BIO M-Protease (Protease for keratin removal) <INCI : Protease>

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Lauren Stone
5 years ago
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cosmetics composition with protease B-102, Songdo Smart Valley, 214

1 (Protease for keratin removal) <INCI : Protease> <A patent application> The application number: Culture fluid or cosmetics composition with protease B-102, Songdo Smart Valley, 214 Songdo-dong, Yeonsu-gu, Incheon, South Korea Tel: Fax:

2 제품 Product 설명 Introduction Protease is enzyme that promotes hydrolysis of peptide-binding in protein or peptide. M-protease is an excellent natural enzyme because it disassembles unnecessary protein on skin by biological principle. Through this effective method, you can expect transparent and soft skin as it increases rejuvenation effect on skin stratum corneum is removed. Characteristics - Stability for cosmetics components: The activity of protease is available even when it Basic Information INCI Protease Main efficacy - Keratin removal - Acne imrovement - Skin rejuvenation is mixed with peeling gel. - High activity of keratin disassemble - Excellent exfoliate: Peeling gel with M-Protease has excellent keratin removal effect compared to singly use of normal peeling gel. - Skin rejuvenation - Keep soft skin - Remove acne - Stability for long-term storage: The activity of protease lasts for 5 months Other Details Recommend Dosage: concentration 0.1~5% Precautions: seal, storage in dark Stability : stable in ph 6.5~8.5 Application: Skin Care Product

M-Protease Characteristics of M-Protease producing strain

as safe) strain Characteristics of BIO M-Protease -

Excellent stability of enzyme Various usage of protein -

rejuvenation - Detergent additive - Animal feed additive -

3 M-Protease Characteristics of M-Protease producing strain - Aerotropism - Rapid increase - GRAS (generally regarded as safe) strain Characteristics of BIO M-Protease - Excellent keratin disassemble - Excellent exfoliate - Excellent stability of enzyme Various usage of protein - Cosmetics Keratin removal Acne improvement Skin rejuvenation - Detergent additive - Animal feed additive - Leather processing - Textile - Sanitary product: digestive medicine, clotbuster, etc.

Excellency of BIO M-Protease Categories M-protease AHA, BHA PAPAINE Classification Enzyme Acid Enzyme Molecular weight 30,000 76~190 23,000~24,000 - Excellent capacity of -Skin irritation by protein

4 Excellency of BIO M-Protease Categories M-protease AHA, BHA PAPAINE Classification Enzyme Acid Enzyme Molecular weight 30,000 76~190 23,000~24,000 - Excellent capacity of -Skin irritation by protein disassemble penetration of low Characteristics - Easy to remove old molecular weight in to Unstable and no vitality dead skin cell dermis - Great stability - Keratolysis Side-effect Non - Danger of sun burn under ultraviolet rays - Cause allergy - Danger of birth of deformed child

5 Characteristics of BIO M-Protease Categories Anionic Surfactant Nonionic Surfactant Polyol stability ph stability Storage stability Chelating Properties 2.5% SDS : >70% maintain vitality (Room temperature, 3 days) 5% Tween affiliation: >100% maintain vitality 5% Aracel affiliation: >100% maintain vitality (Room temperature, 3 days) Sugar-alcohol affiliation >95% maintain vitality (37, 6 months) ph 4~12 (Room temperature, 3 days) Cold storage (below 10 ): stable over 6 months 0.5% EDTA: >95% 활성유지 (Room temperature, 3 days) Advantages of BIO M-Protease - The protease that is currently used for exfoliating cosmetics is Papaine(from papaya) or Bromelein(from Pine apple). It has low substrate specificity and low enzyme stability. So it does not have appropriate function in exfoliating cosmetics. - Stable in wide range of ph - Stable on cosmetics components - High vitality of keratin disassemble - Excellent exfoliate - Skin rejuvenation - Improve acne

6 Stability for long-term storage of BIO M-Protease C.F) Method to measure stability Concentrated M-Protease Stabilize Leave at room temperature periodical collection of specimen Measure vitality of BIO M-Protease using Casein

7 Stability of BIO M-Protease in peeling gel C.F.) Method to measure stability of BIO M-Protease in peeling gel Concentrated M-Protease Mix in peeling ge Leave at room temperature periodical collection of specimen Measure vitality of BIO M-Protease using Casein

8 Efficacy of BIO M-Protease Exfoliate capacity (Use period : 28 days) After use epidermis(um) Stratum corneum(um) Whole skin(um) Before use 29.5 ± ± ± 6.0 Peeling gel (Blank) Peeling gel (M-Protease) 25.2 ± ± ± ± ± ± 4.5 Efficacy - High activity of keratin disassemble - Excellent exfoliate - Skin rejuvenation - Keep soft skin - Remove acne Peeling gel with M-Protease has excellent keratin removal effect compared to singly use of normal peeling gel.

Warm up substrate(1% Casein liquid) for 10 minutes at 37 B. Add BIO M-Protease 0.5% C.

9 Test of protease disassemble ability of BIO M-Protease Effect of disassemble protein of protease Evaluation of ability of protein disassemble A. Warm up substrate(1% Casein liquid) for 10 minutes at 37 B. Add BIO M-Protease 0.5% C. React for 5, 10, 20 minutes in 37 It has excellent disassemble ability when BIO M-protease is added which is high efficient protease.

10 SPECIFICATION Product name : M-Protease ITEMS SPECIFICATIONS 1. INCI Name Protease 2. Active Ingredient Protease 500 unit/ml 3. Appearance Light yellow liquid 4. Oder Characteristic 5. Heavy metal Pb : 20 ppm As : 2 ppm 6. ph 7.5±1 7. Microorganism 100 cfu/g Storage Conditions Store at dark place, 1~20 Recommend Dosage 0.1 to 5 %

COOLING ENZYMATIC PEEL. Rejuvenating fruit exfoliator. FREQUENTLY ASKED QUESTIONS

COOLING ENZYMATIC PEEL. Rejuvenating fruit exfoliator. FREQUENTLY ASKED QUESTIONS COOLING ENZYMATIC PEEL Rejuvenating fruit exfoliator. FREQUENTLY ASKED QUESTIONS COOLING ENZYMATIC PEEL exfoliates and purifies tired, lacklustre skin. Its non-abrasive formula leaves the skin soft, revitalised