INBIOTEC SMART COSMETICS

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2 / Index Index / INDEX PRESENTATION (Inbiotec) 05 INBIOFACE (Inbiotec Facial Treatment) 06 INBIOFAT (Inbiotec Anti-Cellulite Treatment) 08 INBIOHAIR (Inbiotec Hair Strengthening Treatment) 10 INBIOCLEAR (Inbiotec Whitening Treatment) 12 INBIOREGEN (Inbiotec Regenerative Treatment)

3 Presentation / is a company which markets products at the forefront of the cosmetic and beauty industry. Its experience in the industry has allowed it to apply its knowledge to introduce new active ingredients and molecules to the field of beauty care, leading to the presentation of highly effective formulas for cosmetic and dermatological treatments. The incorporation of biotechnologically produced components, such as growth factors, biomimetic peptides and active ingredients of plant and marine origin, is one of the reasons why has been able to develop formulations unlike those commonly available. Our are unique because they act selectively and intelligently, single-handedly stimulate all the necessary regeneration processes to perfection and act directly on the skin tissue through receptors, behaving as antagonists or agonists of cellular mechanisms and modulating, controlling and regulating their biochemical functions. All our formulations are subjected to product stability and safety tests. Tests are also performed to ensure that the packaging materials are compatible with the contents. The principal chemico-physical parameters of each formulation are mechanically and thermodynamically tested in order to predict the chemical stability and microbiological contamination of each production batch. Technical files and declarations of conformity with current European, US and other countries standards exist for all our formulations. Thanks to biotechnology, it is now possible to develop cosmetics with programmed ingredients, i.e. active ingredients developed to perform a clear and specific function on the skin which act at the root of the problem, providing everything necessary to recover its full beauty and plenitude. Presentation / Consequently, they act on the skin at different levels: They stimulate the synthesis of the proteins which form the extracellular matrix (collagen, elastin, fibronectin and laminin). They enhance and accelerate skin healing. They regenerate and restructure the epidermis. S They attenuate inflammatory skin reactions, regulate the pro-irritating cytokines and protect the DNA against UVA and UVB radiation, while suppressing the activity of the melanocyte-stimulating hormone and melanin synthesis. They inhibit the degradation of collagen and elastin in the face of damage caused by the external environment (UV, pollution, etc.) and aging. Inbioface (Inbiotec Facial Treatment) Inbiofat (Inbiotec Anti-Cellulite Treatment) Inbiohair (Inbiotec Hair Strengthening Treatment) Inbioclear (Inbiotec Whitening Treatment) Inbioregen (Inbiotec Regenerative Treatment) 04 05

4 INBIOFACE FACIAL AQUA, SODIUM HYALURONATE, PROPYLENE GLYCOL, PHENOXYETHANOL, SODIUM CHLORIDE, DEFINED CELL CULTURE MEDIA (HV-63) HYDROLYZED WHEAT PROTEIN, HYDROLYZED CORN PROTEIN, HYDROLYZED OAT PROTEIN, HYDROLYZED SOY PROTEIN, ETHYLHEXYLGLYCERIN, DISODIUM PHOSPHATE, POTASSIUM PHOSPHATE, POTASSIUM SORBATE, NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1, NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH- POLYPEPTIDE-76, NICOTIANA BENTHAMIANA SH-POLYPEPTIDE-6. Inbioface / Facial PLANT-EGF (SH-OLIGOPECTIDE-1) Produced in plants, this ingredient renews the epidermis and stimulates the synthesis of collagen to improve the elasticity, firmness and luminosity of the skin. PLANT-TGF BETA 2 (SH-POLYPEPTIDE-76) The synthetic growth factor TGF beta 2 produced in plants through biotechnology. This biotechnological active ingredient serves as a powerful booster for the synthesis of matrix proteins, such as collagen and fibronectin, making it ideal for mature