PRODUCT CATALOG. +1 (855)

Transcription

1 PRODUCT CATALOG C O M P O U N D I N G +1 (855)

2 HUMCO GLOBAL HEADQUARTERS 201 W. 5th St, Floor 12 Austin, TX REMIT PAYMENTS TO 7400 Alumax Drive Texarkana, TX PHONE & FAX +1 (855) toll free +1 (512) (512) fax compounding@humco.com ONLINE ORDERING PROFESSIONAL SERVICE HOURS Monday-Friday, 8:30 AM - 5:30 PM Central Standard Time PHARMACEUTICAL RESOURCE CENTER & CUSTOMER SERVICE +1 (855) toll free +1 (512) crc@humco.com Formulation questions Stability testing & BUD data Penetration studies Request a sample Certificate of Analysis SHIPPING - FREE UPS Ground Service is free for DTP (Direct-to-Pharmacy) accounts on orders of more than $100 and weighing less than 200 pounds in the lower 48 states. For orders less than $100, shipping charges based on weight will apply. Excludes hazardous materials, oversized (larger than 84 ) items, drop shipped, and any items requiring special handling. ALASKA & HAWAII US published rate OUTSIDE THE U.S. Please call your International Representative for current shipping charges HAZARDOUS MATERIALS Per package fee of $25 in addition to air or ground shipping charge. BACK ORDERS We will notify you if any items are unavailable to ship. All back orders will be shipped free, UPS 3 day service, unless otherwise specified. SDS & BUD STUDIES Available online at 2 HUMCO +1 (855)

3 CONTENTS ABOUT HUMCO HUMCO COMPOUNDING PRODUCT LIST ACTIVE PHARMACEUTICAL INGREDIENTS VALIDATED STABILITY STUDIES CREAMS & LOTIONS GEL BASES & OINTMENTS PRE-MIXED EXCIPIENT BASES ORAL VEHICLES MISCELLANEOUS INGREDIENTS (855) HUMCO 3

4 ABOUT HUMCO Humco, founded in 1872, is a diversified global pharmaceutical company. Humco is focused on developing, manufacturing and commercializing innovative pharmaceuticals and high-quality over-thecounter (OTC) medicines for patients around the world. With headquarters in Austin, TX, Humco serves over 45,000 pharmacies through its Pharmaceutical Segment and its Consumer OTC Products franchise. The Company is anchored by its leading non-sterile compounding delivery vehicles, including topical and transdermal creams, syrups and suspensions. Humco also serves consumers through its established and diverse Consumer OTC Products business of over 160 items with product placement in all major drug, food, and mass-market retail chains, along with independent, locally owned pharmacies. 4 HUMCO +1 (855) Humco s leading team of professionals have strong expertise ranging from product development to commercialization in the Company s state-of-the-art FDA registered, cgmp compliant facilities. With a presence in approximately 20 countries, Humco is committed to working with pharmacists, physicians, healthcare providers and patients to deliver innovative and meaningful treaments that help people around the world live longer, healthier lives.

5 HUMCO COMPOUNDING Humco proudly manufactures and distributes a diversified line of pharmaceutical products. We focus on developing products that offer dynamic solutions and help to fulfill unmet patient and pharmacist needs. Humco has a vast portfolio of pharmaceuticals that aid in imperative solutions across several key therapeutic categories including: Pain Management Infectious Disease Hormone Replacement Therapy Wound Care Dermatology and Aesthetics Humco has established a leading reputation for developing, manufacturing, and commercializing a diversified line of non-sterile topical and oral pharmaceutical compounding delivery vehicles. Our patented compounding products range from ready-to-use topical creams and gels to oral syrups and suspensions. Our products are designed to provide an optimal delivery system for a variety of formulations based on the desired route of administration and therapeutic intent. Humco s delivery vehicles are tailored to meet pharmacist s non-sterile compounding needs while reducing the compounding preparation time and improving therapeutic outcome for patients. In addition to our delivery vehicles, Humco offers an extensive selection of Active Pharmaceutical Ingredients (APIs) that are conveniently packaged in a variety of sizes to effectively accommodate the needs of pharmacists, hospitals, and pharmaceutical companies. OUR APPROACH: We can be counted on We get the job done We take responsibility We find a better way We succeed as a team +1 (855) HUMCO 5

6 TOPICAL BASES & VEHICLES CREAMS & LOTIONS Anhydrous Base VERSATILE TOPICAL CREAM GENEDERM DERMATOLOGICAL TOPICAL CREAM HRT Botanical HORMONE THERAPY TOPICAL CREAM HRT Heavy HORMONE THERAPY TOPICAL CREAM Liposomal Heavy VERSATILE TOPICAL CREAM Liposomal Regular VERSATILE TOPICAL CREAM Multibase VERSATILE TOPICAL CREAM lb/454 g $ g $ lb/454 g $ lb/4500 g $ lb/454 g $ lb/4500 g $ lb/18200 g $ lb/454 g $ lb/4500 g $ lb/18200 g $ lb/454 g $ lb/4500 g $ lb/18200 g $ lb/454 g $ lb/4500 g $ lb/18200 g $ GEL BASES & OINTMENTS Lavare WOUND WASH GEL PLO20 Flowable VERSATILE TOPICAL LIGHT CREAM PLO20 Non-Flowable VERSATILE TOPICAL CREAM Universal Water Gel VERSATILE TOPICAL GEL g $ g $ g $ lb/454 g $ lb/454 g $ lb/4500 g $ lb/454 g $ lb/4500 g $ PRE-MIXED EXCIPIENT BLENDS Emulsion Concentrate VISCOSITY ENHANCER oz $ oz $ gal $ PENcream VERSATILE TOPICAL CREAM RECURA ANTIFUNGAL TOPICAL CREAM SALTSTABLE LO PAIN MANAGEMENT TOPICAL CREAM SALTSTABLE LS ADVANCED PAIN MANAGEMENT TOPICAL CREAM Sanare Advanced SCAR THERAPY BASE lb/454 g $ lb/4500 g $ lb/18200 g $ g $ g $ lb/454 g $ lb/4500 g $ lb/18200 g $ g $ g $ g $ g $ g $ g $ USP GUIDELINES It is the responsibility of the pharmacists to follow USP Guidelines and state-specific rules on proper compounding procedures and techniques. Compounders should refer to USP Chapter <795> and <1075>, which relate to non-sterile compounding, to help define good compounding practice and provide general information on acceptable strength, quality and purity. 6 HUMCO +1 (855)

7 Our compounding bases and vehicles are ready-made with wetting agents already incorporated into the base. Most formulations will not require any additional wetting or milling, greatly reducing the compounding preparation time. ORAL VEHICLES Cherry Syrup SYRUP VEHICLE oz/473 ml $ gal/3.8 L $65.00 Syrpalta (No Color) SYRUP VEHICLE oz/473 ml $16.00 Flavor Blend SYRUP & SUSPENDING VEHICLE oz/473 ml $ gal/3.8 L $80.00 Versa Free SYRUP VEHICLE oz/473 ml $ gal/3.8 L $85.00 Flavor Plus SUSPENDING VEHICLE oz/473 ml $ gal/3.8 L $80.00 Versa Plus SUSPENDING VEHICLE oz/473 ml $ gal/3.8 L $85.00 Flavor Sweet-SF SYRUP VEHICLE oz/473ml $ gal/3.8 L $80.00 Flavor Sweet SYRUP VEHICLE oz/473 ml $ gal/3.8 L $80.00 Mouthwash-AF ALCOHOL FREE MOUTHWASH BASE Mouthwash-GP GENERAL PURPOSE MOUTHWASH BASE Mouthwash-OM MOUTHWASH BASE FOR ORAL MUCOSITIS Raspberry Syrup SYRUP VEHICLE Simple Syrup SYRUP VEHICLE Sorbitol Solution 70% USP SYRUP oz/236 ml $ oz/236 ml $ oz/236 ml $ oz/473 ml $ oz/473 ml $ gal/3.8 L $ gal/19 L $ oz/473 ml $6.50 BULK PRICING AVAILABLE Contact us for pricing on bulk quantities +1 (855) Syrpalta (Red) SYRUP VEHICLE oz/473 ml $16.00 *Prices are current at time of printing (July 1, 2017); however, pricing and specifications are subject to change without notice. Please contact the Resource Center or visit the website for updated pricing (855) HUMCO 7

