ElfaMoist AC Humectant

Transcription

1 AkzoNobel Surface Chemistry ElfaMoist AC Humectant High-performance humectant for deep, instant and 3-hour moisturization, even after one application.

2 INCI: Acetamidoethoxyethanol AkzoNobel s latest innovative skin care ingredient provides the personal care industry with the ability to meet consumers demand for long-lasting and high-performance products without the negative sensory impact of other humectants. ElfaMoist AC humectant is an effective new active that easily penetrates inside the skin (stratum corneum), delivers and increases hydration keeping skin moisturized for over 3 hours, even after one application. Equally important, ElfaMoist AC humectant performs exceptionally without showing disruption to the skin barrier, making it safe and gentle on the skin. With ElfaMoist AC humectant, formulators can create the finest skin care products in a wide variety of leave-on as well as rinse-off products. Key Benefits for Formulators High moisturizing efficacy (instant and over 3 hours) Effective penetration and deposition properties Non-sticky, easily spreadable aesthetics ph and hydrolytic stability 1% active (as supplied) Easy to formulate, liquid form Synergistic effect with other humectants Compatible with most commonly used ingredients Does not impact the color of your formulation Improves freeze thaw stability of emulsions Preservative free Nitrosamine free Key Benefits for Consumers During Application Great absorbency Lubricity in skin feel Excellent spreadability After Application Lack of stickiness/tackiness Highly effective skin hydration Instant and long-lasting moisturization (over 3 hours)

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4 ElfaMoist AC humectant offers high moisturizing efficacy (instantly and over 3 hours), after a single application How does ElfaMoist AC humectant work? Designed by AkzoNobel scientists, ElfaMoist AC humectant interacts with water and keratin (skin protein) to keep the water molecules tightly bound in the stratum corneum. This binding mechanism ensures that ElfaMoist AC humectant continues to improve hydration initially as well as over 3 hours. In-vitro and in-vivo tests indicate the binding mechanism of ElfaMoist AC humectant and its high-performance capabilities. Figure 1: Function of ElfaMoist AC humectant on skin Moisturization Efficacy Measured by Corneometer Comparison with premium humectants In-vivo moisturizing efficacy is measured by the ingredient s ability to increase the water content in the skin (stratum corneum). The measuring principle of the Corneometer is based on the dielectric constant in the medium and water has the greatest impact on the dielectric constant of the skin. Therefore, any increase in water content on skin can be determined by corneometer measurements. Results: ElfaMoist AC humectant performed significantly better than other premium moisturizing agents in the marketplace initially and over the 3 hours of study. Figure 2: In-vivo Corneometer study (1% active ingredient in.5% Carbomer gel) Change in Moisture (arbitrary units) Time (hours) ElfaMoist AC Sodium PCA Water (Negative Control) Dermis Epidermis ElfaMoist AC Stratum Corneum Dermis Note: Gels with 1% active level of either ElfaMoist AC humectant, a control with water, as well as various commercial benchmarks were applied in a 4cm diameter circle on the volar forearm of panelists. Moisture levels of the stratum corneum were measured prior to application of the gel and 3 minutes, 1, 2, 4, 6, 24, and 3 hours after application. FORMULATION USED IN THE STUDY Ingredients Weight % Deionized water 88.5 Compound 1. DMDM Hydantoin (and) Iodopropynyl Butylcarbamate.5 Carbomer, Carbopol 94 Polymer.5 TEA.5

5 Instant and long-lasting moisturization The in-vivo corneometer study demonstrated that ElfaMoist AC humectant is capable of delivering outstanding instant (Figure 3) and long-lasting moisturization benefit (Figure 4) by increasing hydration in the stratum corneum and effectively retaining water over 3 hours. Results: Through Corneometer testing, it has been confirmed that ElfaMoist AC humectant instantly increases the water content of the stratum corneum and effectively retains the water over 3 hours. ElfaMoist AC humectant performs better than other premium humectants initially and at 3 hours. Figure 3: In-vivo Corneometer 1-hour study of 1% active ElfaMoist AC humectant compared with benchmarks and water Relative skin hydration after 1 hour Figure 4: In-vivo Corneometer 3-hour study of 1% active ElfaMoist AC humectant compared with benchmarks and water 1.4 Relative skin hydration after 3 hours Water Water Saccharide Isomerate Saccharide Isomerate Sodium PCA Sodium PCA ElfaMoist AC ElfaMoist AC Note: Corneometer measurements 3 Hr. study using 1% active competitor ingredients in.5% Carbopol 94 Gel. Comparison with glycerin Furthermore, ElfaMoist AC was evaluated using Corneometer vs. Glycerin at 5% active over 3 hours. Results: ElfaMoist AC humectant shows in-vivo skin moisturization efficacy better than Glycerin the benchmark for moisturization in the industry at 5% active levels (Figure 5). Therefore, when compared directly with Glycerin, ElfaMoist AC has demonstrated better performance instantly as well as over 3 hours. Figure 5: In-vivo t-test Corneometer (5% active ingredient in.5% Carbomer gel) at 5% active over 3 hours Actual Corneometer Readings hr 1hr 2hr 4hr 6hr 24hr 3hr Glycerin ElfaMoist AC p <.2 p >.1 Number of experiments: 8 Note: Gels with 5% active level of ElfaMoist AC humectant and Glycerin, were applied in a 4cm diameter circle on the volar forearm of panelists. Moisture levels of the stratum corneum were measured prior to application of the gel and 3 minutes, 1, 2, 4, 6, 24, and 3 hours after application. Performs significantly better than premium humectants

