Pareth-9 C13-15 Pareth-21* C14-15 Pareth-4* C14-15 Pareth-7* C14-15 Pareth-8* C14-15 Pareth-11* C14-15 Pareth-12* C14-15 Pareth-13* C20-22 Pareth-30* C20-40 Pareth-3 C20-40 Pareth-10 C20-40 Pareth-24* C20-40 Pareth-40 C20-40 Pareth-95 C22-24 Pareth-33 C30-50 Pareth-3* C30-50 Pareth-10* C30-50 Pareth-40* C40-60 Pareth-3* C40-60 Pareth-10* C11-15 Sec-Pareth-12* C12-14 Sec-Pareth-3* C12-14 Sec-Pareth-5 C12-14 Sec-Pareth-7 C12-14 Sec-Pareth-8* C12-14 Sec-Pareth-9* C12-14 Sec-Pareth-12* C12-14 Sec-Pareth-15* C12-14 Sec-Pareth-20* C12-14 Sec-Pareth-30* C12-14 Sec-Pareth-40* C12-14 Sec-Pareth-50* Capryleth-4* Capryleth-5* Ceteareth-2 Ceteareth-3 Ceteareth-4 Ceteareth-5 Ceteareth-6 Ceteareth-7 Ceteareth-8* Ceteareth-9* Ceteareth-10 Ceteareth-11* Ceteareth-12 Ceteareth-13* Ceteareth-14* Ceteareth-15 Ceteareth-16* Ceteareth-17* Ceteareth-18* Ceteareth-20 Ceteareth-22 Ceteareth-23* Ceteareth-24* Ceteareth-25 Ceteareth-27* Ceteareth-28* Ceteareth-29* Ceteareth-30 Ceteareth-33 Ceteareth-34* Ceteareth-40* Ceteareth-50 Ceteareth-55* Ceteareth-60* Ceteareth-80* Ceteareth-100* Ceteth-1 Ceteth-2 Ceteth-3 Ceteth-4* Ceteth-5* Ceteth-6 Ceteth-7* Ceteth-10 Ceteth-12 Ceteth-13* Ceteth-14* Ceteth-15 Ceteth-16 Ceteth-17* Ceteth-18* Ceteth-20 Ceteth-23* Ceteth-24 Ceteth-25 Ceteth-30* Ceteth-40* Ceteth-45* Ceteth-150* Cetoleth-2* Cetoleth-4* Cetoleth-5* Cetoleth-6* Cetoleth-10* Cetoleth-11* Cetoleth-15* Cetoleth-18* Cetoleth-20* Cetoleth-22* Cetoleth-24* Cetoleth-25 Cetoleth-30* Coceth-3* Coceth-5* Coceth-6* Coceth-7 Coceth-8 Coceth-10 Coceth-20* Coceth-25* Deceth-3 Deceth-4* Deceth-5 Deceth-6* Deceth-7 Deceth-8 Deceth-9 Deceth-10* Decyltetradeceth-5* Decyltetradeceth-10* Decyltetradeceth-15* Decyltetradeceth-20* Decyltetradeceth-25* Decyltetradeceth-30* Hexyldeceth-2* Hexyldeceth-20* Hydrogenated Dimer Dilinoleth-20* Hydrogenated Dimer Dilinoleth-30* Hydrogenated Dimer Dilinoleth-40* Hydrogenated Dimer Dilinoleth-60* Hydrogenated Dimer Dilinoleth-80* Hydrogenated Laneth-5* Hydrogenated Laneth-20* Hydrogenated Laneth-25* Hydrogenated Talloweth-12* Hydrogenated Talloweth-25* Isoceteth-5* Isoceteth-7* Isoceteth-10 Isoceteth-12* Isoceteth-15* Isoceteth-20 Isoceteth-25 Isoceteth-30* Isodeceth-4* Isodeceth-5* Isodeceth-6 Isolaureth-3* Isolaureth-6 Isolaureth-10* Isomyreth-3* Isomyreth-9* Isosteareth-2 Isosteareth-3 Isosteareth-5 Isosteareth-8* Isosteareth-10 Isosteareth-12* Isosteareth-15* Isosteareth-16* Isosteareth-20 Isosteareth-22* Isosteareth-25* Isosteareth-50* Laneth-5 Laneth-10* Laneth-15 Laneth-16 Laneth-20 Laneth-25 Laneth-40 Laneth-50* Laneth-60* Laneth-75* Laureth-1 Laureth-2

