Innovave and mild ACTIVES SURFACTANTS EMULSIFIERS

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1 moaonouoaol Innovave and mild ACTIVES SURFACTANTS EMULSIFIERS

2 KALICHEM ITALIA A CONSISTANT PARTNER IN THE DEVELOPMENT OF RAW MATERIALS >> MARKET BACKGROUND KALICHEM ITALIA specializes in the development and producon of innovave raw materials: Natural Emulsifiers, Surfactants and Acve ingredients. With more than 15 years of experience, our mission is to research and develop new chemical raw materials for the cosmecs industry, to meet the demands and expectaons of the market, in parcular R&D of natural vegetal derived ingredients and new cosmeceucals. Due to scienfic commitment, we pride ourselves with a tradion of original and innovave products: constant development of new acve principles, technologies, experiments alternave to animal tesng, maximum safety of the formulas, thus developing efficient, safe, original ingredients. >> A RESEARCHING SOUL Scienfic research has always been part of Kalichem s DNA since its foundaon in 24. Every new Kalichem product is the result of the hard work of a number of sciensts and researchers who are commi=ed to the research and the realizaon of products based on avant-garde cosmec technologies. Kalichem s high level of Scienfic Research and the dermo-cosmec quality of its products are widely recognized and proven Invesng in research is a high priority : a high percentage of the total turnover of the Kalichem Group is dedicated to base research and product development; number of specialists are engaged daily in Research Centres which collaborate with Kalichem; the R&D Kalichem laboratory works closely with the most presgious universies and the most influenal research centres all over the world a green company: We make use of renewable sources. as much as possible Our raw materials are from sources as close as possible in order to decrease the CO 2 emission during the shipping. We have a responsable management of our wastes as coded in our environmental manual.our producon is natural based and for a natural posionning. Our cosmec raw materials are natural and of vegetal origin. Our research is based on innovave technologies and is carried out in associaon with major University Research Instutes. Acve principles, excipients and technical ingredients are being connuosly developed and scienfically validated This is a concrete approach to new environmental challenges through the technological and progressive support of a responsible cosmec chemistry. Thanks to the considerable scienfic commitment, Kalichem boasts a tradion of original and innovave products

3 INGREDIENTS CLASSIFICATION FROM ITALIAN INNOVATION Kalichem Italia can provide three groups of products: THE TECHNOLOGY << 1. Technical ingredients. 2. Acves and funconal ingredients. 3. Commodies (in parcular for the Italian market). For all ingredients we have Cerficaons with regards to their quality, safety and efficacy in line with the most rigorous norms and the most elevated technical and qualitave standards and a vast and updated documentaon. Many of them are also Patented and Ecocerfied. Our acve are dived in the following categories: Dermatological an age The era of cosmec ingredients as simple decorang acves is over. Today s focus is oriented in using ingredients aimed to provide dermatological added value. Kalichem acves work on innovave mechanisms of acon through specific pathways to bring physiological benefits at different levels to improve the skin condion and prevent ageing. Moisturiza on emolliency Having a moisturized skin means working on its epidermis, and more specifically on the hydro-lipidic film. Such a film is composed of fats and hydrophilic substances, whose balance is fundamental to keep the skin properly moisturized. Kalichem acves work on both such factors improving physiologically the skin hydraon. Face body care Kalichem acves for face/body care are based on patented technologies and/or the use of extracts whose acon is addressed to specific acons: working on several applicaons, like cellulite, acne support treatment, deodorants, de-reddening, etc. Kalichem speciales bring innovaon through the thorough selecon of natural acves and the creaon of synergies between them. Sun care Kalichem suncare acves are comprehensive of sunscreen boosters, acves preserving skin elascity and able to reduce the UV related stress on the dermis, and speciales working on the reducon of the erythema and the typical reddening events caused by sun exposure: in other words, smart soluons both for pre and aner sun exposure Hair care Working on the hair health has become one of the greatest challenge in cosmecs. Kalichem acves work both on the health status of the hair bulb, and on the upper structures composing it, through nourishing and film-forming features. In depilatories the strategy to counteract hair regrowth relies on different mechanism working on the pigmentaon and the reduced smulaon of the hairs regrowth. Make up Make up industry is today running on a new path trying to conciliate the tradional approach based on the use of synthec ingredients with the new one, characterized by the strong influence of green. Ingredients for mascara, son focus acves, elascity enhancer and strong anoxidants. Kalichem gets in this market segment with cuong edge technologies. Oral care Changing the rules of oral care. Revoluonary as it may sound, that s what happened with Kalichem oral care acves. The introducon of the physiological Calcium Hydroxyapate changed radically the approach in oral care, making obsolete the use of fluorides and creang a new opon to abrasive acve ingredients An -mosquito ac on Innovang through the use of plants and of the nature. Changing the world of repellents with the strength of fragrances. Kalichem offers a new and revoluonary acve ingredient, based on an extract from an Italian plant.

