WORESANA. THE ACTIVE INGREDIENT FROM RYE The patented cosmetic active ingredient from fermented organic rye for sustainable skincare WORESANA

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Emory Byrd
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1 WORESANA CONCENTRATE WORESANA FLUID WORESANA SERUM WORESANA THE ACTIVE INGREDIENT FROM RYE The patented cosmetic active ingredient from fermented organic rye for sustainable skincare

WORESANA CONCENTRATE WORESANA FLUID WORESANA SERUM WHY RYE? Rye (secale cereale) is a widespread cereal crop of the sweet grass family (poaceae) grown in temperate climate zones.

2 WORESANA CONCENTRATE WORESANA FLUID WORESANA SERUM WHY RYE? Rye (secale cereale) is a widespread cereal crop of the sweet grass family (poaceae) grown in temperate climate zones. Rye is an all-round talent. It even grows on barren soil since it is very tough and undemanding. Rye was used in traditional pharmacy to strengthen the immune system and to treat asthma and bronchitis. It has been discovered that the risk of cancer is considerably lower amongst Scandinavians, who mainly eat rye grain, than in southern countries where wheat products are preferred. Even menopausal complaints are almost unheard of here. WHY FERMENTATION? Leaven was discovered over 6000 years ago as the result of spontaneous fermentation. Since then the process has been continuously cultivated. Early on it was recognized that rye enzymes can also be helpful to the skin and can be used as a compress on burns and broken skin. The controlled fermentation used today followed by careful pasteurization is what makes lots of active agents in rye bio-available such as a large cocktail of amino acids, enzymes, pentosans and β-1,3 glucan. WORESANA The brand stands for outstanding quality. A 100% natural substance. The patented active ingredient WORESANA for the cosmetic industry, can be used for natural peeling, it plumps up the skin, is an antiirritant, helps generate collagen, has an anti-aging effect and natural anti-dandruff active agents, for balanced cosmetic ranges and for hair care ranges. The various products are equally suitable for conventional cosmetics and the exacting field of natural cosmetics. Source: KAMPFFMEYER Food Innovation GmbH WORESANA concentrate WORESANA fluid WORESANA serum

3 WORESANA Amino acid composition Glutamic Acid Proline Aspartic Acid Leucine Glycine Valine Alanine Phenylalanine Lysine Serine Threonine Arginine Isoleucine Tyrosine Histidine The products can easily be processed in hot or cold state, are approved throughout the world and are BDIH compliant. WORESANA concentrate and serum can be supplied in non-preserved form as long as the whole container is used immediately after opening. Sodium benzoate/potassium sorbate or pentylene glycol are used as preservatives. Other preservatives are available on request. All WORESANA products have a shelf life of 2 years unopened at room temperature. In addition to WORESANA for cosmetics, a specially certified quality for medical products according to ISO can be supplied under the description Ryeactive. COMPOSITION Rich in bio-available active agents. WORESANA has an effective skin-balancing effect due to a pure and natural cocktail of bio-available active ingredients comprising the following components: a wide spectrum of acids such as lactic, malic and acetic acids, amino acids, polysaccharides, vitamins, biotin, minerals and trace elements. As well as these, rye contains 6-8% pentosans (wheat only has 2-3%). These mucilages have a high water binding ability and thus very good filmogenic properties on the skin. We would like to highlight the following groups of substances: Amino Acids: WORESANA provides 6 out of the 8 essential amino acids for the skin. These components make up an important component of the Natural Moisturising Factor (NMF). They have water binding properties and can fend off free radicals. Antioxidants and Vitamins: Of the vitamins, the high concentrations of pantothenic acid (vitamin B5) and nicotinamide in WORESANA should be highlighted in particular. Pantothenic acid can contribute to soothing the skin and quicker skin regeneration. Nicotinamide plays a role where various skin diseases such as dermatitis and acne are concerned and is also significant in ceramide and cholesterol synthesis, which in turn have a stabilising effect on the skin barrier. Wrinkles and hyperpigmentation can thus be reduced. Substances in WORESANA α Tocopherol Vitamin B1 Vitamin B2 Vitamin B3 Typical Analysis Values 1.4 μg / 100 ml 22 μg / 100 ml 1.8 μg / 100 ml 24 μg / 100 ml Folic acid Pantothenic acid Nicotinamide 0.2 μg / 100 ml 83 μg / 100 ml 172 μg / 100 ml

