The Safety and Efficacy of a Sustainable Marine Extract for the Treatment of Thinning Hair
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1 The Safety Efficacy of a Sustainable Marine Extract for the Treatment of Thinning Hair A Summary of New Clinical Research Alopecia thinning hair are highly prevalent conditions affecting a large proportion of men women In the U.S alone, 50% of women will suffer from hair loss at some point in their lives 50% of men experience hair loss before the age of % of womenunder theageof 50, who presentedat a dermatology clinic for non-hair concerns, exhibited diffused hair loss diagnosed at greaterthanludwigstageii. 2 By theageof 30, 25% of Caucasianmenshow signs of rogenic balding by age 60, 67% are bald or balding. 3 1 Rogers et al., J Am AcadDermatol Gan & Sinclair,J InvestigDermatolSympProc Stough et al. Mayo ClinProc
2 Diet nutrition can greatly influence the hair condition alopecia Various factors can lead to hair loss: Androgenic alopecia is generally the most common type in men Causesofhairlossorthinninghairhasprovenmore complex inwomen Diet, medications, past existing medical conditions, a family history of alopecia The negative impact of malnutrition on hair is already well established. 1-3 Little systematic attention has been paid to the impact of average western diets on hair growth. Isolated reports have evaluated the influence of various dietary supplements such as: Millet Extracts, Biotin, L-Cystine, B-complex vitamins 4 Omega 3 6 fatty acids antioxidants including Lycopene 5 Pantothenic Acid 6 1 Trost et al., J Am AcadDermatol Strumia, Am J ClinDermatol Patel et al., Indian J Pediatr Trueb, Hair Growth Disorders Le Floc'h et al., J Cosmet Dermatol Lengge et al., Therapy Fish Fish Protein-Rich Protein-Rich Diet Diet Healthy Healthy looking looking Hair Hair Skin Skin Study of Scinavian Inuitsin 1980 s Moisture retention elasticity in Skin Pigment Anagen lifecycle benefits for hair Diet rich in deep sea marine protein AminoMar Complex A proprietary blend of proteins, lipids, glycosaminoglycans derived from sustainable marine sources present only in Viviscal 2
3 Double-blind, placebo-controlled clinical trials have established the safety efficacy of Viviscal Study Duration of Study (months) Double-Blind Placebo-Controlled Participants Ablon Dayan, Yes Yes 40 females Ablon, Yes Yes 60 females Bloch, No No 52 females Pinski, 2014 c N/A No No 20 males 20 females Thomas J. Stephens & Associates et al., Yes Yes 72 females Ablon, Yes Yes 15 females Jackson, No No 16 African American females Thomas J. Stephens & Associates, Weeks No No 16 females The following studies were conducted prior to Lifes2good, Inc. s involvement with Viviscal Pereira, No No 200 males d Majass et al., No No 23 males 61 females Lassus et al., No No 30 males Lassus Eskelinen, Yes Yes 40 males e Lassus Santalahti, No No 20 males 20 females Daily treatments of Viviscal significantly increases the thickness caliber of the vellus hair 72 subjects with self-perceived thinning hair were romized in two groups. Subjects received daily doses of Viviscal or a placebo for 6 months. Thickness of the vellushair was measured in a 0.25 cm 2 area of scalp utilizing phototrichogram imaging. Viviscal Placebo Vellus Hair Thickness * The thickness of vellushair increased by 7.4% after 6 months of dietary supplement *Thomas J. Stephens & Associates et al.,
4 Daily intake of Viviscal increases the number of terminal vellus hairs while reducing the shed hair count 60 women with self-perceived thinning were romized to Viviscal or a placebo for 3 months. The change in hair count was assessed on a 4 cm 2 area of scalp using phototrichograms. Vellus Hair Thickness ** 32% Baseline 0 ** * Terminal Vellus Hair Shed Hair Hair The number of terminal hairs increased by 32% in the Viviscal group 8.2% The number of vellushairs increased by 8.2% Shed hair count decreased by 39% 3 months 39% Ablon, Dermatology Research Practice Viviscal significantly enhances existing hair growth diameter 40 women were romized to either receive daily doses of Viviscal or a placebo for 6 months The change in hair count was assessed on a 4 cm 2 area of scalp using phototrichograms Terminal Hair Baseline 3 months 6 months ** 80% Viviscal Placebo 57% increase in hair count after 3 months of daily treatments with Viviscal 80% increase in hair count after 6 months of daily treatments Viviscal Ablon& Dayan, Journal of Clinical Aesthetic Dermatology
5 Current treatments for alopecia thinning hair provide limited success Current treatment options include topical formulations, prescription medications, oral supplements. FDA Approved Non-FDA Approved Dietary Minoxidil, Finasteride (men only) Anti-rogens (women): Spironolactone, Flutamide, Cyproterone acetate, Cimetidine 5-alpha reductase inhibitors (women): Finasteride, Dutasteride Estrogens (women): 17 α-estradiol estrogen, Receptor antagonists Melatonin Millet Extract, Pantothenic Acid, CYP-Complex, Biotin, L-Cystine, B-complex vitamins These are often used in combination as no one treatment has been proven fully effective when used alone. Moreover, topical as well as prescription medications can entail unwanted side effects on patients van Zurrenet al., Br J Dermatol van Zurrenet al., Cochrane Database SystRev Irwig,Curr OpinEndocrinolDiabetes Obes Viviscal Cosmetics work from the outside to create the optimal environment for healthy hair growth. The shampoo, conditioner elixir contain the proprietary complex Ana:Tel, which is proven to promote thicker, fuller looking hair. Ana:Telcontains clinically tested ingredients derived from natural sources, such as pea sprouts. 5
6 Thin to Thick Shampoo Cleanses with a light, creamy lather Rinses out easily Refreshing botanical scent that lasts Free from SLS & SLES, Parabens Artificial Colors 93% of users said it produced enough foam 94% of shampoo users said it rinsed out easily 8 out of 10 users said their hair felt smooth Thin to Thick Conditioner Weightless formula Lightly moisturizes Leaves hair looking thicker, fuller gorgeous Sulfate-Free, Free of Parabens & Artificial Colors 85% of conditioner users said their hair felt smooth after the first use 87% said their wet hair was easier to comb through after the first use 9 out of 10 women said it did not weigh down their hair 6
7 Lightweight Body-boosting Leave-in treatment for thicker looking hair Sulfate-Free, Free of Parabens & Artificial Colors Thin to Thick Elixir 94% of elixir users said it was easy to apply 85% said their hair felt thicker & fuller after drying, after 1 week of use 88% said it did not weigh down their hair Directions: Apply 2-3 pumps (depending on hair length) onto the palm of your h disperse throughout damp hair using your fingers, or comb through. Alternatively, use as a styling aid on dry hair as required. Suitable for everyday use. Conceal Densify Fibers Thicker Looking Hair Instantly Volumizesthe appearance of your hair in seconds Unique, easy-to-use Precision Comb Applicator delivers instant results Lasts all day in wind rain Washes out easily with shampoo Suitable for men women of all hair types *New* Innovative Applicator 7
SPECIAL TOPIC. Apothekon, Inc., St Paul, MN b. Lifes2good, Inc., Chicago, IL c. Center for Dermatology and Aesthetics, San Antonio, TX d
September 2015 s15 Volume 14 Issue 9 (Supplement) Copyright 2015 ORIGINAL ARTICLES SPECIAL TOPIC The Safety and Efficacy of a Sustainable Marine Extract for the Treatment of Thinning Hair: A Summary of
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