THERE S NOW A MICROSILVER LINING

Transcription

1 When it comes to managing bacterial resistance, skin and ear conditions adjunctively: THERE S NOW A MICROSILVER LINING BETTER TOGETHER - ENHANCED EFFICACY (Antibiofilm), Ceramide III (Lipid Barrier), Chlorhexidine (Antimicrobial) and azoles (Antifungal) YOUR GUIDE TO A MICROSILVER LINING VOLUME SIX (JANUARY 2017)

2 ENHANCED ANTISEPTIC AND ANTIBIOFILM ACTIVITY 1 Breakdown of Biofilm (MicroSilver - Ag + ) 2 Preventing Spread of Biofilm (MicroSilver - Ag + ) 3 Destroys bacteria and yeast (CHX, azoles) Scientific studies demonstrate that the generated silver ions: - Cause the inactivation of intracellular enzymes. - Cause the inhibition of trans-membrane transport proteins. - Damages bacterial DNA and prevents replication. MicroSilver, by its positive charge influx, decreases bacterial adhesion and destabilizes the Biofilm. The Activity of Micronized Silver in Skin and Ear Infections Supporting Original Study 7 In vitro activity of micronized silver and a micronized silver-containing shampoo against Staphylococcus pseudintermedius and Pseudomonas aeruginosa biofilms D. DEBABOV*, C. NOORBAKHSH*. S. MANNALA, P. STEINRUCKE, P. MOREAU and W. ROSENKRANTZ *Emeryville Pharmaceutical Services, Emeryville, CA. USA; VetBiotek, Inc., Largo, FL, USA; Institute for Molecular Biotechnology, Jena, Germany; PMO Consulting, Limoges, France; Animal Dermatology Clinic. Irvine, CA, USA The aim of this study was to determine the activity of micronized silver in plain solutions as well as a topical product used for skin and ear infections against Staphylococcus pseudintermedius and Pseudomonas aeruginosa biofilms. Both canine pathogens have been shown capable of producing biofilm. The anti-biofilm activity of silver ions is a novel alternative in topical therapy against bacterial infection. Minimum biofilm eradication concentration (MBEC) values provide estimates on the concentration of an antimicrobial product required to eradicate bacterial biofilm. The MBEC values of MicroSilver alone and a 0.1% microsilver containing antiseptic antifungal shampoo (BioHex Shampoo VetBiotek Laboratories, Largo, FL, USA) against P. aeruginosa and S. pseudintermedius were determined utilizing the Calgary Biofilm Device (CBD), a reproducible assay of biofilm susceptibilities to antimicrobials. All concentrations of micronized silver (from 0.5% to 0.05%) eradicated biofilm in MBEC assays (MBEC < 0.05%). The study involving the shampoo also indicated that the shampoo eradicated biofilms. The results indicate that micronized silver and micronized silver containing topical products are effective at eradicating the biofilm in an established in vitro model for P. aeruginosa and S. pseudintermedius. Source of funding: VetBiotek Inc. Research & Development funds. Conflict of interest: Shajan Mannala is head of research and development for VetBiotek Inc., Largo, FL (USA); Peter Steinrucke is employed in the research and development department of BioGate company, producer of micronized silver (Germany): Philippe Moreau and Wayne Rosenkrantz are employed on the medical advisory board for VetBiotek Laboratories, Largo, FL (USA).