8 ACTIVE PHARMACEUTICAL INGREDIENTS Amantadine Hydrochloride, USP Amitriptyline Hydrochloride, USP Baclofen, USP Benzocaine, USP Bupivacaine Hydrochloride, USP Cyclobenzaprine Hydrochloride, USP DHEA (Micronized) (Prasterone) Diclofenac, USP Doxycycline Hyclate, USP Estradiol, USP (Micronized) Estriol, USP (Micronized) Estrone USP g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ Fluconazole, USP Flurbiprofen, USP Fluticasone Propionate, USP (Micronized) Gabapentin, USP Ibuprofen, USP Ketamine Hydrochloride, USP Ketoprofen, USP Lidocaine Hydrochloride, USP Methimazole, USP Miconazole, USP Pentoxifylline, USP Phenytoin Sodium, USP g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ HUMCO +1 (855)

9 Prilocaine, USP Progesterone, USP (Micronized) Promethazine Hydrochloride, USP Testosterone, USP (Micronized) Tetracaine Hydrochloride, USP g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ Liothyronine, USP (T3) Levothyroxine, USP (T4) Thyroid, USP (Porcine) Verapamil Hydrochloride, USP API Standards & Testing g $ g $ g $ g $ gm $ gm $ g $ g $ g $ Before Humco considers purchasing an Active Pharmaceutical Ingredient (API), we pre-qualify our suppliers to ensure that they manufacture the API under current Good Manufacturing Practices, as expected in ICH Q7A requirements. Once the API is received, a statistical sample is taken and tested in our on-site laboratories. Through comprehensive and thorough testing, we ensure the identity of the API and that the potency meets the USP requirements and are comparable to the manufacturer s Certificate of Analysis (CofA). We use qualified and calibrated state-of-the-art analytical equipment under the Laboratory Controls delineated in 21 CFR 211. A few examples of these include: Fourier Transform Infrared Spectrophotometer (FTIR) Ultra Violet/Visible Light Spectrophotometer (UV/Vis) Identification by Chemical Reactions Identification by Flame High Pressure Liquid Chromatography (HPLC) Gas Chromatograph (GC) Thin Layer Chromatography (TLC) Titrations Humco is committed to adhering to the highest quality standards to ensure that our products are consistently valued as the best option for patients and pharmacists (855) HUMCO 9

10 VALIDATED STABILITY STUDIES The Beyond-Use-Date study evaluates the potency and stability of a formula over a course of time, from 30 days to 180 days. Below is an alphabetical listing of the API s studied for stability with correlating bases used for the compounded preparations. Please note, strength depends on percentage of API used. See appropriate product page for details. Active Ingredient HRT Botanical HRT Heavy Liposomal Heavy Liposomal Regular Multibase PENcream PLO20 Non-Flowable PLO20 Flowable RECURA SaltStable LO SaltStable LS Advanced Amitriptyline HCl 90 Baclofen 90 Benzocaine 90 Bupivacaine HCl 90 Capsaicin 90 Clomipramine HCl Cyclobenzaprine HCl Dehydroepiandrosterone 90 Dexamethasone 90 Diclofenac 90 Diclofenac Na 90 Diltiazem Diphenhydramine HCl 90 Estradiol Estriol Estrone Fluconazole 180 Fluoxetine HCl Flurbiprofen 90 Gabapentin Haloperidol Hydroquinone 90 Ibuprofen Ketamine HCl 90 Ketoprofen Lactic Acid 90 Lidocaine Lidocaine HCl 90 Menthol 90 Methimazole Methyl Salicylate 90 Metoclopramide 90 Metronidazole Miconazole 180 Pentoxifylline 90 Phenytoin 90 Piroxicam HUMCO +1 (855)

11 Active Ingredient HRT Botanical HRT Heavy Liposomal Heavy Liposomal Regular Multibase PENcream PLO20 Non-Flowable PLO20 Flowable RECURA SaltStable LO SaltStable LS Advanced Prednisolone Prednisone Progesterone Promethazine Testosterone Tetracaine HCl Verapamil HCl 90 Active Ingredient Flavor Blend Flavor Sweet/SF Flavor Plus Versa Free Versa Plus Acetazolamide Allopurinol Alprazolam Amiodarone HCl Amlodipine Besylate Atenolol Captopril Clonidine HCl Chloroquine HCl Cisapride Dapsone Diltiazem HCl Dipyridamole Enalapril Maleate Flecainide Acetate Flucytosine HCl Hydralazine HCl 63 Ketoconazole Lactic Acid Lamotrigine Metolazone Metoprolol Tartrate Nifedipine Omeprazole 90 Procainamide HCl Pyrazinamide Quinidine Sulfate Rifampin Sildenafil Citrate Spironolactone Tetracycline Verapamil HCl (855) HUMCO 11

12 Creams Wound & Lotions Scar ANHYDROUS BASE VERSATILE TOPICAL CREAM lb $50.00 Humco s Anhydrous Base is designed for low-load hydrophilic and high-load lipophilic actives that are unstable in water. Compatible with numerous drugs across a broad range of applications, Anhydrous Base is cosmetically elegant with an exceptional sensory evaluation profile over other anhydrous bases, providing a smooth, light, and silky feel. ANHYDROUS BASE BENEFITS: Contains absolutely no water Non-greasy Cosmetically elegant smooth, light, silky feel Preservative-free & petroleum-free Easy to use actives can be directly incorporated without wetting 180-day BUD with all API s based on USP 795 Fragrance-free & dye-free Mixing Tips Mixing Speed rpm for 2-5 minutes If Dispensing in a Pump, Airless Pump Dispensers are Recommended Specific Gravity 0.95 Color ANHYDROUS BASE PROPERTIES Transdermal Penetration API Compatibility Typical Applications Light Beige Hydrophilic 10% & Lipophilic 20% Total API Load - 20% Dermatology HRT Pain Management Sports Medicine Veterinary Medicine Wound Care SAMPLE FORMULAS: Glutathione 20% Topical Glutathione (L) Reduced 20% Anhydrous Base qs 100% Recommended Penetration Enhancer: 50% Lecithin in Isopropyl Palmitate Hydro/Lido/Nife 2.5/1.5/1% Topical Hydrocortisone 2.5% Lidocaine HCl 1.5% Nifedipine 1% Anhydrous qs 100% 12 HUMCO +1 (855)