6 Active Delivery In a study conducted by TRI/Princeton, the efficacy of ElfaMoist AC humectant was measured and compared with Glycerin, the industry's benchmark for moisturization. Attenuated total reflectance (ATR) Fourier Transform Infrared (FTIR) imaging spectroscopy was used to analyze and visualize the deposition and penetration of these actives in the skin (stratum corneum). ATR-FTIR imaging spectra were collected at the skin surface before treatment (control), on the skin surface after treatment (deposition) and then after sequential tape strips (penetration). Deposition and penetration Results: The deposition of both ElfaMoist AC humectant and benchmark on the human skin can be observed after 3 min treatment (skin after treatment). Skin barrier To better understand the effects of the product application on the skin, TRI/Princeton also verified if both active penetrations disturbed the skin barrier (Figure 6). To assess this parameter, the CH 2 peak position from the lipid was observed. The increase of a few cm-1 in the high frequencies of the CH 2 bands reflects a modification of the acyl chain packing. The CH 2 peak position is a relevant marker to analyze the lipid organization in the stratum corneum. Results: ElfaMoist AC humectant is effective at depositing and penetrating into to the stratum corneum without disturbing the skin barrier. The lack of significant differences observed in the lipid order indicates that ElfaMoist AC humectant and benchmark do not disturb the skin barrier function and are gentle the skin. (Figure 7) Results: The penetration of the products inside the human skin can be detected up to layer 6 (the lowest layer analyzed in the study) for both ElfaMoist AC humectant and benchmark products (Figure 6). The active penetrations correlate and are associated with a skin moisturizing effect (increase in skin hydration). Figure 6: Deposition and penetration efficacy by FTIR imaging Lipid order (skin lipid organization) Less ordered Skin control Skin after treatment ElfaMoist AC Glycerin Product/Amide II Area band ratio.25.2 Skin control ElfaMoist AC Glycerin More ordered Skin layer 2 Skin layer Skin after treatment Deposition Skin layer 6.5 Skin layer 2 Figure 7: ATR-FTIR image showing CH 2 peak position Skin layer 4 Penetration Note: In the ATR-FTIR image presented above, the higher the value (red), the higher is lipid disorder. Skin layer 6 Note: The ATR-FTIR image shows the 19-1 cm-1 to cm-1 band area ratio which normalizes the product peaks (19-1 cm-1) to the Amide II peaks ( cm-1). In the ATR-FTIR images presented in this section, the higher the ratio, the redder is the image and the higher is the actives concentration. Figure 6 shows results recorded with 5% aqueous solution -.25mL of solution per square centimeter (12.5mg/skin cm).

7 Effective at depositing, penetrating and delivering hydration to the stratum corneum without disturbing the skin barrier

8 Sensory Evaluations External sensory evaluation Sensory evaluation involves the detection and description of a product s sensory characteristics. Sensory testing was done by Sensory Spectrum to determine skin-feel properties among skincare formulation samples using ElfaMoist AC humectant and other premium humectants. They were evaluated by expert panelists trained in Skinfeel Descriptive Analysis methodology. Results: ElfaMoist AC humectant has statistically lower stickiness when compared with, Sodium PCA, and Saccharide Isomerate (Figure 8 and 9). Figure 8 and 9: 5% active solutions evaluated by Sensory Spectrum Stickiness Immediate Afterfeel Stickiness After 2 min. Afterfeel ElfaMoist AC ElfaMoist AC Sodium PCA Sodium PCA Saccharide Isomerate Saccharide Isomerate Note: Indicates significant difference at 95% confidence. Non-tacky, easily spreadable and better aesthetics than most premium humectants