4 DERMATOLOGICAL ANTIAGE >> APALIGHT [1-5%] << Hides skin spots and wrinkles since the first applicaon through opcal effect Increases skin Elascity of 1% aner 1 month Reduces skin roughness of 9% aner 1 month SoN Focus acve ingredient Gives a glowing look to the skin Boosts sun protecon more than TiO2 when combined with filters Physiological ingredient, Cosmos approved [ % ] = me = aner 4w ELASTICITY +1% ROUGHNESS - 9% >> CIKADERM [1-5%] << Contains Croton Lechleri, popular extract from Amazzonia Increases Collagen, Fibronecn and Integrins producon Speeds up the formaon of scar ssue Prevents the formaon of Stretch Marks Reduces Itching, Stretch Marks roughness and redness Targeted for restoring treatments for dry hands and damaged skin Increases skin elascity; one of the most effecve an-aging extract in nature BEFORE AFTER >> OXISOL [.1-3%] << Reduces of 3% the polluon related toxicity Anoxidant much more effecve than Vit.C, Vit. E., Resveratrol Stable structure, it works faster and longer than common anoxidants Boosts UV-A &UV-B protecon Ideal for geong anaging creams with SPF and UVA Protecon Factor Reduces the ageing process caused by InfraRed radiaons Watersoluble [ Lldh release (24h) ] 12 6 = OXISOL = COMPARISON ANTI POLLUTION BASE CREAM -3% [kmoltrolox/mmol] ANTI OXIDANT VIT.C VIT.E BHT RESVERATROL >> KALINAT [ %] << Increases skin elascity of 26% Increases skin thickness of 8%, giving a repulping effect Increases the producon of stem cells and fibroblasts Immune system modulator Reducon of 4% of pre-exisng wrinkles, +5% moisturizaon Targets molecularly A2 Adenosine receptor on fibroblasts Regularizes the microcirculaon (dark circles treatment) Cell regenerang acon (for Medical Devices & Cosmeceucals) >> KALILIGHT [1-5%]<< Winner of the PCHi China as most innovave brightening and whitening raw material Skin Spot Correcon both in short and long term SoN-focus effect : immediate coverage of skin spots and wrinkles Long term effect: direct reducon of Eumelanin through Tyrosinase inhibion / Long term effect: shins Eumelanin producon into Pheomelanin producon / Anoxidant features (Glutathione & Cysteine acon) ITA Grade :+4.2%, very close to Hydroquinone +2,2 % skin brightness, -4,3% change of shade of skin color [ cutometer # ],5,4,3,2,1 = me = aner ELASTICITY +25,6%

5 MOISTURIZATION EMOLLIENCY >> OLIVOIL PCA [1-2%] << Skin moisturizer working on the hydrolipidic film Composed of Olive Oil fa=y acids (more skin biocompable than other vegetal oils ) to restore the skin barrier in the epidermis Composed of PCA (most found compound in skin Natural Moisturizing Factor) to hydrate skin surface through water binding. Increases skin moisturizaon of +19% and gives +13% emolliency To be used as an emollient/moisturizer in washes & skin care >> KEMIDERM NMF V [1-5%] << Reproducon of the physiological Natural Moisturizing Factor Specialty containing sugars, aminoacids, PCA, Urea, Alfa-Hydroxyacids Increases directly the skin moisturizaon binding water from the environment to skin surface Urea forms well known emollient compounds with skin fats increasing the final moisturizaon of the skin Vegetable based ingredient [ % ] [medium moist.factor] = Gel with OPCA = Gel with Water EMOLLIENCY MOISTURIZATION +13% +19% = NMF V = Na Pca MOISTURIZATION [ 1 hour ] [ 1 week ] >> KEMIDERM KMF [1-5%] << Reproducon of the physiological Natural Moisturizing Factor Specialty containg sugars, aminoacids, PCA, Urea, Alfa-Hydroxyacids Increases directly skin moisturizaon binding water from the environment to skin surface Contains phospholipids creang a liposomic structure Prolonged moisturizaon & retarded release of its acve ingredients [medium moist.factor] = KMF = NMF V = Na Pca MOISTURIZATION [ 1 hour ] [ 1 week ]

