Journal of Pharmacological and Biophysical Research

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1 Skin Pharmacol Physiol 30(1) 1 54 (2017) print ISSN online e-issn Journal of Pharmacological and Biophysical Research S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney

2 A valuable tool for clinical practice Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 52 Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases J. Serup W. Bäumler Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases Jørgen Serup Wolfgang Bäumler Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases : Serup, J. (Copenhagen); Bäumler, W. (Regensburg) VIII p., 242 fig., 239 in color, 8 tab., 2017 CHF / EUR / USD Hard cover or online prices for personal customers Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN e-isbn Current Problems in Dermatology, Vol. 52 Series Editor: Itin, P. (Basel); Jemec, G.B.E. (Roskilde) ISSN / e-issn Listed in MEDLINE/Pubmed, Thomson Reuters indices Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: Tattooing breaches the skin and can, therefore, cause a variety of complications. This book covers the full spectrum of issues clinical practitioners may encounter when treating affected patients. Introductory chapters include educational information on methods for tattooing, types of tattoos, tattoo inks, and tattoo ink toxicology. The focus is on the diagnosis and classification of tattoo complications. In this regard, a comprehensive atlas of acute and chronic complications serves as a valuable tool. Further chapters summarize available therapies, their rationale, and indication. This includes various medical and surgical treatments with a review of dermatome shaving. Lastly, tattoo removal by gold standard YAG lasers and the more recent pico-second lasers is discussed with the optimal therapeutic outcome in mind. Dermatologists, plastic surgeons, general practitioners, laser surgeons, and other specialists treating tattoo complications will find this book to be an indispensable resource. It also includes information relevant for a broad range of stakeholders in the tattoo business, including authorities and regulators. Contents Preface: Serup, J.; Bäumler, W. From Technique of Tattooing to Biokinetics and Toxicology of Injected Tattoo Ink Particles and Chemicals: Serup, J. Individual Risk and Prevention of Complications: Doctors Advice to Persons Wishing a New Tattoo: Serup, J. Tattoo Infections, Personal Resistance, and Contagious Exposure through Tattooing: Serup, J. Diagnostic Tools for Doctors Evaluation of Tattoo Complications: Serup, J. How to Diagnose and Classify Tattoo Complications in the Clinic: A System of Distinctive Patterns: Serup, J. Medical Treatment of Tattoo Complications: Serup, J. Surgical Treatment of Tattoo Complications: Sepehri, M.; Jørgensen, B. Laser Treatment of Tattoos: Basic Principles: Bäumler, W. Removal of Tattoos by Q-Switched Nanosecond Lasers: Karsai, S. New and Advanced Picosecond Lasers for Tattoo Removals: Adatto, M.A.; Amir, R.; Bhawalkar, J.; Sierra, R.; Bankowski, R.; Rozen D.; Dierickx, C.; Lapidoth, M. Laser Surgeon, Client Education, and Satisfaction with Tattoo Removal: Hutton Carlsen, K.; Esmann, J.; Serup, J. Guide to Treatment of Tattoo Complications and Tattoo Removal: Serup, J.; Bäumler, W. Atlas of Illustrative Cases Index of Cases Author Index/Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger representative. The easiest way to order: Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI17256

3 Official Organ of the Society for Dermopharmacy Journal of Pharmacological and Biophysical Research Founded in 1988 by H. Schaefer as Skin Pharmacology Edited by H.F. Merk Skin Pharmacology and Applied Skin Physiology Incorporating Bioengineering and the Skin Editor J. Lademann, Berlin Honorary Editor H.F. Merk, Aachen Associate P.M. Elias, San Francisco, Calif. J.W. Fluhr, Berlin H.I. Maibach, San Francisco, Calif. H. Mukhtar, Madison, Wis. M. Roberts, Brisbane, Qld. C. Surber, Basel P.C.M. van de Kerkhof, Nijmegen Editorial Board P. Elsner, Jena A. Farkas, Zurich N. Garcia Bartels, Berlin R.H. Guy, Bath S. Hedtrich, Berlin E.M. Jackson, Bonney Lake, Wash. H. Kandárová, Ashland, Mass. L. Kemeny, Szeged J. Kresken, Viersen J. Krutmann, Düsseldorf B. Lange-Asschenfeldt, Klagenfurt am Wörthersee R. Neubert, Halle T. Ruzicka, Munich M. Schäfer-Korting, Berlin M. Schmuth, Innsbruck S. Seidenari, Modena P.W. Wertz, Iowa City, Iowa J. Wohlrab, Halle L. Zastrow, Monaco N. Ahmad, Madison, Wis. C. Antoniou, Athens J.M. Baron, Aachen E. Benfeldt, Roskilde E. Berardesca, Rome K. De Paepe, Brussels Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

