PRODUCT CATALOG. +1 (855)

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1 PRODUCT CATALOG C O M P O U N D I N G +1 (855)

2 CONTENTS HUMCO GLOBAL HEADQUARTERS 201 West 5th Street Floor 12 Austin, TX PHONE FAX +1 (855) toll free +1 (512) (512) fax compounding@humco.com ONLINE ORDERING REMIT PAYMENTS TO 700 Alumax Drive Texarkana, TX SHIPPING - FREE UPS Ground Service is free for DTP (Direct-to-Pharmacy) accounts on orders of more than $100 and weighing less than 200 pounds in the lower 8 states. For orders less than $100, shipping charges based on weight will apply. Excludes hazardous materials, oversized (larger than 8 ) items, drop shipped, and any items requiring special handling. ALASKA HAWAII US published rate ABOUT HUMCO HUMCO COMPOUNDING PRODUCT LIST ACTIVE PHARMACEUTICAL INGREDIENTS VALIDATED STABILITY STUDIES CREAMS LOTIONS GEL BASES OINTMENTS BULK COMPOUNDING DRUG SUBSTANCES PRE-MIXED EXCIPIENT BASES ORAL VEHICLES MISCELLANEOUS INGREDIENTS PROFESSIONAL SERVICE HOURS Monday-Friday, 8:30 AM - 5:30 PM Central Standard Time HAZARDOUS MATERIALS Per package fee of $25 in addition to air or ground shipping charge. CONTACT PHARMACEUTICAL RESOURCE CENTER CUSTOMER SERVICE +1 (855) toll free +1 (512) crc@humco.com BACK ORDERS We will notify you if any items are unavailable to ship. All back orders will be shipped free, UPS 3 day service, unless otherwise specified. Formulation questions Stability testing BUD data Penetration studies Request a sample Certificate of Analysis MSDS BUD STUDIES Available online at 2 HUMCO +1 (855) (855) HUMCO 3

3 ABOUT HUMCO HUMCO COMPOUNDING Humco, founded in 1872, is a diversified global pharmaceutical company. Humco is focused on developing, manufacturing and commercializing innovative pharmaceuticals and high-quality over-thecounter (OTC) medicines for patients around the world. With headquarters in Austin, TX, Humco serves over 5,000 pharmacies through its Pharmaceutical Segment and its Consumer OTC Products franchise. The Company is anchored by its leading non-sterile compounding delivery vehicles, including topical and transdermal creams, syrups and suspensions. Humco also serves consumers through its established and diverse Consumer OTC Products business of over 160 items with product placement in all major drug, food, and mass-market retail chains, along with independent, locally owned pharmacies. HUMCO +1 (855) Humco s leading team of professionals have strong expertise ranging from product development to commercialization in the Company s state-of-the-art FDA registered, cgmp compliant facilities. Humco proudly manufactures and distributes a diversified line of pharmaceutical products. We focus on developing products that offer dynamic solutions and help to fulfill unmet patient and pharmacist needs. With a presence in approximately 20 countries, Humco is committed to working with pharmacists, physicians, healthcare providers and patients to deliver innovative and meaningful treatments that help people around the world live longer, healthier lives. Humco has a vast portfolio of pharmaceuticals that aid in imperative solutions across several key therapeutic categories including: Pain Management Infectious Disease Hormone Replacement Therapy Wound Care Dermatology and Aesthetics Humco has established a leading reputation for developing, manufacturing, and commercializing a diversified line of non-sterile topical and oral pharmaceutical compounding delivery vehicles. Our patented compounding products range from ready-to-use topical creams and gels to oral syrups and suspensions. Our products are designed to provide an optimal delivery system for a variety of formulations based on the desired route of administration and therapeutic intent. Humco s delivery vehicles are tailored to meet pharmacist s non-sterile compounding needs while reducing the compounding preparation time and improving therapeutic outcomes for patients. In addition to our delivery vehicles, Humco offers an extensive selection of Active Pharmaceutical Ingredients ( APIs ) that are conveniently packaged in a variety of sizes to effectively accommodate the needs of pharmacists, hospitals, and pharmaceutical companies. +1 (855) HUMCO OUR APPROACH: We can be counted on We get the job done We take responsibility We find a better way We succeed as a team 5

4 TOPICAL BASES VEHICLES CREAMS LOTIONS Anhydrous Base VERSATILE TOPICAL CREAM GENEDERM DERMATOLOGICAL TOPICAL CREAM HRT Botanical HORMONE THERAPY TOPICAL CREAM HRT Heavy HORMONE THERAPY TOPICAL CREAM Liposomal Heavy VERSATILE TOPICAL CREAM Liposomal Regular VERSATILE TOPICAL CREAM Multibase VERSATILE TOPICAL CREAM PENcream VERSATILE TOPICAL CREAM RECURA ANTIFUNGAL TOPICAL CREAM SALTSTABLE LO PAIN MANAGEMENT TOPICAL CREAM SALTSTABLE LS ADVANCED PAIN MANAGEMENT TOPICAL CREAM lb $ g $ g $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ lb $ g $ g $ lb $ lb $ lb $ g $ g $ g $ Sanare Advanced SCAR THERAPY BASE GEL BASES OINTMENTS Lavare WOUND WASH GEL PLO20 Flowable VERSATILE TOPICAL LIGHT CREAM PLO20 Non-Flowable VERSATILE TOPICAL CREAM Universal Water Gel VERSATILE TOPICAL GEL g $ g $ g $ g $ g $ g $ lb $ lb $ lb $ lb $ lb $ lb $ BULK COMPOUNDING DRUG SUBSTANCES Diclofenac Sodium 3% Cream TOPICAL CREAM Lidocaine-Prilocaine Cream, USP TOPICAL CREAM Lidocaine 5% Ointment, USP TOPICAL OINTMENT g Call for Pricing g Call for g Pricing g Call for Pricing PRE-MIXED EXCIPIENT BLENDS Emulsion Concentrate VISCOSITY ENHANCER oz $ oz $ gal $ USP GUIDELINES It is the responsibility of the pharmacists to follow USP Guidelines on proper compounding procedures and techniques. Compounders should know and keep current on USP Chapter <795> and <1075>, which relate to non-sterile compounding. Its purpose is to help define good compounding practice and provide general information to enhance the compounder s ability to compound preparations that are of acceptable strength, quality and purity. Our compounding bases and vehicles are ready-made with wetting agents already incorporated into the base. Most formulations will not require any additional wetting or milling; greatly reducing the compounding preparation time. ORAL VEHICLES Buffer Cream BUFFERING AGENT FOR ORAL SUSPENSIONS Cherry Syrup SYRUP VEHICLE Flavor Blend SYRUP SUSPENDING VEHICLE Flavor Plus SUSPENDING VEHICLE Flavor Sweet-SF SYRUP VEHICLE Flavor Sweet SYRUP VEHICLE Mouthwash-AF ALCOHOL FREE MOUTHWASH BASE Mouthwash-GP GENERAL PURPOSE MOUTHWASH BASE Mouthwash-OM MOUTHWASH BASE FOR ORAL MUCOSITIS Raspberry Syrup SYRUP VEHICLE Simple Syrup SYRUP VEHICLE lb $ oz $ gal $ oz $ gal $ oz $ gal $ oz $ gal $ oz $ gal $ oz $ oz $ oz $ oz $ oz $ gal $ gal $ Sorbitol Solution 70% USP SYRUP Syrpalta (Red) SYRUP VEHICLE Syrpalta (No ) SYRUP VEHICLE Versa Free SYRUP VEHICLE Versa Plus SUSPENDING VEHICLE oz $ oz $ oz $ oz $ gal $ oz $ gal $75.00 *Prices are current at time of printing-september 2016, however, pricing and specifications are subject to change without notice. Please contact the Resource Center or visit the website for updated pricing. BULK PRICING AVAILABLE Contact us for pricing on bulk quantities +1 (855) HUMCO +1 (855) (855) HUMCO 7

