Sino Hyal TM Hyaluronan Technology. Personal Care. The control of water is a source of beauty. FarmaSino Europe Life sciencies knowledge

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1 Sino Hyal TM Hyaluronan Technology Personal Care The control of water is a source of beauty

2 Sino Hyal TM Hyaluronan Technology HYALURNIC HAS BEEN IN THE CSMETIC MARKET FR A LNG TIME. WHY? Because it works! And it works very well. Let s see: some actives imitate the phisiological activity of existing molecules within the human body, taking part in skin processes in order to obtain the desired objective. Hyaluronic acid is a different case, it is not imitating any other s behavior. It exists itself, it is not copying any other molecule, and this is a guarantee of success.

3 Sino Hyal TM THE CNTRL F WATER IS A SURCE F BEAUTY Hyaluronic (or its sodium hyaluronate salt) is controlling the water in our skin, acting as a phisical structure in the skin, and also as a water atraction structure. Both things, at the same time, are responsible of its role in the skin. Lack of hyaluronic acid could leads to a skin dehydration situation. Taking into consideration these premises, we could deduce, that if your levels of hyaluronic are correct you do not need any help to keep your moisturization level, but this is not easy with are current way of living. Hyaluronic is continously suffering a catabolic and anabolic process, and, as time goes by, the percentage of this compound decresases in our body, and consequently our level of hydration is affected. Hyaluronic molecule can be understood as a sponge, and its capacity of being a building block and attracting water is directly rated to the density of this sponge. EFFECTS Molecular weight is the parameter that impact the capacity of absorbing water. Within our body, molecular weights range from to Daltons, and this also afects the capacity of going into deeper skin stratum. Mechanism: Water Attraction or Low Evaporation Effect: Deeper Hydration or Film Forming EFFECTS F Hyaluronic Acid N THE SKIN: Without HA Attracted water With HA

4 CHEMICAL DESCRIPTIN It is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Composed of D-glucuronic acid and D-Nacetylglucosamine, linked via alternating β-1,4 and β-1,3 glycosidic bonds. CH CH 2 H H CH CH 2 H H H H H H HN CH 3 H H HN CH 3 n - 1 PRDUCTIN With a long experience with sodium hyaluronate, the production team has the capacity of answering any technical demand promptly. The manufacturing and quality control expertise has been audited and approved. TLBX Sino Hyal TM Molecular Weight Application INCI: Sodium Hyaluronate HMW M Da External Film MMW M Da Film / Hydration LMW M Da Fast Hydration VLMW M Da Internal Hydration INCI: Hyaluronic Acid HAC Da Easy penetration Taylor made grades can be requested

5 Company Farmasino Europe is a subsidiary of Farmasino Pharmaceuticals, 135 people with a common objective, becoming a leader in the Personal Care world. We are a new concept of chinese company, we call it version 2.0. Besides cost we consider quality, traceability and environment. What else? Regulatory aspects, of course! This point of view allows us to be considered as a partner all around the world. For us, nowadays, ocassional business has no sense, we offer a long term relationship. How and why? We have our own chemical factory in Anjui. There, we produce API s and chemical intermediates sold around the world. ur factory is an IS-9001 audited company, and also and HSAS certified company with manufactures conforming to GMP practice. We think that the added value is not having several factories, but controlling different chemical technologies. Following this idea, we invested our resources in developing a Research and Development Centre in Jiangsu (Jiangssu Life Sciences and Technology Innovation Park). 35 people, and four departments at your disposal, as follows: - The Chemical synthesis department - The Quality Control and Quality Assurance department - The New drug registration department - The International Regulatory Affairs Department This structure has allowed us to individuate the right partners, who can work with us under an agreement. Working with us you know with whom you are working. This means traceability. This policy permits the control of the factory through presential acces and also through a doubble checking for the key analytical parameters in our lab. It is also possible the development of taylor made products or taylor made analytical specifications. 2.0: new ideas, new concepts, new points of view. ur team in Europe is linked to our company in China, because we need to fulfill the European requirements, and this can only be done with European people. More? Warehousing facilities: Shanghai warehouse covers an area of sqm. What about Europe? ur first logistic center is located nearby Milano, and it is our first step to grow with our European customers. Yan Li Bo ur sales strategy considers two ways of working: key partners, that are assisted straight from Farmasino and other companies that need special support from our key distributors, the same business model is applied to every area of Life Sciences that we work on.

6 Scan to view the video Scan to view the website Europe China Via Cavour 30, Crema (CR) Italy T F info@farmasinoeurope.com