13 GENEDERM Creams & Lotions DERMATOLOGICAL BASE FOR WRINKLES GENEDERM provides a firming effect on the skin - tightening and smoothing fine lines and wrinkles. It is uniquely formulated with Sodium Polystyrene Sulfonate, a film forming polymer that creates a matrix and provides excellent binding to the skin, allowing the base to adapt to changes in facial expressions and movement without cracking or peeling. GENEDERM can be used to reduce the appearance of fine lines and wrinkles. GENEDERM BENEFITS: Suitable for all skin types Comfortable - Allows skin to breathe Can be worn for 4-8 hours, including night-time application Can be applied without API s for wrinkle treatment Visible results after first application g $ Common Actives in Wrinkle Care: Vitamin E 200IU/g Antioxidant to reduce the signs of aging and photo-aging GENEDERM PROPERTIES ph Viscosity 50, ,000 cps Physical Format Light Cream Vitamin C 2-10% (as Ascorbyl Palmitate) Antioxidant to reduce the signs of aging Niacinamide 2% Stabilizing effect on epidermal barrier function, seen as the reduction in trans-epidermal water loss Color API Compatibility Typical Applications Opaque, Off-White Hydrophilic 10% & Lipophilic 10% Total API Load - 20% Dermatology Wrinkles Estradiol 0.01% and Estriol 0.3% After treatment for 6 months, elasticity and firmness of the skin had markedly improved; wrinkle depth and pore sized had decreased by %; skin moisture had increased and wrinkle depth decreased significantly SAMPLE FORMULA: Anti Wrinkle: Alpha-Lipoic Acid 5% Ascorbyl Palmitate 2% Estriol Micro Powder 0.3% Niacinamide 2% Tretinoin 0.025% Propylene Glycol 10% GENEDERM qs 100% Alpha-Lipoic Acid 5% Twelve weeks treatment with a cream improves clinical characteristics related to photo-aging of facial skin +1 (855) HUMCO 13

14 Clinical Study "Product is non- irritating and reduces visibility of fine lines... a small amount goes a long way easy to use skin feels soft, smooth, refreshed and firm it is not greasy and has pleasant smell it felt high quality. GENEDERM CLINICAL STUDY STUDY Evaluation of Key Parameters on Outer Parts of 30 Panelist's Eyes, In Vivo, Using Image Analysis In one of the most innovative research projects ever undertaken in medical aesthetics, The Consumer Product Testing Company' captures the PRIMOS and VISIA image analysis, and opinions on wrinkle length, number, and area from 30 female subjects, ages 35 to 65, with mild to moderate crow's feet (coarse wrinkles) in the outer canthus eye area. The relative skin surface was analyzed as a composite and as a single point in any plane thereby making it possible to examine and compare several cutaneous parameters. The outer parts of the eyes of thirty panelists were used to evaluate several key parameters over eight weeks. RESULTS 'The Consumer Product Testing Company' key findings:. For women seeking aesthetic treatment, opinions found (89%) positive response for softened line/wrinkles around eyes, (89%) positive response for made skin feel firmer/tighter, and (100%) positive response for easy to use as daily skin care regimen.. PRIMOS image analysis found (71%) of women with wrinkle length decrease..visia image analysis found (82%) of women with wrinkle number decrease and (79%) of women with wrinkle area decrease. Parameter Genederm Roughness 14% Decrease Residual Length 9% Decrease Average Amplitude 10% Decrease Primary Wrinkle. 9% Decrease Number of Peaks 10% Reduction 14 HUMCO +1 (855)

15 GENEDERM Dermatological Wrinkle Base has been proven to reduce or decrease five key parameters in relation to wrinkle reduction. "The evaluation of parameters indicates that the use of Genederm produced smoothing and restructuring of the skin s surface after seven days of product application." - Advanced Scientific Imaging Consulting, leading analytical laboratory View Full Study at (855) HUMCO 15

16 Creams Wound & Lotions Scar HRT BOTANICAL CERTIFIED HYPOALLERGENIC HRT BASE lb $ lb $ HRT Botanical is an oil-in-water, light cream, certified hypoallergenic base, with all natural ingredients and antioxidants. It has a lotion consistency and provides sustained skin penetration. Ideal for lipophilic APIs used in hormone replacement therapy (HRT). HRT BOTANICAL BENEFITS: Sustained skin penetration and absorption Paraben-free & fragrance-free Natural ingredients & natural preservatives Added antioxidants, botanicals, and herbal extracts Certified hypoallergenic Cosmetically elegant Ideal for vaginal preparations HRT BOTANICAL PROPERTIES ph 6.5 Specific Gravity 1.00 Viscosity 60,000 cps Physical Format Light Cream Color Light Beige Transdermal Penetration + + API Compatibility Lipophilic - 20% Typical Applications Hormone Replacement Beyond-Use-Date (BUD) ACTIVE INGREDIENT Estradiol 1% Estriol 1% Estrone 0.5% Prednisolone 5% Progesterone 20% Testosterone 5% BUD 120 Days 150 Days 180 Days 180 Days 16 HUMCO +1 (855)

17 HRT HEAVY HRT BASE WITH 180 DAY BUD Creams & Lotions HRT Heavy is a heavier cream base than HRT Botanical ; it allows for deep skin penetration and absorption. It is specifically designed for male and female hormone replacement therapy (HRT) and has a moderate to high API carrying capacity lb $ lb $ lb $ HRT HEAVY BENEFITS: Sustained skin penetration and absorption Paraben-free Natural ingredients Cosmetically elegant Ideal for intra-vaginal preparations Stability/potency of 180 days for all hormone APIs ph 7.5 Specific Gravity 1.04 HRT HEAVY PROPERTIES Viscosity Physical Format Color 165,000 cps Cream White Transdermal Penetration API Compatibility Lipophilic - up to 40% Typical Applications Hormone Replacement Beyond-Use-Date (BUD) ACTIVE INGREDIENT Estradiol 1% Estriol 1% Estrone 0.5% Progesterone 20% Testosterone 5% BUD 180 Days 180 Days 180 Days 180 Days 180 Days +1 (855) HUMCO 17

18 Transdermal Study Humco s PENcream, Anhydrous Base, HRT Heavy, and HRT Botanical are Validated Transdermal Vehicles PROGESTERONE TRANSDERMAL STUDY Study Evaluation of the Percutaneous Absorption of Progesterone, In Vitro, Using the Epiderm Skin Model The progesterone study evaluated the percutaneous absorption pharmacokinetics of progesterone in the following Humco bases: HRT Botanical, HRT Heavy, Anhydrous Base and PENcream. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. Formulas were tested on standardized sections for the percutaneous absorption of progesterone over a 12-hour dose period. At pre-selected times after dose application, the dermal receptor solution was completely removed and replaced with fresh receptor solutions; an aliquot was saved for subsequent analysis. Samples were analyzed for progesterone content by High Performance Liquid Chromatography (HPLC). The in vitro human Epiderm skin model is a proven tool, valuable for the study of percutaneous absorption and determination of pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model. Transdermal Drug Absorption: Avoids hepatic first pass effect, reducing adverse reactions to certain drugs Reduces minor gastrointestinal tract irritation and systemic toxicity Helps avoid possible drug interactions with food and intestinal flora Can be applied to different parts of the body (site rotation) 18 HUMCO +1 (855)

19 5% PROGESTERONE Transdermal Study PENcream, Anhydrous Base, HRT Botanical, and HRT Heavy have been proven to transport Progesterone into and through human skin, performing more effectively than our competitor's base. % Permeation Flux (ug/cm2/hr) % Progesterone Permeation Through the Stratum Corneum Competitor s Base HRT Botanical Competitor s Base HRT Botanical HRT Heavy HRT Heavy Progesterone Progesterone Flux VS Time 0.30 Competitor s Base Anhydrous Base Humco's Anhydrous Base PENCream PENCream HRT Botanical HRT Heavy Anhydrous Base PENCream Results The data did indicate that progesterone penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration to a peak flux occurring at approximately 12 hours after dose application. HRT Botanical, HRT Heavy, Anhydrous Base, and PENcream delivered more progesterone than our competitor's base. The total percent of applied dose that penetrated past the stratum corneum with our competitor s base is 20% less than Humco s HRT Botanical, HRT Heavy, Anhydrous Base, and PENcream Time View Full Study at (855) HUMCO 19

