-5 th Generation- Poly-L-Lactic Acid. Thread Lifting
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1 PLLA -5 th Generation- Poly-L-Lactic Acid Thread Lifting
2 Careis What is PLLA? 5 th Generation of polymer suture extracted from plants A type of AHA (Alpha-Hydroxy Acid) Originally developed and marketed in Europe since 1999 in over 150,000 clinical cases and in over 30 countries to date Used for numerous years in soluble suture material and other devices, including absorbable sealants, flow restrictors, fixation systems, fixation screw, and in tissue generation Currently being used in 46 countries in the world The U.S FDA & Korea FDA has approved PLLA for use in wrinkle filler respectively
3 Careis Poly-L-lactic acid Poly-L-lactic acid is a biocompatible and biodegradable polymer from the alpha-hydroxy-acid family Poly-L-lactic acid can be thought of as an approximate nonsurgical equivalent to facial fat grafting Serving in a rejuvenative capacity, PLLA is inserted into the subcutaneous plane to gradually cause volumetric expansion over time Unlike other dermal fillers that are intended to correct discrete facial deficiencies (e.g. lines, folds, and attenuated lips), PLLA is designed to provide volumetric expansion of volume-deficient areas The stimulatory action of PLLA is one of the main characteristics that differentiate it from other fillers PLLA provides a semi permanent to correct facial volume loss
4 Mechanism of Action Metabolism CO2 H2O Hydrolysis (Non-enzymatic) Glucose PLLA Polymer Lactic Acid monomers Metabolic products PLLA degradation occurs through non-enzymatic hydrolysis into lactic acid monomers that are metabolized into CO2, H2O or incorporated into glucose. The mechanism of action occurs through the stimulation of fibroblasts in response to a subclinical tissular inflammation. It is this fibroplasia that produces the desired cosmetic result. After the certain period, there is no evidence of fibrosis and the PLLA particles disappear. Careis
5 Careis Collagen stimulator < PLLA & Collagen production at a period of 12 months and 30 months > 12 months after PLLA insertion Cohesion of PLLA with collagen tissue and histiocyte 30 months after PLLA insertion Absorption of PLLA materials
6 Careis Wrinkle Improvement Improvement Ra ate for Wrinkle WEEK MONTH MONTH MONTH MONTH MONTH MONTH 25 U.S FDA has approved of 25 months of consistent effects with PLLA Improvement effects from 3 week till 25 month continuously
7 How PLLA works? Wrinkles before treatment When PLLA is inserted, the PLLA is absorbed inserted volume immediately with a slight increase in wrinkle fills out the wrinkles and volume depth defects Stimulation of your own facial collagen production resulting in a natural, soft build-up of the connective tissue, smoothing out wrinkles and contour defects; 8 weeks after treatment Clear improvement and disintegration of PLLA Careis
8 Careis Benefits Biodegradable Biocompatible Nonimmunogenic Long lasting filler material over period of several months; its effects may last up to 2 years Treatment for the sagging Effective product for the voluminization of the face and correction of unaesthetic scars A refined, more youthful looking appearance PLLA is totally eliminated from the body in 18 months Safety
9 Careis Polydioxanone vs Poly-L-Lactic acid PDO PLLA Generation of Polymer 3 rd Generation 5 th Generation Durability Efficacy Diameter change in Saline solution after 50 days 6 months Dermal disintegration & great absorbability Safety No infection Easy procedure 0.172μm 0.172μm (No change) More than 18 months (up to 24 months) Long-term safety (decomposed into CO2 & H2O& Glucose) Facial lifting & restoration fullness to lost facial volume Long lasting Cost efficiency 0.170μm 0.191μm (12% increase) lifting & volume
10 Changes in PLLA thread thickness by moisture Careis
11 Careis The story of PLLA thread Up to year of 2011, only monofilament thread was available in the markets. By improving the shape and function over time, PLLA has been used both in Europe and the United States since PLLA (Poly-L-lactic acid) PDO (Polydioxanone) Mono-filament 6 months lasting Poly-filament - bio-absorbable polymer The most recent development in thread lifting Positive impact of methodology Optimize treatment outcome More consistent cosmetic effects - last up to 24 months
12 Careis PLLA Thread Applications & Specification (1) Mono (Basic) Type Gauge Length MONO (Basic) 31G 29G 27G 26G 12mm 40mm 50mm 50mm 60mm 90mm
13 Careis PLLA Thread Applications & Specification (2) Screw (Strong Face Lifting) -Patent no : Type Gauge Length SCREW 29G 27G 26G 40mm 50mm 60mm
14 Careis PLLA Thread Applications & Specification (3) Double Screw (Lifting & Volume) -Patent no: X Twin (Face Contouring, Body line lifting, Hip up, Breast up, Arms, Abdomen) -Patent no: Type Gauge Length DOUBLE SCREW 27G 25G 40mm 50mm 70mm Type Gauge Length 2X TWIN 27G 40mm 50mm 26G 90mm
15 Careis PLLA Thread Applications & Specification (4) Net (Volume) CHAIN (Wrinkle) Type Gauge Length 29G 40mm NET 27G 50mm 26G 60mm Type Gauge Length 29G 40mm CHAIN 27G 50mm 26G 60mm
16 Careis PLLA Thread Applications & Specification (5) Broom (wrinkle & volume) Type Gauge Length BROOM 25G 30mm 40mm 50mm
17 Plla Thread Before & After Case
18 CASE 1- (1) Effects : to add volume to face overall (side view)
19 CASE 1- (2) Effects : to add volume to face overall (front view)
20 CASE 2 Effects : to remove forehead wrinkles & wrinkles around eyes
21 CASE 3 Effects : to remove smile line & treatment of sagging under eyes
22 CASE 4
23 CASE 5
24 Thank You
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