Over 60 different applications. Modular handpieces make the difference

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2 No devie will do more than the Harmony XL to help you suessfully attrat, treat and retain the broadest range of lients to grow your pratie profitably. Ten distint tehnologies, many with integrated ontat ooling 60+ aestheti/medial appliations High output energy for greater effiay Expandable and upgradeable Inludes omponents for Laser360 skin rejuvenation High patient and linial staff satisfation Easily transportable from room to room and between failities Today s aestheti patients have a wide variety of needs. Now you an suessfully meet them all with Harmony XL. The Harmony XL is the world s most expandable platform for aestheti laser and light treatments. Modular in design, it uses up to ten distint tehnologies built into one ompat unit, and the multi-appliation system an treat more than 60 different aestheti onditions. Key parameters of every output an be preisely ontrolled for any therapeuti level. Best of all, you an always upgrade your Harmony XL to inlude future tehnologies still in development. Over 60 different appliations The Harmony XL gives you ultimate flexibility to treat a wide variety of patient-requested proedures. The platform expands to inlude the tehnologies most relevant to your pratie and needs, so it an grow with you as your pratie grows. Modular handpiees make the differene All the Harmony XL handpiees are designed for minimal or no disomfort to the patient, with no loss of effetiveness. Use them in ombination for a wide variety of treatment options. One of the most popular options is the Laser360 protool for easy skin rejuvenation. The relatively new proedure uses 3 handpiees from the Harmony XL system to treat a wide range of age and photo-damage symptoms. Patients ahieve outstanding results in just 60 days, with minimal or no downtime.

3 Popularity of Aestheti Proedures Body Contouring Not available on the Harmony System. See an Aent XL representative. 7% Pigmented & Vasular Lesions AFT-515SVL AFT-540VP 9% 12% Skin Resurfaing High Power Pixel 2940 Er:YAG 11% 3% 3% Ane Redution AFT-420 Skin Tightening NIR-ST 1 26% 29% Tattoo Removal QS Nd:YAG 1064/532 Skin Rejuvenation AFT-570SR/SSR 2 Hair Removal NIR SHR The Harmony System has been the hub of our laser servies. The quality of the treatments is real and palpable. Our patients line up to get their spots removed with our AFT system and to have their fae resurfaed with our Pixel. They get a super deep treatment with great results and minimal down time. John Hamel, MD Founder and Owner of Complete Laser Clini sine Indiated for photothermolysis (photooagulation or oagulation) of soft tissue and other aestheti onditions 2 Indiated for the treatment of benign utaneous vasular and benign pigmented epidermal lesions inluding dyshromia and other aestheti onditions

4 State-of-the-Art Tehnologies Harmony XL delivers the latest in tehnial performane with an unrivaled edge: modularity and upgradeability. Buy only the tehnologies you need now, and expand as you expand the sope of your aestheti pratie. Beause the tehnology is in the handpiees (not the system), an expansion or upgrade is simple and quik. Even more, the system features a detahable design where the top and bottom split apart. This innovation makes it very easy to move Harmony XL from room to room. The Alma Lasers differene Harmony XL aommodates Advaned Fluoresene Tehnology (AFT) pulsed light and laser tehnology in the same system. Its high power allows for higher fluene treatments but patient omfort is optimized through the proprietary IN-Motion TM tehnology, unique to Alma Lasers. For additional patient omfort, you also have your hoie of ontat-ooled or non-ooled handpiees. Exlusive to Alma Lasers, Harmony XL boasts the Pixel tehnology a breakthrough for frationated ablative treatments. In addition, you an inlude one or all of the following tehnologies to expand your servie options: Advaned Fluoresene pulsed light for the treatment of ane, vasular and pigmented lesions, leading to skin rejuvenation. NEW! Now available with integrated ontat ooling Near Infrared for deep dermal heating and NEW virtually painfree hair removal High Power Pixel 2940 Er:YAG for frationated ablative skin resurfaing of mild age and photo-damaged skin, as well as for minimally ablative resurfaing proedures Long-pulse 1064 Nd:YAG for leg veins and other vasular lesions Pulsed UVB for restoration of lost pigment and psoriasis Q-Swithed Nd:YAG for dark olored tattoo removal and dermal pigmented lesions Frequeny Doubled Nd:YAG for lighter olored tattoo treatment Long-pulse 1320 Nd:YAG for the non-ablative treatment of faial wrinkles to improve the appearane of photo-aged skin NEW! LED handpiee for topial heating leading to inreased blood flow, temporary relaxation of musles and relief of pain AFT spetral onversion AFT takes formerly unused short-wavelength light and onverts it into part of the usable spetrum. Fluene Converted Ultraviolet To Optimal Spetrum Wavelength