skins. TGF-β Their biological roles are well known: in general, they exert a paracrine effect on fibroblast proliferation and myofibroblast differentiation, leading to both*: A strong stimulation of the expression of extracellular matrix (ECM) proteins, like collagen, fibronectin, and integrins. Inhibition of matrix degradation by stimulating synthesis of matrix metalloproteinase (MMPs) inhibitors (TIMPs). AMINO ACID, VITAMIN AND MINERAL COMPLEX Acts as a biorevitalizer to improve the texture of the skin and minimize the effects of wrinkles on the face. Used as an adjuvant in physical and chemical treatments, such as depigmentation-exfoliation, laser therapy, dermabrasion, radiofrequency treatment, dermal filling, botulinum toxin treatment, etc. HYALURONIC ACID Sterile, isotonic and biodegradable hyaluronic acid gel with a high molecular weight (mean concentration of hyaluronic acid - 10 mg / ml, free of endotoxins), outstanding for the treatment of age-related skin conditions, including dehydration of the stratum corneum, the loss of tonicity and elasticity, and the formation of wrinkles. EPIDERMIS DERMIS COLLAGEN ELASTIN Inbioface / Facial ANTI-AGING REVITALIZER Innovative ingredients for anti-aging treatment. Contains amino acids, minerals, antioxidants and vitamins, making it the most effective line of products to prevent the aging of the skin. Growth factors and the peptides that imitate them are the key ingredients in the product. /01 /03 Revitalizes dry, tired-looking, dull skin. EPIDERMIS DERMIS COLLAGEN ELASTIN Rejuvenates the skin and helps reduce wrinkles. Based on innovative technologies, Inbioface contains special chemical peptide compounds and recombinant proteins. These ingredients ensure the constant renewal of the skin at cell level, its rapid regeneration and recovery, and nutrition of the dermal cells. We can conclude that Imbioface is easy to apply, its positive effects are quickly perceptible, all the patients studied are highly satisfied and excellent results are achieved following treatment on both the neck and face. The results show an increase in ground substance in all the biopsies undertaken and a reduction in fragmented elastic fibres. Improves skin elasticity and the generation of new skin cells. Massage one vial per session into the area being treated in circular movements. The use of electroporation or a dermo roller is recommended. The absorption of the product depends on the characteristics of the patient. One session per week is recommended for the first two months, followed by a maintenance session once every month

5 INBIOFAT ANTI-CELLULITE AQUA, POLYSORBATE 80, ALCOHOL, LECITHIN, PHENOXYETHANOL, SODIUM CHLORIDE, CAFFEINE, ESCIN, SILICA, CARNITINE, BUTYLENE GLYCOL, GLYCERIN, TEA-HYDROIODIDE, HEDERA HELIX EXTRACT, GLYCINE SOJA GERM EXTRACT, LYSOLECITHIN, RUSCUS ACULEATUS ROOT EXTRACT, ASPARTAME, XANTHAN GUM, MALTODEXTRIN, CARRAGEENAN, HYDROGENATED LECITHIN, POTASSIUM SORBATE, CAPRYLYL GLYCOL, SODIUM SALICYLATE, COLEUS FORSKOHLII ROOT EXTRACT, ETHYLHEXYLGLYCERIN, DISODIUM PHOSPHATE, POTASSIUM PHOSPHATE, TRIPEPTIDE-1, HYALURONIDASE, TRIPEPTIDE-41. ADIPOREGULINE Adiporeguline Inhibits lipogenesis by acting on the GLUT4 receptors and activates lipolysis by stimulating the hydrolysis of triglycerides and their elimination. Inhibits phosphodiesterase. Anti-cellulite action. HYALURONIDASE Hyaluronidase helps depolymerize glycosaminoglycans. LIPOREDUCTYL CG-LIPOXYN Inbiofat / Anti-Cellulite Liporeductyl Venotonic effect. Favours the activation of the microcirculation and inhibits phosphodiesterase. Anti-cellulite action. CG-Lipoxyn acts on the GLUT4 receptors. Inbiofat / Anti-Cellulite INNOVATIVE PRODUCT WITH LIPOLYTIC ACTION Inbiofat is a balanced, synergic mixture which contains ingredients tried and tested in the treatment of the different problems associated with cellulite. It acts by reducing the build-up of fat and the thickness of the skin in the area being treated. /01 /03 Especially indicated for skin with cellulite and fat deposits. Thanks to the production of elastin, also improves skin elasticity, providing firmness and reducing adipose tissue. Treatment of areas where fat builds up: abdomen. saddlebags. chin. lanks. knees. bra folds. HEMODYNAMIC EFFECT which dilates the blood and lymphatic micro-vessels, leading to a notable increase in the metabolism of the connective tissue and enhancing the capacity to drain catabolized products. The result is particularly noted in the rigidity and sclerosis of the connective tissue because it increases the permeability of and ease with which retained hydrophilic and lipophilic matter is disseminated, leading to a notable reduction in fat. LIPID-REDUCING EFFECT on fat which has built up in the hypodermic tissue. The preparations which reduce the concentration of tissue lipids act by: A Inhibiting the synthesis of lipoproteins. B Modifying the intravascular metabolismr. C Increasing their catabolism or elimination. ANTI-INFLAMMATORY EFFECT which reduces swelling of the cellulite nodules, drains the water and lipids which have built up, and smooths out diffused or clustered folds. Massage one vial per session into the area being treated in circular movements. The use of electroporation or a dermo roller is recommended. The technique is simple. The product is massaged into the adipose tissue to activate the circulation and help the active ingredients penetrate the area. Can be used to treat any area in which fat builds up: abdomen, saddlebags, chin, flanks, knees, bra folds, etc. The user can continue with his/her daily life immediately afterwards. The Treatment can be combined with other treatments such as acupressure, carboxytherapy or radiofrequency treatment to favour the circulation and the elimination of fat, and obtain greater firmness. Depending on the case, approximately 4-6 sessions are normally required. Continue with a maintenance session once a month

6 INBIOHAIR HAIR STRENGTHENING AQUA, BUTYLENE GLYCOL, 2,4-PYRIMIDINEDIAMINE 3-OXIDE, PHENOXYETHANOL, SODIUM CHLORIDE, DEXTRAN, ETHYLHEXYLGLYCERIN, DEFINED CELL CULTURE MEDIA (HV-63), DISODIUM PHOSPHATE, POTASSIUM PHOSPHATE, ACETYL TETRAPEPTIDE-1, TRIFOLIUM PRATENSE FLOWER EXTRACT, PPG-26 BUTETH-26, PEG-40 HYDROGENATED CASTOR OIL, COPPER TRIPEPTIDE-1, APIGENIN, OLEANOLIC ACID, BIOTINOYL TRIPEPTIDE-1, SH-OLIGOPEPTIDE-2, SH- POLYPEPTIDE-1, NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-9. CAPIXYL A bio-active complex which prevents and reduces hair loss and stimulates hair growth. Its effectiveness is based on two ingredients: TRIFOLIUM PRATENSE (RED CLOVER) KOPEXIL Molecule derived from Minoxidil with no side effects (does not affect blood pressure). Prevents excessive collagen synthesis by inactivating the enzyme Lysyl Hydroxylase. Scientifically proven to stimulate hair growth. Inbiohair / Hair Strengthening Several studies have proven its effectiveness inhibiting 5-alpha reductase types I and II. It is also an effective modulator of chronic inflammation, a powerful antioxidant and reduces the damage caused by free radicals. BIOMIMETIC PEPTIDE (ACETYL TETRAPEPTIDE-3) Has been demonstrated to help anchor hair fibre better. Stimulates ECM proteins. Also has a direct effect on hair follicles, increasing their size with a larger number of fibres and enhancing their vitality. PROCAPYL Stimulates microcirculation in the scalp and inhibits follicle atrophy caused by dihydrotestosterone and aging of the follicle. CONCENTRATION OF GROWTH FACTORS 10 ppm of each Growth Factor / vial. MULTI COMPLEX VITAMINS 24 AMINO ACIDS MINERALS 3 COENZYMES 4 NUCLEIC ACIDS Inbiohair / Hair Strengthening HAIR STRENGTHE- NING PRODUCT WITH BIOMIMETIC PEPTIDES Helps combat hair loss and alopecia in men and women. Induces hair growth by revitalizing the follicles and improving blood circulation. Improves scalp problems and increases the thickness and volume of the hair. Product to treat