3 Excerpts from clinician s brief roundtable DS = At University of Florida officially about 60% of the skin infections we culture are resistant to routinely used antibiotics! WR = In our practice in Tustin, California, in /190 cases or 26% were methicillin resistant Staphylococcus pseudintermedius (MRSP). In the same location, 2 years later, we repeated the study, and found 139/233 cases or 60% were MRSP. So this is alarming as we doubled the number of MRSP in a 2-year period! CG = It is not only how you kill the organisms but how you prevent resistance from developing. Multi-modal approaches are needed so having, for example, Miconazole, Chlorhexidine and MicroSilver should be more effective at preventing resistance. DS Domenico Santoro DVM, PhD, DACVD CG Craig Griffin DVM, DACVD SW Stephen White DVM, DACVD JA John Angus DVM, DACVD WR Wayne Rosenkrantz DVM, DACVD Studies on file, Bio-Gate AG SW = So biofilms are present and probably more often than we think we simply don t document it JA = So it is not only the combination of the ingredients to kill bacteria that matters, but also the addition of Ceramide III. This will contribute to a positive reaction in patients with pyoderma, as we know they have altered skin barrier function. WR = It would appear that the MicroSilver has benefits as a preventative agent for biofilm formation. In addition to shampoo therapy, other delivery systems (i.e., mousse, gels, lotions or sprays) may be more effective for localized disease. JA = My experience with the MicroSilver is amazing. It is a radical leap forward in ear therapy. Ceramide III (Cer 3) Skin Identical Molecule Lipid Structure Damage Supports against Transepidermal Water Loss (TEWL) Helps to Restore the Lipid Barrier Aids in the Protection and Sealing of the Barrier Barrier Disruption Increased Water Loss (TEWL) Ceramide III Causes of Barrier Disruption Environmental Stress - Allergic Response - Low Humidity Genetics Aging Process Increased Allergen Penetration / Sensitivity

4 ANTISEPTIC ALLERGY HexaDerm Max Shampoo 4% Chlorhexidine Deep Cleansing and Deodorizing Soap-Free Antiseptic Shampoo Indicated for use in skin conditions responsive to Chlorhexidine BioHex Shampoo 2% Chlorhexidine and 2% Miconazole Antiseptic Cleansing Soap-Free Shampoo Indicated for use in skin conditions responsive to Chlorhexidine and/or Miconazole LOOK FOR THE LOGO Ceramide III New Name, Same Formula! BioHex Mousse COMING SOON 3% Chlorhexidine and Climbazole Formulated with MicroSilver, Ceramide III and Climbazole Leave-on "Waterless" Antiseptic Cleansing Mousse Indicated for use in skin conditions responsive to Chlorhexidine and/or Climbazole To be used between bathing or when bathing is not practical Available in 200 ml pump bottle BioHex Wipes 2% Chlorhexidine Formulated with MicroSilver, Ceramide III and Climbazole Antiseptic Wipes formulated in an Aqueous Base Indicated for safe use on lip/nasal folds, vulva, screw tail and other skin folds For interdigital cleansing Cleansing of intertriginous areas Available in 50 Count Pads In an effort to identify our innovative ingredients, we have placed unique logos on our products. These logos represent the innovation, technology and quality in VetBiotek products. BioCalm Shampoo 1% Pramoxine Formulated with MicroSilver, STIMU-TEX AS, Colloidal Oatmeal and Ceramide III Soothing Soap-Free Shampoo for Relief of Itching BioCalm Mousse 1% Pramoxine Leave-on "Waterless" Mousse for the Relief of Itching Indicated for use on itchy skin between bathing or when bathing is not practical Available in 200 ml pump bottle BioCalm Spray 2.4% Lidocaine Formulated with MicroSilver, Pemulen, Glycofilm and Ceramide III Antiseptic and Anesthetic Spray for Localized Skin Irritaions Indicated for use on hot spots, itchy feet and non-specific lesions Available in 2 oz. SEBORRHEA Alcohol Free BioSeb Shampoo 2% Salicylic Acid and 10% Ethyl Lactate Antiseptic Degreasing Shampoo Helps to remove scales, flakes and excessive oils Available in 8 oz. and 16 oz. BioSeb Mousse COMING SOON 2% Salicylic Acid and 10% Ethyl Lactate Leave-on "Waterless" Antiseptic Mousse To be used between bathing or when bathing is not practical Helps to remove scales, flakes and excessive oils Available in 200 ml pump bottle EAR THERAPY UltraOtic RINSE 0.2% MicroSilver and Lactic Acid Non-Antibiotic Otic Rinse Formula Helps provide and maintain a healthy ear canal Available in 4 oz. UltraOtic CONCENTRATE 0.5% Climbazole, 0.5% MicroSilver and Ceramide Ill Non-Antibiotic Otic Formula Advanced Management of Otic Conditions Antibiofilm complex enhances efficacy Available in box of 20-1 ml pipettes w/dispensing sleeves