6 FACE BODY CARE >> ANTIDERM << Dereddens the skin and increases moisturizaon Composed of natural an-inflammatories, ansepc, emollient and moisturizing compounds (Panthenol, Allantoin, Glycirrhenic Acid, Copaiba Balsam, Olive Oil) Targeted for sensive skin creams, an-couperose creams, soothing baby creams >> BATTERIKAL << Based on the combinaon of 4 vegetable oils (Olive, Andiroba, Manuka, Copaiba Balsam). Effecve against Streptococcus, Staphilococcus and acne bacteria It can be used for the treatment vs Acne to counteract the related bacteria growth and to reduce its count. It works against Staphylococcus, which metabolizes human sweat and is a cause of bad odors. To be used as acve in Dehodorant creams, wet wipes >> CIKADERM [1-5%] << Contains Croton Lechleri, popular extract from Amazzonia Increases Collagen, Fibronecn and Integrins producon Speeds up the formaon of scar ssue Prevents the formaon of Stretch Marks Reduces Itching, Stretch Marks roughness and redness Targeted for restoring treatments for dry hands and damaged skin Increases skin elascity; one of the most effecve an-aging extract in nature [reddening score] Time [ ] STREPTOCOCCUS STAPHYLOCOCCUS = ANTIDERM = without PROPIONIBACTERIUM ACNES DEREDDENING BEFORE AFTER MIC MBC >> LIPOREDUX PRO FOR [1-5%]<< Combinaon of 3 synergic lipolic compounds (CLA-Carnine-Forskolin) CLA Carnine is a synergisc blend with which Carnine absorpon is maximized; CLA furthermore induces increase of physiological Carnine producon Reduces the thigh circumference of -2,34 cm Proved to reduce the Orange Peel effect, and improve the skin tone compactness. Gives a long term acon; the body gets no used to its effect No side effects, no interference with cardiovascular system and roid >> MIX OXI STOP [5-2%] << Slows down hair regrowth of 3-4% Helps reduce the hair intense pigmentaon, through the reducon of the post depilatory skin stressing condions (Aloe, Chamomilla, Mimosa extracts) Retards hair re-growth (Papaya extract) Reduces irritaon and redness aner depilaon [%] [ % of volunteers] [applica on] = Liporedux Pro For = Caffeine [wash out] POSITIVE RESPONSE [applica on] [wash out] me [w] SLOWER r.t. HAIR RE-GROWTH MUCH SLOWER regrowth me VERY MUCH SLOWER r.t.