5 ACTIVE PHARMACEUTICAL INGREDIENTS API Standards Testing Amantadine Hydrochloride, USP Amitriptyline Hydrochloride, USP Baclofen, USP g $ g $ g $ g $ g $ g $ g $ g $ Fluconazole, USP Fluticasone Propionate, USP (Micronized) Gabapentin, USP g $ g $ g $ g $ g $ g $ Before Humco considers purchasing an API, we pre-qualify our suppliers to ensure that they manufacture the API under current Good Manufacturing Practices, as expected in ICH Q7A requirements. Once the API is received, a statistical sample is taken and tested in our on-site laboratories. Through comprehensive and thorough testing, we ensure the identity of the API and that the potency meets the USP requirements and are comparable to the manufacturer s CofA. We use qualified and calibrated state-of-the-art analytical equipment under the Laboratory Controls delineated in 21 CFR 211. A few examples of these include: Benzocaine, USP Bupivacaine Hydrochloride, USP Cyclobenzaprine Hydrochloride, USP Diclofenac, USP Doxycycline Hyclate, USP Estradiol, USP (Micronized) g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $60.00 Ibuprofen, USP Ketoprofen, USP Lidocaine Hydrochloride, USP Miconazole, USP Phenytoin Sodium, USP Progesterone, USP (Micronized) g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ g $ Fourier Transform Infrared Spectrophotometer (FTIR) Ultra Violet/Visible Light Spectrophotometer (UV/Vis) Identification by Chemical Reactions Identification by Flame High Pressure Liquid Chromatography (HPLC) Gas Chromatograph (GC) Thin Layer Chromatography Estriol, USP (Micronized) g $ g $ Promethazine Hydrochloride, USP g $ g $61.00 Titrations Estrone USP Flurbiprofen, USP g $ g $ g $ g $ g $ Tetracaine Hydrochloride, USP Verapamil Hydrochloride, USP g $ g $ g $ g $ g $ g $ Humco is committed to adhering to the highest quality standards to ensure that our products are consistently valued as the best option for patients and pharmacists. 8 HUMCO +1 (855) (855) HUMCO 9

6 VALIDATED STABILITY STUDIES The Beyond-Use-Date study evaluates the potency and stability of a formula over a course of time, from 30 days to 180 days. Below is an alphabetical listing of the API s studied for stability with correlating bases used for the compounded preparations. Please note, strength depends on percentage of API used. See appropriate product page for details. Active Ingredient HRT Botanical HRT Heavy Liposomal Heavy Liposomal Regular PLO20 Non-Flowable PLO20 Flowable RECURA Amitriptyline HCl 90 SaltStable LO SaltStable LS Advanced Baclofen 90 Benzocaine 90 Bupivacaine HCl 90 Capsaicin 90 Clomipramine HCl Cyclobenzaprine HCl Dehydroepiandrosterone 90 Dexamethasone 90 Diclofenac 90 Diclofenac Na 90 Diltiazem Diphenhydramine HCl 90 Estradiol Estriol Estrone Fluconazole 180 Fluoxetine HCl Flurbiprofen 90 Gabapentin Haloperidol Hydroquinone 90 Ibuprofen Ketamine HCl 90 Ketoprofen Lactic Acid 90 Lidocaine Lidocaine HCl 90 Menthol 90 Methimazole Methyl Salicylate 90 Metoclopramide 90 Metronidazole Miconazole 180 Pentoxifylline 90 Phenytoin 90 Piroxicam Active Ingredient HRT Botanical HRT Heavy Liposomal Heavy Active Ingredient Liposomal Regular Prednisolone Prednisone Progesterone Promethazine Testosterone Tetracaine HCl Flavor Blend Verapamil HCl 90 Flavor Sweet/SF Multibase PENcream Multibase PENcream Flavor Plus Acetazolamide Allopurinol Alprazolam Amiodarone HCl Amlodipine Besylate Atenolol Captopril 1 1 Clonidine HCl Chloroquine HCl Cisapride Dapsone Versa Free Diltiazem HCl Dipyridamole Enalapril Maleate Flecainide Acetate Flucytosine HCl Hydralazine HCl Ketoconazole Lactic Acid Lamotrigine Metolazone Metoprolol Tartrate Nifedipine Procainamide HCl Pyrazinamide Quinidine Sulfate Rifampin Sildenafil Citrate Spironolactone Tetracycline Verapamil HCl PLO20 Non-Flowable PLO20 Flowable Versa Plus RECURA SaltStable LO SaltStable LS Advanced 10 HUMCO +1 (855) (855) HUMCO 11

7 Creams Wound Lotions Scar ANHYDROUS BASE GENEDERM Creams Lotions VERSATILE TOPICAL CREAM DERMATOLOGICAL BASE FOR WRINKLES lb $50.00 Sensory Evaluation Profile of Anhydrous Base compared to other standard anhydrous bases: Humco s base is superior in all areas - wetness, absorbency, gloss silkiness Humco s Anhydrous Base is designed for low-load hydrophilic and high-load lipophilic actives that are unstable in water. Intense studies validate its compatibility with numerous drugs across a broad range of applications. It is cosmetically elegant with an exceptional sensory evaluation profile over other anhydrous bases, providing a smooth, light, and silky feel. ANHYDROUS BASE BENEFITS: Contains absolutely no water Non-greasy Validated proven drug compatibility Cosmetically elegant smooth, light, silky feel Preservative-free petroleum-free Easy to use actives can be directly incorporated without wetting 180-day BUD with all API s Fragrance-free dye-free Specific Gravity ANHYDROUS BASE PROPERTIES Transdermal Penetration API Compatibility 0.95 g/cm³ Light Beige Hydrophilic 10% Lipophilic 20% Total API Load - 20% Dermatology HRT Immunotherapy Pain Management Sports Medicine Veterinary Medicine Wound Care GENEDERM provides a firming effect on the skin - tightening and smoothing fine lines and wrinkles. It is uniquely formulated with Sodium Polystyrene Sulfonate, a film forming polymer that creates a matrix and provides excellent binding to the skin, allowing the base to adapt to changes in facial expressions and movement without cracking or peeling. GENEDERM can be used to reduce the appearance of fine lines and wrinkles. GENEDERM BENEFITS: Suitable for all skin types Comfortable - Allows skin to breathe Can be worn for -8 hours, including night-time application Can be applied without API s for wrinkle treatment Visible results after first application GENEDERM PROPERTIES ph Viscosity API Compatibility 50, ,000 cps Light Cream Opaque, Off-White Hydrophilic 10% Lipophilic 10% Total API Load - 20% Dermatology Wrinkles g $ Common Actives in Wrinkle Care: Vitamin E 200IU/g Antioxidant to reduce the signs of aging and photo-aging Vitamin C 2-10% (as Ascorbyl Palmitate) Antioxidant to reduce the signs of aging Niacinamide 2% Stabilizing effect on epidermal barrier function, seen as the reduction in trans-epidermal water loss Estradiol 0.01% and Estriol 0.3% After treatment for 6 months, elasticity and firmness of the skin had markedly improved; wrinkle depth and pore sized had decreased by %; skin moisture had increased and wrinkle depth decreased significantly Mixing Tips Mixing Speed rpm for 2-5 minutes If Dispensing in a Pump, Airless Pump Dispensers are Recommended SAMPLE FORMULAS: Glutathione 20% Topical Glutathione (L) Reduced 20% Anhydrous Base qs 100% Recommended Penetration Enhancer: 50% Lecithin in Isopropyl Palmitate Methimazole 5% Topical Methimazole 5% Anhydrous Base qs 100% Recommended Wetting Agent: Emu Oil SAMPLE FORMULA: Anti Wrinkle: Alpha-Lipoic Acid 5% Ascorbyl Palmitate 2% Estriol Micro Powder 0.3% Niacinamide 2% Tretinoin 0.025% Propylene Glycol 10% GENEDERM qs 100% Alpha-Lipoic Acid 5% Twelve weeks treatment with a cream improves clinical characteristics related to photo-aging of facial skin 12 HUMCO +1 (855) (855) HUMCO 13

