Journal of Pharmacological and Biophysical Research

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1 Skin Pharmacol Physiol 30(3) (2017) print ISSN online e-issn /spp Journal of Pharmacological and Biophysical Research S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney

2 A valuable tool for clinical practice Current Problems in Dermatology Editors: P. Itin, G.B.E. Jemec Vol. 52 Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases Editors J. Serup W. Bäumler Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases Editors Jørgen Serup Wolfgang Bäumler Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases Editors: Serup, J. (Copenhagen); Bäumler, W. (Regensburg) VIII p., 242 fig., 239 in color, 8 tab., 2017 CHF / EUR / USD Hard cover or online prices for personal customers Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN e-isbn Current Problems in Dermatology, Vol. 52 Series Editor: Itin, P. (Basel); Jemec, G.B.E. (Roskilde) ISSN / e-issn Listed in MEDLINE/Pubmed, Thomson Reuters indices Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: Tattooing breaches the skin and can, therefore, cause a variety of complications. This book covers the full spectrum of issues clinical practitioners may encounter when treating affected patients. Introductory chapters include educational information on methods for tattooing, types of tattoos, tattoo inks, and tattoo ink toxicology. The focus is on the diagnosis and classification of tattoo complications. In this regard, a comprehensive atlas of acute and chronic complications serves as a valuable tool. Further chapters summarize available therapies, their rationale, and indication. This includes various medical and surgical treatments with a review of dermatome shaving. Lastly, tattoo removal by gold standard YAG lasers and the more recent pico-second lasers is discussed with the optimal therapeutic outcome in mind. Dermatologists, plastic surgeons, general practitioners, laser surgeons, and other specialists treating tattoo complications will find this book to be an indispensable resource. It also includes information relevant for a broad range of stakeholders in the tattoo business, including authorities and regulators. Contents Preface: Serup, J.; Bäumler, W. From Technique of Tattooing to Biokinetics and Toxicology of Injected Tattoo Ink Particles and Chemicals: Serup, J. Individual Risk and Prevention of Complications: Doctors Advice to Persons Wishing a New Tattoo: Serup, J. Tattoo Infections, Personal Resistance, and Contagious Exposure through Tattooing: Serup, J. Diagnostic Tools for Doctors Evaluation of Tattoo Complications: Serup, J. How to Diagnose and Classify Tattoo Complications in the Clinic: A System of Distinctive Patterns: Serup, J. Medical Treatment of Tattoo Complications: Serup, J. Surgical Treatment of Tattoo Complications: Sepehri, M.; Jørgensen, B. Laser Treatment of Tattoos: Basic Principles: Bäumler, W. Removal of Tattoos by Q-Switched Nanosecond Lasers: Karsai, S. New and Advanced Picosecond Lasers for Tattoo Removals: Adatto, M.A.; Amir, R.; Bhawalkar, J.; Sierra, R.; Bankowski, R.; Rozen D.; Dierickx, C.; Lapidoth, M. Laser Surgeon, Client Education, and Satisfaction with Tattoo Removal: Hutton Carlsen, K.; Esmann, J.; Serup, J. Guide to Treatment of Tattoo Complications and Tattoo Removal: Serup, J.; Bäumler, W. Atlas of Illustrative Cases Index of Cases Author Index/Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger representative. The easiest way to order: /cupde Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI17256

3 Official Organ of the Society for Dermopharmacy Journal of Pharmacological and Biophysical Research Founded in 1988 by H. Schaefer as Skin Pharmacology Edited by H.F. Merk Skin Pharmacology and Applied Skin Physiology Incorporating Bioengineering and the Skin Editor J. Lademann, Berlin Honorary Editor H.F. Merk, Aachen Associate Editors P.M. Elias, San Francisco, Calif. J.W. Fluhr, Berlin H.I. Maibach, San Francisco, Calif. H. Mukhtar, Madison, Wis. M. Roberts, Brisbane, Qld. C. Surber, Basel P.C.M. van de Kerkhof, Nijmegen Editorial Board P. Elsner, Jena A. Farkas, Zurich N. Garcia Bartels, Berlin R.H. Guy, Bath S. Hedtrich, Berlin E.M. Jackson, Bonney Lake, Wash. H. Kandárová, Ashland, Mass. L. Kemeny, Szeged J. Kresken, Viersen J. Krutmann, Düsseldorf B. Lange-Asschenfeldt, Klagenfurt am Wörthersee R. Neubert, Halle T. Ruzicka, Munich M. Schäfer-Korting, Berlin M. Schmuth, Innsbruck S. Seidenari, Modena P.W. Wertz, Iowa City, Iowa J. Wohlrab, Halle L. Zastrow, Monaco N. Ahmad, Madison, Wis. C. Antoniou, Athens J.M. Baron, Aachen E. Benfeldt, Roskilde E. Berardesca, Rome K. De Paepe, Brussels Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

