Company & Brand Identity. Educational manual December 2015 Hair products

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1 Company & Brand Identity Educational manual December 2015 Hair products

2 INCI Medica is based on the leading concepts in the wellbeing and anti-aging arena. Our products deliver proven results based on the most advanced Biocosmeceutical and cell biology technologies. All our products have proven effectiveness with zero side effects. INCI Medica s world-leading cell biologists, cosmeceutical chemists and experts in natural raw materials and plant extracts lead our three R&D centers in order to find pioneering solutions to targeted problems. All products are clinically proven, dermatologists & clinically tested. All INCI Medica s products are registered under the American, Canadian and EU authorities regulations.

3 Hair Loss Related Terms and Facts Alopecia- The scientific term of hair loss, or baldness. It may refer to either hair loss from head or body. A.G.A- Andro Genetic Alopecia, also known simply as pattern balding, is the most common cause of hair loss in both men and women. DHT (Dihydrotestosterone) kills hair follicle and stops hair growth in particular areas. Some 70% of men and 40% of women are affected by A.G.A to some degree and at some point in their lives. Percent of men with noticeable hair loss Age 35 Age 60 Age 80 Age 85 40% 65% 70% 80%

4 M.AG.A. Male AndroGenetic Alopecia, also known as male pattern balding. Testosterone turns into DHT (Dihydrostestosterone) and damages hair follicles causing hair loss in well-defined pattern, usually beginning above the temples, along with thinning of the crown and progressing into partial or complete baldness. F.A.G.A- Female AndroGenetic Alopecia. With women this type of balding usually causes thinning of the hair over the entire head rather than in defined pattern common to hair loss in men. DHT Dihydrotestosterone (the male hormone also found, in trace levels in women) interact with 5-alpha reductase enzyme found in the hair follicle s oil glands and is converted to DHT. The DHT then causes hair follicles to shrink and then renders them incapable of growing healthy hair.

5 Hair miniaturization due to A.G.A Testosterone 5 alpha reductase DHT (dihydrotestosterone) DHT shortens the hair growth cycle (shorter anagen phase & longer telogen Miniaturizes the follicles Produces progressively shorter finer hairs Hair loss

6 Scientific Solution The INCI Medica Professional & Home use Prevents and reverses A.G.A in 3 steps 1. Scalp peeling 2. Hair roots serum 3. Scalp vibrating Meso-therapy pen/ roller

7 Factors affecting hair loss Hair loss stems from many factors: Sensitivity of the follicles to the DHT Hormone causes miniaturization of the hair. Decrease in blood circulation causes the scalp to become thin and brittle. The result is less nourishment reaches the follicles. These conditions over time cause the hair to become thinner, shorter and weaker. The hair eventually falls out and does not regrow. The hair changes from strong and thick to thin and weak. The hair grows shorter and shorter. Eventually the hair falls out. As more hairs continue to be affected by hair loss factors less hair is visible. Balding becomes evident.

8 The perfect environment for hair growth INCI Medica s hair regrowth systems are powerfull and effective techniques that increase blood circulation to the scalp, which brings with it nutrients to the hair. The hair becomes thicker, stronger, grows longer, and becomes in general healthier. With continued use of INCI Medica s systems, hair continue to strengthen, thicken and regrow.

9 Hair regrowth systems major active ingredients for:

10 Nine special plant extracts were selected to be part of the formula; each one of them was chosen due to its unique function and its contribution to the whole process of stimulating the hair roots to produce healthy hair. 1. Epilobium Fleischeri Extract Promotes outstanding sebum regulation capacity (inhibition of 5a-reductase enzyme), reduces the size of pores and oily appearance on the scalp, and is a powerful anti-inflammatory (inhibitor of IL-1 and IL-8). 2. Algae extract Inhibits the transformation of testosterone to DHT 3. Linum Alpinum Flower/Leaf/Stem extract an Anti-inflammatory, Anti- Oxidant, soothing and calming extract. 4. Urtica Dioica (Nettle) extract An ancient medicinal herb for scalp treatment and improving hair condition.