5 OTICS VetOtic Ear Cleanser 0.15% Salicylic Acid and 2.7% Lactic Acid Cleansing Solution for Ears and Skin Safe and gentle routine cleanser Available in 8 oz. and 16 oz. Milytic Otic Ear Cleanser Micellar Dewaxing Solution for Ears and Skin Excellent ceruminolytic cleanser Helps to remove tear stains Great for cleaning skinfolds and non-specific lesions Available in 8 oz. BioTris Flush 0.1% Miconazole, EDTA and Tromethamine Antiseptic Solution for Cleansing and Flushing of Ears and Skin Available in 4 oz. and 16 oz. GROOMING New Name! HylaGroom Shampoo Hypoallergenic EFA Soap-Free Hypoallergenic EFA Grooming Shampoo Use in routine grooming Helps to moisturize dry skin HylaGroom Mousse Hypoallergenic EFA Hypoallergenic EFA Grooming Mousse To be used between bathing or when bathing is not practical Helps to moisturize dry skin Available in 200 ml pump bottle Aloe Oatmeal Shampoo Aloe Vera and Colloidal Oatmeal Soap-Free Soothing Shampoo for Itchy and Dry Skin For use in routine grooming Available in 16 oz. and Gallon VETERGEN Seborrhea Shampoo Salicylic Acid 2% and Solubilized Sulfur 2% Antiseborrheic and Keratoplastic Soap-Free Shampoo Available in 8 oz. and 16 oz. *Compare to Sebolux Shampoo 3% Benzoyl Peroxide Shampoo Benzoyl Peroxide 3% Antiseptic, Keratolytic, Degreasing and Follicular Flushing Soap-Free Shampoo Available in 8 oz. and 16 oz. *Compare to Pyoben Shampoo Antiseptic KC Shampoo Chlorhexidine 2% and Ketoconazole 1% Antiseptic Cleansing Soap-Free Shampoo *Compare to KetoChlor Shampoo Antiseptic KC Leave on Conditioner Chlorhexidine 2% and Ketoconazole 1% Antiseptic Conditioner Reduces Antimicrobial Skin Adhesion Available in 8 oz. *Compare to Resi-KetoChlor Antiseptic KC Pads Chlorhexidine 2% and Ketoconazole 1% Antiseptic Topical Cleansing Pads Available in 60 Count Pads 1% Hydrocortisone Leave on Conditioner Hydrocortisone 1% Gentle, Anti-Itch Astringent and Cooling Conditioner Available in 8 oz. *Compare to Resi-Cort *Registered trademarks of Virbac Animal Health ** NOW WITH CERAMIDE III (Cer 3) By supplementing the skin with exogenous ceramides through lipid replacement therapy, we may be able to help in restoring normal barrier function. **Available Custom Label and Stocked by Select Distribution Michael Rossi, DVM, MNS, DACVD Coastal Veterinary Dermatology - Houston, TX