8 Clinical Study "Product is non- irritating and reduces visibility of fine lines... a small amount goes a long way easy to use skin feels soft, smooth, refreshed and firm it is not greasy and has pleasant smell it felt high quality. GENEDERM CLINICAL STUDY STUDY Evaluation of Key Parameters on Outer Parts of 30 Panelist's Eyes, In Vivo, Using Image Analysis In one of the most innovative research projects ever undertaken in medical aesthetics, The Consumer Product Testing Company' captures the PRIMOS and VISIA image analysis, and opinions on wrinkle length, number, and area from 30 female subjects, ages 35 to 65, with mild to moderate crow's feet (coarse wrinkles) in the outer canthus eye area. The relative skin surface was analyzed as a composite and as a single point in any plane thereby making it possible to examine and compare several cutaneous parameters. The outer parts of the eyes of thirty panelists were used to evaluate several key parameters over eight weeks. RESULTS 'The Consumer Product Testing Company' key findings:. For women seeking aesthetic treatment, opinions found (89%) positive response for softened line/wrinkles around eyes, (89%) positive response for made skin feel firmer/tighter, and (100%) positive response for easy to use as daily skin care regimen.. PRIMOS image analysis found (71%) of women with wrinkle length decrease..visia image analysis found (82%) of women with wrinkle number decrease and (79%) of women with wrinkle area decrease. GENEDERM Dermatological Wrinkle Base has been proven to reduce or decrease five key parameters in relation to wrinkle reduction. Parameter Roughness Residual Length Average Amplitude Primary Wrinkle. Number of Peaks Genederm 1% Decrease 9% Decrease 10% Decrease 9% Decrease 10% Reduction > "The evaluation of parameters indicates that the use of Genederm produced smoothing and restructuring of the skin s surface after seven days of product application." - Advanced Scientific Imaging Consulting, leading analytical laboratory View Full Study at 1 HUMCO +1 (855) (855) HUMCO 15

9 Creams Wound Lotions Scar HRT BOTANICAL HRT HEAVY Creams Lotions CERTIFIED HYPOALLERGENIC HRT BASE HRT BASE WITH 180 DAY BUD lb $ lb $20.00 HRT Botanical is an oil-in-water, light cream, certified hypoallergenic base, with all natural ingredients and antioxidants. It has a lotion consistency and provides sustained skin penetration. Ideal for high lipophilic API concentrations. HRT Heavy is a heavier cream base than HRT Botanical ; it provides deeper skin penetration. It is specifically designed for male and female hormone restoration formulations and has a low to moderate API carrying capacity lb $ lb $ lb $ HRT BOTANICAL BENEFITS: Sustained skin penetration Paraben-free fragrance-free Natural ingredients natural preservatives Added antioxidants, botanicals, and herbal extracts Certified hypoallergenic Cosmetically elegant Ideal for vaginal preparations HRT HEAVY BENEFITS: Sustained skin penetration Paraben-free Natural ingredients Cosmetically elegant Ideal for intra-vaginal preparations Validated stability/potency of >90 days for all hormone APIs HRT BOTANICAL PROPERTIES HRT HEAVY PROPERTIES ph 6.5 ph 7.5 Specific Gravity 1.00 g/cm³ Specific Gravity 1.0 g/cm³ Viscosity 60,000 cps Viscosity 165,000 cps Light Cream Cream Light Beige White Transdermal Penetration + + Transdermal Penetration API Compatibility Lipophilic - 20% API Compatibility Lipophilic - 20% Hormone Replacement Hormone Replacement Published Studies Beyond-Use-Date (BUD) Published Studies Beyond-Use-Date (BUD) ACTIVE INGREDIENT BUD ACTIVE INGREDIENT BUD Estradiol 1% (Estriol, Estrone) Estradiol 1% (Estriol, Estrone) 150 Days Estriol 1% (Estradiol, Estrone) 120 Days Estriol 1% (Estradiol, Estrone) 180 Days Estrone 0.5% (Estradiol, Estriol) 150 Days Estrone 0.5% (Estradiol, Estriol) 120 Days Prednisolone 5% Metronidazole - 2% Progesterone 20% 180 Days Progesterone 20% 180 Days Testosterone 5% 180 Days Testosterone 5% 180 Days 16 HUMCO +1 (855) (855) HUMCO 17

10 Transdermal Study PROGESTERONE TRANSDERMAL STUDY 5% PROGESTERONE Transdermal Study PENcream, Anhydrous Base, HRT Botanical, and HRT Heavy have been proven to transport Progesterone into and through human skin, performing significantly more effectively than our competitor's base. Humco s PENcream, Anhydrous Base, HRT Heavy, and HRT Botanical are Validated Transdermal Vehicles Study Evaluation of the Percutaneous Absorption of Progesterone, In Vitro, Using the Epiderm Skin Model The progesterone study evaluated the percutaneous absorption pharmacokinetics of progesterone in the following Humco bases: HRT Botanical, HRT Heavy, Anhydrous Base and PENCream. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. Formulas were tested on standardized sections for the percutaneous absorption of progesterone over a 12-hour dose period. At pre-selected times after dose application, the dermal receptor solution was completely removed and replaced with fresh receptor solutions; and an aliquot was saved for subsequent analysis. Samples were analyzed for progesterone content by High Performance Liquid Chromatography (HPLC). The in vitro human Epiderm skin model is a proven tool, valuable for the study of percutaneous absorption and determination of pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model. Flux (ug/cm2/hr) % Progesterone Permeation Through the Stratum Corneum % Permeation Competitor s Base Progesterone Flux VS Time 0.30 Competitor s Base HRT Botanical Competitor s Base HRT Botanical HRT Heavy Time 8 HRT Heavy Progesterone 12 Anhydrous Base Humco's Anhydrous Base PENCream PENCream HRT Botanical HRT Heavy Anhydrous Base PENCream Results The data did indicate that progesterone penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration to a peak flux occurring at approximately 12 hours after dose application. HRT Botanical, HRT Heavy, Anhydrous Base, and PENCream delivered more progesterone than our competitor's base. The total percent of applied dose that penetrated past the stratum corneum with our competitor s base is 20% less than Humco s HRT Botanical, HRT Heavy, Anhydrous Base, and PENcream. Transdermal Drug Absorption: Avoids hepatic first pass effect, reducing adverse reactions to certain drugs Reduces minor gastrointestinal tract irritation and systemic toxicity Helps avoid possible drug interactions with food and intestinal flora Can be applied to different parts of the body (site rotation) > View Full Study at 18 HUMCO +1 (855) (855) HUMCO 19