9 Results: ElfaMoist AC humectant has statistically superior spreadability and slipperiness than Sodium PCA,, and Saccharide Isomerate (Figures 1 and 11). Figure 1: 5% active solutions evaluated by Sensory Spectrum Spreadability ElfaMoist AC Sodium PCA Saccharide Isomerate In-house sensory evaluation Furthermore, internal subjective testing done by eight panelists also evaluated tack and spreadability of ElfaMoist AC humectant and Glycerin as the benchmark during the rubout phase as well as after feel tack/stickiness. Results: ElfaMoist AC humectant demonstrated better tack and spreadability during rub out as well as during the after feel than the benchmark. (Table 1) Comparisons were performed using 1% active raw material. Table 1: In-house subjective evaluation of 1% active raw material Pick-up Attribute Stickiness Rub-out Attribute Spreadability After feel Attribute Stickiness Glycerin 1/8 /8 1/8 ElfaMoist AC Humectant + statistically different at a 95% confidence level. (+) 7/8 (+) 8/8 (+) 7/8 Indicates significant difference at 95% confidence. Figure 11: 5% active solutions evaluated by Sensory Spectrum Slipperiness Texture Analyzer evaluation for spreadability This method measures the force required to spread a sample in order to investigate textural attributes of personal care products such as lotions, creams, gels for the purpose of texture mapping and sensory correlation. The texture analyzer assesses textural properties by comparing force, distance, and time data. The texture analyzer was used to evaluate the force required to spread both ElfaMoist AC humectant and benchmark. Results: This texture analyzer study on the neat raw material (1% active) demonstrates ElfaMoist AC humectant requires statistically less force to spread the samples compared to the benchmark. This objective evaluation technique demonstrates good agreement with the subjective evaluation results from Sensory Spectrum and those carried out in-house. (Figure 12) ElfaMoist AC Sodium PCA Saccharide Isomerate Figure 12: Spreadability evaluated by Texture Analyzer 4 Indicates significant difference at 95% confidence. Force (gms) Glycerin Spreadability ElfaMoist AC

10 Stability ph and viscosity stability ElfaMoist AC humectant has shown excellent ph & viscosity stability during freeze/thaw cycles and at 25 C, 45 C and 5 C over a period of twelve weeks, after adjusting the ph to the desired range for skincare formulations. Figure 13: ElfaMoist AC humectant ph stability prepared at 1% aqueous and ph adjusted to 5.5 ph Figure 14: Viscosity stability neat ElfaMoist AC humectant Viscosity (cps) Time (weeks) Time (weeks) 25 C 45 C 5 C F/T 25 C 45 C 5 C F/T (RV Emulsion freeze-thaw stability The benefit ElfaMoist AC humectant imparts to an O/W emulsion was demonstrated by comparing the two formulations listed in Table 2. The formulation with 5% ElfaMoist AC humectant remained freeze-thaw stable after three cycles as demonstrated below in Figure 15 compared to the Base formulation without ElfaMoist AC humectant which failed after one cycle. Table 2: Oil/Water emulsion formulations for freeze-thaw stability testing INCI Phase A A BASE B 5% ElfaMoist AC Water (Aqua) 41.12% 41.12% Disodium EDTA.5%.5% Acrylates/C1-3 Alkyl Acrylate Crosspolymer.5%.5% Dehydroxanthan Gum.5%.5% Phase B Ethylhexyl Benzoate 1.% 1.% Avobenzone 3.% 3.% Ethylhexyl Salicylate 5.% 5.% Homosolate 12.% 12.% Octocrylene 4.% 4.% Benzophenone-3 6.% 6.% Stearate (and) PEG-1 Stearate 2.% 2.% Paraffin Wax.2%.2% Phase C Triethanolamine.8%.8% Water (Aqua) 2.% 2.% Phase D Styrene/Acrylates Copolymer 2.2% 2.2% Cyclopentasiloxane 3.5% 3.5% Phenoxyethanol (and) Ethylhexylglycerin.5%.5% Tapioca Starch (and) Polymethylsilsesquioxane 3.% 3.% Silica.25%.25% ElfaMoist AC humectant - 5.% Water (Aqua) 5.% - Total 1.% 1.% Figure 15: 5% Base formulation (left) separates after one freeze thaw cycle whereas formulation with 5% ElfaMoist AC humectant remains freeze-thaw stable after three cycles