20 Creams & Lotions lb $ lb $ lb $ LIPOSOMAL HEAVY MOISTURIZING TRANSDERMAL LIPOSOMAL BASE Liposomal Heavy is formulated with additional emulsifiers to allow for higher API loads and solvent concentrations to be incorporated. Added emollients provide excellent moisturization an ideal choice for dry and/or dehydrated skin. LIPOSOMAL HEAVY BENEFITS: Cosmetically elegant excellent moisturizing effect Faster absorption & deeper penetration than HRT bases API compatibility virtually all actives Natural preservatives Water & oil-soluble Ideal for cosmetic facial applications Paraben-free LIPOSOMAL HEAVY PROPERTIES ph 6.0 Beyond-Use-Date (BUD) ACTIVE INGREDIENT BUD Dexamethasone 1.5% Diclofenac 4% Diltiazem 2% Gabapentin 6% Haloperidol 0.1% Hydroquinone 5% Piroxicam 0.5% Promethazine 5% Specific Gravity 1.00 Viscosity Format Color 250,000 cps Heavy Cream White Transdermal Penetration API Compatibility Typical Applications Recommended Use Hydrophilic 10% Lipophilic 10% Total API Load 20% Dermatology Pain Management Sports Medicine Higher API Loads Dry/Dehydrated Skin Chemical Peels Pigmentation Treatments 20 HUMCO +1 (855)

21 LIPOSOMAL REGULAR Creams & Lotions TRANSDERMAL LIPOSOMAL BASE Liposomal Regular is a cosmetically elegant, liposomal transdermal base with excellent skin penetration and moisturizing capabilities. It is formulated to incorporate lipophilic and hydrophilic actives and penetrate deeper and faster than HRT bases lb $ lb $ lb $ LIPOSOMAL HEAVY BENEFITS: Cosmetically elegant excellent moisturizing effect Faster absorption & deeper penetration than HRT bases API compatibility virtually all actives Natural preservatives Water & oil-soluble Ideal for cosmetic facial applications Paraben-free LIPOSOMAL REGULAR PROPERTIES ph 7.5 Specific Gravity 1.00 Viscosity Format 120,000 cps Light Cream Color Off-White Transdermal Penetration API Compatibility Typical Applications Recommended Use Hydrophilic 5% Lipophilic 5% Total API Load 10% Dermatology Pain Management Hormone Therapy Veterinary Medicine Lower API Loads Cosmetic Preparations Beyond-Use-Date (BUD) ACTIVE INGREDIENT Dehydroepiandrosterone 1.23% Estradiol 0.5% Gabapentin 12.28% Methimazole 5% Progesterone 4.8% BUD 60 Days Mixing Tip Recommended to Reduce Oxidation: Sodium Bisulfite - 0.5% +1 (855) HUMCO 21

22 Creams & Lotions MULTIBASE lb $ lb $ lb $ HIGHLY VERSATILE OIL-IN-WATER CREAM BASE A versatile, oil-in-water natural vanishing cream that uses oleosomic emulsifiers and penetration enhancers. It is an oil-free moisturizing base that provides natural skin penetration. MultiBase is designed for both hydrophilic and lipophilic actives and exhibits superior stability in the presence of low-ph, high-ph, and high-alcohol compounds, allowing for flexible compounding and formulation options. MULTIBASE BENEFITS: Mineral oil-free, gluten-free, and propylene glycol-free Noncomedogenic Enhanced drug absorption & penetration Ideal for vaginal preparations Stable over a broad range ph API compatibility hydrophilic & lipophilic Natural ingredients moisturizers derived from berries, grapes, plums, and pears & emulsifiers derived from vegetable fatty acids & palm oil; thickening agents derived from coconut oil Beyond-Use-Date (BUD) ACTIVE INGREDIENT Capsaicin 1.2% Lactic Acid 8.5% Lidocaine 8% Menthol 8% Methyl Salicylate 20% Metronidazole 8% Phenytoin 8% Progesterone 10% Testosterone 2% BUD 180 Days 180 Days MULTIBASE PROPERTIES ph 7.0 Specific Gravity 0.90 Viscosity Physical Format Color 250,000 cps Heavy Cream White Transdermal Penetration + + API Compatibility ph Compatibility Hydrophilic 10% & Lipophilic 20% Total API Load - 30% Salt Tolerance Salt Forms - 10% SAMPLE FORMULAS: HRT Cream: Progesterone 20% Glycerin 10% Multibase qs 100% Analgesic Cream: Capsicum Oleoresin 0.6% Methyl Salicylate 10% Menthol 4% Multibase qs 100% Typical Applications Hormone Replacement Dermatology Pain Management Sports Medicine 22 HUMCO +1 (855)

23 PENCREAM TRANSDERMAL OIL-IN-WATER VANISHING BASE PENcream is an elegant oil-in-water vanishing cream formulated for enhanced transdermal penetration and absorption. This elegant alternative to PLO, with added emollients, provides a better rub-in and longer-lasting moisturizing effects without irritation. PENcream is compatible with a diverse range of hydrophilic and lipophilic actives, has a high API load capacity, and is ideal for hybrid formulations. Creams & Lotions lb $ lb $ lb $ PENCREAM BENEFITS: Free of BHT, EDTA, parabens, and urea Enhanced penetration capability efficacious API absorption Hydrophilic & lipophilic compatibility high loads Natural ingredients less irritation than PLO Cosmetically elegant lasting moisturizing effect Applies easily no sticky residue Beyond-Use-Date (BUD) PENCREAM PROPERTIES ph 7.0 Specific Gravity 0.96 Viscosity Physical Format Color 300,000 cps Heavy Cream White Transdermal Penetration API Compatibility Typical Applications SAMPLE FORMULAS: Hydrophilic & Lipophilic - Total API Load - 30% Pain Management Veterinary Medicine ACTIVE INGREDIENT Clomipramine HCl 7.5% Fluoxetine HCl 7.5% Gabapentin 6% Ibuprofen 10% Ketoprofen - 10% Lidocaine 15% Methimazole 7.5% Metoclopramide 2% Metronidazole 3% Promethazine 5% Tetracaine HCl 2% BUD Veterinary: Methimazole 7.5% PENcream qs 100% Pain Management Cream 1: Amitriptyline 2% Diclofenac 1% Gabapentin 5% PENcream qs 100% Mixing Tips Water Soluble Powders: If needed, may levigate with Alcohol, Dimethyl Sulfoxide (DMSO), Glycerin, Polyethylene Glycol (PEG) 300 or 400, Propylene Glycol, or Purified Water Oil-Soluble Powders Can be Directly Incorporated +1 (855) HUMCO 23

24 Creams & Lotions RECURA TOPICAL BASE FOR ANTIFUNGAL ACTIVES Item No NDC No Size 500 g 2500 g RECURA topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis. Utilizing penetration enhancers, RECURA provides good penetration into toenails, fingernails, and skin, works well with a variety of antifungal agents, and compounds easily. It has been intensively studied, patented, and peer-reviewed in order to validate the compatibility of the cream with a number of active ingredients. Price $ $ RECURA Peer Reviewed Studies: RECURA BENEFITS: IJPC, Jan/Feb Penetration Ability - contains penetration enhancers and natural oils to facilitate active drug absorption Drug Compatibility - both oil and water soluble powders can be levigated with alcohol Compound Diversity - contains penetrating agents for better nail absorption, natural oils for better skin absorption, and is alcoholdispersible for viscosity adjustment 2016, Pgs IJPC, Mar/Apr 2017, Pgs RECURA PROPERTIES ph Physical Format Viscous Cream Color Opaque, Light Lavender Typical Applications Fungal treatment on toenails, fingernails, and skin Published Studies Beyond-UseDate (BUD) ACTIVE INGREDIENT SAMPLE FORMULAS: BUD Fluconazole 10% 180 Days Miconazole 10% 180 Days Nail Cream 1: Miconazole 3 g RECURA 27 g Nail Cream 2: Fluconazole 3 g RECURA 27 g Skin Cream: Clotrimazole 0.6 g Ibuprofen 0.6 g RECURA 28.8 g View Full Study at 24 HUMCO +1 (855) RE co cr su