4 Guidelines for Authors Submission Manuscripts written in English should be submitted using the online submission website: Should you have any problems with your submission, please contact the Editorial Office: Professor Dr. med. J. Lademann Editorial Office Skin Pharmacology and Physiology S. Karger AG PO Box CH 4009 Basel (Switzerland) Tel Fax Conditions All manuscripts are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of Skin Pharmacology and Physiology and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. The journal consists of the following sections: 1. Editorials 2. Reviews 3. Original Papers 4. Short Communications 5. GD Communications Short Communications Authors may apply to have their paper treated as a short communication. Condition for this is a brief definite report of important results. Final decision whether a paper will be published as a short communication will be made by the. A publication time of two months after acceptance is intended. Conflicts of Interest Authors are required to disclose any sponsorship or funding arrangements relating to their research and all authors should disclose any possible conflicts of interest. Conflict of interest statements will be published at the end of the article. Arrangement Title page: The first page of each paper should indicate the title, the authors names, the institute where the work was conducted, and a short title for use as running head. Full address: The exact postal address of the corresponding author complete with postal code must be given at the bottom of the title page. Please also supply phone and fax numbers, as well as address. Key words: Please supply 3 10 key words in English that reflect the content of the paper. Abstract: Each paper needs an abstract in English of not more than 200 words. The abstract is of utmost importance. It should consist of four paragraphs, labeled Background/Aims, Methods, Results and Conclusion, describing briefly the problem addressed by the study, how the study was performed, the salient results, and what the authors conclude from the results. Footnotes: Avoid footnotes. Tables and illustrations: Tables and illustrations (both numbered in Arabic numerals) should be sent in separate files. Tables require a heading and figures a legend, also in a separate file. Due to technical reasons, figures with a screen background should not be submitted. When possible, group several illustrations in one block for reproduction (max. size mm). Black and white half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800 1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF per page. References: In the text, identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Do not alphabetize; number references in the order in which they are first mentioned in the text. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal : Uniform requirements for manuscripts submitted to biomedical journals ( Examples: (a) Papers published in periodicals: Chatel J-M, Bernard H, Orson FM: Isolation and characterization of two complete Ara h 2 isoforms cdna. Int Arch Allergy Immunol 2003;131: (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: / (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, (d) Edited books: DuBois RN: Cyclooxygenase-2 and colorectal cancer; in Dannenberg AJ, Dubois RN (eds): COX-2. Prog Exp Tum Res. Basel, Karger, 2003, vol 37, pp Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists. Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at Supplementary Material Multimedia files and other supplementary files, directly relevant but not essential to the conclusions of a paper, enhance the online version of a publication and increase its visibility on the web. These files will undergo editorial review. The reserve the right to limit the scope and length of the supplementary material. Multimedia and supplementary material should meet production quality standards for publication without the need for any modification or editing. Files should not exceed 10 Mb in size. Figures and tables need to have titles and legends, and all files should be supplied separately and labeled clearly. All supplementary material should be referred to in the main text. A DOI number will be assigned to supplementary material and it will be hosted online at under a CC BY license. Authors will be charged a processing fee of CHF for supplementary material. Self-Archiving/Green Open Access Karger permits authors to archive their pre-prints (i.e. pre-peer review) or post-prints (i.e. accepted manuscript after peer review but before production) on their personal or their institution s internal website. In addition, authors may post their accepted manuscripts in public Open Access repositories and scientific networks (e.g. ResearchGate or Mendeley) no earlier than 12 months following publication of the final version of their article. For all self-archiving, the posted manuscripts must: Be used for noncommercial purposes only Be linked to the final version on Include the following statement: This is the peer-reviewed but unedited manuscript version of the following article: [insert full citation, e.g. Cytogenet Genome Res 2014;142: (DOI: / )]. The final, published version is available at DOI number]. It is the author s responsibility to fulfill these requirements. For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. Manuscripts to be archived in PubMed Central due to funding requirements will be submitted by Karger on the author s behalf [see Funding Organizations (NIH etc.)]. For self-archiving Author s Choice TM (Gold Open Access) articles, see Author s Choice TM S. Karger AG, Basel karger@karger.com The Guidelines for Authors are available at:

5 Author s Choice TM Karger s Author s Choice TM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at The option is available for a onetime fee of CHF 3,000.00, which is a permissible cost in grant allocation. More information can be found at The final, published version of the article may be posted at any time and in any repository or on other websites, in accordance with the relevant Creative Commons license. Reposted Open Access articles must: Follow the terms of the relevant Creative Commons license Be linked to the final version on Include the following statement: The final, published version of this article is available at DOI number]. It is the author s responsibility to fulfill these requirements. For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. Funding Organizations (NIH etc.) The U.S. National Institutes of Health (NIH) Public Access Policy mandates that accepted, peer-reviewed manuscripts are archived in its digital database, PubMed Central (PMC), within 12 months of the official publication date. As a service to authors, Karger submits NIH-funded articles to PMC on behalf of the authors immediately upon publication. The NIH assigns a PMCID within approximately 1 month and the manuscript will appear in PMC after a 12-month embargo. For authors making their paper Open Access through Author s Choice TM, the embargo will be overridden, thereby accelerating the accessibility of the article. Karger also complies with other funders requirements (including Wellcome Trust and RCUK) for submission to PMC. Authors should include information on their grants in the Acknowledgements section of their papers. Page Charges There are no page charges for papers of 5 or fewer printed pages (including tables, illustrations and references). Each additional complete or partial page is charged to the author at CHF The allotted size of a paper is equivalent to approximately 15 double-spaced manuscript pages (including abstract, tables, illustrations and references). Proofs Unless indicated otherwise, proofs are sent to the corresponding author and should be returned with the least possible delay. Alterations other than the correction of printer s errors are charged to the author. Reprints Order forms and a price list are sent with the proofs. Orders submitted after the issue is printed are subject to considerably higher prices. Read it online: Series Editor D.J. Goldberg, New York, N.Y. Aesthetic Dermatology An innovative global approach to evidence-based aesthetic medicine In the new book series Aesthetic Dermatology, innovations in techniques, such as laser therapy, as well as pharmacologic and cosmetic procedures are presented. Each volume is edited by one or several authorities in their respective field who invite contributors from all over the world to share their versatile experience. Thoroughly researched and evidence-based findings are discussed along with innovations in therapy. The series represents an update on key areas of aesthetic dermatology that will interest both plastic surgeons and aesthetic dermatologists. Aesthetic Dermatology Editor: D.J. Goldberg Vol. 3 Cosmetic Photodynamic Therapy Editor M.H. Gold Aesthetic Dermatology Founded: 2014 Field of Interest: Dermatology Listed in bibliographic services, including: Google Scholar ISSN e-issn Vol. 3: Cosmetic Photodynamic Therapy Editor: Gold, M.H. (Nashville, Tenn.) VIII p., 34 fig., 26 in color, 10 tab., 2016 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn Vol. 2: Radiofrequency in Cosmetic Dermatology : Lapidoth M. (Petach Tikva); Halachmi S. (Herzelia Pituach) VI p., 46 fig., 36 in color, 2 tab., 2015 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn Vol. 1: Laser Treatment of Vascular Lesions : Bard, S.; Goldberg, D.J. (New York, N.Y.) VIII p., 44 fig., 44 in color, 8 tab., 2014 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn *online prices for personal customer **online prices for institutional purchase Prices subject to change, VAT not included. EUR price for eurozone countries, USD price for USA and Latin America only KI S. Karger AG, Basel karger@karger.com The Guidelines for Authors are available at:

6 General Information ISSN Print Edition: ISSN Online Edition: Journal Homepage: Publication Data: Skin Pharmacology and Physiology is published 6 times a year. Volume 30 with 6 issues appears in Copyright: 2017 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Please enquire about reduced rates for members of related societies. Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.com. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: kargerusa@karger.com France Enter & Read Albertine Luginbuhl 23, rue du Départ, boite Paris France t: +33 (0) e: albertineluginbuhl@orange.fr South East Asia, China and Taiwan Karger Regional Office (Malaysia) Level A, PJ Exchange No. 16A, Persiaran Barat Petaling Jaya Selangor Darul Ehsan Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 51F Raffles City Centre 268 Xi Zang Middle Road Huang Pu District Shanghai P.R. China t: f: e: service@karger.cn r.chew@karger.cn w: India, Bangladesh, Sri Lanka Karger India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: r.kumar@kargerindia.com w: Change of Address: Both old and new address should be sent to the subscription source S. Karger AG, Basel karger@karger.com The Journal Home Page is available at:

7 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

8 ENDORSED BY BPPD Bali Tourism Promotion Board PERDOSKI Indonesian Society of Dermatology Bali International Convention Centre The Westin Resort - Nusa Dua 11 th EDITION Great location and organization, excellent talks, very impressed by the number of participants. TATJANA PAVICIC, DERMATOLOGIST, GERMANY Attended all sessions that I could, and learned an incredible amount of helpful information. DIANE DUNCAN, PLASTIC SURGEON, USA One of the best conferences I have ever attended, with world class speakers. SUSIE RENDRA INTAN, DERMATOLOGIST, INDONESIA MORE INFORMATION AND REGISTER ON IMCAS.COM IMCAS Asia is under process of accreditation by SKP IDI, the local organism that grants Continuing Medical Education (CME) credits to Indonesian doctors The first e-learning platform dedicated to dermatology, plastic surgery and aesthetic science F17223 my Note Searh any topic and get access to hundreds of videos MORE THAN VIDEOS ACADEMY.IMCAS.COM FOLLOW US IMCASACADEMY

9 DERMATOLOGIE IM ALLTAG: DERMATOLOGIE DANS LA VIE QUOTIDIENNE: dos & dont s Wissenschaftliche Organisation/ Organisation scientifique Prof. L. Borradori Prof. D. Simon Prof. N. Yawalkar Prof. R. Hunger PD Dr. H. Beltraminelli (Inselspital Bern, Universitätsklinik für Dermatologie, Bern) SAVE THE DATE Administrative Organisation/ Secrétariat administratif Convention Team Lucerne AG Oberseeburg 10, 6006 Luzern Tel ctlag@bluewin.ch Jahresversammlung 99ème Réunion annuelle KURSAAL BERN Wissenschaftliches Programm / Programme scientifique Plenarvorträge/Session plénière Key Lecture 1: Syphilis: Interpretation der Serologie und Behandlung Prof. Dr. Stephan Lautenschlager, Zürich Key Lecture 2: Connectivites: immunosérologie et schéma d investigation Prof. Dr. Pascale Roux Lombard, Genève Key Lecture 3: Borrelien: Diagnostik in der Praxis PD Dr. Martin Hartmann, Heidelberg (D) Key Lecture 4: Lichttherapie: wann und wie? Prof. Dr. Rolf-Markus Szeimies, Recklinghausen (D) Key Lecture 5: Disorders of hyperpigmentation and hypopigmentation: diagnostic algorithms Prof. Dr. Jean Bolognia, New Haven (USA) Key Lecture 6: Les lasers en pratique: pièges à eviter (no-go) Dr. Maurice Adatto, Genève Key Lecture 7: Mollusques e verrues: approche en cabinet Dr. Anne Marie Calza, Genève Key Lecture 8: Basalzellkarzinom: Therapiealgorithmus PD Dr. Severin Läuchli, Zürich Workshop der Arbeitsgruppen SGDV / Ateliers des groupes de travail SSDV Klinisch-pathologische Korrelationen / Corrélations anatomo-cliniques Thematische Fallvorstellungen und Diskussion aus den Kliniken / Présentation thématiques et discussion de cas cliniques par les services Freie Mitteilungen / Communications orales Symposien und Workshops / Symposia et ateliers Organisiert von / Organisé par: AbbVie AG, Allergan AG, Amgen Switzerland AG, Celgene GmbH, Eli Lilly (Suisse) SA, Galderma Schweiz AG, Janssen-Cilag AG, LEO Pharma, MEDA Pharma GmbH, Novartis Pharma Schweiz AG, Pierre Fabre (Suisse) SA Rahmenprogramm / Programme cadre Führung durch die Ausstellung im Zentrum Paul Klee mit anschliessendem Apéro und Nachtessen (Freitag, ) Visite guidée à travers l exposition au Centre Paul Klee puis apéritif et dîner dans le musée (Vendredi, ) F17211 ANMELDUNG online ab INSCRIPTION online dès le : ABSTRACT DEADLINE:

10 October 15-17, 2017 Wroclaw, Poland w.itchwro F17210 ORGANIZERS: International Forum for the Study of Itch Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland

11 The first dermatology journal dedicated exclusively to case reports Editor-in-Chief K.S. Ibler, Roskilde open access peer-reviewed fast online publication Editorial Board R. Antaya, New Haven, Conn. C. Berking, Munich F. Dalgard, Oslo F.W. Danby, Hanover, N.H. M.A. de Rie, Amsterdam V. del Marmol, Brussels L. Emtestam, Stockholm F. Furukawa, Wakayama U. Gieler, Giessen R. Gniadecki, Copenhagen Case Reports in Dermatology Founded: 2009 Category: Clinical Research Field of Interest: Dermatology Listed in bibliographic services, including: PubMed/PubMed Central, Web of Science, Google Scholar, DOAJ, Scopus, Embase D. Ioannides, Thessaloniki P. Itin, Basel G.B.E. Jemle, Roskilde L. Kemeny, Szeged J. Lademann, Berlin R.A. Lee, La Jolla, Calif. K. Matsunaga, Nagoya R. Na, Beijing E.P. Prens, Rotterdam H. Riad Kottb, Doha T. Shiohara, Tokyo This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of dermatology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-oflife, and survivorship issues. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times. 2017: Vol. 9 3 issues per volume online only Language: English e-issn More information at KF17014

12 Towards a personalized approach Y Journal Publication Dermatology 232(suppl 1) 1 32 (2016) 232 S1 16 print online ISSN e-issn ISBN Therapeutic Use of Ingenol Mebutate in Dermatology Guest Editor Günther F.L. Hofbauer, Zurich Therapeutic Use of Ingenol Mebutate in Dermatology Editor Günther F.L. Hofbauer S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney Therapeutic Use of Ingenol Mebutate in Dermatology Editor: Hofbauer, G.F.L. (Zurich) IV + 32 p., 27 fig., 27 in color, soft cover, 2016 CHF / EUR / USD Soft cover and online prices for personal customers Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN (soft cover) e-isbn Special Topic Issue Vol. 232, Suppl.1 (2016), Dermatology Included in subscription Listed in Journal Citation Reports, PubMed/MEDLINE, Current Contents, Scopus, Embase Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Although ingenol mebutate is registered for the topical treatment of actinic keratoses, it can be used to treat various other conditions. This is because, once applied, the drug directly destroys skin cells and induces inflammation. In this special topic issue of Dermatology select authors share their clinical experience thereby providing a guide to novel uses. Topics include the application of ingenol mebutate with occlusion and a reduced number of applications when treating actinic keratoses. Other cases illustrate the authors experience with conditions beyond actinic keratosis such as Bowen s disease, warts, basal cell carcinoma, and lentigo maligna. Dermatologists need to adapt treatments to their patients individual needs. This case collection serves as an indispensable resource when choosing a suitable approach. Contents Preface: Hofbauer, G.F.L. Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis: Tzika, E.; Masouyé, I.; Mühlstädt, M.; Laffitte, E. Ingenol Mebutate 500 μg on the Cheekbones with Concomitant Conjunctivitis: Gaide, O.; Cattin, V. Ingenol Mebutate 500 μg for Treatment of the Scalp in Refractory Field Cancerization: Gaide, O.; Clayton, H.; Girardin, M.; Kuonen, F. Successful Treatment of Relapsing Bowen s Disease with Ingenol Mebutate: The Use of Dermoscopy to Monitor the Therapeutic Response: Mainetti, C.; Guillod, C.; Leoni-Parvex, S. Bowenoid Actinic Keratosis and Bowen s Disease Treated Successfully with Ingenol Mebutate: Mohanna, M.T.; Hofbauer, G.F.L. Ingenol Mebutate 150 mg as Physician-Directed Treatment of Bowen s Disease Under Occlusion: Alkhalaf, A.; Hofbauer, G.F.L. Ingenol Mebutate vs. Daylight Photodynamic Therapy in a Kidney Transplant Recipient: Mühlstädt, M. Ingenol Mebutate for Lentigo Maligna: A Case Report: Gadaldi, K.; Feldmeyer, L.; Yawalkar, N.; Hunger, R.E. Ingenol Mebutate Treatment in a Patient with Gorlin Syndrome: Stieger, M.; Hunger, R.E. Author Index/Subject Index Department: Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger distributor. The easiest way to order: Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI16440

