Pulse Electroporation Healing Zone Aesthetics

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1 Pulse Electroporation Healing Zone Aesthetics

2 Various TDD Technologies Electroporation - Using short electrical modulated pulses of high voltage to create transient aqueous pores in the skin. Iontophoresis Using low voltage electrical current to drive charged product through the skin. Sonophoresis Using ultrasound to disrupt the stratum corneum. Thermal energy Using heat to make the skin more permeable Magnetophoresis - has been investigated as a means to increase assimilation across the skin. Needle Free Injection - devices for firing molecules through the skin at high velocity

3 Electroporation Non-invasive Alternative to mesotherapy Virtual mesotherapy or without needles Painless procedure Introduction of drugs Alternating current Acts as a virtual syringe Changes direction (polarity) continuously slowly Generating new pores Micro and macromolecules 500,000 Dalton as collagen Dalton as hyaluronic acid Rearrange the structure in the cells of the outer layer of skin

4 Electroporation For electroporation we need: Membrane potential: volts Disrupt lipid layer Open biological channels (aquous) These channels stay open several seconds Change polarity constantly

5 Background The application of an electrical pulse momentarily disrupts the cell membrane, allowing entry of product. When the pulse ceases, the membrane returns to its original structure, leaving retained product that has penetrated into the interior of the cell in place.

6 Electroporation Electric doors called biological channels Electric pulse changes membrane polarity By slowly changing the polarization we do not cause electrolysis This disrupts lipid layer

7 Open Channels

8 Intercellular Communications

9 Cellular Penetration

10 Electroporation This effect lasts for seconds, therefore allowing the introduction of substances. Hydrofilic and hydrophobic molecules penetrate at the rate of 1g every minutes. Continuous formation and appearance of biological channels Dramatically increases skin permeability.

11 Conclusion Electroporation is a process that uses high-voltage current to make cell membranes permeable to allow the introduction of new materials. In a practical sense Electroporation is opening a door that allows us to insert products into the body.

12 Methodology Research documents 4 times better results when you do an exfoliation such as a peel or micromicrodermabrasion before Electroporation. This eliminates dead cells from the Keratinic layer. This changes the skin potential and makes it easier to create biological channels.

13 Comparison with No Microdermabrasion - No Dermoelectroporation No Microdermabrasion - Dermoelectroporation Only Microdermabrasion Only - No Dermoelectroporation Microdermabrasion & Dermoelectroporation

14 Indications Introduction of substances for: Skin treatment Cellulite Flaccidity Wrinkles Obesity Collagen production

15 Contraindications Pacemakers, heart valves or other active implants. Epilepsy Pregnant women Immediately after Botox Skin outbreaks or on infected tissue Metal plates or other metal objects Ulcer or gastroenteritis

16 Wrinkles Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion. Optional: Use a micro roller after microderm. Select Protocol: Power: 70% - 80% Time of application: minutes Amount of product: 4 to 6 cc, divided into face, neck, and décolleté Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during five to six weeks After one session every two weeks for one month A monthly session as maintenance

17 Décolleté Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion. Optional: Use a micro roller after microderm. Select Protocol: Power: 70% - 80% Time of application: minutes Amount of product: 4 cc Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during five to six weeks After one session every two weeks for one month A monthly session as maintenance

18 Body Firming Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion. Optional: Use a micro roller after microderm. Select Protocol: Power: 80% - 90% Time of application: minutes Amount of product: 5 to 6 cc (depending if we have to reduce or reaffirm) Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during six to eight weeks After one session every two weeks for one month A monthly session as maintenance

19 Breast Firming Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion or gentle enzyme peel. Select Protocol: Power: 80% - 90% Time of application: minutes Amount of product: 3 to 4 cc Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during six to eight weeks After one session every two weeks for one month A monthly session as maintenance

20 Facial Rejuvenation Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion. Optional: Use a micro roller after microderm. Select Protocol: Power: 70% + Face, 30-40% Lips Time of application: minutes Amount of product: 5 to 6 cc, divided into face, neck, and chest (also hands) Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during three to four weeks After one session every two weeks for one month A monthly session as maintenance

21 Localized Obesity Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion. Optional: Use a micro roller after microderm. Select Protocol: Power: 85% - 95% Time of application: minutes Amount of product: 6 to 10cc Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during six to eight weeks After one session every two weeks for one month A monthly session as maintenance

22 Cellulite Instruction: Clean and dry skin the skin. Exfoliate by microdermabrasion. Optional: Use a micro roller after microderm. Select Protocol: Power: 85% - 95% Time of application: minutes Amount of product: 6 to 10cc Method: Circular motion, soft and slow until completely absorbed Frequency of session: One session a week during six to eight weeks After one session every two weeks for one month A monthly session as maintenance

23 ELECTROPORATION Healing Zone Aesthetics

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