Development Of Nutraceuticals And. and Traditional Plants: The Ml Malaysian Experience

Transcription

1 Development Of Nutraceuticals And Cosmeticeuticals From Indigenous and Traditional Plants: The Ml Malaysian Experience Prof Dr. Farida Habib Shah Universiti Tunku Abdul Rahman Also, Novel Plants Sdn Bhd

2 The Melaka Experience: Biotechnology Initiatives Melaka Biotechnology Corporation Melaka Institute t of Biotechnology Melaka Biotech Holdings Sdn Bhd

3 Malaysia is one of the 12 mega-diversity countries of the world and also one of the 25 identified d biodiversity hotspots in the world. The 12 countries above together contain at least 60% of the world s known spp. Malaysia contains about 7% of the world s spp.

4 Plant Species Diversity in Malaysia Malaysia is listed as the 4 th most biodiversity in Asia with over 15,000 flowering plants and over 3000 species of medicinal plants

5 According to Malaysia National Policy of Biodiversity, there are needs to conserve the biodiversity: Economic Benefits Food Security Environmental Stability National Biological Heritage Educational, Scientific Out of 3000 listed medicinal plants, only about 50 are litd ill d hd i tifi ll f exploited commercially and researched scientifically for their medicinal properties.

6 Why the need to document the plant biodiversity? Basis of global food security Resurgence of interest to use plants as medicines Increasing great demands of plant based drugs Provide better understanding of the plants at their genetic level The need for effective and sustainable information gathering and dissemination system for local economic plant species.

7 Out of 3000 listed medicinal plants, only about 50 are exploited commercially and researched scientifically for their medicinal properties. According to WHO, use of herbal medicine needs to be 1. Regulated so that there is no case of inappropriate use e.g. wrong identification of plant species 2. O f good quality of herbal medicines 3. Proper standardisation and optimisation 4. Constant Supply of raw materials

8 1. Objectives 1. To screen indigenous and traditional plants in process of discovery of new plant resources for plant extracts to be used in cosmeceuticals and nutricosmetics industries. 2. To scale-up the production of these extracts and /or bioactive compounds for commercial use. 3. To develop formulation for product development

9 The Initial Steps An Integrated Approach

10 Activities Screen plants for different groups of compounds Set up related activities, tissue culture, farming, extraction units etc Setting up database with DNA barcoding for documentation and standards Development of down stream activities

11 Extraction of oils and Terpenoids, etc Database integration and DNA barcoding Screening and chemotyping Plants species Invitro production Suspension culture Farm growing Buy back for product Buy back for product development

12 2.0 Activities Screening of > 200 Malaysian medicinal and aromatic ao a cpa plants sspeces species for: o: 1. Essential oils 2. Terpenoids 3. Phytosterol compounds 4. Anti oxidants 5. Antibacterial 6. Antifungal 7. Anti tumour activity

13 3. Spin- off companies InVitro tech Sdn Bhd -Supply of banana and medicinal plants for growth to growers in all states Tropical Bioessence Sdn Bhd-Processing of Herbs for down stream cosmetics and aromatherapy and perfume DNA Marker Technologies Sdn Bhd

14 THE NEXT STEP

15 Extraction of oils and terpenoids Database intergration and barcoding Screening and chemotyping Plants species Invitro production Suspension culture Farm growing Extracts for Nutricosmetics And Cosmeceuticals Buy back for product development

16 What are Cosmeceutical and Nutricosmetic Products? C ti l Nutricosmetics ti Cosmeceuticals A class of cosmetic products A blending of the words cosmetics and pharmaceutical Incorporate the potential ti health benefits of specific nutrients and food components (e.g., vitamins, phytochemicals, enzymes, antioxidants and essential oils) into skin products, such as anti-aging i creams and moisturizers Applied directly to the skin, creating beauty from outside. A class of cosemetic products with nutraceutical properties Products developed to aid skin health, but are ingested, are called nutricosmetics Aim to create radiant beauty from the inside out.

17 Nutraceuticals 'A nutraceutical is any substance that is a food or a part of a food and provides medical or health h benefits, including the prevention and treatment of disease. Such products may range from isolated nutrients, dietary supplements and specific diets to genetically engineered designer foods, herbal products, and processed foods such as cereals, soups and beverages.

18 Needs for Cosmeceutical and Nutricosmetic Products Long tradition of interest in Cosmeceutical and products and foods to nutricosmetics enhance beauty in the Asia Pacific market products are attempting ti to fill the growing consumer natural and organic beauty demand for more products believe in the healthful hf lproducts and concept of beauty from the capture part of the inside out. global multibillion dollar market for skin care products. Long tradition of interest in 72% of women who buy Continues to support this region as an important launching area for new cosmeceutical products.

19 Cosmeceutical and Nutricosmetic Products: Market and Growth Cosmeceuticals Current estimated $66 billon skin care market. Sales of cosmeceuticals have grown into a $14 billion industry worldwide. Japan is a leader in beauty supplements, which account for 15% or $319 million of overall sales of dietary supplements. Nutricosmetic Estimated current nutricosmetics market is $1 to $2 billion US market for oral beauty products grew at ~16% between 2001 and 2006 Continued US market growth predicted a market value of $1.3 billion by In China, beauty supplements represent 13% or $558 million of overall dietary supplement sales. Market for nutricosmetics also experienced ~13% growth during the period in Europe when it reached a market value of $836 million.