11 Creams Lotions LIPOSOMAL HEAVY LIPOSOMAL REGULAR Creams Lotions lb $ lb $ lb $ MOISTURIZING TRANSDERMAL LIPOSOMAL BASE Liposomal Heavy is formulated with additional emulsifiers to allow for higher API loads and solvent concentrations to be incorporated. Added emollients provide excellent moisturizationan ideal choice for dry and/or dehydrated skin. TRANSDERMAL LIPOSOMAL BASE Liposomal Regular and Liposomal Heavy are cosmetically elegant, liposomal transdermal bases with excellent skin penetration and moisturizing capabilities. They are formulated to incorporate lipophilic and hydrophilic actives and penetrate faster than HRT bases lb $ lb $ lb $ LIPOSOMAL HEAVY AND LIPOSOMAL REGULAR BENEFITS: Cosmetically elegant excellent moisturizing effect Faster absorption deeper penetration than HRT bases API compatibility virtually all actives Natural preservatives Water oil-soluble Ideal for cosmetic facial applications Paraben-free PROPERTIES LIPOSOMAL HEAVY LIPOSOMAL REGULAR ph Specific Gravity 1.00 g/ml 1.00 g/ml Viscosity 250,000 cps 120,000 cps Format Heavy Cream Light Cream White Off-White Transdermal Penetration API Compatibility Hydrophilic 10% Lipophilic 10% Total API Load 20% Hydrophilic 5% Lipophilic 5% Total API Load 10% Published Studies Beyond-Use-Date (BUD) ACTIVE INGREDIENT Dehydroepiandrosterone 1.25% Dexamethasone 1.5% (Haloperidol, Lorazepam) Diclofenac % Diltiazem 2% Estradiol 0.5% (Estriol) Gabapentin 6% Gabapentin 12.5% Haloperidol 0.1% (Dexamethasone, Lorazepam) Hydroquinone 5% (Glycolic Acid) Methimazole 5% Piroxicam 0.5% Progesterone 5% Promethazine 5% LIPOSOMAL REGULAR BUD 60 Days LIPOSOMAL HEAVY BUD Recommended Use Dermatology Pain Management Immunotherapy Sports Medicine Higher API Loads Dry/Dehydrated Skin Chemical Peels Pigmentation Treatments Dermatology Pain Management Hormone Therapy Veterinary Medicine Lower API Loads Cosmetic Preparations Mixing Tip Recommended to Reduce Oxidation: Sodium Bisulfite - 0.5% 20 HUMCO +1 (855) (855) HUMCO 21

12 Creams Lotions lb $ lb $ lb $ Published Studies Beyond-Use-Date (BUD) ACTIVE INGREDIENT Capsaicin 1.2% (Menthol, Methyl Salicylate) Lactic Acid 8.5% Lidocaine 8% (Metronidazole, Phenytoin) Menthol 8% (Capsaicin, Methyl Salicylate) Methyl Salicylate 20% (Capsaicin, Menthol) Metronidazole 8% (Lidocaine, Phenytoin) Phenytoin 8% (Lidocaine, Metronidazole) Progesterone 10% Testosterone - 2% SAMPLE FORMULAS: HRT Cream: Progesterone 20% Glycerin 10% Multibase qs 100% Analgesic Cream: Capsicum Oleoresin 0.6% Methyl Salicylate 10% Menthol % Multibase qs 100% MULTIBASE HIGHLY VERSATILE OIL-IN-WATER CREAM BASE A versatile, oil-in-water natural vanishing cream that uses oleosomic emulsifiers and penetration enhancers. It is a great oil-free moisturizing base that provides natural skin penetration. MultiBase is designed for both hydrophilic and lipophilic actives and exhibits superior stability in the presence of low and high ph, high salt, high ethanol, and high polar compounds, allowing for flexible compounding and formulation options. MULTIBASE BENEFITS: Mineral oil-free, gluten-free, and propylene glycol-free Noncomedogenic Enhanced drug absorption penetration Ideal for vaginal preparations Stable over a broad range ph API compatibility hydrophilic lipophilic Natural ingredients moisturizers derived from berries, grapes, plums, and pears; emulsifiers derived from vegetable fatty acids palm oil; thickening agents derived from coconut oil BUD 180 Days 180 Days Anti-Wrinkle Cream: Retinoic Acid 0.05% Glycerin 10% Multibase qs 100% MULTIBASE PROPERTIES ph 7.0 Specific Gravity Viscosity 0.90 g/cm³ 250,000 cps Heavy Cream White Transdermal Penetration + + API Compatibility ph Compatibility Hydrophilic 10% Lipophilic 20% Total API Load - 30% Salt Tolerance Salt Forms - 10% Solvent Compatibility Polar Non-Polar Hormone Replacement Dermatology Pain Management Sports Medicine PENCREAM PENCream is an elegant oil-in-water vanishing cream formulated for enhanced transdermal penetration. This elegant alternative to PLO, with added emollients, provides a better rub-in and longer-lasting moisturizing effects without irritation. PENCream is highly compatible with a diverse range of hydrophilic and lipophilic actives, has a high API load capacity, and is ideal for hybrid formulations. PENCREAM BENEFITS: Free of BHT, EDTA, parabens, and urea Enhanced penetration capability efficacious API absorption Hydrophilic lipophilic compatibility high loads Natural ingredients less irritation than PLO Cosmetically elegant lasting moisturizing effect Applies easily no sticky residue Validated API compatibility Creams Lotions TRANSDERMAL OIL-IN-WATER VANISHING BASE PENCREAM PROPERTIES ph 7.0 Specific Gravity Viscosity 0.96 g/cm³ 300,000 cps Heavy Cream White Transdermal Penetration API Compatibility Hydrophilic Lipophilic - Total API Load - 30% Pain Management Veterinary Medicine Immunotherapy lb $ lb $ lb $ Published Studies Beyond-Use-Date (BUD) ACTIVE INGREDIENT Clomipramine HCl 7.5% Fluoxetine HCl 7.5% Gabapentin 6% (Ketoprofen, Lidocaine) Ibuprofen 10% Ketoprofen - 10% - (Gabapentin, Lidocaine) Lidocaine 15% (Gabapentin, Ketoprofen) Methimazole 7.5% Metoclopramide 2% Metronidazole 3% Promethazine 5% Tetracaine HCl 2% SAMPLE FORMULA: Pain Management Cream: Gabapentin 5% Lidocaine 15% Ketoprofen 10% Dimethyl Sulfoxide 5% PENCream qs 100% BUD Mixing Tips Water Soluble Powders: Levigate with Alcohol, Dimethyl Solfoxide (DMSO), Glycerin, Polyethylene Glycol (PEG) 300 or 00 or Purified Water Oil-Soluble Powders Can be Directly Incorporated 22 HUMCO +1 (855) (855) HUMCO 23

13 Creams Lotions Creams Lotions Your Compounding Vehicle to help you RECURA TOPICAL COMPOUNDING CREAM TOPICAL BASE FOR ANTIFUNGAL ACTIVES Item No NDC No. Size g g RECURA topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis. Utilizing penetration enhancers, RECURA provides good penetration into toenails, fingernails, and skin, works well with a variety of antifungal agents, and compounds easily. It has been intensively studied, patented, and peer-reviewed in order to validate the compatibility of the cream with a number of active ingredients. Price $ $ RECURA Peer Reviewed Study RECURA BENEFITS: Penetration Ability - contains penetration enhancers and natural oils to facilitate active drug absorption Drug Compatibility - both oil and water soluble powders can be levigated with alcohol Compound Diversity - contains penetrating agents for better nail absorption, natural oils for better skin absorption, and is alcoholdispersible for viscosity adjustment in IJPC Jan/Feb 2016 Issue Pgs RECURA PROPERTIES ph Viscous Cream Opaque, Light Lavender Fungal treatment on toenails, fingernails, and skin Published Studies Beyond-UseDate (BUD) ACTIVE INGREDIENT BUD Fluconazole 10% 180 Days Miconazole 10% 180 Days RECURA topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis. ABOUT RECURA RECURA can be formulated to hold and help in the delivery of various antifungal active ingredients In Vitro testing in a novel nail model suggests the potential utility of RECURA topical cream to enhance delivery of antifungal actives across the nail SAMPLE FORMULAS: Nail Cream 1: Miconazole 3 g RECURA 27 g Nail Cream 2: Fluconazole 3 g RECURA 27 g Skin Cream: Clotrimazole 0.6 g Ibuprofen 0.6 g RECURA 28.8 g Peer reviewed study1 in in vitro nail models comparing drug absorption with RECURA vs. marketed prescription solutions RECURA is for topical use only and is not for oral, ophthalmic, or intravaginal use Manufactured By: > View Full Study at 2 HUMCO +1 (855) Humco 512 E 11th St, Ste 201, Austin, Texas USA Tel. (512)7-700 Fax (512)7-71 compounding@humco.com Turner R et al., A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis, INTL. J. PHARM. COMPOUNDING 2016;20(1): (855) HUMCO 25