7 SUN CARE >> ANTIDERM [5%] << Ideal acve ingredient for aner sun Lowers the toxic effects related to prolonged UV exposure Dereddens the skin and increases skin moisturizaon It can be used in the oily phase for the formulaon of sunscreens Composed of natural an-inflammatories, ansepc, emollient and moisturizing compounds (Panthenol, Allantoin, Glycirrhenic Acid, Copaiba Balsam, Olive Oil), rebalancing skin normality. >> APALIGHT [3-6%]<< Physical sunscreen booster In order to declare SPF, it must be combined to registered filters. Tested in Vivo, when combined with organic filters, it boosts SPF be=er than TiO₂ in SPF 15,3,5+ formulas, and boosts ZnO SPF features. No whitening effect at the applicaon Not nanomaterial (and not biopersisant, it is easily metabolized by human body) Cosmos approved >> OLIVOIL AVENATE EMULSIFIER [2-1%] << Liquid crystal emulsifier, based on Olive Oil fa=y acids and aminoacids and polypepdes from Oat / Allows a uniform distribuon of the sun filters on the skin / High dermocompabilty: Olive Oil fa=y acids have the same termodinamic behavior of skin cells membranes, and restore skin barrier (with a big reducon of the TEWL) Avoids sun-exposure related dryness and a loss of elascity, and prolonging sun tan / Specific to formulate sunscreens and regenerang ANer sun Oat aminoacids create a son silky velvety protecve layer on the skin / Emulsifies up to 5% of oily phase, with no HLB restricons [reddening score] IN VIVO SPF ] [TEWL] = ANTIDERM = without DEREDDENING Time [ ] = with Apalight = with TiO2 SUN PROTECTION FACTOR +9% +2% +18% SPF15 SPF3 SPF5+ TRANS EPIDERMAL WATER LOSS Basal SLES SLES Water was 1% was 1% was 9.5% OAE was,5% >> OLISUN [5-35%] << Innovave technology of pre-solubilized filters for cold emulsions making Allows having already solubilized and stable different UV-A & UV-B filters (including some filters tradionally tough to work with). Gives SPF loons and sprayable emulsions working at cold, with simple water addion. With acrylic polymer gives SPF gels, with addion of Lipidic Consistency factors gives SPF creams [IN VITRO SPF] SPF concentra on [%] >> OXISOL [3%] << Wide spectrum booster, working both on SPF and UVA protecon Improves SPF more than approved UV-B filters Improves UVA-Protecon factor Water Soluble, easy to use Photo-stable Stabilizes UV-A Protecon Factor, counteracng Avobenzone loss of efficacy. Dualisc booster: stable and free radicals scavenger to prevent Photo Ageing and Infrared related ageing IIN VITRO SPF / UVA PF ] = SPF = UVA - PF 3 TIMES MORE 2,5 TIMES MORE Oxisol Mixed Mx filters + filters 3% Oxisol

8 HAIR CARE >> OLIVOIL FRUTTOSIDE [2-2%] << Condioning surfactant based on Olive Oil and Fructose Increases hair shining and sonness more than Cocoglucoside Hyper delicate on skin and mucous (targeted for products with low eye irritaon) TEWL be=er than the other known mild surfactants in the market Foam and viscosity booster, to be used as primary or secondary surfactant [evalua on scale] = OFS = SLES SHINING +4% 3 TIMES SOFTNESS >> STIMUCAP [1-3%] << Based on the combinaon of the patented synergisc specialty CLA- Glutathione and Sodium DNA CLA Glutathione gives a combined an-oxidant an-inflammatory acon to counteract hair fibrosis and stress Sodium DNA has been proven to be able to thicken and increase hair count, through a strong regenerave and proliferave acon Tested in vivo vs Minoxidil, it gives be=er resistance to tracon (less hair fallen) and is more pleasant during and aner the applicaon No side effects, it is very well tolerated and with a high funconal impact >> HYDROLIZED PROTEINS [,5-5%] << [hair res. Score] 2,5 2 1,5 1 = Smucap = Minoxidil HAIR RESISTANCE me [w] Kemicher/ Hydrolyzed Keran: the same component of the hair. Acve specific for nourishing hair shan and regenerate damaged hair Kemisilk/ Hydrolyzed Silk: Aminoacids and polipepdes from Sericin, known protein providing film forming,velvety and silky aner feel on the skin and hair Kemigran/Hydrolyzed Wheat Protein: volumizing and condioning ac- ve, specific for hair loons, masks, balms, shampoos Also available: Rice, Soy, Milk, Collagen hydrolyzed protein