6 Joint Support 2.0 INNOVATIVE NEW INGREDIENTS FOR JOINT HEALTH Rose Lemarie, DVM, DACVS Osteoarthritis is one of the most commonly diagnosed canine diseases. Dogs often become arthritic due to injury, obesity, aging, or immune mediated diseases. There is no cure for this painful, debilitating condition in which the inflammatory cycle is self perpetuating, resulting in cellular death and cartilage destruction. Affected patients often require treatment for the rest of their lives. Treatment options include pharmaceuticals such as NSAIDs, supplements, weight loss and exercise regimens, and surgical intervention. Nutritional supplements may be used alone or in conjunction with other therapeutic options to enhance BiovaPlex Bioactive Compounds efficacy and decrease side effects and complications. Nutritional supplements have been used for decades in both human and veterinary medicine, beginning with glucosamine and chondroitin. Other compounds such as hyaluronic acid, MSM, essential fatty acids, and others have been used in products and foods over the years. Scientific support for the safety and efficacy of these products has historically been spotty and results/claims have often been anecdotal. In recent years, additional supplements have been developed and better studies have been performed to determine mechanism of action and efficacy of these compounds. Undenatured Collagen II (UC-II) derived from chicken sternum has been shown to result in significant declines in overall pain, pain during limb manipulation and lameness after physical exertion in canine osteoarthritic patients. Although the complete mechanism of action is not entirely understood, a small amount of UC-II taken orally has been shown to modulate the immune response targeted at type-ii collagen in joint cartilage, resulting in improved mobility and flexibility over time. AyuFlex is a clinically proven organic product for joint health. It is derived from edible fruits of Terminalia chebula, an ancient Ayurvedic plant and standardized to high levels of bioactives. It has been used in India for thousands of years for its anti-inflammatory and analgesic effects without the adverse effects that are associated with acetaminophen and NSAIDs. BiovaPlex is a product developed from hydrolyzed Egg Shell Membrane (ESM). ESM has been shown to reduce both pain and stiffness in human and veterinary osteoarthritic patients. A randomized Active Ingredients Elastin Desmosine/Isodesmosine Collagen Total Glucosaminoglycans (GAG) Transforming Growth Factor-Beta Calcium* Antioxidants Biological Activity Joint, Tissue, Skin and Vascular Elasticity Joint, Tissue, Skin and Vascular Elasticity Support of Joint and Connective Tissue Health Support of Joint and Connective Tissue Health Immune Regulation Cellular Proliferation / Differentiation None* ORAC 448µm TE/gram *The content of calcium in BiovaPlex is negligible, verifying minimal contamination of the product by components from the mineralized eggshell. controlled study revealed a significant decrease in proinflammatory cytokines after oral supplementation with ESM. No side effects have been attributed to ESM in human or veterinary patients.** VitaBerry is a proprietary blend of berry extracts and acts as a potent antioxidant. Antioxidant effects are measured by Oxygen Radical Absorbance Capacity (ORAC). VitaBerry has the highest ORAC available in a veterinary product. Non steroidal anti-inflammatory drugs or NSAIDS alleviate pain and inflammation by blocking the metabolism of arachidonic acid. Although they are relatively safe and effective, serious side effects can occur. The use of nutritional supplements and herbal products may help to decrease the NSAID dose and/or duration of treatment. In some cases, NSAID usage may be discontinued. This multimodal approach can dramatically decrease the chance of side effects associated with chronic NSAID usage. Dr. Rose Lemarie is a native of Arkansas who currently makes her home in New Orleans, Louisiana. She received her DVM from Louisiana State University in 1991 followed by a rotating internship in Companion Animal Medicine and Surgery at the Virginia Maryland Regional College of Veterinary Medicine in Blacksburg, Virginia. Dr. Lemarie returned home to Louisiana where she completed her residency training in Veterinary Surgery and became a Diplomate of the American College of Veterinary Surgeons. In 2000, Dr. Lemarie cofounded Southeast Veterinary Specialists in Metairie, Louisiana where she served as the head of the Surgery department until 2016 when the business was acquired by MedVet Medical & Cancer Centers for Pets. Dr. Lemarie currently resides on the famed Bourbon Street in New Orleans with her husband and wire-haired dachshund (Andouille) and cat (Rice). **Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study Kevin J. Ruff 1, Anne Winkler 2, Robert W. Jackson 3, Dale P. DeVore 4 and Barry W. Ritz 5