14 Creams Lotions SALTSTABLE LO SALTSTABLE LS ADVANCED Creams Lotions READY-TO-USE TRANSDERMAL PAIN BASE READY-TO-USE TRANSDERMAL PAIN BASE lb $ lb $ lb $ SaltStable LO is a ready-to-use transdermal cream base providing an elegant alternative to traditional PLOs. It s uniquely designed for long shelf, temperature, and physical stability; it will not separate in the presence of high levels of ionic substances or when refrigerated. It uses emulsifiers and hydrocolloids that provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO is cosmetically elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility. SaltStable LS Advanced is an extension and enhancement of SaltStable LO. SaltStable LS Advanced is a scientifically advanced, extremely durable, robust and versatile transdermal cream base formulated with a silogel that provides a smooth, silky dry feel. SSLS Advanced is designed for all actives and is non-specific to salt; it also exhibits superior API carrying capacity (high loads) of multiple actives in one formulation. SaltStable LS Advanced demonstrates excellent stability without the need to add emulsifiers g $ g $ g $ SALTSTABLE LO BENEFITS: SALTSTABLE LS ADVANCED BENEFITS: Efficacious active drug absorption Validated in vitro transdermal penetration API compatibility Temperature stable two-year shelf stable Hydrophilic compatibility high levels of ionic powders can be directly incorporated Lipophilic compatibility moderate levels of oil-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 00, or alcohol Cosmetically elegant not tacky or sticky Increased stability with a high percent of APIs multiple actives Validated in vitro transdermal vehicle up to 8 APIs in one formulation Less sticky less tacky because of silogel (silicone-based organogel) Off-white, cosmetically elegant cream API compatibility compatible with all actives, non-specific to salt Time saving ready-to-use base, no need for wetting or adding thickening agents Ideal for formulations with multiple actives high API loads Published Studies Beyond-Use-Date (BUD) Published Studies Beyond-Use-Date (BUD) ACTIVE INGREDIENT BUD SALTSTABLE LO PROPERTIES SALTSTABLE LS ADVANCED PROPERTIES ACTIVE INGREDIENT BUD Amitriptyline HCl 2% (Lidocaine) ph 7.0 ph Baclofen 2% Benzocaine 20% (Lidocaine, Tetracaine) Specific Gravity 1.00 g/cm³ Specific Gravity 0.90 g/cm³ Bupivacaine HCL 1% Clomipramine HCl 5% Cyclobenzaprine HCl 2% Diphenhydramine HCl 10% Fluoxetine HCl 5% Gabapentin 6% Ketoprofen 10% Lidocaine 10% (Benzocaine, Tetracaine) Methimazole 5% Metronidazole 2% Viscosity 300,000 cps Heavy Cream Light Beige Transdermal Penetration API Compatibility Hydrophilic 35% Lipophilic 10% Total API Load - 35% Pain Management Veterinary Medicine Sports Medicine Viscosity 1,200,000 cps Heavy Cream Off White Transdermal Penetration API Compatibility Hydrophilic 30% Lipophilic 0% Total API Load - 0% Pain Management Veterinary Medicine Sports Medicine Cyclobenzaprine HCl 2% Diclofenac Na 5% Flurbiprofen 10% Gabapentin 10% Ibuprofen 3% Ketamine HCl 10% Ketoprofen 20% Licocaine HCl 5% Pentoxyfylline 3% Promethazine 5% Verapamil HCl 10% Tetracaine HCl % (Benzocaine, Lidocaine) 26 HUMCO +1 (855) (855) HUMCO 27

15 Transdermal Study SALTSTABLE LS ADVANCED TRANSDERMAL STUDY STUDY Evaluation of the Percutaneous Absorption of Pentoxifylline + Ketamine HCl + Ibuprofen + Cyclobenzaprine HCl + Diclofenac Na + Baclofen + Bupivacaine HCl + Gabapentin, In SaltStable LS Advanced, Into Human Skin, In Vitro, Using the Franz Skin Finite Dose Model Using Humco s SaltStable LS Advanced, the study was designed to evaluate the percutaneous absorption pharmacokinetics of pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin in a single formulation using Humco s SaltStable LS Advanced base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. The eight drugs were selected due to their frequent use in compounding topical pain formulations along with compounding multiple actives in one formulation. The formula was tested on standardized sections with Humco s SaltStable LS Advanced transdermal compounding base, for the percutaneous absorption of the formula over a 8-hour dose period. At pre-selected times after dose application, the dermal receptor solution was removed in its entirety, replaced with fresh receptor solution, and an aliquot saved for subsequent analysis. High Performance Liquid Chromatography (HPLC) analyzed the samples for pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin content. The in vitro human Epiderm skin model has proven to be a valuable tool for the study of percutaneous absorption and the determination of the pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer surface of the skin and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption can be accurately determined in this model. RESULTS Humco s SaltStable LS Advanced compounding base is a proven transdermal delivery vehicle able to deliver multiple drugs beyond the stratum corneum, simultaneously into and through the human skin after a single dose. The data indicates that Humco s SaltStable LS Advanced delivered pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl, and gabapentin simultaneously (and intact) into and through human epidermal cultures, in vitro, from the test formulation provided. The absorption profiles indicate pentoxifylline, ketamine HCl, ibuprofen, diclofenac Na, and bupivacaine HCl had a steady penetration occurring for 32 hours after dose application. And cyclobenzaprine HCl, baclofen and gabapentin had a steady penetration occurring for 8 hours after dose application. TESTED FORMULA Baclofen...2% Bupivacaine...1% Cyclobenzaprine HCl.2% Diclofenac Na...5% Gabapentin...6% Ibuprofen...3% Ketamine HCl...10% Pentoxifylline...3% SaltStable LS Advanced...qs 100% Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flux (ug/cm2/hr) Cyclobenzaprine Flux VS Time Time Ibuprofen Flux VS Time Time Breakthrough Study: SaltStable LS Advanced has been proven to deliver eight drugs Creams Lotions simultaneously through human skin in-vitro Baclofen Flux VS Time Flux (ug/cm2/hr) Flux (ug/cm2/hr) Time 2 Diclofenac Flux VS Time 0 Time Time 32 8 Ketamine Flux VS Time Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flux (ug/cm2/hr) Bupivacaine Flux VS Time Time Gabapentin Flux VS Time 0 2 Time Pentoxifylline Flux VS Time Time HUMCO +1 (855) (855) HUMCO 29

16 Transdermal Study - - SANARE ADVANCED TRANSDERMAL STUDY 10% FLURBIPROFEN Transdermal Study 5% LIDOCAINE Transdermal Study - - SANARE ADVANCED Scar Therapy Base has been proven to transport multiple drugs into and through human skin, performing significantly more effectively than our competitor s base. Sanare Advanced out-performs Competitor s Base by 23-28% STUDY Evaluation of the Percutaneous Absorption of Flurbiprofen + Lidocaine The study evaluated the percutaneous absorption pharmacokinetics of Humco s Sanare Advanced Scar Base. Absorption TESTED FORMULA was measured in human epidermal cultures, in vitro, using the finite Flurbiprofen...10% dose technique and Franz Diffusion Lidocaine...5% Cells. Sanare Advanced...qs 100% The formula was tested on standardized sections with two different transdermal compounding bases. At pre-selected times after dose application, the dermal receptor solution was completely removed and replaced with fresh receptor solution; and an aliquot was saved for subsequent analysis. Samples were analyzed for flurbiprofen and lidocaine content by High Performance Liquid Chromatography (HPLC). The in vitro human Epiderm skin model is a proven tool, valuable for the study of percutaneous absorption and determination of pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model. Flux (ug/cm2/hr) Flux (ug/cm2/hr) Flurbiprofen Flux VS Time Time Lidocaine Flux VS Time Time Sanare Advanced Competitor's Base Sanare Advanced Competitor's Base RESULTS The data did indicate that flurbiprofen penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 8 hours after dose application. Sanare Advanced performed significantly better than our competitor's base at delivering flurbiprofen through human skin. The data also indicated that lidocaine penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 8 hours after dose application. Humco s Sanare Advanced performed significantly better than our competitor s base at delivering lidocaine through human skin. The total percent of applied dose that penetrated past the stratum corneum with our competitor s base is 23% less with flurbiprofen and 28% less with lidocaine than Humco s Sanare Advanced. > View Full Study at 30 HUMCO +1 (855) (855) HUMCO 31

