탈모에대한최근연구동향. (Recent research trend of alopecia)
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1 탈모에대한최근연구동향 (Recent research trend of alopecia)
2 목차 Introduction ( 탈모의종류, 모낭의구조및특성들 ) 현재쓰이는탈모치료법 새로운탈모치료법인세포치료제소개 ( 동국대개발 )
3 탈모란 (alopecia)? Alopecia has no difficulty in life but it affects on social activities 탈모증은경미한머리카락의가늘어짐부터완전한대 머리까지 Alopecia type scarring Non-scarring fibrosis non-fibrosis Destructive present hair follicle hair follicle temporal alopecia eternal alopecia More than one million person suffer from abnormal alopecia in Korean males. (about one person per ten persons) congenital alopecia ( 先天的脫毛 ) androgenic alopecia ( 男性形脫毛 ) alopecia areata ( 圓形脫毛 ) telogen hair loss ( 休止期脫毛 ) seborrhoic alopecia ( 脂漏性脫毛 )
4 Alopecia Alopecia has no difficulty in life but it affects on social activities More than one million person suffer from abnormal alopecia in Korean males. (about one person per ten persons) Alopecia type scarring fibrosis Destructive hair follicle eternal alopecia Non-scarring non-fibrosis present hair follicle temporal alopecia congenital alopecia ( 先天的脫毛 ) androgenic alopecia ( 男性形脫毛 ) alopecia areata ( 圓形脫毛 ) telogen hair loss ( 休止期脫毛 ) seborrhoic alopecia ( 脂漏性脫毛 )
5 탈모의종류 1. 휴지기탈모 (telogen effluvium) 2. 의학적질병의증상 (symtom of medical disease) 3. 머리백선증 (tinea capitis) 4. 약물부작용 5. 원형탈모증 6. 외상탈모증 7. 남성탈모증 8. 여성형탈모증
6 What is hair? The mature hair follicle is a small but complex and dynamic organ, and it provides important functions that promote social interactions. The hair follicle is composed primarily of epidermal and dermal tissues. The dermal components of the follicle, namely the dermal papilla and dermal sheath, are derived from the same mesenchyme. The hair follicles are self-renewing and contain reservoirs of multipotent stem cells, which can regenerate epidermis and are thought to play an impotent role during wound healing. The hair follicle is known that each hair follicle repeats a cyclic process consisting of three phases: a growing phase (anagen), a regressing phase (catagen), and a resting phase (telogen).
7 Researches related to hair follicle hair growth/reduction agent and drug (composition) hair pigmentation control hair cosmetic/tonic agent (composition) hair assay kit/monoclonal antibody/diagnostic technique cell therapy/tissue engineering hair removal electric/magnetic application to hair research hair transplantation
8 다양한탈모치료들 1. 약물치료 ( 프로페시아, 아보다트 ) 2. 모발이식 3. 그외시술들 4. 새로개발된약물혹은임상중인치료법
9 탈모치료를위한모낭세포치료제개발 Development of Hair Cell Therapy Product for alopecia
10 I. 모낭세포치료제의필요성
11 국내총탈모인구증가 실진료환자 (만 여성 남성 명 ) 탈모로인한실진료환자수 (2001~2008) 가 2001 년에비해 60% 증가! 국민건강보험공단건강정책연구원발간자료
12 대륙별탈모인구수 hair restoration surgeries performed in 2006 (patients) Surgical and Non-surgical patients (patients ) Ref. : International Society of Hair Surgery: 2007 PRACTICE CENSUS RESULTS
13 탈모시장규모 미국시장규모 한국시장규모 구분 시장규모 예상시장규모 (2012 년 ) 탈모시장 2008년 20억달러 40억달러 모발이식 2006년 1억2천만달러 2억3천만달러 탈모시장 2조원 3조원 2008년모발이식 3,500억원 7,000억원 산출근거 1) Hair loss treatment & removal in the US: IBISWorld industry report, ( ) 2) International Society of Hair Surgery: 2007 Practice census results 3) 3조머리시장잡기머리싸움뜨겁다. ( 탈모층 20대까지확대-두피케어시장 20-30%)/ 한국마케팅신문 ( ) 4) 신차별화필요 / Biz & Issue ( ) 5) 탈모시장 : 모발관리제품, 모발관리서비스, 탈모치료제, 가발, 모발이식등포함
14 [ 해외임상시험사례 ] Aderans Research Institute (U.S.A) Outline of Aderans hair regeneration Hair forming cell (DPCs) culture and expand Single DPCs transplantation Hair follicle neogenesis Hair regeneration Phase 1 Phase 2 - The treatment was safe in all patients. - New hair: 60~70/100 injection - The number of hairs increased 65%! - The number of hairs over 30 um in diameter increased 71%
15 동국대학교 Self-aggregation method cell culture in 10%FBS-DMEM cell culture in DPFM formation of DP-like tissue (DPLT) 모유두유사조직 1 개당약 3,000~4,000 개의세포로구성 DPFM (dermal papilla forming media) IMDM + high vitamin + high amino acid + trace element + hydrocortisone + HGF (Ref: PCT KR ) In vitro efficacy test In vivo efficacy test nude mouse Day 0 Day 20 Day 15
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