25 Creams & Lotions Your Compounding Vehicle to help you TOPICAL COMPOUNDING CREAM RECURA topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis. ABOUT RECURA RECURA can be formulated to hold and help in the delivery of various antifungal active ingredients In Vitro testing in a novel nail model suggests the potential utility of RECURA topical cream to enhance delivery of antifungal actives across the nail Peer reviewed study1 in in vitro nail models comparing drug absorption with RECURA vs. marketed prescription solutions RECURA is for topical use only and is not for oral, ophthalmic, or intravaginal use Manufactured By: Humco 512 E 11th St, Ste 201, Austin, Texas USA Tel. (512) Fax (512) compounding@humco.com Turner R et al., A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis, INTL. J. PHARM. COMPOUNDING 2016;20(1): (855) HUMCO 25

26 Creams & Lotions SALTSTABLE LO READY-TO-USE TRANSDERMAL PAIN BASE lb $ lb $ lb $ Beyond-Use-Date (BUD) Benzocaine 20% ACTIVE INGREDIENT Diphenhydramine HCl 10% Fluoxetine HCl 5% Gabapentin 6% Ketoprofen 10% Lidocaine 10% Methimazole 5% Metronidazole 2% Promethazine 5% Tetracaine HCl 4% SaltStable LO is a ready-to-use transdermal cream base providing an elegant alternative to traditional PLOs. It is uniquely designed with a long shelf life and is temperature stable. It will not separate in the presence of high levels of ionic substances or when refrigerated. Added emulsifiers and hydrocolloids provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO is cosmetically elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility. SALTSTABLE LO BENEFITS: Efficacious active drug absorption In vitro transdermal penetration & API compatibility Temperature stable & two-year shelf stable Hydrophilic compatibility high levels of ionic powders can be directly incorporated Lipophilic compatibility moderate levels of oil-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 400, or alcohol Cosmetically elegant not tacky or sticky Natural ingredients resulting in less irritation BUD SALTSTABLE LO PROPERTIES ph 7.0 Specific Gravity 1.00 Viscosity Physical Format Color 300,000 cps Heavy Cream Light Yellow Transdermal Penetration API Compatibility Typical Applications Hydrophilic 35% & Lipophilic 10% Total API Load 35% Pain Management Veterinary Medicine Sports Medicine SAMPLE FORMULAS: BLT: Lorazepam Formula: Pain Management Cream: Benzocaine 20% Lidocaine 6% Tetracaine 4% SaltStable LO qs 100% Lorazepam 0.5% SaltStable LO qs 100% Baclofen 2% Diclofenac 3% Gabapentin 3% Citric Acid 2% Ethoxy Diglycol 8% Salt Stable LO qs 100% 26 HUMCO +1 (855)

27 SALTSTABLE LS ADVANCED Creams & Lotions READY-TO-USE TRANSDERMAL PAIN BASE SaltStable LS Advanced is an extension and enhancement of SaltStable LO. SaltStable LS Advanced is a scientifically advanced, extremely durable, robust and versatile transdermal cream base formulated with a silogel that provides a smooth, silky dry feel. SSLS Advanced is designed for all actives and is non-specific to salt; it also exhibits superior API carrying capacity (high loads) of multiple actives in one formulation. SaltStable LS Advanced demonstrates excellent stability without the need to add emulsifiers g $ g $ g $ SALTSTABLE LS ADVANCED BENEFITS: Increased stability with a high percent of APIs & multiple actives Validated in vitro transdermal vehicle up to 8 APIs in one formulation Less sticky & less tacky because of silogel (silicone-based organogel) Off-white, cosmetically elegant cream API compatibility compatible with all actives, non-specific to salt Time saving ready-to-use base, no need for wetting or adding thickening agents Ideal for formulations with multiple actives & high API loads Beyond-Use-Date (BUD) SALTSTABLE LS ADVANCED PROPERTIES ph Specific Gravity 0.90 Viscosity Physical Format Color 1,200,000 cps Heavy Cream Off White Transdermal Penetration API Compatibility Typical Applications SAMPLE FORMULAS (90 DAYS): Hydrophilic 30% & Lipophilic 40% Total API Load - 40% Pain Management Veterinary Medicine Sports Medicine ACTIVE INGREDIENT Baclofen 2% Bupivacaine HCL 1% Diclofenac Na 5% Flurbiprofen 10% Gabapentin 10% Ibuprofen 3% Ketamine HCl 10% Ketoprofen 20% Lidocaine HCl 5% Pentoxyfylline 3% Verapamil HCl 10% BUD Baclofen 2% Bupivacaine 1% Diclofenac 5% Gabapentin 6% Ibuprofen 3% Ketamine HCl 10% Pentoxifylline 3% SSLS Advanced qs 100% Baclofen 2% Clonidine 0.2% Gabapentin 10% Ketamine 5% SSLS Advanced qs 100% Diclofenac 5% Ibuprofen 3% Pentoxifylline 3% Verapamil 10% SSLS Advanced qs 100% Baclofen 2% Flurbiprofen 10% Lidocaine HCl 5% Pentoxifylline 3% SSLS Advanced qs 100% +1 (855) HUMCO 27

28 Transdermal Study SALTSTABLE LS ADVANCED TRANSDERMAL STUDY STUDY Evaluation of the Percutaneous Absorption of Pentoxifylline + Ketamine HCl + Ibuprofen + Cyclobenzaprine HCl + Diclofenac Na + Baclofen + Bupivacaine HCl + Gabapentin, In SaltStable LS Advanced, Into Human Skin, In Vitro, Using the Franz Skin Finite Dose Model Using Humco s SaltStable LS Advanced, the study was designed to evaluate the percutaneous absorption pharmacokinetics of pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin in a single formulation using Humco s SaltStable LS Advanced base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. The eight drugs were selected due to their frequent use in compounding topical pain formulations along with compounding multiple actives in one formulation. The formula was tested on standardized sections with Humco s SaltStable LS Advanced transdermal compounding base, for the percutaneous absorption of the formula over a 48-hour dose period. At pre-selected times after dose application, the dermal receptor solution was removed in its entirety, replaced with fresh receptor solution, and an aliquot saved for subsequent analysis. High Performance Liquid Chromatography (HPLC) analyzed the samples for pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin content. The in vitro human Epiderm skin model has proven to be a valuable tool for the study of percutaneous absorption and the determination of the pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer surface of the skin and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption can be accurately determined in this model. RESULTS Humco s SaltStable LS Advanced compounding base is a proven transdermal delivery vehicle able to deliver multiple drugs beyond the stratum corneum, simultaneously into and through the human skin after a single dose. The data indicates that Humco s SaltStable LS Advanced delivered pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl, and gabapentin simultaneously (and intact) into and through human epidermal cultures, in vitro, from the test formulation provided. The absorption profiles indicate pentoxifylline, ketamine HCl, ibuprofen, diclofenac Na, and bupivacaine HCl had a steady penetration occurring for 32 hours after dose application. And cyclobenzaprine HCl, baclofen and gabapentin had a steady penetration occurring for 48 hours after dose application. 28 HUMCO +1 (855)

29 Creams & Lotions Breakthrough Study: SaltStable LS Advanced has been proven to deliver eight drugs simultaneously through human skin in-vitro. TESTED FORMULA Baclofen...2% Bupivacaine...1% Cyclobenzaprine HCl.2% Diclofenac Na...5% Gabapentin...6% Ibuprofen...3% Ketamine HCl...10% Pentoxifylline...3% SaltStable LS Advanced...qs 100% Flux (ug/cm2/hr) Baclofen Flux VS Time Time 48 Flux (ug/cm2/hr) Bupivacaine Flux VS Time Time Cyclobenzaprine Flux VS Time Diclofenac Flux VS Time Gabapentin Flux VS Time Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flux (ug/cm2/hr) Time Time Time Ibuprofen Flux VS Time Ketamine Flux VS Time Pentoxifylline Flux VS Time Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flux (ug/cm2/hr) Time Time Time (855) HUMCO 29

