WHY IS THE SKIN BARRIER SO ESSENTIAL?

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2 WHY IS THE SKIN BARRIER SO ESSENTIAL? Skin disorders. Not only are they uncomfortable for pets and a big annoyance for your clients, they pose a threat to the overall health of the animal. Even more importantly, they pose a threat to the human-pet bond. So the best medicine goes beyond simply treating the symptoms. To keep the bond strong and pets healthy in the long run, it s essential to maintain a healthy skin barrier. EFFECTS OF A DEFECTIVE SKIN BARRIER Dry skin Bacterial colonization Yeast overgrowth Allergen penetration Abnormal cell turnover A HEALTHY SKIN BARRIER Retains moisture Maintains normal bacterial and yeast flora Prevents penetration of allergens Ensures normal cell turnover

3 FOUR FORMULAS.ONE SOLUTION. Each Douxo formula is specifically designed by skin condition, to ensure optimal delivery of the ingredients, and to make application easy. And all contain our exclusive pro-ceramide phytosphingosine. So that no matter the formula, the result is always a healthy, strengthened skin barrier. CALM Stops the vicious cycle of itching with a multi-targeted approach. Helps manage the vicious cycle of pruritus Provides relief from skin inflamation Helps restore the skin barrier Moisturizes CHLORHEXIDINE Helps manage bacteria and yeast overgrowth, as well as associated inflammation. Contains antiseptic chlorhexidine and climbazole Helps soothe inflammation associated with skin infections Helps restore the skin barrier Moisturizes SEBORRHEA Helps manage kerato-seborrheic disorders. Maintains normal ceramide levels Restores the skin barrier Helps rebalance the production of scales and sebum MAINTENANCE Specially formulated to help keep the most sensitive skin and ears healthy. For routine grooming and ear cleaning Gentle formula adapted to skin and ear physiology of dogs and cats

4 TREATMENT, SIMPLIFIED. We believe that treating skin problems shouldn t have to be problematic. So we created new dosage forms like pads, mousses and micro-emulsion, that serve as an alternative to shampoo. MEANING LESS WORK LESS WATER & LESS TIME. 92 % of pet owners found using Douxo Mousse more practical than regular shampoo.* This also means that your clients can confidently comply with the care you recommend, knowing that treatment time can also mean bonding time. *Data on file, Sogeval a Ceva group company, 2011; n = 42

5 ONE MOLECULE CAN MAKE ALL THE DIFFERENCE. precursor of ceramides supports the skin barrier soothes inflammation helps maintain normal skin flora IT HELPS RESTORE THE SKIN BARRIER, RESULTING IN A HEALTHIER PET. Douxo Calm Formula helps restore the skin barrier and decrease inflammation * NORMAL HEALTHY SKIN BARRIER basket weave stratum corneum (SC) thin epidermis with straight horizontal basal membrane no dermal inflammation CHRONIC DISRUPTION OF SKIN BARRIER OBTAINED BY TAPE STRIPPING thin compact SC epidermal thickening (acanthosis) inflammatory infiltrate (AFTER 5 DAYS) DOUXO CALM MOUSSE close to normal skin barrier basket weave stratum corneum (SC) thin epidermis with straight horizontal basal membrane only subtle inflammation PLACEBO impaired skin barrier compact SC with nucleated cells (parakeratosis) mild acanthosis moderate inflammation *An Emulsion Restores the Skin Barrier by Decreasing Skin ph and Inflammation in a Canine Experimental Model. D.Pin, et Al., J. Comp. Path 2014, Vol

6 RANGE A complete line of innovative products Easy Easier Easiest Local CALM MOUSSE MICRO-EMULSION GEL 6mL CHLORHEXIDINE SEBORRHEA MOUSSE MICRO-EMULSION PADS 30 pads MOUSSE MICRO-EMULSION SPOT-ON 25 x 2 ml MAINTENANCE Skin Ear MICELLAR SOLUTION 250mL DOUXO is a registered trademark of Sogeval S.A Ceva Animal Health, LLC

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