9 Laureth-3 Laureth-4 Laureth-5 Laureth-6 Laureth-7 Laureth-8 Laureth-9 Laureth-10 Laureth-11 Laureth-12 Laureth-13* Laureth-14 Laureth-15* Laureth-16 Laureth-20 Laureth-21 Laureth-23 Laureth-25 Laureth-30 Laureth-38* Laureth-40* Laureth-50* Methoxy PEG-7* Methoxy PEG-10* Methoxy PEG-16 Methoxy PEG-25* Methoxy PEG-40* Methoxy PEG-100* Myreth-2 * Myreth-3 Myreth-4 Myreth-5* Myreth-10 Noneth-8* Octyldodeceth-2* Octyldodeceth-5* Octyldodeceth-10* Octyldodeceth-16 Octyldodeceth-20 Octyldodeceth-25 Octyldodeceth-30* Oleth-2 Oleth-3 Oleth-4 Oleth-5 Oleth-6* Oleth-7* Oleth-8 Oleth-9* Oleth-10 Oleth-11* Oleth-12 Oleth-15 Oleth-16 Oleth-20 Oleth-23* Oleth-24* Oleth-25 Oleth-30 Oleth-35* Oleth-40* Oleth-44* Oleth-45* Oleth-50 Oleth-82 Oleth-100* Oleth-106 Palmeth-2* PEG-16 Cetyl/Oleyl/Stearyl/Lanolin Alcohol Ether* PEG-Cetyl Stearyl Diether* PEG-4 Distearyl Ether PEG-4 Ditallow Ether* PEG-15 Jojoba Alcohol* PEG-26 Jojoba Alcohol* PEG-40 Jojoba Alcohol* PEG-3 Methyl Ether* PEG-4 Methyl Ether* PEG-6 Methyl Ether* PEG-7 Methyl Ether* PEG-7 Propylheptyl Ether PEG-8 Propylheptyl Ether Steareth-1* Steareth-2 Steareth-3* Steareth-4 Steareth-5* Steareth-6 Steareth-7* Steareth-8* Steareth-10 Steareth-11* Steareth-13* Steareth-14* Steareth-15* Steareth-16 Steareth-20 Steareth-21 Steareth-25 Steareth-27* Steareth-30 Steareth-40* Steareth-50 Steareth-80* Steareth-100 Steareth-200 Steareth-60 Cetyl Ether* Talloweth-4 Talloweth-5 Talloweth-6 Talloweth-7* Talloweth-18* Trideceth-2* Trideceth-3 Trideceth-4* Trideceth-5 Trideceth-6 Trideceth-7 Trideceth-8 Trideceth-9 Trideceth-10 Trideceth-11* Trideceth-12 Trideceth-15* Trideceth-18* Trideceth-20* Trideceth-21* Trideceth-50* Undeceth-3 Undeceth-5 Undeceth-7* Undeceth-8* Undeceth-9* Undeceth-11 Undeceth-40* Undecyleneth-6* 3 includes Butyl Methacrylate, t-butyl Methacrylate, Cyclohexyl Methacrylate, Ethoxyethyl Methacrylate, 2-Ethoxy Ethoxy Ethyl Methacrylate, Ethylene Glycol Dimethacrylate, HEMA, Di-HEMA Trimethylhexyl Dicarbamate, Hexyl Methacrylate, Hydroxyethylmethacrylate Acetoacetate, Hydroxypropyl Methacrylate, Isobornyl Methacrylate, Isobutyl Methacrylate, Isopropylidenediphenyl Bisglycidyl Methacrylate, Lauryl Methacrylate, Methoxydiglycol Methacrylate, PEG-4 Dimethacrylate, Pyromellitic Glycidyl Dimethacrylate, Tetrahydrofurfuryl Methacrylate, Triethylene Glycol Dimethacrylate, Trimethylolpropane Trimethacrylate, and Urethane Methacrylate 4 This group includes the following ingredients (those ingredients not in current use are indicated with an asterisk): Cocamidopropyl Betaine, Minkamidopropyl Betaine*, Almondamidopropyl Betaine, Myristamidopropyl Betaine, Oatamidopropyl Betaine, Apricotamidopropyl Betaine*, Oleamidopropyl Betaine*, Avocadamidopropyl Betaine*, Olivamidopropyl Betaine, Babassuamidopropyl Betaine, Palmamidopropyl Betaine*, Behenamidopropyl Betaine*, Palmitamidopropyl Betaine*, Canolamidopropyl Betaine*, Palm Kernelamidopropyl Betaine, Capryl/Capramidopropyl Betaine, Ricinoleamidopropyl Betaine*, Coco/Oleamidopropyl Betaine*, Sesamidopropyl Betaine*, Coco/Sunfloweramidopropyl Betaine, Shea Butteramidopropyl Betaine, Cupuassuamidopropyl Betaine*, Soyamidopropyl Betaine, Isostearamidopropyl Betaine*, Stearamidopropyl Betaine*, Lauramidopropyl Betaine, Tallowamidopropyl Betaine*, Meadowfoamamidopropyl Betaine*, Undecyleneamidopropyl Betaine, and Milkamidopropyl Betaine*, Wheat Germamidopropyl Betaine