7 BioFlex TM ACTIVE Joint and General Wellness Glucosamine, Perna Canaliculus, Hyaluronic Acid, MSM, Creatine, Omega Complex, Featuring: BiovaPlex and VitaBerry Combines 3 ACTIVE ingredients with Glucosamine, Perna, MSM, Creatine and Omega complex in an upgraded palatable soft chew, for better overall wellness and joint support in ACTIVE DOGS. BioFlex TM ULTRA Management of Joint Degradation Glucosamine, MSM, Creatine, Boswellia, Grape Seed Extract, Hyaluronic Acid, Featuring: UC-II and AyuFlex Combines new ULTRA ingredients with UC-II (maintain joint integrity) and Boswellia (natural COX-2 and LOX-5 enzyme inhibition), for better joint health in AGING DOGS. 1 (Eggshell Membrane) For greater joint mobility and a lustrous coat Aids in reducing shedding 1 Supports increased mobility and flexibility of the joint 2 High ORAC source of natural berry antioxidants (Terminalia chebula) Natural analgesic and anti-edema properties Palatable Soft Chews 3 Helps in joint lubrication and collagen production 2 Helps in joint lubrication and collagen production Palatable Soft Chews Available in Soft Chew Sizes: 60ct., 120ct., and 240ct. Available in Soft Chew Sizes: 60ct. and 120ct. VET-3Caps TM HA High Levels of Omega-3 with Low Molecular Weight Hyaluronic Acid (LMWHA) Omega-3 Fish Oil (EPA & DHA), Vitamin E, Hyaluronic Acid, Vitamin A Palmitate and Vitamin D3 Omega-3 Supplement to Support: Healthy skin and coat The management of natural inflammatory responses Low Molecular Weight Hyaluronic Acid (LMWHA): Increases the moisture content of the skin from the inside out Aids in the prevention of transepidermal water loss Available in 60ct.: Small, Medium and Large Breeds VET-SAMe TM Formulated to Control Liver Enzymes and Provide Cognitive Support S-Adensoyl L-Methionine (SAMe), Andrographis paniculata and Ginkgo biloba extract Ginkgo biloba is a natural plant extract that has been used for thousands of years to promote: Cognitive support Increased blood flow Andrographis paniculata is a natural plant extract that is combined with S-Adenosyl L-Methionine to provide synergistic hepatic protection. Proven hepatoprotective action of andrographolides Known cardio protective agent Pre-glutathione provider Studies show Andrographis paniculata provide better liver protection than leading brand ingredients² Available in 30ct.: 100 mg, 225 mg, and 425 mg Enteric Coated Tablets 2Ref: Visen et. al. (1993) J. Ethnopharmacol. 40:

8 MARKETING AND BRANDING SOLUTIONS Customize Your Label in 3 Simple Steps Clinic Information - Needed to ensure that we can communicate to both you and your distributor as quickly and efficiently as possible to expedite your order. Initial Order * - This order can be cancelled or changed at any time - Nothing will be shipped until final approval and go ahead is given from you. Every new SKU you add to your custom label line, is eligible for a one time Buy One Case, Get One Case of equal or lesser value for FREE! Logo - For design and creation of label. The higher the resolution, the better the print quality of your label (Vector art, jpg, pdf.) Please to Jules@VetBiotek.com New SKU BOGO! Clinic Name: Street Address: City: State: Zip Code: Clinic Phone Number: Contact Person at Clinic: Website: Distributor: Distributor Representative: For colors see logo Use colors from website Utilize the following colors Follow VetBiotek stock product colors per product Use stock photos I will photos to use on labels No photos of animals on labels Include Website Facebook Twitter Keep the VetBiotek stock product names Use Pre-Approved, user friendly, hard to google product names (i.e. Joint Support) I have names I would like to submit for approval for my labels. Notes: Special Volume Incentive for Re-Orders - Buy 6 Cases, Mix & Match, Get 1 Case Free of Equal or Lesser Value. No Limit. *Free Shipping when you Buy 2 Cases in the Continental United States THE VETBIOTEK STORY: Other: Advancing Veterinary Care with Innovative Solutions VetBiotek provides innovative solutions for veterinary medicine. The VetBiotek management team has over 200 years of cumulative experience in the veterinary industry with over 120 years specifically in veterinary dermatology. Our goal is to bring the most advanced, novel ingredients to the veterinary marketplace to assist veterinarians in their management of joint support, liver and dermatological conditions. MicroSilver and Ceramide III are the most advanced ingredients available to help manage seborrhea, allergy, and bacterial conditions including MRSP. VetBiotek is a US employee owned and operated company out of Largo, Florida. All of our products are made in the USA. We sell only to licensed veterinarians through a limited distribution network Belcher Road S., Suite 260 Largo, Florida Office: Proudly made in the USA *VETBIOTEK has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. MICROSILVER BG is a trademark of Bio-Gate AG. STIMU-TEX is a trademark of DSM IP Assets B.V. AyuFlex is a trademark of Natreon, Inc. VitaBerry is a registered trademark of VDF FutureCeuticals, Inc. BiovaPlex is a registered trademark of Biova, LLC UC-II is a registered trademark of InterHealth N.I. LITPRODUCTG