11 5. Panax Ginseng root extract The famous traditional Chinese medicinal herb; promotes blood circulation and scalp s metabolism. 6. Artemisia Umbelliformis extract Powerful Anti-Oxidant and free radical scavenging, Anti-Inflammatory, Antimicrobial. 7. Trifolium Pratense Extract (red Clover) - Enriched with Biochanin A Isoflavone, a powerful inhibitor of 5a-reductase enzyme. 8. Arctium Lappa root extract (Burdock) - Is a traditional medicinal herb in Europe and in the Chinese medicine for blood purifying and scalp treatment. 9. Zingiber Officinale (Ginger) root extract An ancient traditional Chinese & Western medicinal herb with more than 80 active ingredients, it promotes blood circulation and scalp s metabolism.

12 The Proteins & Minerals; Nourishing & feeding the hair roots Proteins were selected (Hydrolyzed Rice Bran Protein & Glycine Soja (Soybean) Protein) to nourish and feed the hair roots and give them life again Powerful Anti-Oxidants Magnesium Ascorbil Phosphate (the most powerful and stable Vitamin C) scavenges and destroys free radicals Superoxide Dismutase antioxidant defense in nearly all living cells exposed to oxygen. CuZnSOD reduces free radical damage to scalp, minimizes inflammation, protects cell membranes, reduces and reverses fibrosis Panthenol (Pro-Vitamin B5) binds to the hair shaft, nourishes and moisturizes, gives body to the hair, coats the hair and protects it from pollution and environmental aggression

13 INCI Medica Regrowth Hair system Vs Major Competitors INCI Medica Totally hormone-free Increases blood circulation Suitable for men and women of all hair types Natural active Ingredients Creates wound healing process Stimulates new blood vessels Reactivates dormant cell follicles Zero side effects Thicker & longer hair regrowth Supports hair anchoring even after stopping use of the system Major Competitors Drug based- Minoxidil Finasteride (propecia) Increase blood circulation Suitable mostly for men - not an optimal solution for women Chemical and Hormone based such as minoxidil None Reactivates dormant cell follicles Minoxidil Side effects: unwanted facial hair on women, skin irritation, dandruffs & head aches Fine new hair only The new regrown hair falls immediately after stopping use Minoxidil based products

14 Internet connection is required to view the video (This video is for Reload which is the same as HR9)

15 Clinical Trial and Efficacy report Participants Included participants Number of participants Participants who completed the study Analyzed participants Reason(s) Participant # 3 was untraceable Participant # 9 was untraceable Participant # 17 was untraceable Participant # 34 was declared non-compliant

16 Before After

17 Before After 45 days

18 TEST RESULTS TOTAL APPRECIATION AND ORGANOLEPTIC CHARACTERISTICS Aspect Very pleasant Pleasant Texture Very pleasant Pleasant Easy to apply Very pleasant Pleasant Easily absorbed Very pleasant Pleasant Easy to spread Very pleasant Pleasant Suitable to your scalp Very pleasant Pleasant 88% 12% 92% 8% 97% 3% 96% 4% 94% 6% 91% 9%

19 Scalp s skin thickness and elasticity A significant thickness increase was shown in the Dermis and Epidermis layers after 45 days of use, this shows acceleration of Collagen IIV and Elastin production along with increasing density of the skin layers. The average of two sides/dimensional/volumetric increased: 16.4% which provides firm anchoring of the roots and strong effect on the follicle size which also support better anchoring. The deterioration of the scalp s skin condition was completely stopped. The increase was observed on 99% of the participants. CONCLUSION: The present study has proven the effectiveness of the use of Scalp Peeling product as a scalp s skin repair and restorative process (patent pending as part of the Reload system).

20 Automated Photo Trichogtam (PTG): TrichoScan Introduction TrichoScan is, compared to conventional and Contrast-Enhanced (CE) PTGCEPTG, an investigator-independent, automated software program, validated by Good Clinical Practice (GCP), for the analysis of hair growth, which was developed as there was need for a sensitive tool to automatically monitor hair loss and the response to treatment. TrichoScan operates with defined values for intra- and interclass correlation between the same and different investigators. TrichoScan software analysis relies on images taken from a small analyzed area of the scalp, which is barely visible after the measurement procedures completed. Technology Indication

21 The table shown is representing the average of the results Trichoscan measures Results after: 45 days Average results Hair Density per 1 cm2 Increased : 21% Average results Density Terminal Hair per 1 Increased: 29% cm2 Average results Hairs in Telogen mode (falling mode) Decreased :24%

22 Hair Regrowth System

23 The innovation behind hair science Unique hair activating system for Men and Women specially designed for the department stores and pharmacies.