30 Transdermal Study SANARE ADVANCED TRANSDERMAL STUDY STUDY Evaluation of the Percutaneous Absorption of Flurbiprofen + Lidocaine Sanare Advanced out-performs Competitor s Base by 23-28% The study evaluated the percutaneous absorption pharmacokinetics of Humco s Sanare Advanced Scar Base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. TESTED FORMULA Flurbiprofen...10% Lidocaine...5% Sanare Advanced...qs 100% The formula was tested on standardized sections with two different transdermal compounding bases. At pre-selected times after dose application, the dermal receptor solution was completely removed and replaced with fresh receptor solution; and an aliquot was saved for subsequent analysis. Samples were analyzed for flurbiprofen and lidocaine content by High Performance Liquid Chromatography (HPLC). The in vitro human Epiderm skin model is a proven tool, valuable for the study of percutaneous absorption and determination of pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model. View Full Study at 30 HUMCO +1 (855)

31 10% FLURBIPROFEN Transdermal Study 5% LIDOCAINE Transdermal Study - - SANARE ADVANCED Scar Therapy Base has been proven to transport multiple drugs into and through human skin, performing significantly more effectively than our competitor s base. Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flurbiprofen Flux VS Time Time Lidocaine Flux VS Time Time Sanare Advanced Competitor's Base Sanare Advanced Competitor's Base RESULTS The data did indicate that flurbiprofen penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 48 hours after dose application. Sanare Advanced performed significantly better than our competitor's base at delivering flurbiprofen through human skin. The data also indicated that lidocaine penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 48 hours after dose application. Humco s Sanare Advanced performed significantly better than our competitor s base at delivering lidocaine through human skin. The total percent of applied dose that penetrated past the stratum corneum with our competitor s base is 23% less with flurbiprofen and 28% less with lidocaine than Humco s Sanare Advanced (855) HUMCO 31

32 Creams & Lotions g $ g $ g $ Common Actives in Scar Care: Pentoxifylline % Decreases collagen production, increases activity of collagenase in dermis, inhibits fibroblast hyperactivity Betamethasone 0.1% Steroid and anti-inflammatory Dimethyl Sulfone 2% Anti-inflammatory EGCg % Antioxidant Caffeine 0.1 1% Induces differentiation and proliferation in epidermal keratinocytes - - SANARE ADVANCED TOPICAL SILICONE BASE FOR SCAR THERAPY & OTHER CONDITIONS Sanare Advanced is an elegant, topical anhydrous silicone gel designed for scar therapy treatment and management. It is uniquely formulated with Carapa Guaianensis Seed Oil found in the Amazon rainforest, an exceptional ingredient that promotes skin renewal, inflammation reduction, and healing. Added emollients and emulsifiers allow for versatile compounding for scar and other skin conditions. SANARE ADVANCED BENEFITS: Provides barrier protection Increased skin penetration Formulated for higher loads of polar salt APIs Skin renewal and inflammation reduction Soy, gluten, and irritant free 180-day BUD based on USP 795 SANARE ADVANCED PROPERTIES Specific Gravity 1.12 Physical Format Solubility in Water Viscous Gel Insoluble Collagenase 350 u/g Reduces collagen production Hyaluronidase 250 u/g Breaks down collagen Color Typical Applications Opaque, Off-White New Scars Old Scars Surgical Scars Acne Scars Keloids Stretch Marks Scar Tissue Dermatological Applications Tranilast 1 10% Antioxidant, decreases redness and swelling, inhibits collagen synthesis SAMPLE FORMULAS: Dosage: Apply 2-6 grams topically to affected area 2-4 times daily for 10 to 14 weeks or as directed. Mixing Tips Recommended Wetting Agent: Fatty Acid Esters (Isopropyl Palmitate), Fatty Alcohols (Oleyl Alcohol), or Anhydrous Alcohol (Ethanol 200 Proof) Maximum Amount 10% Recommended to Reduce Stickiness: Cyclomethicone 5-10% Keloids & Hypertrophic Scars: Betamethasone Valerate 0.1% Tranilast 1% Sanare Advanced qs 100% Post Surgical Scars/ New Scars: Collagenase 350 u/g Hyaluronidase 250 u/g Sanare Advanced qs 100% Post Surgical Scars with Pain: Gabapentin 15% Lidocaine 3% Prilocaine 3% Sanare Advanced qs 100% Age Spots & Wrinkles: Hydroquinone 8% Hydrocortisone 1% Kojic Acid 4% Tretinoin 0.05% Sanare Advanced qs 100% Rosacea: Metronidazole 1% Niacinamide 4% Sanare Advanced qs 100% Acne Scars: Lipoic Acid 0.5% Tretinoin 0.1% Sanare Advanced qs 100% 32 HUMCO +1 (855)

33 - LAVARE Gel Bases & Ointments WATER-WASHABLE WOUND CARE BASE Lavare is a Polyethylene Glycol (PEG) based occlusive, water-soluble gel specifically formulated for wound management by promoting a moist environment allowing for optimal healing. Lavare contains organic Meadowsweet Extract potentially providing germicidal, anti-inflammatory, and healing properties along with the ability to deliver APIs topically to sensitive wound sites. LAVARE BENEFITS: Adherent base occlusive Water-washable allowing for easy cleaning and debridement Maintains a moist wound site providing an optimal healing environment API Compatibility hydrophilic and lipophilic actives Soy and gluten free ph 6.0 Specific Gravity 1.12 Physical Format Solubility in Water Color Typical Applications SAMPLE FORMULAS: LAVARE PROPERTIES Non-Flowable Gel Complete White Wounds Ulcers Burns Cuts Abrasions Dermatological Applications Dosage: Apply up to 4 grams topically 3 times daily as directed, up to 12 grams per day g $ g $ g $ Common Actives in Wound Care: Misoprostol % Synthetic analogue of prostaglandin E1, attenuate the inflammatory process and promotes collagen formation by inhibiting IL-1 and TNF, modulates inflammation and decreases wound healing time Phenytoin 5% Stimulates collagen deposition, fibroblast proliferation, glucocorticoid antagonism, and has antibacterial activity Lidocaine 4% Topical anesthetic Metronidazole 2% Deodorizing effect of Metronidazole correlate with eradication of anaerobic infection Nifedipine 2% Ca2+ channel blocker that greatly improves tissue perfusion and improves healing time Gentamicin 0.2% Antibiotic No Odor/ No Pain: Misoprostol % Phenytoin 5% Lavare Gel qs 100% Odor / No Pain: Misoprostol % Phenytoin 5% Metronidazole 2% Lavare Gel qs 100% No Odor / Pain: Misoprostol % Phenytoin 5% Lidocaine 4% Lavare Gel qs 100% Infected Wound: Misoprostol % Phenytoin 5% Gentamicin 0.2% Lavare Gel qs 100% Infected Wound: Gentamicin 0.1%/g Clindamycin 0.1%/g Polymyxin 2,000 u/g Lavare Gel qs 100% Wound Care: Ketoprofen 2% Lidocaine 2% Misoprostol % Phenytoin 2% Aloe Vera 0.2% Lavare Gel qs 100% Mixing Tip Recommended Wetting Agent: Glycerin, Maximum Amount 10% +1 (855) HUMCO 33