17 Creams Lotions - - SANARE ADVANCED - LAVARE Gel Bases Ointments g $ g $ g $ Common Actives in Scar Care: Pentoxifylline % Decreases collagen production, increases activity of Collagenase in dermis, inhibits fibroblast hyperactivity Betamethasone 0.1% Steroid and anti-inflammatory Dimethyl Sulfone 2% Anti-inflammatory EGCg % Antioxidant Caffeine 0.1 1% Induces differentiation and proliferation in epidermal keratinocytes Collagenase 350 u/g Reduces collagen production Hyaluronidase 250 u/g Breaks down collagen Tranilast 1 10% Anti-collagen Mixing Tips Recommended Wetting Agent: Fatty Acid Esters (Isopropyl Palmitate), Fatty Alcohols (Oleyl Alcohol), or Anhydrous Alcohol (Ethanol 200 Proof) Maximum Amount 10% Recommended to Reduce Stickiness: Cyclomethicone 5-10% TOPICAL SILICONE BASE FOR SCAR THERAPY OTHER CONDITIONS Sanare Advanced is an elegant, topical anhydrous silicone gel designed for scar therapy treatment and management. It is uniquely formulated with Carapa Guaianensis Seed Oil found in the Amazon rainforest, an exceptional ingredient that promotes skin renewal, inflammation reduction, and healing. Added emollients and emulsifiers allow for versatile compounding for scar and other skin conditions. SANARE ADVANCED BENEFITS: Provides barrier protection Increased skin penetration Formulated for higher loads of polar salt APIs Skin renewal and inflammation reduction Soy, gluten, and irritant free Specific Gravity Solubility in Water SANARE ADVANCED PROPERTIES SAMPLE FORMULAS: Keloids Hypertrophic Scars: Betamethasone Valerate 0.1% Tranilast 1% Sanare Advanced qs 100% Post Surgical Scars/ New Scars: Collagenase 350 u/g Hyaluronidase 250 u/g Sanare Advanced qs 100% 1.12 g/ml Viscous Gel Insoluble Opaque, Off-White New Scars Old Scars Surgical Scars Acne Scars Keloids Stretch Marks Scar Tissue Dosage: Apply 2-6 grams topically to affected area 2- times daily for 10 to 1 weeks or as directed. Post Surgical Scars with Pain: Gabapentin 15% Lidocaine 3% Prilocaine 3% Sanare Advanced qs 100% Age Spots Wrinkles: Hydroquinone 8% Hydrocortisone 1% Kojic Acid % Tretinoin 0.05% Sanare Advanced qs 100% Rosacea: Metronidazole 1% Niacinamide % Sanare Advanced qs 100% Acne Scars: Lipoic Acid 0.5% Tretinoin 0.1% Sanare Advanced qs 100% WATER-WASHABLE WOUND CARE BASE Lavare is a Polyethylene Glycol (PEG) based occlusive, water-soluble gel specifically formulated for wound management by promoting a moist environment allowing for optimal healing. Lavare contains organic Meadowsweet Extract potentially providing germicidal anti-inflammatory and healing properties along with the ability to deliver APIs topically to sensitive wound sites. LAVARE BENEFITS: Adherent base occlusive Water-washable allowing for easy cleaning and debridement Maintains a moist wound site providing an optimal healing environment API Compatibility hydrophilic and lipophilic actives Soy and gluten free ph 6.0 Specific Gravity Solubility in Water SAMPLE FORMULAS: No Odor/ No Pain: Misoprostol 0.002% Phenytoin 5% Lavare Gel qs 100% Odor / No Pain: Misoprostol 0.002% Phenytoin 5% Metronidazole 2% Lavare Gel qs 100% LAVARE PROPERTIES 1.12 g/cm³ Non-Flowable Gel Complete White No Odor / Pain: Misoprostol 0.002% Phenytoin 5% Lidocaine % Lavare Gel qs 100% Infected Wound: Misoprostol 0.002% Phenytoin 5% Gentamicin 0.2% Lavare Gel qs 100% Wounds Ulcers Burns Cuts Abrasions Dermatological Applications Dosage: Apply up to grams topically 3 times daily as directed, up to 12 grams per day. Infected Wound: Gentamicin 0.1%/g Clindamycin 0.1%/g Polymyxin 2,000 u/g Lavare Gel qs 100% Wound Care: Ketoprofen 2% Lidocaine 2% Misoprostol 0.002% Phenytoin 2% Aloe Vera 0.2% Lavare Gel qs 100% g $ g $ g $ Common Actives in Wound Care: Misoprostol 0.002% Synthetic analogue of prostaglandin E1, attenuate the inflammatory process and promote collagen formation by inhibiting IL-1 and TNF, modulates inflammation and decreases wound healing time Phenytoin 5% Stimulates collagen deposition, fibroblast proliferation, glucocorticoid antagonism, and has antibacterial activity Lidocaine % Topical anesthetic Metronidazole 2% Deodorizing effect of Metronidazole correlate with eradication of anaerobic infection Nifedipine 2% Ca2+ channel blocker that greatly improves tissue perfusion and improves healing time Gentamicin 0.2% Antibiotic Mixing Tip Recommended Wetting Agent: Glycerin, Maximum Amount 10% 32 HUMCO +1 (855) (855) HUMCO 33