24 HR9 Scalp Activator is a special fruits peeling dedicated to remove dead cells layer from the scalp s skin. It accelerates cell renewal for better anchoring for existing and new hair, opens pores. This important stage will allow easy absorption of the HR9 Hair Activator. HR9 Hair Activator is formulated with powerful selected plants extracts and unique peptides. The active ingredients are easily absorbed effectively on hair roots by supplying nutrition, blocking the DHT, awakening dormant hair roots, and energizing both active and reactivated hair roots thus triggering substantial increase in hair growth as well as dramatic improvement in the quality of the hair strands themselves. Derma Roller stimulates blood circulation and improves penetration of active ingredients. The Derma Roller will enable you to maximize absorption of the active ingredients into the skin of your scalp.

25 The Three step solution Step 1. Use of HR9 Scalp Activator for Men/Women Men***On a clean and dry scalp, apply small amount (a few drops) directly to necessary areas with a pad or directly to the scalp with the dropper. Gently massage product in a criss-cross motion (horizontally and vertically) to ensure proper coverage. Gently massage the scalp for 1 minute. Make sure to apply the Activator on the scalp and not into the hair to avoid waste of the product. Use the HR9 Scalp Activator twice a week. Women***Divide the hair with horizontal lines (same process as coloring hair roots) and pour a few drops of the HR9 Scalp Activator directly onto the scalp and gently massage into the scalp. Repeat the process with vertical lines (in a criss-cross motion). Use the HR9 Scalp Activator twice a week.

26 Step 2. Use of HR9 Hair Activator for Men/Women Men***Apply a sufficient amount of HR9 Hair Activator immediately after finishing step 1(enough to cover the necessary areas, same as step one). Gently rub the Activator onto your scalp with your fingers. Apply from top of the head toward the forehead up to the original hair line. Make sure to apply the Activator directly onto the scalp and not on the hair to avoid waste of product. Use the HR9 Hair Activator twice a week. Women***Divide the hair with horizontal lines (same process as coloring hair roots) and pour a few drops of the Active Anchoring Serum directly onto the scalp and gently massage the product into the scalp. Repeat the process with vertically lines in a criss cross motion. Use the HR9 Hair Activator twice a week.

27 Step 3. Led Vibrating Derma Roller Men***Roll the LED Vibrating Derma Roller vertically and horizontally over the scalp between minutes. Press gently and slowly, discontinue if you feel irritation. If your hair is short, use the LED Vibrating Derma Roller over the hair. If your hair is long and or you feel that the LED Vibrating Derma Roller pulls your hair, make horizontal part with a comb, Using one hand flatten down the hair from one side of the part and roll the Micro Needling roller over the part. Keep doing so until you cover the whole area. Repeat the process with vertically parts. Leave on the product for 4 hours or, preferably, sleep with product on your scalp. Wash your hair 4 hours post with Argan Intensive Roots Strengthening Shampoo. Women***Divide your hair in horizontal sections (same as coloring hair roots) and with one hand flatten down the hair from one side of the part and roll the Micro Needling roller over the part. Keep doing so until you cover the whole area. Repeat the same process with vertically parts. Use the LED Vibrating Derma Roller over the scalp between minutes.. Press gently and slowly, discontinue if you feel irritation. Leave on the product for 4 hours or, preferably, sleep with product on your scalp. Wash your hair 4 hours post with Argan Intensive Roots Strengthening Shampoo

28 Before After 45 days

29 Before After 45 days

30 Shampoos, Conditioners & Mask for Reload, HR9 & Hair Medica Keratin Anti Chlorine & Hard Water Shampoo. Thoroughly removes the Chlorine and softens the hair. Keratin Lave On Conditioner. Styling conditioner, improves thickness & strength. Omega Scalp Shampoo for healthy scalp skin Argan Intensive Roots Strengthening Shampoo. Complimentar y for Reload Hair System - thickness & strength Ceramide Strengthening Conditioner. Reloads hair thickness & strength Argan Anti Dandruff Shampoo. Argan & Kertain & Silk Hair Mask. Intensive hair mask. Nourishing & moisturizing with silky feeling

31 INCI Medica Head office: 23 Lesmill Road, Unit 205 Toronto ON, M3B 3P6, Canada

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