9 MAKE UP >> APALIGHT [1-5%]<< Mineral Make up SoN Focus Effect Gives a glow appearance to the skin from the first applicaon Hides skin wrinkles and blemishes immediately Ideal for loose powders as illuminang acve Boosts SPF (Color cosmecs with SPF) Ideal physical sunscreen booster for lipscks and color cosmecs creams >> KALINAT [,1 -,25%] << Increases skin elascity of 26% Increases skin thickness of 8%, giving a repulping effect Increases the producon of stem cells and fibroblasts Immune system modulator Reducon of 4% of pre-exisng wrinkles, +5% moisturizaon Targets molecularly A2 Adenosine receptor on fibroblasts Regularizes the microcirculaon (dark circles treatment) before aner >> KALILIGHT [1-5%]<< Mineral Make up SoN Focus Effect Hides skin wrinkles and blemishes immediately Ideal for color cosmecs as illuminang, whitening acve Strong an-oxidant (Glutathione and Cysteine contribuon) Winner of the PCHi China as most innovave brightening and whitening raw material >> OLIVOIL AVENATE EMULSIFIER [2-1%] << Liquid crystal emulsifier, based on Olive Oil fa=y acids and aminoacids and polypepdes from Oat / Allows a uniform distribuon of pigments / High dermocompabilty: Olive Oil fa=y acids have the same termodinamic behavior of skin cells membranes, and restore skin barrier (with a big reducon of the TEWL) Emulsifies up to 5% of oily phase, with no HLB restricons Olivoil fa=y acids are very stable mineral and pigments suspender Ideal for foundaon mousse, colored creams, mascara, primesrs, etc.. Silky aner feel but totally green, >> STIMUCAP [1-3%] << Based on the combinaon of the patented synergisc specialty CLA- Glutathione and Sodium DNA Eyelashes thickener (the specialty contains DNA, raw material proven to increase and thicken hair in women), Sumucap gives them a natural and healthier look. CLA works as prostaglandin modulator, able to control the process of the inflammaon Glutathione is one of the strongest an-oxidants in nature Smucap reduces also the itching sensaon more than benchmark acves. Very fine Homogeneous % IMPROVEMENT IN HAIR THICKNESS 17,9 IMPROVEMENT IN HAIR COUNT 13,5

10 ORAL CARE >> KALIDENT [3-1%] << Remineralizing acve ingredient Opon to Fluorides and abrasive acves in new generaon toothpaste formulaons Microlesions repairer An-caries acon Filler of dental scratches, it prevents hypersensivity Increases of one shade of white the color of the tooth Boosts the removal of bacterial plaque >> OLIVOIL FRUTTOSIDE [2-5%] << Based on the combinaon of Olive oil with vegetable aminoacids and Fructose Mild surfactant with delicate and efficient cleaning acon on tooth and gums Foaming agent performing be=er than SLES, and foam booster for sulphates and other mild surfactants Surfactant tasng be=er than other commonly used surfactants in oral care Ecocert approved >> OLIVOIL GLUTAMMATE [2-5%] << Olivoil Glutamate: based on the combinaon of Olive Oil with sugar cane derived Glutamic Acid Mild surfactant with delicate and efficient cleaning acon on tooth and gums Foaming agent performing be=er than SLES in Ross Miles measurement Surfactant tasng be=er than other commonly used surfactants in oral care Ecocert approved ANTI-MOSQUITO ACTION [ mm of foam ] [ mm of foam ] = OFS = SLES ROSS MILES TEST (FOAMING) % +38% = OGS = SLES ROSS MILES TEST (FOAMING) +15% +2% >> FLYBLOK [3-5%] << Natural molecule (Catalpolo) from a selected species of the plant Catambra, from Italy. Mosquitos are repelled by the slight odor of the raw material. Tested in vivo, with single applicaons it helps reduce the number of bites from mosquitos Not toxic, vegetal Ideal for sprays, loons, wet wipes, creams, environmental products [ % of volunteers] = Flyblok = Placebo LESS THAN 2 BITES / NIGHT

11 ALSO AVAILABLE FULL BROCHURES TECHNICAL FILES FORMULATION TIPS MARKETING DOCUMENTS SAMPLES LITERATURE Please feel free to ask for any further detail at:

12 ANTIDERM APALIGHT BATTERIKAL CIKADERM FLYBLOK OLISUN OXISOL KALIDENT KALILIGHT KALINAT LIPOREDUX PRO FOR MIX OXI STOP STIMUCAP Head Office and Produc&on: Via Alessandrini Re<zato (BS) Brescia - ITALY Tel: Fax: kalichem@kalichem.it w w w. k a l i c h e m. i t