5 Take the guesswork out of laser aesthetis Whatever your medial speialty, Alma Lasers has made it easy for all physiians to offer light-based aestheti servies through a treatment protool that uses Harmony XL tehnologies alled Laser360 TM. Laser360 is a popular and very easy way to help improve a patient s skin olor, texture, tone and laxity. It uses 3 tehnologies, takes 60 days and offers a omplete range of skin rejuvenation results. Laser360 meets the key needs of an aging patient s skin, and it an be ustomized to meet eah patient s speifi needs. Use it to treat areas suh as the fae, nek, hest, and hands, or anywhere the skin has been touhed by age or photo-damage. Laser360 How Laser360 treats the most ommon age-related skin omplaints Before Color with Advaned Fluoresene Tehnology (AFT) Treat superfiial vasular and pigmented irregularities to improve a patient s skin olor. You ll use a series of approximately five treatments using one of the AFT handpiees on Harmony XL : SR/SR (ooled)(skin rejuvenation) SVL/SVL (ooled)(superfiial vasular/pigmented) VP/VP (ooled)(vasular/pigmented lesions) Tehnologies In Depth: AFT AFT is the next generation of intense pulsed light. It takes formerly unused short-wavelength light and onverts it into part of the usable spetrum through a speial filtering system. It inreases emission and penetration, for safer and more effetive treatments. After Photos ourtesy of: Rik Jakson, MD AFT also delivers Equally Distributed Fluene, whih means that every pulse has uniform energy density aross the entire output fae. This fluene ensures repeatable results and remarkable safety. AFT yields a more effiient system for ideal linial improvements, less disomfort and minimal skin damage.

6 Skin Color Handpiees Handpiee Appliations Tehnology Wavelength (nm) Pulse Widths/ Mode Spot Size Pulse Repetition Rate (Hz) Energy Density SVL SVL (ooled) VP VP (ooled) Superfiial vasular lesions Superfiial vasular lesions Vasular and pigmented lesions Vasular and pigmented lesions AFT , 12, 15 ms 6.4 m 2 2/ J/m 2 AFT , 12, 15 ms 3 m 2 2/ J/m 2 AFT , 12, 15 ms 6.4 m 2 2/ J/m 2 AFT , 12, 15 ms 3 m 2 2/ J/m 2 SR Skin rejuvenation AFT , 12, 15 ms 6.4 m 2 2/ J/m 2 SR (ooled) Skin rejuvenation AFT , 12, 15 ms 3 m 2 2/ J/m 2 Texture and tone Give your patients a more youthful appearane with the High Power Pixel 2940 skin resurfaing laser on Harmony XL. A series of two to four virtually pain-free treatments will gradually stimulate new ells to replae aged and photo-damaged skin, with little patient downtime. Tehnologies In Depth: Pixel With the High Power Pixel 2940, preprogrammed laser energy passes through the patented Pixel miro optis lens array and penetrates the skin, affeting just perent of the surfae. It reates an ablative thermal hannel at the pixel area a miro-injury without disturbing the surrounding tissue. Those miro-injured areas start the proess of healing and the untreated area ats as a reservoir for rapid restoration. As ollagen remodels, skin tightens and texture improves. The gentleness of the proedure allows deliate areas suh as the nek, hest and hands to be treated as safely as the fae with little risk of infetion. There is little downtime or disomfort, and no analgesia, gels or other disposables are required. Before After Photos ourtesy of: Guilherme Olsen de Almeida, MD Pixel 2940 for frationated ablation With the Pixel 2940, the ablation zone is 9 x 9 mm in size, with a penetration depth of µm. The handpiee operator an deide the appropriate dot pattern. Skin Texture and Tone Handpiee Handpiee Appliations Tehnology Wavelength (nm) Pulse Widths/ Mode Spot Size Pulse Repetition Rate (Hz) Energy Density Frational ablative skin resurfaing Frationated Er:YAG Short, Medium, Long 7 x 7 mm Pixels 9 x 9 mm Pixels mj/p High Power Pixel 2940 Skin resurfaing, laser peel Er:YAG 2940 Gentle Peel (1 20 µm) Skin Remodeling ( µm) 1, 4 mm 5 Up to 1200 mj/p Surgi-Light (utting)

