DigniLife. Unique scalp cooling retain hair and quality of life during chemotherapy.

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1 DigniLife Unique scalp cooling retain hair and quality of life during chemotherapy

2 The cancer diagnosis is a shock. Then the therapy leaves its imprint. You can help your patients minimise the visible signs. Systemic cancer therapy brings with it severe side effects such as nausea, vomiting or dyshaemopoiesis, which are currently alleviated to a great extent by effective concomitant therapies. The idea of scalp cooling for the prevention of chemotherapy-induced hair loss is not new. The principle is based on two modes of action, presented in outline in the flowchart below. However, chemotherapy-induced alopecia is generally expected as this is seen as an unavoidable side-effect. Patient surveys* however, show that in hindsight, hair loss is the worst accompanying symptom of chemotherapy for many patients. Reduced blood flow (perfusion) Reduced temperature (cooling the scalp) Reduced active substance delivery and activity Reduced metabolic rate (metabolism) Hair loss/ alopecia Survival of the hair cells Nausea Reduced physical capacity, fatigue Damage to internal organs 60 (e.g. liver, kidneys) Patients often lose their sense of self being due to alopecia, with lasting effects not only during chemotherapy, but sometimes even after the hair has grown back and this is psychologically challenging for many patients Pre-chemotherapy Post-chemotherapy The use of ice packs and gel caps were often unpleasant for patients, without actually achieving the desired effect. They were also impractical and involved a great deal of staff input. For about 10 years now we have been developing the first automated systems to ensure evenly distributed scalp cooling. With DigniLife we now offer the latest generation in customised cooling with sensor controls, including safe and successful application in your practice or hospital. * Result of patient survey by 2hm & Associates GmbH, 02/2012, all information given in %

3 DigniLife the new generation in scalp cooling The entire performance range fully customised. Established method, new approach Scalp cooling can prevent chemotherapy-induced alopecia. With DigniLife we offer you a sophisticated concept for successfully integrating this treatment option into routine in your clinic or surgery. DigniLife treats you as an individual We will work with you to put together your own personalised solution for your patients, using a modular approach. This way, the package we put together for you will be based on your individual requirements, and is ideally tuned to the established practices in your facility.... and will allow successful routines. Simplified routine application and high treatment success rates are our top priority: we accompany you where, when and how you would like us to because every team is different and requires a custom-made solution. This sets the foundations for the best possible treatment success. Targeted implementation n Integration of the scalp cooling treatment into your established procedures n Easy to use in your routine n Tailored support according to your requirements n Customised cooling by sensor control Treatment with comfort and convenience Patients who opt for this treatment * are highly motivated from the start and are prepared to put in the extra effort. They are thrilled when they keep their hair. Prof. Felberbaum (Kempten-Oberallgäu Hospital) * DigniLife scalp cooling The people around me were not able to tell by my hair that I was having chemotherapy. Alexandra K. (DigniLife patient)

4 This makes DigniLife so safe and unique. Scientific support Targeted implementation n Interactive planning phase based on individual requirements n Working together for tailored solutions for seamless integration into established workflows and processes n Passing on specialist expertise for the highest quality standards Treatment with comfort and convenience n Very high level of patient comfort thanks to gentle, customised cooling with the DigniCap System n Simplified use and safe treatment n Supporting materials increase efficiency and minimise input Not too cold, but cold enough Scalp cooling systems have been available for some time, with varying degrees of success. DigniLife features a sensor-controlled scalp cooling mechanism, which maintains the temperature at above 0 C throughout the entire application period. While taking the individual patient reaction into consideration, the cooling is controlled in such a way that a constant therapy temperature is achieved and that the cooling is only as intense as is required for an effective therapy. Pleasant for the patient... The cooling cap is made of soft silicon, which stays unchanged even at the treatment temperature. The cap remains easy to handle and fits every head shape. Due to the constant treatment temperature, DigniLife can also be used in cases in which the hair has already thinned. and safe for you The complete cooling application procedure is electronically recorded. Therefore, you can document the flawless operation of the system this is important for the quality management in your clinic or surgery and also allows subsequent detailed evaluation. Scientific support Tailored communication n Scientific background information, support and advice n User networking and promoting cooperation n Provision of milestones from published studies Tailored communication n Professional information material for doctors and nurses n Clear patient information n Support to promote the range of treatments available based on individual requirements

5 Design and specifications may be subject to change due to further product development. Changes are confirmed by their appearance on a newer document and verification according to its date of issue. Copyright 2015 Sysmex Europe GmbH Distributor United Kingdom and Republic of Ireland: Sysmex UK Ltd. Sysmex House, Garamonde Drive, Wymbush, Milton Keynes, MK8 8DF, United Kingdom Phone Fax info@sysmex.co.uk Distributor: Sysmex Europe GmbH Bornbarch 1, Norderstedt, Germany Phone Fax lifescience@sysmex-europe.com Manufacturer: Dignitana AB P.O. Box 24022, SE Lund, Sweden You will find your local Sysmex representative s address under ZE EN.N.11/15