34 Gel Bases & Ointments PLO20 FLOWABLE PRE-MADE FLOWABLE PLO lb $65.00 HUMCO'S PLO20 FLOWABLE VS TRADITIONAL PLO & COMPETITOR'S BASE Humco's PLO20 Flowable... 44% Competitor s Base... 39% Traditional PLO... 17% Cumulative % Permeation of Methimazole through the Stratum Corneum PLO20 Flowable is a robust, ready-to-use transdermal base that represents the next generation of pluronic lecithin organogel (PLO) bases. This cosmetically elegant base has a lotion consistency that allows for incorporating high levels of APIs. It contains the same stability properties as PLO20 Non-Flowable, allowing for versatile compounding. PLO20 Flowable provides enhanced chemical penetration that allows a deeper skin permeation than does PLO20 Non-Flowable. This product is designed to accept the incorporation of high levels of lipophilic actives and moderate levels of hydrophilic actives. PLO20 FLOWABLE & PLO20 NON-FLOWABLE BENE- FITS: Enhanced penetration more efficacious drug absorption API compatibility high lipophilic & moderate hydrophilic carrying capacity Adjustable viscosity PLO20 & PLO20 Flowable may be blended Temperature & shelf stable Cosmetically elegant Validated API compatibility & penetration No wetting or milling high levels of oil-soluble powders & moderate levels of water-soluble powders may be directly incorporated PROPERTIES PLO20 FLOWABLE PLO20 NON-FLOWABLE ph Specific Gravity SAMPLE FORMULA: Fluoxetine 5mg/0.1ml Fluoxetine HCl 5% Grain Alcohol 2% PLO20 Flowable qs 100% Viscosity 30,000 cps 300,000 cps Format Light Cream/Lotion Heavy Cream Color Light Yellow Light Yellow Transdermal Penetration API Compatibility Hydrophilic 10% Lipophilic 30% Total API Load 30% Hydrophilic 10% Lipophilic 10% Total API Load 10% Best Use High Levels of Lipophilics Low Levels of Lipophilics Typical Applications Pain Management Sports Medicine Veterinary Medicine Pain Management Sports Medicine Diabetes & Wound Care Veterinary Medicine 34 HUMCO +1 (855)

35 PLO20 NON-FLOWABLE Gel Bases & Ointments PRE-MADE PLO PLO20 Non-Flowable is a ready -to- use, absorption- enhanced transdermal vehicle that is an elegant alternative to PLO transdermal systems. It contains penetration enhancers to facilitate more efficacious active drug absorption, emollients for a better rub- in, preservatives for increased mold resistance, along with emulsifiers allowing for better cold- temperature stability. PLO20 Non-Flowable may be blended for viscosity optimization without wetting agents or milling to thin the formula, thus allowing for versatile compounding. Beyond-Use-Date (BUD) ACTIVE INGREDIENT PLO20 FLOWABLE PLO20 NON-FLOWABLE Diltiazem 2% Gabapentin 6% Haloperidol 2% Ibuprofen 10% 60 Days Ibuprofen 20% Ketoprofen 10% Methimazole 5% Piroxicam 1% 60 Days Piroxicam 2% 60 Days Prednisolone 5% Prednisone 5% Prednisone 10% Promethazine 5% lb $ lb $ SAMPLE FORMULA: Anti-Nausea/Pain Management Cream: Promethazine 5% PLO20 Non-Flowable qs 100% WHEN DO YOU NEED PLO20 OR PLO20 FLOWABLE? When you want more efficacious active drug absorption. When you want to incorporate high levels of lipophilic substances. When you want a creamier base than a traditional PLO that is more cosmetically elegant and less sticky. When you want a penetrating cream that can be shipped in cold temperatures (855) HUMCO 35

36 Gel Bases & Ointments UNIVERSAL WATER GEL VERSATILE TOPICAL GEL BASE lb $ lb $ Universal Water Gel is an oil and salt tolerant blend using hydrophobic-inclusive cyclodextrins and electrolyte-tolerant polymers that greatly increases the water solubility and stability of incompatible drugs. Ideal for formulas containing higher levels of oils, botanical ingredients, or poorly soluble actives. It provides improvements in solubility, increase in speed of dissolution, together with physical and chemical stability. UNIVERSAL WATER GEL BENEFITS: API compatibility hydrophilic & lipophilic Excellent electrolyte tolerance Bioavailability enhancement Improves active stabilization & compatibility Highly stable across a broad ph range Masks the odor of unpleasant actives Cosmetically elegant Contains alcohol UNIVERSAL WATER GEL PROPERTIES ph 7.0 Specific Gravity 0.95 Viscosity Physical Format Color 750,000 cps Gel Translucent Transdermal Penetration + API Compatibility Typical Applications Hydrophilic & Lipophilic Total API Load - less than 10% Dermatology Pain Management Diabetes & Wound Care SAMPLE FORMULAS: Pain Management: Diclofenac 3% Lidocaine 5% Ethoxy Diglycol 8% Universal Water Gel qs 100% Hormone Therapy: Testosterone 10% Alcohol 10% Universal Water Gel qs 100% 36 HUMCO +1 (855)

37 EMULSION CONCENTRATE Pre-Mixed Excipient Bases COMPOUNDING ENHANCER Emulsion Concentrate is a ph and salt-tolerant emulsifier/hydrocolloid blend that greatly increases emulsification, stability, and thickness of broken emulsions, and separated and thin formulations. It quickly forms emulsions that are fresh, elegant, fast-absorbing, and non-greasy oz $ oz $ gal $ EMULSION CONCENTRATE BENEFITS: Ready-to-use polymer in fluid form API compatibility virtually all APIs Elegant sensory profile Low & high temperature resistant (-5º C 80º C) Ingredient compatibility Broad range of applications ph EMULSION CONCENTRATE PROPERTIES Viscosity Physical Format Color Intended Use API Compatibility 75,000 cps Viscous Gel Opaque Emulsify all types of oily phases Stabilize mineral additives Thicken in adverse conditions very acidic or very alkaline, oxidizing Develop fresh formulas that melt on contact with the skin Virtually all APIs ph Compatibility Salt Tolerance Salt Forms 35% Solvent Compatibility Temperature Stability Polar & Non-Polar Low & High Temperatures DIFFERENT VISCOSITIES ARE ACHIEVED BY VARYING THE AMOUNT OF EMULSION CONCENTRATE: 3% FOR LOTIONS 5% FOR CREAMS +1 (855) HUMCO 37

38 Oral Vehicles MOUTHWASH-GP GENERAL PURPOSE MOUTHWASH BASE oz $9.74 Flavoring Suggestions? For formulations containing Diphenhydramine HCL, use: Banana, Apple, Bubble Gum For formulations containing Nystatin/Bio-Statin Suspension, use: Sour Apple, Watermelon, Cherry Mouthwash-GP is a mouthwash base designed to simplify and standardize the extemporaneous compounding of formulations for delivery to the oral cavity. The ph of Mouthwash-GP is buffered to match the natural ph of saliva. The viscous nature of the Mouthwash-GP product allows the pharmacist to dissolve and/or suspend most of the common actives that are prescribed in Magic Mouthwash. Mouthwash-GP is designed to dissolve or suspend a high amount of active ingredients - maintaining its viscosity when actives are added - such that the oral cavity is coated with medication. The Mouthwash-GP packaging container has added head space which allows for mixing of actives by shaking the container. MOUTHWASH-GP BENEFITS: Oral moisturizer Coats the mouth Container head space for mixing Dye and flavor free Easily tailored with flavors and colors to improve palatability Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives For formulations containing Corticosteroids, use: Bubble Gum, Grape, Apple MOUTHWASH-GP PROPERTIES ph Viscosity 1,500-4,000 cps For formulations containing Antibiotics, use: Grape, Watermelon, Strawberry Physical Format Color Alcohol Content Intended Use API Compatibility Delivery Method Viscous Liquid Solution Clear Liquid 10.6% w/w Chemotherapy mouth ulcers Bacterial/viral oral infections Gingival irritation caused by braces Throat/esophageal sores Compatible with most Magic Mouthwash actives Can be expectorated or swallowed SAMPLE FORMULAS: BLM Magic Mouthwash: Diphenhydramine HCl 0.1% Lidocaine HCl 1% Aluminum Hydroxide/ Magnesium Hydroxide/ Simethicone Suspension 37.5% Mouthwash-GP qs 100% Mary s Magic Mouthwash: Diphenhydramine HCl 0.25% Hydrocortisone 0.05% Nystatin 0.5% Tetracycline HCl 0.65% Mouthwash-GP qs 100% Anti-Viral Mouth Rinse: Acyclovir 5% Mouthwash-AF 45% Lidocaine HCl 1% Deoxy D-Glucose 2% Mouthwash-GP qs 100% 38 HUMCO +1 (855)