7 Alma Lasers has definitely given me the most amazing proedure I an offer my patients. Laser360 s unique ombination of tehnologies provides fast, effetive skin rejuvenation with results my patients and I an ount on. Eduardo Weiss, MD Hollywood Dermatology & Cosmeti Speialists Tightening Deliver deep dermal heating that indues neoollagenesis using the Near-infrared ST handpiee on Harmony XL. A series of three to six treatments produes a tighter, fresher appearane without pain or invasive proedures. Tehnologies In Depth: ST Before The near infrared ST handpiee delivers uniform energy distribution and effetively targets lipids and onnetive tissue. It exerts its biologial effet on the skin through two major mehanisms: Heat-indued ollagen shrinkage and miro-thermal injury Dermal regeneration, repair (healing) and remodeling The ST handpiee produes dramati, yet omfortable deep dermal heating without damage to the epidermis. After Photos ourtesy of: Ilan Karavani, MD Skin Tightening Handpiee Handpiee Appliations Tehnology Wavelength (nm) Pulse Widths/ Mode Spot Size Pulse Repetition Rate (Hz) Energy Density ST Dermal heating NIR , 30, 90 s 6.4 m J/m 3

8 Hair Removal & More In-Demand Appliations IN-Motion TM Tehnology removes pain IN-Motion Tehnology represents a breakthrough in patient omfort, speed of proedures and repeatable linial results. Why? Beause the high peak energies used in traditional photoepilation tehnology must have high ooling before, during and after eah pulse and therefore the handpiee must be stationary during the energy delivery. Alma Lasers unique IN-Motion tehnology ombines onurrent ooling with a gradual thermal rise to the target s therapeuti temperature, without the risk of injury and with muh less pain for the patient. Hair removal Hair removal is the most popular light-based aestheti proedure in the world. Using a novel nm AFT handpiee, Harmony XL an deliver fast, effetive results for permanent hair redution on all skin types, inluding tanned skin. This SHR handpiee now has ontat ooling and uses IN-Motion tehnology for virtually pain-free proedures with no downtime Alma Lasers remarkable Pain Free, Hair Free proedure. How it works To perform light-based hair removal, a large retangular window emitting broadspetrum light is applied to the surfae of the skin. The energy travels harmlessly through the epidermis and dermis until it strikes the hair follile, whih ontains a dense, melanin-rih hair shaft and bulb. The dark-olored melanin absorbs the light and rises quikly in temperature, destroying the hair-produing ells surrounding the follile. Beause the heat is not sustained, however, no damage ours outside the follile area. Before After Photos ourtesy of: Arie Orenstien, MD Hair Removal Handpiees Handpiees Appliations Tehnology Wavelength (nm) Pulse Widths/ Modes Spot Size (m 2 ) Pulse Repetition Rate (Hz) Energy Density (J/m 2 ) SHR (ooled) Pain-free hair removal AFT , 3 & 30 s

9 Ane Clear inflammatory ane lesions without drugs or undesirable side effets, with the AFT Ane Handpiee. Intense blue wavelengths in the range of nm target the porphyrins produed as part of the normal metabolism of p. anes bateria. The interation of the intense blue light and the porphyrins reates singlet oxygen that rapidly destroys the bateria without damaging the surrounding tissue. Ane treatments with AFT are: Non-invasive No topial or systemi drugs Completely painless, no adverse effets or downtime Easy to administer with an ergonomi handpiee design Before Photos ourtesy of: Mihael Shohat, MD After Ane Handpiee Handpiees Appliations Tehnology Wavelength (nm) Pulse Widths/ Modes Spot Size (m 2 ) Pulse Repetition Rate (Hz) Energy Density (J/m 2 ) Ane Ane AFT , 40, 50 ms 6.4 2/3 5 25

10 Medial Appliations Vasular and pigmented lesions Symptoms of Roseea Four handpiees on Harmony XL an treat a wide range of vasular and pigmented lesions, as well as other skin abnormalities. These types of appliations are typially treated in a dermatologi or other traditional medial setting. The AFT VP and the new, ooled VP handpiees take advantage of strong absorption of both melanin and oxyhemoglobin in the nm range. They suessfully treat many vasular and pigmented lesions suh as: Port wine stains, hemangiomas, telangeitasias, symptoms of rosaea, angiomas and Poikiloderma of Civatte Before Lentigos, melasma, seborrihei keratoses, afé-au-lait, dyshromia, ephelides and dyspigmentation For superfiial lesions, shifting muh of the energy to shorter wavelengths that still have strong melanin/oxyhemoglobin absorption yet penetrate less deeply the SVL and new, ooled SVL handpiees offer superior performane. For stubborn lesions, the SVL handpiees omplement the VP handpiees to offer additional range. Melanin/Oxyhemoglobin absorption urves After Photos ourtesy of: E. Follador MD, F. Marini MD, D. D angelo MD Absorption (log sale) Oxyhemoglobin Melanin Water Wavelength (nm)