10 5 This group includes the following ingredients (those ingredients not in current use are indicated with an asterisk): C7-8 Isoparaffin, C8-9 Isoparaffin, C9-11 Isoparaffin, C9-12 Isoparaffin*, C9-13 Isoparaffin*, C9-14 Isoparaffin*, C9-16 Isoparaffin*, C10-11 Isoparaffin, C10-12 Isoparaffin*, C10-13 Isoparaffin, C11-12 Isoparaffin, C11-13 Isoparaffin, C11-14 Isoparaffin*, C12-14 Isoparaffin, C12-20 Isoparaffin*, C13-14 Isoparaffin, C13-16 Isoparaffin, C18-70 Isoparaffin, C20-40 Isoparaffin*, C15-35 Isoparaffin/Isoalkylcycloalkanes*, Isododecane, Isoeicosane, Isohexadecane, and Isooctane 6 includes Salicylic Acid, Calcium Salicylate, Magnesium Salicylate, MEA-Salicylate, Potassium Salicylate, Sodium Salicylate, TEA-Salicylate, Capryloyl Salicylic Acid, C12-15 Alkyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Methyl Salicylate, Myristyl Salicylate, Ethylhexyl Salicylate, Tridecyl Salicylate, Butyloctyl Salicylate and Hexyldodexyl Salicylate 7 This group includes the following ingredients (those ingredients not in current use are indicated with an asterisk): Behentrimonium Chloride, Acetyl Carnitine*, Ceteartrimonium Chloride*, Acetyl Carnitine HCl, Cetrimonium Chloride, Carnitine, Choline Chloride*, Carnitine HCl, Cocotrimonium Chloride, Carnitine Hydroxycitrate, Dodecylhexadecyltrimonium Chloride*, Carnitine PCA*, Hydrogenated Palmtrimonium Chloride*, Palmitoyl Carnitine, Hydrogenated Tallowtrimonium Chloride*, Laurtrimonium Chloride*, Octacosatrimonium Chloride*, Octyldodecyltrimonium Chloride*, Soytrimonium Chloride, Stearoxypropyltrimonium Chloride*, Steartrimonium Chloride, Tallowtrimonium Chloride Cetrimonium Bromide Laurtrimonium Bromide, Myrtrimonium Bromide, Steartrimonium Bromide*, Behentrimonium Methosulfate*, Cetrimonium Methosulfate, Cocoylcholine Methosulfate*, Cocotrimonium Methosulfate, Lauroyl Ethyltrimonium Methosulfate*, Myristoyl Ethyltrimonium Methosulfate*, Palmitoyl Ethyltrimonium Methosulfate*, Stearoyl Ethyltrimonium Methosulfate*, Steartrimonium Methosulfate*, Acrylamide/Ethyltrimonium Chloride* Acrylate/Ethalkonium Chloride Acrylate Copolymer, Acrylamidopropyl Trimonium Chloride/Acrylamide Copolymer*, Acrylamidopropyl-Trimonium Chloride/Acrylates Copolymer Polyquaternium-14*, Polyquaternium-28, Polyquaternium-32, Polyquaternium-33*, Polyquaternium-35, Polyquaternium-36, Polyquaternium-37, Polyquaternium-45*, Polyquaternium-47*, Polyquaternium-48*, Polyquaternium-53*, Polyquaternium-63*, Polyquaternium-73*, Polyquaternium-91*, 8 includes Acrylates/C10-30Alkyl Acrylate Crosspolymer, Acrylates/C12-13 Alkyl Methacrylates/Methoxyethyl Acrylate Crosspolymer, Acrylates Crosspolymer, Acrylates/Ethylhexyl Acrylate Crosspolymer, Acrylates/Ethylhexyl