18 Gel Bases Ointments PLO20 FLOWABLE PLO20 NON-FLOWABLE Gel Bases Ointments PRE-MADE FLOWABLE PLO PRE-MADE PLO lb $65.00 HUMCO'S PLO20 FLOWABLE VS TRADITIONAL PLO COMPETITOR'S BASE Humco's PLO20 Flowable... % Competitor s Base... 39% Traditional PLO... 17% Cumulative % Permeation of Methimazole through the Stratum Corneum PLO20 Flowable is a robust, ready-to-use transdermal base that represents the next generation of pluronic lecithin organogel (PLO) bases. This cosmetically elegant base has a lotion consistency that allows for incorporating high levels of APIs. It contains the same stability properties as PLO20 Non-Flowable, allowing for versatile compounding. PLO20 Flowable provides enhanced chemical penetration that allows a deeper skin permeation than does PLO20 Non-Flowable. This product is designed to accept the incorporation of high levels of lipophilic actives and moderate levels of hydrophilic actives. PLO20 FLOWABLE PLO20 NON-FLOWABLE BENEFITS: Enhanced penetration more efficacious drug absorption API compatibility high lipophilic moderate hydrophilic carrying capacity Adjustable viscosity PLO20 PLO20 Flowable may be blended Temperature shelf stable Cosmetically elegant Validated API compatibility penetration No wetting or milling high levels of oil-soluble powders moderate levels of water-soluble powders may be directly incorporated PROPERTIES PLO20 NON-FLOWABLE PLO20 FLOWABLE ph Specific Gravity 0.97 g/ml 0.97 g/ml Viscosity 300,000 cps 30,000 cps Format Heavy Cream Light Cream/Lotion Light Yellow Light Yellow Transdermal Penetration PLO20 Non-Flowable and PLO20 Flowable are ready-to-use, absorption-enhanced transdermal vehicles that are elegant alternatives to PLO transdermal systems. They contain penetration enhancers to facilitate more efficacious active drug absorption, emollients for a better rub-in, preservatives for increased mold resistance, along with emulsifiers allowing for better cold-temperature stability. PLO20 Non-Flowable and PLO20 Flowable may be blended for viscosity optimization without wetting agents or milling to thin the formula, thus allowing for versatile compounding. Published Studies Beyond-Use-Date (BUD) ACTIVE INGREDIENT PLO20 NON-FLOWABLE PLO20 FLOWABLE Diltiazem 2% Gabapentin 6% Haloperidol 2% Ibuprofen 10% (Piroxicam) 60 Days Ibuprofen 20% (Piroxicam) Ketoprofen 10% (Piroxicam) Methimazole 5% Piroxicam 1% (Ibuprofen, Ketoprofen) 60 Days Piroxicam 2% (Ibuprofen, Ketoprofen) 60 Days Prednisolone 5% Prednisone 5% Prednisone 10% Promethazine 5% lb $ lb $ lb $ SAMPLE FORMULA: Anti-Nausea/Pain Management Cream: Promethazine 5% API Compatibility Hydrophilic 10% Lipophilic 10% Total API Load 10% Hydrophilic 10% Lipophilic 30% Total API Load 30% WHEN DO YOU NEED PLO20 OR PLO20 FLOWABLE? Best Use Low Levels of Lipophilics High Levels of Lipophilics Pain Management Sports Medicine Diabetes Wound Care Veterinary Medicine Pain Management Sports Medicine Immunotherapy Veterinary Medicine When you want more efficacious active drug absorption. When you want to incorporate high levels of lipophilic substances. When you want a creamier base than a traditional PLO that is more cosmetically elegant and less sticky. When you want a penetrating cream that can be shipoed in cold temperatures. 3 HUMCO +1 (855) (855) HUMCO 35

19 Gel Bases Ointments UNIVERSAL WATER GEL DICLOFENAC SODIUM 3% CREAM, USP Bulk Compounding Drug Substances VERSATILE TOPICAL GEL BASE TOPICAL BASE lb $ lb $ Universal Water Gel is an oil and salt tolerant blend using hydrophobic-inclusive cyclodextrins and electrolyte-tolerant polymers that greatly increases the water solubility and stability of incompatible drugs. Ideal for formulas containing higher levels of oils, botanical ingredients, or poorly soluble actives. It provides improvements in solubility, increase in speed of dissolution, together with physical and chemical stability. UNIVERSAL WATER GEL BENEFITS: API compatibility hydrophilic lipophilic Excellent electrolyte tolerance Bioavailability enhancement Improves active stabilization compatibility Highly stable across a broad ph range Masks the odor of unpleasant actives Cosmetically elegant Diclofenac Sodium 3% Cream, USP is a creamy emulsion provided in bulk form as a base for prescription compounding that contains Diclofenac Sodium 3% in a cosmetically elegant cream. Diclofenac 3% Cream, USP was designed specifically to hold additional API's for further compounding, including API's that a pharmacist may choose to aid in pain management. Conveniently packaged with the pharmacist in mind, Diclofenac 3% Cream, USP is available in bulk packaging to save time and money and increase efficiency in place of compounding from unit of use package sizes. DICLOFENAC SODIUM 3% CREAM, USP BENEFITS: Penetration Ability - Contains penetration enhancers to facilitate API absorption Time saving - Packaged in bulk to save time compounding Applies Easily - No sticky residue Diclofenac Sodium Cream 3%, USP FOR PRESCRIPTION COMPOUNDING ONLY Diclofenac Sodium, USP...3.0% Cream % NOT IN DOSAGE UNIT FORM g Call for Pricing UNIVERSAL WATER GEL PROPERTIES ph 7.0 Specific Gravity Viscosity Transdermal Penetration + API Compatibility 0.95 g/cm³ 750,000 cps Gel Translucent Hydrophilic Lipophilic Total API Load - less than 10% DICLOFENAC SODIUM 3% CREAM, USP PROPERTIES ph Viscous vanishing topical cream Brilliant White Compounding Base Dermatology Pain Management Diabetes Wound Care 36 HUMCO +1 (855) (855) HUMCO 37

20 Bulk Compounding Drug Substances LIDOCAINE 5% OINTMENT,USP LIDOCAINE AND PRILOCAINE CREAM, USP Bulk Compounding Drug Substances TOPICAL BASE TOPICAL BASE Lidocaine Ointment 5%, USP FOR PRESCRIPTION COMPOUNDING ONLY Lidocaine, USP...5.0% Ointment % NOT IN DOSAGE UNIT FORM g Call for Pricing Lidocaine 5% Ointment, USP is a water washable ointment provided in bulk form as a base for prescription compounding that contains Lidocaine 5% in a cosmetically elegant cream. Humco s Lidocaine 5% Ointment, USP is a water soluble base containing polyethylene glycol (PEG) 00, polyethylene glycol (PEG) 330, propylene glycol, zinc acetate, and botanical extracts. Lidocaine 5% Ointment, USP was designed specifically to hold additional APIs for further compounding including APIs that a pharmacist may choose to aid in pain management. Conveniently packaged with the pharmacist in mind, Lidocaine 5% Ointment, USP is available in bulk packaging to save time and money and increase efficiency in place of compounding from unit of use package sizes. Lidocaine and Prilocaine Cream, USP is provided in bulk form as a base for prescription compounding that contains Lidocaine 2.5% and Prilocaine 2.5% in a cosmetically elegant cream. Lidocaine and Prilocaine Cream, USP was designed specifically to hold additional APIs for further compounding including APIs that a pharmacist may choose to aid in pain management. Conveniently packaged with the pharmacist in mind, Lidocaine and Prilocaine Cream, USP is available in bulk packaging to save time and money and increase efficiency in place of compounding from unit of use package sizes. LIDOCAINE AND PRILOCAINE CREAM, USP BENEFITS: NOT IN DOSAGE UNIT FORM g Call for g Pricing LIDOCAINE 5% OINTMENT, USP BENEFITS: Adherent base - occlusive Time saving - packaged in bulk to save time compounding Water washable and soluble Applies Easily - No sticky residue Penetration Ability - Contains penetration enhancers to facilitate API absorption Applies Easily - No sticky residue Drug Compatibility - Can hold both hydrophilic lipophilic APIs Time Saving - Packaged in bulk to save time compounding Common Actives for Compounding: Diclofenac Sodium 2-6% Baclofen 2% Ketamine HCL 5-10% Gabapentin 5-10% LIDOCAINE 5% OINTMENT, USP PROPERTIES ph Viscous, water-soluble ointment Translucent White Compounding Base LIDOCAINE AND PRILOCAINE CREAM, USP PROPERTIES ph Viscosity 800,000-1,600,000 cps Viscous Cream Opaque, Off-White Common Actives for Compounding with Lidocaine and Prilocaine Cream, USP: Amitriptyline 2% Diclofenac Sodium 2-6% Gabapentin 6% Meloxicam 0.2% % Compounding Base Topiramate 1.25% Cyclobenzaprine HCl 2% Baclofen 2% Ketamine 5-20% 38 HUMCO +1 (855) (855) HUMCO 39