4 WORESANA CONCENTRATE WORESANA FLUID WORESANA SERUM THE POSITIVE EFFECTS OF WORESANA Diverse positive effects. The range of positive effects with respect to the possible uses of WORESANA are very diverse due to its composition. The most important positive effects are: Enzymatic peeling effect due to natural acids (ph ) Harmonises and balances the natural skin flora by adjusting the ph value of skin Returns skin moisture to normal Antioxidant capacity Stabilises the skin barrier Makes skin smoother and lighter Antibacterial and antifungal Filmogenic properties WORESANA has very high skin tolerance even with a 100% concentration in the application. In various toxicological tests, WORESANA was shown to be within normal limits. WORESANA can therefore even be applied to skin at full strength. Its balanced composition makes for gentle chemical peeling. Antibacterial and Antifungal Activity: WORESANA serum showed significant antibacterial activity against propionibacterium acne and staphilococcus epidermidis after 24 hours even with a 3% concentration in the application. PROPIONIBACTERIUM ACNE DMS 1897 KBE/G Time 0 24 hrs 48 hrs 72 hrs 100% 3.9 x % 3.9 x % 3.9 x % 3.9 x x x x 101 STAPH. EPIDERMIDIS DSM KBE/G Time 0 24 hrs 48 hrs 72 hrs 100% 2.3 x % 2.3 x % 2.3 x % 2.3 x In the case of the yeast fungus malassezia furfur, WORESANA serum showed significant antibacterial activity after 24 hours at a concentration in the application of 10% and after 3 days at a 3% concentration. MALASSEZIA FURFUR DSM 6170 KBE/G Time 0 24 hrs 48 hrs 72 hrs 7 days 100% 3.7 x % 4.1 x x 101 3% 4.3 x x x x x 102 1% 4.4 x x x x x 102

Reduction in inflammatory lesions and comedones during the application of WORESANA concentrate (t 0 = 0) Effect on Blemished Skin: The antibacterial effect of WORESANA and its

An acne spot fluid formulation containing 7.5% WORESANA concentrate was applied to the face of a 14-year old with blemished skin once a day for 21 days.

This result was corroborated in a controlled half-side comparison study (n=5, 19-24 years, male and female).

of the face could be observed respectively. The volunteers also said that their skin felt better generally.

5 Reduction in inflammatory lesions and comedones during the application of WORESANA concentrate (t 0 = 0) Effect on Blemished Skin: The antibacterial effect of WORESANA and its balanced composition make the product ideal for applying to blemished skin. Bacteria and inflammatory processes play a major role here. The following images illustrate this efficacy. An acne spot fluid formulation containing 7.5% WORESANA concentrate was applied to the face of a 14-year old with blemished skin once a day for 21 days. A clear improvement in the skin condition could be seen in the process (see photographs). This result was corroborated in a controlled half-side comparison study (n=5, years, male and female). The test persons with acne vulgaris applied an acne spot fluid formulation containing 10% WORESANA concentrate to one side of their faces for minutes (rinse-off mask) every other day for 6 weeks. It was possible to achieve an improvement in skin condition compared to the untreated area and a reduction in the number of lesions and comedones in comparison to the untreated half of the face could be observed respectively. The volunteers also said that their skin felt better generally. It was also possible to prove the anti-inflammatory activity of WORESANA using the ELISA in-vitro test. Hydration and Skin Roughness: In a study of 16 female volunteers, a significant increase (p<0.05) in skin hydration could be detected using a corneometer after 7 days of daily applications of WORESANA concentrate for minutes in comparison to untreated skin (+6%). Moreover, a significant decrease (p <0.01) in skin roughness was measured using skin micro-topography after 7 days (-7.5%). WORESANA thus contributes to sustained improvement of skin condition when applied regularly on a daily basis. Before After

WORESANA CONCENTRATE WORESANA FLUID WORESANA SERUM Effect on Nails: A quite exceptional aspect of WORESANA that can be highlighted is the treatment and care of nails.