11 Leg veins Treat leg veins with long-pulsed 1064-nm light. The Nd:YAG 1064 laser handpiee oagulates and destroys large, deep, yet osmetially unaeptable blood vessels and leg veins without the use of hemials or needles. This easy-to-use, ergonomi handpiee effetively oagulates oxygenated reddish telangietasias, as well as deoxygenated bluish venule etasia and retiular veins up to 4 mm diameter. Dermatoses The UVB handpiee uses high-power, spetral irradiane in the UVB and UVA wavebands to target and treat dermatoses suh as psoriasis, leukoderma, vitiligo, streth marks (striae distenase), atopi dermatitis (ezema), seborrhei dermatitis and hypopigmented sars. The treatment is muh faster than either PUVA or UVB phototherapy. It involves no drugs and treats only speifi areas to avoid exposure to healthy tissue. NEW! Promote healing The new LED handpiee inorporates an array of diodes that emit yellow light at 590 nm for general body healing. The linial indiations of the LED 590-nm handpiee inlude: Topial heating to promote inreased blood flow Temporary relaxation of musles Relief of pain Non-Laser Handpiees Handpiee Appliations Tehnology Wavelength (nm) Pulse Widths/ Timers Spot Size (m 2 ) Pulse Repetition Rate (Hz) Energy Density (J/m 2 ) SVL SVL (ooled) VP VP (ooled) Superfiial vasular lesions Superfiial vasular lesions Vasular and pigmented lesions Vasular and pigmented lesions AFT , 12, 15 ms 6.4 2/ AFT , 12, 15 ms 3 2/ AFT , 12, 15 ms 6.4 2/ AFT , 12, 15 ms 3 2/ UVB Dermatology onditions LED Dermal Heating LED 590 UVB , 40, 50 ms 6.4 1/ Repeat Up to 70s , 40, 50 ms Up to 70 min 1.5 W Laser Handpiees Handpiee Appliations Tehnology Wavelength (nm) Pulse Width / Mode Spot Size (mm) Pulse Frequeny (Hz) Energy Density/ Fluene Long-pulse 1064 Nd:YAG Vasular lesions 10 ms J/m 2 Nd:YAG Leg veins 15, 45, 600 ms J/m 2

12 Other Appliations Tattoos The Q-Swithed Nd:YAG handpiee on Harmony XL uses two disrete wavelengths to treat a broad range of tattoo olors, inluding: Dark olors like blak, blue and green with 1064-nm wavelength Brighter olors like red, orange and yellow with 532-nm wavelength How it works Tattoo ink and natural pigmentation like melanin absorb short pulse duration/high peak energy Q-swithed pulses so quikly that they reate a photo-aousti effet within the pigment lusters. This effet breaks down the ink into muh smaller partiles that an be more easily removed by the body s natural filtering system. Tattoo removal typially requires six to eight or more treatments, spaed approximately six to eight weeks apart. Using the Q-Swithed Nd:YAG handpiee on Harmony XL means those treatments are: Easy to administer simple to swith between wavelengths Customizable with a wide assortment of spot sizes, along with Quik Snap disposable tips that protet against ross ontamination Also able to treat dermal pigmented lesions suh as nevus of Ota Alma Lasers uses state-of-the-art tehnology ombined with intelligent flexible platforms. The laser heads are easily interhangebable on the Harmony XL. Their tehnial support is superior and ost savings, not to mention the linial results, have been most impressive. Vitoria A. Cirillo-Hyland, MD Cirillo Cosmeti Dermatology Spa Tattoo Removal Before Photos ourtesy of: Arie Orenstien, MD Textural Improvements After Before After Photos ourtesy of: BCK Patel, MD, FACS

13 1320 Nd:YAG Use the 1320 Nd:YAG handpiee to treat fine lines, wrinkles and photo-aged skin, as well as mild ane sars. When used to treat aestheti imperfetions inluding periorbital and perioral wrinkles the 1320nm wavelength ahieves deep penetration and targets seleted waterontaining tissue by raising the dermal temperature. How it works With the 1320 Nd:YAG handpiee, you have Immediate readiness: preprogrammed pulse width and repetition rates mean faster treatments with no down time Easy to administer with an ergonomi handpiee design Improved patient results: lightweight design improves auray Proper ergonomi design: prevent repetitive-motion fatigue Peae of mind: standard safety features prevent aidental double triggering Flexibility to ombine treatment modules: fully-interhangeable handpiee onnets quikly to the Harmony XL platform, making it easy to swith between handpiees Laser Handpiees Handpiee Appliations Tehnology Wavelength (nm) Pulse Width / Mode Spot Size (mm) Pulse Frequeny (Hz) Energy Density Dark-ink tattoo removal Q-Swithed Nd:YAG Q-Swithed Nd:YAG Light-ink tattoo removal Frequeny Doubled Q-Swithed Nd:YAG 20 ns , 2, mj/p 1320 Nd:YAG Ane sars, wrinkles, rejuvenation Nd:YAG , 40, 50 ms J/m 2