11 Excellent long-term stability profile Suggested Applications ElfaMoist AC humectant has demonstrated very good compatibility with a broad range of raw materials and as such it offers an excellent moisturizing benefit in a wide variety of leave-on emulsion systems such as creams, lotions, antiperspirant/deodorant, masks, eye-cream, baby lotions, BB creams, and facial mask sheets. ElfaMoist AC humectant also finds great utility in rinse-off products such as shower gels, moisturizing hand liquid soap, and body washes. Formulation Guidelines ElfaMoist AC humectant is readily water soluble and is easily incorporated into water or into the water phase of an emulsion at ambient or elevated temperature conditions. ElfaMoist AC humectant can also be post added to a formulation during cool down. Storage and Handling ElfaMoist AC humectant can be stored under ambient conditions without undergoing decomposition or degradation. When not in use, the container should be kept covered to prevent dirt, dust, and moisture pick-up. Store in a cool, dry area. This product is freeze thaw stable. This product is best used within 12 months of manufacture. Health and Safety Information on ElfaMoist AC humectant relating to the EU Cosmetics Directive 76/768/EEC is available on request. The suitability of the final formulations should be confirmed in all respect by appropriate evaluation. The marketer is advised to evaluate the final formulation with regard to performance and health and safety. Suggested ph range of final formulations: 3-8 Suggested use levels, as supplied Leave-on moisturizing products (creams, lotions, gels) % Sun care (pre and post sun care products) % Rinse-off products (shower gels, body wash, % hand liquid soap, and skin cleansing systems) Color cosmetics (foundations, BB creams, blushes) %

12 All information concerning our products and/or all suggestions for handling and use contained herein (including formulation and toxicity information) are offered in good faith and are believed to be reliable. However, AkzoNobel Surface Chemistry makes no warranty express or implied (i) as to the accuracy or sufficiency of such information and/or suggestions, (ii) as to any product s merchantability or fitness for a particular use or (iii) that any suggested use (including use in any formulation) will not infringe any patent. Nothing contained herein shall be construed as granting or extending any license under any patent. The user must determine for itself by preliminary tests or otherwise the suitability of any product and of any information contained herein (including but not limited to formulation and toxicity information) for the user s purpose. The safety of any formulations described herein has not been established. The suitability and safety of a formulation should be confirmed in all respects by the user prior to use. The information contained herein supersedes all previously issued bulletins on the subject matter covered. AkzoNobel creates everyday essentials to make people's lives more liveable and inspiring. As a leading global paints and coatings company and a major producer of specialty chemicals, we supply essential ingredients, essential protection and essential color to industries and consumers worldwide. Backed by a pioneering heritage, our innovative products and sustainable technologies are designed to meet the growing demands of our fast-changing planet, while making life easier. Headquartered in Amsterdam, the Netherlands, we have approximately 45, people in around 8 countries, while our portfolio includes well-known brands such as Dulux, Sikkens, International, Interpon and Eka. Consistently ranked as a leader in sustainability, we are dedicated to energizing cities and communities while creating a protected, colorful world where life is improved by what we do. 217 Akzo Nobel N.V. All rights reserved. North America USA and Canada: Akzo Nobel Surface Chemistry LLC 525 West Van Buren Street Chicago IL T T E personalcare.usa@akzonobel.com Mexico: Akzo Nobel Chemiclas S.A. de C.V. Av Ejército Nacional Chapultepec Morales CP Mexico DF México T /95 E personalcare.mexico@akzonobel.com Europe Akzo Nobel Surface Chemistry AB Stenunge Allé 3 SE Stenungsund Sweden T E personalcare.europe@akzonobel.com South America Akzo Nobel LTDA Rodovia Akzo Nobel, 77 Itupeva Sao Paulo, Brazil T E personalcare.southamerica@akzonobel.com Asia Pacific China: Akzo Nobel Chemicals (BoXing) Co., Ltd. Shanghai Branch 22F Eco City No West Nan Jing Road Shanghai, 24 China T E personalcare.china@akzonobel.com Singapore: Akzo Nobel House Surface Chemistry 3 Changi Business Park Vista #5-1 Singapore T E personalcare.sea@akzonobel.com Australia: Akzo Nobel Pty Limited 8 Kellaway Place Wetherill Park NSW 2164 Australia T /69 E personalcare.australia@akzonobel.com India: Akzo Nobel India Limited Plot No 1/1, TTC Industrial Area Thane Belapur Road, Koparkhairane Navi Mumbai 471, Maharashtra India T E personalcare.india@akzonobel.com Version AN_21578_22415