hair loss containing more than 50 active ingredients, including a biomimetic peptide compound, numerous vitamins and amino acids. Prevents hair loss in men and women. Stimulates and strengthens the hair follicles. Moisturizes and nourishes the hair and scalp. /01 Indicated for all types of alopecia (male and female). This product is biodegradable and gradually breaks down before being eliminated from the body. Induces hair growth, revitalizes the follicles and improves blood circulation. Improves scalp problems and increases hair thickness and volume. Massage one vial per session into the area being treated in circular movements. The use of electroporation or a dermo roller is recommended. One session per week is recommended for the first four weeks, followed by a maintenance session once every 2 or 3 months

7 INBIOCLEAR WHITENING AQUA, GLYCERIN, ISOPROPYL ALCOHOL, DEXTRAN, UNDECYLENOYL PHENYLALANINE, PHENOXYETHANOL, SODIUM CHLORIDE, 3-O-ETHYL ASCORBIC ACID, HIBISCUS SABDARIFFA FLOWER EXTRACT, ARBUTIN, GLYCYRRHIZA URALENSIS ROOT EXTRACT, NONAPEPTIDE-1, TROMETHAMINE, KOJIC ACID, ARCTOSTAPHYLOS UVA URSI LEAF EXTRACT, POTASSIUM SORBATE, ETHYLHEXYLGLYCERIN, DISODIUM PHOSPHATE, POTASSIUM PHOSPHATE, GLYCOLIC ACID, LACTIC ACID, MALIC ACID, TARTARIC ACID, CITRIC ACID, OLIGOPEPTIDE-34, NICOTIANA BENTHAMIANA SH-POLYPEPTIDE-7. DEPIGMENTING PLANT COMPLEX Gentle exfoliating effect on the skin which removes the outermost, most coloured layers. This exfoliation process favours the penetration of KOJIC ACID to the deepest layers of the epidermis, where melanin synthesis takes place, and inhibits it, thereby providing a double depigmenting effect. MELANOSTATINE (NONAPÉPTIDO-1) Biomimetic peptide which inhibits the synthesis of α-msh-induced melanin and prevents its hyperproduction in order to keep blemishes and age spots in check. Melanostatine does not interfere with the functions of the melanocytes and is, therefore, an ideal skin-lightening agent for cosmetic products which inhibits melanogenesis without cytotoxicity. Inbioclear / Whitening ARBUTIN Inhibits the formation of melanin pigment by inhibiting Tyrosinase activity. Arbutin is an extremely safe, non-toxic skinlightening agent for external use. SH-POLYPEPTIDE-7 Biotechnological active ingredient capable of generating a natural whitening effect and rejuvenating the skin. Accelerates the re-epithelialization process and activates both fibroblast proliferation and keratinocyte migration. Increases the amount of collagen. Stimulates the formation of granulation tissue and promotes skin regeneration. Aids depigmentation. Improves the appearance of wrinkles. MELANOSTATINE also shows clinical efficacy on Asian skin with a significant lightening effect after just 28 days. CG-TGP2 (OLIGOPEPTIDE-34) Regulates the melanin generated by the enzyme tyrosinase, TRP-1 and TRP-2, and regulates melanosome transfer to Keratinocytes. Decreases the proliferation of activated T cells and increases the antiinflammatory effect. DIMETHYLMETHOXI CHROMAN PALMITATE Tyrosinase is the key enzyme in MELANOGENESIS. CHROMABRIGHT is a cutting-edge molecule which whitens the skin by effectively inhibiting tyrosinase. Unlike other whitening agents which can cause photo-irritation, CHROMABRIGHT has a sunscreen effect which prevents skin damage from UV radiation. Inbioclear / Whitening WHITENING SOLUTION Skin lightening treatment containing active ingredients effective against hyperchromic skin blemishes (freckles, nevi, melasma, lentigines, etc.) and in diminishing the intensity of highly pigmented skin. /01 Hyperpigmentation of mature skin. Treatment of skin which is sensitive and prone to irritation. /03 Post-procedure (median peelings, ablative procedures) hyperpigmentation prevention. Reduces and prevents hyperpigmentation and age spots by inhibiting melanin synthesis in the pigment cells. Prevents the appearance of new blemishes and freckles, allows you to stop and reverse the biological