14 A Prime Opportunity: Aestheti Mediine There are ountless soial reasons for a urrent surge in the popularity of osmeti proedures: an aging population, a strong eonomy and a elebrity ulture that values youthful attrativeness, to name a few. A number of sientifi, medial breakthroughs, however, have also ontributed to the inredible rise of aestheti mediine s popularity. These novel tehnologies espeially multifuntional, upgradeable systems suh as Harmony XL have positioned this market for growth. Aestheti Market Growth % 22.6% 25.4% 30.7% % Average Annual Growth Laser Hair Removal Vasular/Pigmented Legions Skin Rejuvenation Skin Tightening Aestheti proedures will ontinue to inrease in popularity. Soure: Millennium Researh Group, 2006 Just two to six patients a month an over the ost of your Harmony XL investment. A Signifiant Return Harmony XL, and espeially the Laser360 proedure, represent the best opportunity for a growing aestheti pratie to take advantage of the trends in today s osmeti marketplae. An investment in the Harmony XL an provide the opportunity for a signifiant return. It: Inorporates today s most popular appliations in a single system Redues osts to add additional appliations (even ompared to the used market) Requires no onsumables, whih inreases your profit margin

15 Harmony XL Indiations Ane vulgaris Atini helitis Atrophi ane sars Angiomas and spider angiomas Atopi dermatitis Bak ane Beker s nevi Café-au-lait maules Cavernous hemangiomas Cherry hemangiomas Chloasma Cutaneous lesions Debulking benign tumors Debulking ysts Deep and superfiial telangietasias Dyshromia Ephelides (frekles) Epidermal nevi Erythema of roseea Faial, trunal and leg telangietasias Fine lines and wrinkles Hair removal on all skin types, inluding tanned skin Hemangiomas Hyperpigmentation Hypopigmentation Inreased blood flow, relaxation of musle and relief of pain Keloids Keratoses Leg veins Lentigines (senile and solar) Lentigos Leukoderma, inluding vitiligo Melasma Nevi Nevus of Ota Nevus spilus Perioral wrinkles Periorbital wrinkles Permanent hair redution Pigmented lesions Poikiloderma of Civatte Plaques Pseudofolliulitis barbae Psoriasis treatment Port wine stains Redution in red pigmentation in hypertrophi and keloid sars Retiular veins Roseea Sars Seborrhei dermatitis Seborrhei keratoses Skin resurfaing Skin tags Solar lentigos Spider hemangiomas Spider nevi Spider veins Striae Superfiial skin lesions Surgial inision/ exision, vaporization, ablation and oagulation of soft tissue Tattoo removal: blak, blue, green Tattoo removal: light blue, yellow, red Telangietasias Vasular lesions Venous lake Venous malformation Verruae Warts Speifiations for Harmony XL Harmony XL is designed to be a free-standing unit and uses a standard wall outlet. It transports easily from room to room or between failities. Eletrial VAC, 5 A, 50/60 Hz VAC, 2.5 A, 50/60 Hz Weight 133 lbs. (60 kg) Dimensions (WxDxH) 15.7 x 21.7 x 48.5 (39.7 x 55 x 123 m)

16 About Alma Lasers Alma Lasers, Ltd. is a global developer, manufaturer and provider of laser, light-based and radiofrequeny devies for aestheti and medial appliations. Sine 1980, the founders of Alma Lasers have been at the forefront of innovative multi-tehnology / multi-appliation systems designed to meet the unique needs of today s pratitioners. Alma s mission is to provide modular, ost-effetive and high-performane systems that enable pratitioners to onfidently offer safe, effetive and profitable aestheti treatments to their patients Alma Lasers, Ltd. All rights reserved. Alma Lasers Ltd., its logo, Harmony XL, Aent XL and Pixel are the trademarks of Alma Lasers, Ltd. Produt speifiations are subjet to hange without notie. United States 485 Half Day Road, Suite 100 Buffalo Grove, IL Phn (224) Fax (224) ontat@almalasers.om Headquarters 14 Halamish Caesarea Industrial Park Caesarea, Israel Phn Fax HRP200803U000001