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1 background on restylane skinboosters SB0017_Backgrounder_V04.indd 1 07/03/ :27

2 Introducing a new concept in skin care Components of the skin Restylane Skinboosters are a brand new approach to nourishing your skin, especially designed to deliver deep skin hydration. This means increasing hydration levels within the skin to deliver lasting moisturisation and improvements on the skin s surface. SKIN is a dynamic structure, constantly creating, REpLAcING and shedding cells Hyaluronic acid (HA) is a substance that occurs naturally in the body and has many functions, one of which is maintaining hydration in the skin. 1 It attracts and holds on to large amounts of water, resulting in firm, elastic and radiant skin. 1-4 Over time, the quality of the body s HA diminishes. Restylane Skinboosters supplement your natural HA levels through microinjections of a long-lasting, stabilised form of HA that is administered by an aesthetic practitioner. This means that Restylane Skinboosters improve the skin s quality by boosting hydration levels deep inside the skin and increasing its overall smoothness, elasticity and firmness. 1-4 Restylane Skinboosters are versatile treatments that can be used: For men and women of all skin types For people with younger or more mature skin For the face, neck, hands and décolletage For people who want to improve skin structure e.g. for acne-scarred or photo-damaged skin Epidermis Dermis Subcutaneous tissue Three main components of the dermis provide structure, elasticity and volume to the skin and contribute to its overall appearance Collagens A major structural protein in the dermis Account for 18 30% of dermal volume 5 ELASTIN Has the ability to stretch, giving the dermis its elasticity HYALURONIc acid can absorb more than a thousand times its weight in water Gives hydration to the skin and smooths the skin surface A GROUNDBREAKING SKIN TREATMENT FOR HYDRATION THAT LASTS SB0017_Backgrounder_V04.indd /03/ :27

3 Introducing hyaluronic acid How do Restylane skinboosters work? NATURE s moisturiser 3 Hyaluronic acid (HA) occurs naturally in the skin where it performs several functions, including: Retaining moisture within the deeper layers of the skin to help keep it naturally hydrated Giving skin a natural flexibility, so that it can move with the body providing important antioxidative functions in the skin Activating dermal fibroblasts and increase production of collagen and other extracellular matrix components HA has a rapid turnover in healthy, young skin It is constantly being produced, circulated and broken down by the body 1 HA declines with ageing 3 The cycle of HA synthesis and degradation also slows down and becomes less efficient, altering the quality and distribution of natural HA in the skin consequently, skin is less able to retain moisture and loses volume HYDRATION from deep within for visibly glowing skin Restylane Skinboosters contain stabilised, non-animal HA gel. Once injected, the soft, gel-like HA begins to work, absorbing water and bringing deep skin hydration to the treated areas. Replenishing hydration in these areas improves the skin s moisture balance and improves the skin s ability to spring back into shape and results in a firmer, smoother-looking complexion and a healthy glow. 1-4,6 Treatment experience During a Restylane Skinboosters treatment session, a trained practitioner uses a fine needle to administer a series of tiny, hydrating injections of HA in the skin. Each treatment session usually takes between minutes. The Restylane Skinboosters effect builds up gradually and subtly, therefore it is recommended to follow one start-up course, usually 3 treatment sessions, 2 4 weeks apart in order to build up hydration levels. How long does it last? The body naturally produces and breaks down HA on a daily basis. However, the stabilised HA in Restylane Skinboosters degrades slowly over the course of several months. One maintenance treatment about every 6 months is recommended to help to sustain the Restylane Skinboosters effect. Skin loses its shape and it begins to sag, forming fine lines, creases and hollows Eventually, as HA depletion advances, deep wrinkles develop By the age of 50, our skin s HA content is halved SB0017_Backgrounder_V04.indd /03/ :27

4 Proven lasting improvements in skin quality refreshing innovation to meet different patients needs DEMONSTRATED results based on established science HA has a history of cosmetic and medical use and its efficacy and safety been proven in many clinical trials. The patented NASHA technology used in Restylane Skinboosters is the same as that used in the world s most documented injectable non-animal hyaluronic acid: Restylane. Restylane is a globally renowned brand with 16 years of research and 15 million treatments to its name since Restylane offers three product ranges: Restylane fillers to replace volume in wrinkles and lines or increase the fullness of the lips or face MORE mature skin YOUNGER skin Restylane Skinboosters to deliver deep skin hydration for proven and Before After Before After sustained improvements in overall skin quality 1-4 Restylane skincare to protect, hydrate and nourish the surface of the skin on a daily basis. It contains the same type of HA found in the other Restylane products, to help prolong the effects of treatment. AcNE scarring HANDS A versatile product range Before After Before After RESTYLANE VITAL For more mature and sun-damaged skin RESTYLANE VITAL LIGHT For younger or delicate skin SB0017_Backgrounder_V04.indd /03/ :27

5 The company behind Restylane skinboosters Q-MED, a GALDERMA division Q-Med, a Galderma division, develops, manufactures and markets aesthetic and corrective treatments. Since 2011, Q-Med has been wholly owned by Galderma, a pharmaceutical company specialising in dermatology with nearly 4,000 employees in more than 70 countries. The Q-Med site in Uppsala, Sweden, is Galderma s Global Aesthetic Centre of Excellence, with nearly 400 employees as well as world-class research and manufacturing facilities. In addition to Restylane fillers, Restylane Skinboosters and Restylane skincare, Q-Med develops, manufactures and/or markets other high-quality products for aesthetic and medical use: Emervel is a range of hyaluronic acid dermal fillers based on Optimal Balance Technology MacrolANE VRF for body contouring DEFlux to treat of a malformation of the urinary bladder in children DUROlANE to treat osteoarthritis of the knee and hip SolESTA to treat fecal incontinence 1. Kerscher M et al. Dermatol Surg 2008; 34 (5): Williams S et al. J Cosmetic Dermatol 2009; 8: Distante F et al. Dermatol Surg 2009; 35 (Suppl 1): Gubanova E et al. Esteticheskaya Meditsina (Aesthetic Medicine), 2010; 1: [Russian] 5. Ebling F et al. Textbook of Dermatology, 5th edition Blackwell Scientific Publications, New York 6. Kerscher M et al. Stabilized hyaluronic acid-based gel of non-animal origin for rejuvenation of the face, hands and décolletage using an injector device. Poster presented at International Master Course on Aging Skin (IMCAS), Paris, January 2010 SB0017_Backgrounder_V04.indd /03/ :27

6 For QUESTIONS AND MORE INFORMATION, please contact: (Name), (title), Telephone: (number) Mobile: (number) (address) Restylane, Skinboosters, Deflux, Durolane, Macrolane, Solesta and NASHA are all trademarks of Q-Med AB. Emervel is a trademark of Galderma S.A. For more information, please also see or Restylane and NASHA are trademarks of Q-MED AB. SB0017_Backgrounder_V04.indd 10 07/03/ :27

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