39 MOUTHWASH-OM Oral Vehicles MOUTHWASH BASE FOR ORAL MUCOSITIS Mouthwash-OM is a mouthwash base designed to aid symptoms of Oral Mucositis associated with cancer therapy and certain dental conditions. In addition to being alcohol-free, Mouthwash-OM contains excipients that are compatible with water-soluble drugs for the treatment of oral pain, mouth sores, and oral infections. MOUTHWASH-OM BENEFITS: Soothing oral moisturizer Alcohol-free - no burn Container head space for mixing Dye and flavor free Contains botanical extracts Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives May be expectorated or swallowed oz $9.74 SAMPLE FORMULAS: Pain Relief Gargle: Lidocaine HCl 1.5% Sucralfate 5% Diphenhydramine HCl 0.5% Mouthwash-OM qs 100% Xerostomia Rinse: Pilocarpine HCl 1% Mouthwash-OM qs 100% MOUTHWASH-AF ALCOHOL-FREE MOUTHWASH BASE FOR HYDROPHOBIC ACTIVES Mouthwash-AF is a mouthwash base designed to provide solubility of hydrophobic active ingredients while being compatible with the oral mucosa. In addition to being alcohol-free, Mouthwash-AF contains excipients that dissolve and coat the mouth with drugs for the treatment of oral pain, mouth sores, and oral infections. MOUTHWASH-AF BENEFITS: Solubilizers for hydrophobic actives Alcohol-free - no burn Container head space for mixing Dye and flavor free Compatible with hydrophobic and hydrophilic actives Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives May be expectorated or swallowed oz $9.74 SAMPLE FORMULAS: Esophageal Suspension: Budesonide 0.1% Mouthwash-GP or AF qs 100% Anti-Infective Mouthwash: Nystatin 1% Tetracycline HCl 2% Acyclovir 5% Deoxy D-Glucose 2% Mouthwash-AF qs 100% +1 (855) HUMCO 39

40 Oral Vehicles FLAVOR SWEET SYRUP VEHICLE oz $ gal $80.00 Flavor Sweet is a cherry-flavored syrup vehicle formulated to simplify the preparation of oral extemporaneous delivery systems. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension s physical stability. Flavor Sweet contains suitable preservatives and is buffered to a slightly acidic ph to provide a dependable and consistent vehicle. Pink colored, cherry flavored syrup ph 4.5 ph 5.0 Recommended use hydrophilic, acid-stable & hydrophobic actives FLAVOR SWEET-SF SUGAR-FREE SYRUP VEHICLE oz $ gal $80.00 Flavor Sweet SF is a sugar-free and alcohol-free cherry flavored syrup. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension s physical stability. Flavor Sweet SF contains suitable preservatives and is buffered to a slightly acidic ph to provide a dependable and consistent vehicle. Pink colored, cherry flavored, sugar-free syrup ph 4.5 ph 5.0 Recommended use hydrophilic, acid-stable & hydrophobic actives Ideal for diabetic preparations VERSA FREE DYE-FREE, CHEMICAL-FREE, AND SUGAR - FREE SYRUP VEHICLE oz $ gal $85.00 Versa Free is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free syrup vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste. Flavor-free clear liquid syrup ph 4.5 ph 5.0 Natural ingredients & natural preservatives Recommended use hydrophilic, acid-stable & hydrophobic actives Ideal for diabetic, autistic, & allergy-sensitive patients Soy & gluten-free 40 HUMCO +1 (855)

41 FLAVOR PLUS ORAL SUSPENDING VEHICLE Flavor Plus is a unique flavor-free, aqueous based suspending vehicle used to simplify the process of compounding oral non-soluble suspensions. It is buffered to an acidic ph providing a uniform, consistent and stable vehicle. Flavor-free, white liquid suspension ph 3.5 ph 4.0 Recommended use hydrophilic, acid-stable & hydrophobic actives Ideal for diabetic preparations Oral Vehicles oz $ gal $80.00 FLAVOR BLEND ALL-IN-ONE SYRUP/SUSPENDING VEHICLE Flavor Blend is a uniquely formulated flavored oral suspending vehicle designed to simplify the extemporaneous compounding process of oral suspensions. It combines the flavoring agents of Flavor Sweet and the suspending agents of Flavor Plus, along with preservatives and an anti-foam agent to provide an easy preparation of smooth, elegant oral suspensions. Easy to use Light pink liquid blend with a cherry flavor ph 4.5 ph 5.0 Recommended use hydrophilic, acid-stable & hydrophobic actives Incorporate virtually all medicated powders or crushed tablets Ideal for pediatric & geriatric preparations oz $ gal $80.00 VERSA PLUS DYE-FREE, CHEMICAL-FREE, AND SUGAR - FREE SUSPENSION VEHICLE Versa Plus is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free suspension vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste. Flavor-free white liquid suspension ph 3.5 ph 4.0 Natural ingredients & natural preservatives Recommended use hydrophilic, acid-stable & hydrophobic actives Ideal for diabetic, autistic, & allergy-sensitive patients Soy & gluten-free oz $ gal $ (855) HUMCO 41

42 Oral Vehicles ADDITIONAL ORAL VEHICLES Product Cherry Syrup Recommended Use: Ionic & Hydrophilic Actives Ordering Information oz $ gal $65.00 Raspberry Syrup Recommended Use: Ionic & Hydrophilic Actives Simple Syrup Recommended Use: Ionic & Hydrophilic Actives Sorbitol Solution 70%, USP oz $ oz $ gal $ gal $ oz $6.50 Recommended Use: Ionic & Hydrophilic Actives, Diabetic Additives Syrpalta (red) Recommended Use: Ionic & Hydrophilic Actives Syrpalta (without color) Recommended Use: Ionic & Hydrophilic Actives oz $ oz $ HUMCO +1 (855)

43 ADDITIONAL CMPDG INGREDIENTS Miscellaneous Ingredients Almond Oil Sweet, NF Arnica Tincture Barium Sulfate Powder USP Benzoin Compound Tincture USP Bismuth Bicarbonate Powder Coal Tar Topical Solution USP Glycerin USP Iodine Tincture, Mild 2% USP Mineral Oil Light Sweet Oil (Olive Oil) Peruvian Balsam Polyethylene Glycol 300 Propylene Glycol Salicylic Acid Powder USP Strong Iodine Solution (Lugol's) * oz $ oz $ oz $ lb $ oz $ oz $ lb $ oz $ oz $ gal $ gal $ oz $ oz $ gal $ oz $ gal $ oz $ gal $ gal $ oz $ lb $ oz $56.20 * To purchase this item you must have a DEA license on file +1 (855) HUMCO 43

44 HUMCO GLOBAL HEADQUARTERS 201 West 5th Street Suite 1250 Austin, TX (855)