4 Guidelines for Authors Submission Manuscripts written in English should be submitted using the online submission website: /spp Should you have any problems with your submission, please contact the Editorial Office: Professor Dr. med. J. Lademann Editorial Office Skin Pharmacology and Physiology S. Karger AG PO Box CH 4009 Basel (Switzerland) Tel Fax Conditions All manuscripts are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of Skin Pharmacology and Physiology and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. The journal consists of the following sections: 1. Editorials 2. Reviews 3. Original Papers 4. Short Communications 5. GD Communications Short Communications Authors may apply to have their paper treated as a short communication. Condition for this is a brief definite report of important results. Final decision whether a paper will be published as a short communication will be made by the Editors. A publication time of two months after acceptance is intended. Conflicts of Interest Authors are required to disclose any sponsorship or funding arrangements relating to their research and all authors should disclose any possible conflicts of interest. Conflict of interest statements will be published at the end of the article. Arrangement Title page: The first page of each paper should indicate the title, the authors names, the institute where the work was conducted, and a short title for use as running head. 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Prog Exp Tum Res. Basel, Karger, 2003, vol 37, pp Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists. Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at Supplementary Material Multimedia files and other supplementary files, directly relevant but not essential to the conclusions of a paper, enhance the online version of a publication and increase its visibility on the web. These files will undergo editorial review. The Editors reserve the right to limit the scope and length of the supplementary material. 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5 Editors: J. Ring, K. Blaser, M. Capron, J.A. Denburg, S.T. Holgate, G. Marone, H. Saito Author s Choice TM Karger s Author s Choice TM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at. The option is available for a onetime fee of CHF 3,000.00, which is a permissible cost in grant allocation. More information can be found at /authors_choice. The final, published version of the article may be posted at any time and in any repository or on other websites, in accordance with the relevant Creative Commons license. Reposted Open Access articles must: Follow the terms of the relevant Creative Commons license Be linked to the final version on Include the following statement: The final, published version of this article is available at DOI number]. It is the author s responsibility to fulfill these requirements. For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. Funding Organizations (NIH etc.) The U.S. National Institutes of Health (NIH) Public Access Policy mandates that accepted, peer-reviewed manuscripts are archived in its digital database, PubMed Central (PMC), within 12 months of the official publication date. As a service to authors, Karger submits NIH-funded articles to PMC on behalf of the authors immediately upon publication. The NIH assigns a PMCID within approximately 1 month and the manuscript will appear in PMC after a 12-month embargo. For authors making their paper Open Access through Author s Choice TM, the embargo will be overridden, thereby accelerating the accessibility of the article. Karger also complies with other funders requirements (including Wellcome Trust and RCUK) for submission to PMC. Authors should include information on their grants in the Acknowledgements section of their papers. Page Charges There are no page charges for papers of 5 or fewer printed pages (including tables, illustrations and references). Each additional complete or partial page is charged to the author at CHF The allotted size of a paper is equivalent to approximately 15 double-spaced manuscript pages (including abstract, tables, illustrations and references). Proofs Unless indicated otherwise, proofs are sent to the corresponding author and should be returned with the least possible delay. Alterations other than the correction of printer s errors are charged to the author. Reprints Order forms and a price list are sent with the proofs. Orders submitted after the issue is printed are subject to considerably higher prices. Read it online: /chial Chemical Immunology and Allergy... There can be few immunologists in a position to ignore the help provided by these timely reviews... essential reading for virtually all immunologists. Immunology Appearing for the first time in 1939, Progress in Allergy was the first and, for many years, the only international review series in the English language devoted to immunology. The present title, Chemical Immunology and Allergy, reflects the rapidly increasing role of concepts and techniques of molecular and cell biology, as well as the greater emphasis now being placed on research into the biologic problems of immunology, hypersensitivity and immunopathology. Highly specialized, single-topic volumes keep both investigators and practicing physicians up to date with the latest developments in areas of immunology and allergy where recent research has been concentrated. Chemical Immunology and Allergy Vol. 101 Food Allergy: Molecular Basis and Clinical Practice Editors M. Ebisawa B.K. Ballmer-Weber S. Vieths R.A. Wood Chemical Immunology and Allergy Founded: 1939 Fields of Interest: Immunology, Allergy Listed in bibliographic services, including: PubMed/MEDLINE, Google Scholar ISSN e-issn Vol. 101: Food Allergy: Molecular Basis and Clinical Practice Editors: Ebisawa, M. (Sagamihara); Ballmer-Weber, B.K. (Zurich); Vieths, S. (Langen); Wood, R.A. (Baltimore, Md.) XVI p., 19 fig., 4 in color, 56 tab., 2015 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn Vol. 100: History of Allergy Editors: Bergmann, K.-C. (Berlin); Ring, J. (Munich) X p., 257 fig., 127 in color, 20 tab., 2014 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn Vol. 99: Angiogenesis, Lymphangiogenesis and Clinical Implications Editors: Marone, G.; Granata, F. (Naples) XII p., 26 fig., 14 in color, 8 tab., 2014 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn *online prices for personal customer **online prices for institutional purchase Prices subject to change, VAT not included. EUR price for eurozone countries, USD price for USA and Latin America only Vol. 98: Allergy and the Nervous System Editor: Bienenstock, J. (Hamilton, Ont.) XII p., 51 fig., 4 tab., 2012 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn this book is quite unique in this field, by providing a comprehensive and up-dated review of all major research and clinical issues for both experts in this area and those who wish to discover the fascinating world of body-mind interactions in allergy and asthma. Sergio Bonini, Website of the EAACI KI S. Karger AG, Basel karger@karger.com The Guidelines for Authors are available at: /spp_guidelines