13 The latest knowledge in the field Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 51 Perspiration Research H. Yokozeki H. Murota I. Katayama Perspiration Research Hiroo Yokozeki Hiroyuki Murota Ichiro Katayama Perspiration Research : Yokozeki, H. (Toyko); Murota, H.; Katayama, I. (Osaka) VIII p., 61 fig., 41 in color, 10 tab., 2016 CHF / EUR / USD Hard cover and online prices for personal customers Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN e-isbn Current Problems in Dermatology, Vol. 51 Series Editor: Itin, P. (Basel); Jemec, G.B.E. (Roskilde) Listed in MEDLINE/Pubmed, Thomson Reuters indices Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: Research into perspiration developed dramatically during the last 15 years, continually enhancing our understanding of the pathogenesis of sweating disorders. It has since been elucidated that in addition to its temperature-regulating function perspiration offers bactericidal protection as well. In this book select authors further broaden our perspective on perspiration. Their contributions cover a variety of new aspects, offering insight into the sweat glands major role during the onset of disorders such as parapsoriasis, lichen planus, and lichen amyloidosis and highlighting the importance of Malassezia - an allergen in sweat that exacerbates atopic dermatitis and cholinergic urticaria. Further roles of the sweat glands are being discussed, including as storage of stem cells for replenishing epidermal cells in the case of thermal burns or as water retention sites for replenishing moisture in the stratum corneum. In addition, a novel analysis of the sweat glands threedimensional structures, using high-speed en-face optical coherence tomography (OCT), is being introduced. Offering an in-depth overview of the latest knowledge in perspiration research, this book serves as an essential reference for all medical staff and researchers in the field. Contents Preface: Yokozeki, H.; Murota, H.; Katayama, I. New Pathologies of Skin Disorders Identified from the History of Perspiration Research: Yokozeki, H. Classification of Systemic and Localized Sweating Disorders: Ohshima, Y.; Tamada, Y. New Findings on the Mechanism of Perspiration Including Aquaporin-5 Water Channel: Inoue, R. Old and New Approaches for Assessing Sweating: Murota, H. Sweat as an Efficient Natural Moisturizer: Shiohara, T.; Sato, Y.; Komatsu, Y.; Ushigome, Y. Genetic Disorders with Dyshidrosis: Ectodermal Dysplasia, Incontinentia Pigmenti, Fabry Disease, and Congenital Insensitivity to Pain with Anhidrosis: Wataya-Kaneda, M. Histamine Modulates Sweating and Affects Clinical Manifestations of Atopic Dermatitis: Takahashi, A.; Tani, S.; Murota, H.; Katayama, I.; Mizukawa, Y. Sweating in Systemic Abnormalities: Uremia and Diabetes Mellitus: Murota, H. Abberant Sudomotor Functions in Sjögren s Syndrome: Comparable Study with Atopic Dermatitis on Dry Skin Manifestation: Katayama, I. Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis: Satoh, T. Dyshidrotic Eczema and Its Relationship to Metal Allergy: Nishizawa, A. Pathophysiology and Treatment of Hyperhidrosis: Fujimoto, T. New Etiology of Cholinergic Urticaria: Tokura, Y. Sweat Allergy: Hiragun, T.; Hide, M. Perspiration Functions in Different Ethnic, Age, and Sex Populations: Modification of Sudomotor Function: Lee, J.-B.; Kim, J.-H.; Murota, H. Author Index/Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger distributor. The easiest way to order: Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI16421