processes of aging, and normalizes skin functions by balancing ph levels and sebaceous gland secretion, which serves a moisture-retaining and barrier function, maintaining the youthful appearance of the skin. Couperose skin. /04 Massage one vial per session into the area being treated in circular movements. The use of electroporation or a dermo roller is recommended. Weekly sessions are recommended until the lesion disappears. Skin-aging prevention. Whitening treatments aim to reduce or eliminate blemishes of melanic origin. For some types of blemishes, it is necessary to combine several techniques

8 INBIOREGEN REGENERATIVE AQUA, BUTYLENE GLYCOL, SODIUM HYALURONATE, PHENOXYETHANOL, SODIUM CHLORIDE, DEFINED CELL CULTURE MEDIA (HV-63), ETHYLHEXYLGLYCERIN, POTAS- SIUM PHOSPHATE, HYDROLYZED VEGETABLE PROTEIN, ADENOSINE TRIPHOSPHATE, SODIUM CHONDROITIN SULFATE, COPPER TRIPEPTIDE-1, DISODIUM PHOSPHATE, OLIGOPEPTIDE-24, DECAPEPTIDE-4, OCTAPEPTIDE-11, ACETYL OCTAPEPTIDE-3. CG-EDP3 (OLIGOPEPTIDE-24) Minimizes scars and reduces wrinkles, generating new cells in the skin. CG-IDP2 (DECAPEPTIDE-4) Strengthens the elasticity of the skin by inducing the synthesis of collagen and elastin. Anti-aging and wound healing. ACETYL DECAPEPTIDE-3 Reduces and prevents expression lines and wrinkles by actively generating new skin cells. COPPER TRIPEPTIDE-1 CG-Seperin (Octapeptide-11) Reduces and prevents lines and wrinkles by actively generating new skin cells. Enhances skin tone that brimms with vitality and energy. Inbioregen / Regenerative Prevents expression lines by generating new skin cells. ADENOSINE TRIPHOSPHATE Hydrolyzed collagen and elastin activated by ATP (adenosine triphosphate). The union of an amino acid molecule from these hydrolysates and ATP creates aminoacyl-adenylate, the activated form of the amino acid capable of joining other amino acids to form proteins. This is the process which occurs in nature in protein biosynthesis. The amino acid complex plus ATP is capable of interacting better with other analogous groups, in the skin for example, leading to a higher rate of protein formation. This significantly revitalizes the skin. CYTOKINES Highly biologically active biochemical components, cytokines are proteins which carry out an essential function: cytokinesis, i.e. cell proliferation, by stimulating mitosis, or cell division, and the biological activation, growth and differentiation of cells. They can, therefore, be considered cell growth factors. They cause a perceptible increase in cell proliferation in the skin, resulting in an anti-aging, anti-wrinkle, reparative and biostimulant action. Inbioregen / Regenerative SKIN TISSUE REGENERATOR The SKIN REGENERATING COMPLEX acts on both the surface and the deepest layers of the cutaneous tissue, smoothing out the skin and causing the outermost, more deteriorated layers to disappear, while also producing a significant increase in the activity, metabolism and regenerative power of the skin in general. Skin regenerator and rejuvenator. Solution containing more than 60 active ingredients, including a biomimetic EGF peptide compound, numerous vitamins and amino acids. Its high flavonoid, anthocyanin and polysaccharide content means it has a softening, regenerative, protective, anti-inflammatory and free-radical neutralizing effect. /01 Scars, stretch marks and sag- /03 ging. Enhances skin elasticity and regulates collagen and elastin. Acts on aging skin, acne and open pores. Reduces and prevents expression wrinkles thanks to its great regenerative power. Owing to its content of natural alpha hydroxy acids, it has a gentle exfoliating effect. Moisturizing power. Massage one vial per session into the area being treated in circular movements. The use of electroporation or a dermo roller is recommended. One session per week is recommended for the first 4 weeks, followed by a maintenance session once every month

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