20 Oral Beauty Products Market Value

21 Novel Applications of Nutricosmetics The best delivery product vehicles are fortified foods & beverages beauty oriented dietary supplements Products must be easy-to-use multifunctional such as food and beverage products address both health concerns and appearance. Examples of nutricosmetics Yogurts enriched with beauty-enhancing ingredients ready-to-drink tea anti-aging jams antioxidant-rich chocolate-based beauty products

22 Plant Bioactives for Cosmeceutical and Nutricosmetic i Products-Addressing Gaps Demand for fresh and innovative nutricosmetic products Screening for novel plant bioactives (antioxidants, anti-aging metabolites) from new edible plant sources (go with native plants) Demand for innovative product-delivery strategies and vehicles Applying new cutting-edge technologies in delivery mechanisms in the pharmaceutical and nanotechnology industries Demand for stronger scientific evidence and quality standard d to support and certify the efficacy Rigorous and systematic scientific studies to sustain the knowledge base for any claims

23 Native Plant Bioactives in Cosmetics & Nutricosmetics Different products that provide unique benefits to the customer; for example, Functional product (anti-aging, aging anti-oxidant), organic or green product consisting of natural native plant materials. Native and novel ingredients >> marketing advantage Scientifically proven bioactivity >>quality assurance Scientifically formulated bioactivity >> custom made Room for development >> growth, with Quality Control

24 Smart Partnerships In this case : Novel Plants Sdn Bhd with Melaka Institute and Acelbio Pty Ltd ( Australia and China)

25 Technology and dproduct Development Platforms for Cosmetics & Nutricosmetics Step 1: Selection, collection & pretreatment of materials Advanced extraction technology Step 2: Screening of extracts using chemical assays Step 3: Functional test using biological assays Step 4: Quality control and standardization of extracts Step 5: Product development by formulating w/ extracts Step 6: Stability test of developed product

26 Herbal technology. Standardization & quality control with proper integration of modern scientific techniques & traditional knowledge is important. Roles of Molecular Markers in Herbal Drug Technology 1. Authentication of plant species of medical 1. Authentication of plant species of medical importance. 2. Genotyping & quick identification of botanical samples. 3. Detection of adulteration/substitution 4. Marker assisted selection of desirable chemotypes 5. Medicinal plant breeding 6. Applications in foods & nutraceuticals

27 DEVELOPMENT OF DNA MARKER DATABASE FOR MEDICINAL, AROMATIC AND ORNAMENTAL PLANTS IN MALAYSIA : BIODIVERSITY CONSERVATION IN MALAYSIA Shah F.H., Nurul A.H., DNA MARKER TECHNOLOGIES SDN BHD DNA Fingerprinting Lab, Melaka Institute of Biotechnology for correspondence: shahf2@yahoo.com

28 DNA Marker for identification of different 2 varieties of Pegaga (Centella asiatica) E6 E7 E8 PB PA PB PA PB PA a. Pegaga air- (PA) b. Pegaga bulat- (PB) E6 E7 E8 PB PA PB PA PB PA

29 DNA Marker for identification of different 3 varieties of Kacip Fatimah (Labisia pumila) var. pumila var. lanceolata var. alata A1 A2 A6 A9 A13 A1 A2 A6 A9 A13 A1 A2 A6 A9 A13 M ram: 1. (variety pumila) A1 A2 A6 A9 A13 A1 A2 A6 A9 A13 A1 A2 A6 A9 A13 M 2. (variety lanceolata) A1 A2 A6 A9 A13 A1 A2 A6 A9 A13 A1 A2 A6 A9 A13 M 3. (variety alata)

30 Steps for development Cosmetics & Nutricosmetics Discover native plant materials with bioactive ingredients Extract the bioactive ingredients from bioactive natural materials Bioactivity testing using chemical and bioassay platforms Quality control and standardization of extracts Formulate the Cosmetics & Nutricosmetic products with extracts and stability test of products

31 The Malaysian Native Plant Initiative What is special about these native plants for business? - Malaysian l i local lbranding differentiation i i - Novel ingredients product differentiation - Higher activity performance differentiation - Synergy combined bioactive extracts potential - Scientifically proven Quality differentiation

32 Business Opportunities for Commercializing Cosmeceuticals and Nutricosmetics Products in Egypt!!!!

33 Doing Business WHAT - The Opportunities to be Different: New natural bioactives in your products Discover new bioactives and start t a trend Scientifically proven bioactives and formulation Quality and safety control Long shelf life bioactivity Cost advantages High efficacy formulation at low concentrations Cost effective quality control Handle wide range of seasonal plant material variations

34 WHY we re Unique: Doing Business Established technologies & protocols made available Suitability for industrial scale-up Scientifically proven & formulated products Novel bioactives continually developed d Access through licensing or commissioned R&D

35 How you can be involved HOW - Do business : Develop prototypes with your extracts Develop scale-up process through licensed technology Mass produce through license with us/ other stakeholders C ti I ti Cosmetics Innovation Workshop Feb 2009

36 COLLABORATION for (MENA) and HALAL market Europe China Middle East/ Pakistan Africa India MALAYSIA MIDDLE EAST AND THE MUSLIM WORLD Population: l.8 billion 112 countries Trade value: USD 150billion

37 Track Record NOVEL PLANTS SDN BHD MD, Prof ffarida Shah h (25 years in Plant Molecular Biology and Biotechnology) ACELBIO LTD ( China Pty Ltd) Associate Professor Wei Zhang Chairman, AcelBio Pty Ltd (Bioprocessing i and Bioproducts)

38 THANK YOU Novel Plants Sdn Bhd

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