6 General Information ISSN Print Edition: ISSN Online Edition: Journal Homepage: /spp Publication Data: Skin Pharmacology and Physiology is published 6 times a year. Volume 30 with 6 issues appears in Copyright: 2017 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Please enquire about reduced rates for members of related societies. Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.com. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: kargerusa@karger.com France Enter & Read Albertine Luginbuhl 23, rue du Départ, boite Paris France t: +33 (0) e: albertineluginbuhl@orange.fr South East Asia, China and Taiwan Karger Regional Office (Malaysia) Level A, PJ Exchange No. 16A, Persiaran Barat Petaling Jaya Selangor Darul Ehsan Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 51F Raffles City Centre 268 Xi Zang Middle Road Huang Pu District Shanghai P.R. China t: f: e: service@karger.cn r.chew@karger.cn w: India, Bangladesh, Sri Lanka Karger India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: r.kumar@kargerindia.com w: Change of Address: Both old and new address should be sent to the subscription source S. Karger AG, Basel karger@karger.com The Journal Home Page is available at: /spp

7 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

8 Medical Statistics has never been easier! D.E. Matthews. V.T. Farewell Using and Understanding Medical Statistics 5th, revised and extended edition >tuberculosis Alive Dead Control Treatment 51 4 > sher.test(tuberculosis) Fisher's Exact Test for Count Data data: tuberculosis p-value= David E. Matthews Vernon T. Farewell Using and Understanding Medical Statistics 5th, revised and extended edition exp(a + bx) Pr(Y=1 X=x) = 1 + exp(a + bx) T= (O1 E1)2 E1 + (O2 E2)2 E2 Matthews, D.E. (Waterloo, Ont.); Farewell, V.T. (Cambridge) Using and Understanding Medical Statistics 5th, revised and extended edition XX p., 48 fig., 103 tab., 2015 CHF / EUR / USD (hard cover + online supplementary material) Online version for institutional purchase Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN (hard cover + online supplementary material) e-isbn ebook available on: Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: The fifth revised edition of this highly successful book presents the most extensive enhancement since Using and Understanding Medical Statistics was first published 30 years ago. Without question, the single greatest change has been the inclusion of source code, together with selected output, for the awardwinning, open-source, statistical package known as R. This innovation has enabled the authors to deemphasize formulae and calculations, and let software do all of the heavy lifting. This edition also introduces readers to several graphical statistical tools, such as Q-Q plots to check normality, residual plots for multiple regression models, funnel plots to detect publication bias in a metaanalysis and Bland-Altman plots for assessing agreement in clinical measurements. New examples that better serve the expository goals have been added to a half-dozen chapters. In addition, there are new sections describing exact confidence bands for the Kaplan-Meier estimator, as well as negative binomial and zero-inflated Poisson regression models for overdispersed count data. The end result is not only an excellent introduction to medical statistics, but also an invaluable reference for every discerning reader of medical research literature. Contents Preface to the Fifth Edition Prefaces to the Previous Editions Basic Concepts Tests of Significance Fisher s Test for 2 2 Contingency Tables Approximate Significance Tests for Contingency Tables Some Warnings concerning 2 2 Tables Kaplan-Meier or Actuarial Survival Curves The Log-Rank or Mantel-Haenszel Test for Comparing Survival Curves An Introduction to the Normal Distribution Analyzing Normally Distributed Data Linear Regression Models for Medical Data Binary Logistic Regression Regression Models for Count Data Proportional Hazards Regression The Analysis of Longitudinal Data Analysis of Variance Data Analysis The Question of Sample Size The Design of Clinical Trials Further Comments regarding Clinical Trials Meta-Analysis Epidemiological Applications Diagnostic Tests Agreement and Reliability References Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger distributor. The easiest way to order: /medical_statistics Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI15406

9 /spp Original Papers 139 Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism Liu, J.; Xu, Y. (Dalian); Lin, T.-K. (Tainan); Lv, C. (Dalian); Elias, P.M.; Man, M.-Q. (San Francisco, CA) 146 An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants Genovese, L. (London); Corbo, A. (Camerino); Sibilla, S. (London) 159 Development of a Synthetic Substrate for the in vitro Performance Testing of Sunscreens Sohn, M.; Malburet, C.; Baptiste, L.; Prigl, Y. (Grenzach-Wyhlen) Review 115 Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function Tessema, E.N. (Halle (Saale)); Gebre-Mariam, T. (Addis Ababa); Neubert, R.H.H.; Wohlrab, J. (Halle (Saale))