14 Three BMA awards for Karger Publishers We are delighted to announce that three Karger titles received Highly Commended awards by the British Medical Association in their prestigious 2016 Medical Book Competition: In the category Internal Medicine In the category Oncology Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 48 Tattooed Skin and Health J. Serup N. Kluger W. Bäumler Developments in Ophthalmology Editor: F. Bandello Vol. 55 Retinal Pharmacotherapeutics Quan Dong Nguyen Eduardo B. Rodrigues Michel Eid Farah William F. Mieler Diana V. Do Progress in Tumor Research (formerly Progress in Experimental Tumor Research) : R.A. Stahel, S. Peters Vol. 42 Immuno-Oncology O. Michielin G. Coukos Tattooed Skin and Health : Serup, J. (Copenhagen); Kluger, N. (Helsinki); Bäumler, W. (Regensburg) X p., 110 fig., 85 in color, 25 tab., hard cover, 2015 ISBN e-isbn Retinal Pharmacotherapeutics : Nguyen, Q.D. (Omaha, Nebr.); Rodrigues, E.B. (São Paulo); Farah, M.E. (São Paulo); Mieler, W.F. (Chicago, Ill.); Do, D.V. (Omaha, Nebr.) XVI p., 83 fig., 71 in color, 33 tab., hard cover, 2016 ISBN e-isbn Immuno-Oncology : Michielin, O.; Coukos, G. (Lausanne) VI p., 8 fig., 5 in color, 11 tab., hard cover, 2015 ISBN e-isbn Karger titles which received awards in previous BMA Medical Book Competitions Olszewski and Baxter s Cytoarchitecture of the Human Brainstem J.A. Büttner-Ennever A.K.E. Horn 3rd, revised and extended edition Progress in Respiratory Research Editor: C.T. Bolliger Vol. 38 Paediatric Bronchoscopy K.N. Priftis M.B. Anthracopoulos E. Eber A.C. Koumbourlis R.E. Wood Developments in Ophthalmology : F. Bandello, W. Behrens-Baumann Vol. 47 Macular Edema A Practical Approach Editor Gabriel Coscas Co- José Cunha-Vaz Anat Loewenstein Gisèle Soubrane KI

15 Original Papers 1 Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy Richters, R.J.H.; Falcone, D. (Nijmegen); Uzunbajakava, N.E.; Varghese, B. (Eindhoven); Caspers, P.J.; Puppels, G.J. (Rotterdam); van Erp, P.E.J.; van de Kerkhof, P.C.M. (Nijmegen) 13 Nrf2- and Bach1 May Play a Role in the Modulation of Ultraviolet A-Induced Oxidative Stress by Acetyl-11-Keto-β-Boswellic Acid in Skin Keratinocytes Yang, S.; Zhou, B.; Xu, W.; Xue, F.; Nisar, M.F.; Bian, C.; Huang, X.; Yang, L.; Zhang, Y. (Chongqing); Bartsch, J.W. (Marburg); Zhong, J.L. (Chongqing) 24 The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice Yamate, Y.; Hiramoto, K.; Sato, E.F. (Suzuka) 36 Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial Gueniche, A.; Castiel-Higounenc, I. (Aulnay-sous-Bois) 46 Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR Alonso, M.R.; Anesini, C. (Buenos Aires) Short Communication 42 Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo Motofei, I.G. (Bucharest); Rowland, D.L. (Valparaiso, IN); Georgescu, S.R.; Tampa, M.; Paunica, S.; Constantin, V.D.; Balalau, C.; Manea, M. (Bucharest); Baleanu, B.C. (Erkelenz); Sinescu, I. (Bucharest)

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