Acrylate/Glycidyl Methacrylate Crosspolymer, Acrylates/PEG-4 Dimethacrylate Crosspolymer, Acrylates/Steareth-20 Methacrylate Crosspolymer, Acrylates/Vinyl Isodecanoate Crosspolymer, Acrylates/Vinyl Neodecanoate Crosspolymer, Allyl Methacrylate/Glycol Dimethacrylate Crosspolymer, Allyl Methacrylates Crosspolymer, Butyl Acrylate/Glycol Dimethacrylate Crosspolymer, C8-22 Alkyl Acrylates/Methacrylic Acid Crosspolymer, Glycol Dimethacrylate/Vinyl Alcohol Crosspolymer, Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer, Lauryl Methacrylate/Sodium Methacrylate Crosspolymer, Methacrylic Acid/PEG-6 Methacrylate/PEG-6 Dimethacrylate Crosspolymer, PEG/PPG-5/2 Methacrylate/Methacrylic Acid Crosspolymer, Potassium Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Acrylates Crosspolymer-2, Sodium Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Acrylates/Vinyl Isodecanoate Crosspolymer, and Stearyl/Lauryl Methacrylate Crosspolymer 9 includes Almondamide DEA, Apricotamide DEA, Avocadamide DEA, Babassuamide DEA, Behenamide DEA, Capramide DEA, Cocamide DEA, Cornamide DEA, Cornamide/Cocamide DEA, Hydrogenated Tallowamide DEA, Isostearamide DEA, Lanolinamide DEA, Lauramide DEA, Lauramide/Myristamide DEA, Lecithinamide DEA, Linoleamide DEA, Minkamide DEA, Myristamide DEA, Oleamide DEA, Olivamide DEA, Palm Kernelamide DEA, Palmamide DEA, Palmitamide DEA, Ricebranamide DEA, Ricinoleamide DEA, Sesamide DEA, Shea Butteramide/Castoramide DEA, Soyamide DEA, Stearamide DEA, Tallamide DEA, Tallowamide DEA, Undecylenamide DEA, and Wheat Germamide DEA 10 DEA salts include: Diethanolamine Bisulfate, DEA-C12-13 Alkyl Sulfate, DEA-C12-15 Alkyl Sulfate, DEA-C12-13 Pareth-3 Sulfate, DEA- Cetyl Sulfate, DEA-Cocoamphodipropionate, DEA-Dodecylbenzenesulfonate, DEA-Isostearate, DEA-Laureth Sulfate, DEA-Lauryl Sulfate, DEA-Linoleate, DEA-Methyl Myristate Sulfonate, DEA-Myreth Sulfate, DEA-Myristate, DEA-Myristyl Sulfate, DEA Stearate 11 TEA-containing ingredients include: Magnesium/TEA-Coco-Sulfate, Sodium/TEA C12-13 Pareth-3 Sulfate, TEA-C10-15 Alkyl Sulfate, TEA- C11-15 Alkyl Sulfate, TEA-C12-13 Alkyl Sulfate, TEA-C12-14 Alkyl Sulfate, TEA-C12-15 Alkyl Sulfate, TEA-C11-15 Pareth Sulfate, TEA- C12-13 Pareth-3 Sulfate, TEA-Canolate, TEA-Cocoate, TEA-Coco-Sulfate, TEA-Glyceryl Dimaleate, TEA-Hydrochloride, TEA-Hydrogenated

11 Cocoate, TEA-Isostearate, TEA-Lactate, TEA-Laurate, TEA-Laurate/Myristate, TEA-Laureth Sulfate, TEA-Lauryl Sulfate, TEA-Myristate. TEA-Oleate, TEA-Oleyl Sulfate, TEA-Palmitate, TEA-PEG-3 Cocamide Sulfate, TEA-Sorbate, TEA-Stearate, TEA-Sulfate, TEA-Tallate, and TEA- Undecylenate when TEA-Lactate is used in cosmetics similar to other alpha hydroxyl acids, the qualifications on safety included in the Lactic Acid safety assessment also should be heeded.

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13 Cosmetic Ingredient Review, th Street, NW, Suite 310, Washington, DC ph fax