Relevant tests with 40% WORESANA serum in the form of a nail care preparation show this impressively.

6 WORESANA CONCENTRATE WORESANA FLUID WORESANA SERUM Effect on Nails: A quite exceptional aspect of WORESANA that can be highlighted is the treatment and care of nails. The combination of substances that build up nails with antifungal and antibacterial activity is ideal for reconstructing chipped nails. Relevant tests with 40% WORESANA serum in the form of a nail care preparation show this impressively. Nail Care Product with WORESANA after 12 Weeks Application: Finished products with up to 100% active ingredients are available. Product applications using WORESANA Blemished skin Oily skin Dry skin Athlete s foot and nail fungus Hair and scalp care, anti-dandruff Gentle peeling for feet, hands and face Cleansing products Make-up products with care aspect POSSIBLE APPLICATIONS USING WORESANA The possible applications of the various WORESANA products are diverse. WORESANA concentrate is left in its natural state and still contains solid bits of rye. The bits of rye are also left in their natural state in the WORESANA fluid but are reduced to smaller pieces. WORESANA serum on the other hand is filtered and is therefore clear so it no longer contains any solid bits of rye. All WORESANA products have a pleasant aroma like fresh bread. Age spots Aging skin After sun There is practically no limit to the galenical possibilities using the three WORESANA products. INCI Name: Lactobacillus / Rye flour / ferment Recommended Use Level: 1% to 10% in each case. WORESANA concentrate can also be used at 100% in the form of a mask.

WORESANA concentrate WORESANA fluid WORESANA serum INCI Lactobacillus/Rye Flour Ferment Lactobacillus/Rye Flour Ferment Lactobacillus/Rye Flour Ferment Filtrate Face and body masks X* X X Creams,

7 WORESANA concentrate WORESANA fluid WORESANA serum INCI Lactobacillus/Rye Flour Ferment Lactobacillus/Rye Flour Ferment Lactobacillus/Rye Flour Ferment Filtrate Face and body masks X* X X Creams, lotions X X Shampoo X X X Hair conditioner X X X Hair repair kit X X Tonic (clear) Spray X X Soaps X X Peeling X* X X Lipstick X X Nail care X* X X * 100% WORESANA concentrate can be supplied filled in individually printed sachets. WORESAN THE COMPANY A strong team built around rye. Woresan GmbH was founded in 2001 as a supplier to the cosmetic and healthcare industry. The company is based in Isernhagen near Hanover and is certified to ISO (Medical Devices). A team of engineers consisting of chemists, process engineers, quality managers and business economists works on the continuous improvement of the products. The rye that is used comes mainly from Northern Germany; it is cultivated in a sustainable way and is BIO certified. Woresan focuses on: Development of fermented active agents from rye Protection of the processes and products Development of new fermentation products from cereals Close support of affiliated companies and partners Special rye requirements are always considered. Just ask!

8 McKinley Resources, Inc. McKinley Resources is located in Dallas, TX USA and is a supplier of over-the -counter active ingredients and cosmetic specialty chemicals and actives. We focus on providing solutions for anti-aging, anti-inflammation, anti-acne, antioxidant and skin lightening formulations with clinical claim substantiation. We strive to be a one-stop source that provides customers with high-quality products, the supporting technical information and valuable insight on product application. McKinley Resources has been in business for over 10 years serving both domestic and international customers. We take pride in providing our partners with a short lead-time, competitive pricing, irradiation services, and superior customer support. McKinley Resources, Inc. P.O. Box Dallas, TX USA Phone: 1 (972) Fax: 1 (972) info@mckinleyresources.com Website:

Table of Contents. Marketing Trends Chemical & Physiological Composition of Hair Fision KeraVeg18 Comparisons:

Table of Contents. Marketing Trends Chemical & Physiological Composition of Hair Fision KeraVeg18 Comparisons: Fision KeraVeg18 Table of Contents Marketing Trends Chemical & Physiological Composition of Hair Fision KeraVeg18 Comparisons: Amino Acid Distribution Hair Strengthening Studies Elasticity Studies Wet