21 Pre-Mixed Excipient Bases EMULSION CONCENTRATE BUFFER CREAM Oral Vehicles oz $ oz $ gal $ COMPOUNDING ENHANCER Emulsion Concentrate is a ph and salt-tolerant emulsifier/hydrocolloid blend that greatly increases emulsification, stability, and thickness of broken emulsions, and separated and thin formulations. It quickly forms emulsions that are fresh, elegant, fast-absorbing, and non-greasy. EMULSION CONCENTRATE BENEFITS: Ready-to-use polymer in fluid form API compatibility virtually all APIs Elegant sensory profile Low high temperature resistant (-5º C 80º C) Ingredient compatibility Broad range of applications ph Viscosity Intended Use EMULSION CONCENTRATE PROPERTIES 75,000 cps Viscous Gel Opaque Emulsify all types of oily phases Stabilize mineral additives Thicken in adverse conditions very acidic or very alkaline, oxidizing Develop fresh formulas that melt on contact with the skin SWEETENED BUFFERING AGENT FOR ORAL SUSPENSIONS Buffer Cream is a sweetened buffering agent in powder form developed to provide an alkaline buffer for compounding oral proton pump inhibitor (PPI) suspensions. It provides immediate release and rapid absorption of PPI actives and is free of milk and protein. Buffer Cream is highly palatable with added sweeteners for either flavored or unflavored alkaline solutions to help overcome patient compliance difficulties. BUFFER CREAM BENEFITS: Alkaline buffer Immediate release rapid absorption Validated long-term stability Masks unpleasant tastes API compatibility all PPIs Flavor versatility Suspension Stability API Compatibility Flavor Versatility BUFFER CREAM PROPERTIES White Powder with Translucent Sheen Up to 35 days All PPI s (Proton Pump Inhibitors) Any Flavor lb $28.60 WHEN DO YOU NEED HUMCO'S BUFFER CREAM? When you want a sweetened buffer product for preparing oral suspensions When you want an alkaline buffer When you want palatability When you want a product that contains no milk or protein API Compatibility Virtually all APIs ph Compatibility Salt Tolerance Salt Forms 35% Solvent Compatibility Temperature Stability Applications Polar Non-Polar Low High Temperatures Ethanol, Propylene Glycol, Butylene Glycol, Glycerin, Hexylene Glycol, Methylpropane Diol, Acetone, Vegetable Oils, Silicone Oils, Mineral Oils, Esters Sun Filters Long-Term Stability ACTIVE INGREDIENT STABILITY Lansoprazole Stable - 21 Days at 25 C Omeprazole Stable - 35 Days at 25 C Pantoprazole Stable - 7 Days at 25 C DIFFERENT VISCOSITIES ARE ACHIEVED BY VARYING THE AMOUNT OF EMULSION CONCENTRATE: 3% FOR LOTIONS 5% FOR CREAMS SAMPLE FORMULA: Instructions: 1. Add omeprazole to 90 ml - 8.% sodium bicarbonate, refrigerate for at least 1 hour and mix until dissolved. 2. Add ompreazole solution to Humco Buffer Cream to qs volume ml and shake well. 3. Add flavor is desired. Omeprazole 10 mg/ml Suspension: Humco Buffer Cream 5 g Omeprazole 1.2 g 8.% Sodium Bicarbonate qs 120 ml 0 HUMCO +1 (855) (855) HUMCO 1

22 Oral Vehicles MOUTHWASH-GP MOUTHWASH-OM Oral Vehicles GENERAL PURPOSE MOUTHWASH BASE MOUTHWASH BASE FOR ORAL MUCOSITIS oz $9.7 Flavoring Suggestions? For formulations containing Diphenhydramine HCL, use: Banana, Apple, Bubble Gum For formulations containing Nystatin/Bio-Statin Suspension, use: Sour Apple, Watermelon, Cherry For formulations containing Cortisone Steroids, use: Bubble Gum, Grape, Apple For formulations containing Antibiotics, use: Grape, Watermelon, Strawberry Mouthwash-GP is a mouthwash base designed to simplify and standardize the extemporaneous compounding of formulations for delivery to the oral cavity. The ph of Mouthwash-GP is buffered to match the natural ph of saliva. The viscous nature of the Mouthwash-GP product allows the pharmacist to dissolve and/or suspend most of the common actives that are prescribed in Magic Mouthwash. Mouthwash-GP is designed to dissolve or suspend a high amount of active ingredients - maintaining its viscosity when actives are added - such that the oral cavity is coated with medication. The Mouthwash-GP packaging container has added head space which allows for mixing of actives by shaking the container. MOUTHWASH-GP BENEFITS: Oral moisturizer Coats the mouth Container head space for mixing Dye and flavor free Easily tailored with flavors and colors to improve palatability Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives ph Viscosity Alcohol Content Intended Use API Compatibility Delivery Method SAMPLE FORMULAS: BLM Magic Mouthwash: Diphenhydramine HCl 0.1% Lidocaine HCl 1% Aluminum Hydroxide/ Magnesium Hydroxide/ Simethicone Suspension 37.5% Mouthwash-GP qs 100% MOUTHWASH-GP PROPERTIES 1,500 -,000 cps Viscous Liquid Solution Clear Liquid 10.6% w/w Chemotherapy mouth ulcers Bacterial/viral oral infections Gingival irritation caused by braces Throat/esophageal sores Compatible with most Magic Mouthwash actives Can be expectorated or swallowed Mary s Magic Mouthwash: Diphenhydramine HCl 0.25% Hydrocortisone 0.05% Nystatin 0.5% Tetracycline HCl 0.65% Mouthwash-GP qs 100% Anti-Viral Mouth Rinse: Acyclovir 5% Mouthwash-AF 5% Lidocaine HCl 1% Deoxy D-Glucose 2% Mouthwash-GP qs 100% Mouthwash-OM is a mouthwash base designed to aid symptoms of Oral Mucositis associated with cancer therapy and certain dental conditions. In addition to being alcohol-free, Mouthwash-OM contains excipients that are compatible with water-soluble drugs for the treatment of oral pain, mouth sores, and oral infections. MOUTHWASH-OM BENEFITS: Soothing oral moisturizer Alcohol-free - no burn Container head space for mixing Dye and flavor free Contains botanical extracts Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives MOUTHWASH-AF ALCOHOL-FREE MOUTHWASH BASE FOR HYDROPHOBIC ACTIVES Mouthwash-AF is a mouthwash base designed to provide solubility of hydrophobic active ingredients while being compatible with the oral mucosa. In addition to being alcohol-free, Mouthwash-AF contains excipients that dissolve and coat the mouth with drugs for the treatment of oral pain, mouth sores, and oral infections. MOUTHWASH-AF BENEFITS: Solubilizers for hydrophobic actives Alcohol-free - no burn Container head space for mixing Dye and flavor free Compatible with hydrophobic and hydrophilic actives Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives oz $9.7 SAMPLE FORMULAS: Pain Relief Gargle: Lidocaine HCl 1.5% Sucralfate 5% Diphenhydramine HCl 0.5% Mouthwash-OM qs 100% Xerostomia Rinse: Pilocarpine HCl 1% Mouthwash-OM qs 100% oz $9.7 SAMPLE FORMULAS: Esophageal Suspension: Budesonide 0.1% Mouthwash-GP or AF qs 100% Anti-Infective Mouthwash: Nystatin 1% Tetracycline HCl 2% Acyclovir 5% Deoxy D-Glucose 2% Mouthwash-AF qs 100% 2 HUMCO +1 (855) (855) HUMCO 3

23 Oral Vehicles FLAVOR SWEET FLAVOR PLUS Oral Vehicles SYRUP VEHICLE ORAL SUSPENDING VEHICLE oz $ gal $62.00 Flavor Sweet is a cherry-flavored syrup vehicle formulated to simplify the preparation of oral extemporaneous delivery systems. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension s physical stability. Flavor Sweet contains suitable preservatives and is buffered to a slightly acidic ph to provide a dependable and consistent vehicle. Pink colored, cherry flavored syrup ph.5 ph 5.0 Recommended use hydrophilic, acid-stable hydrophobic actives Flavor Plus is a unique flavor-free, aqueous based suspending vehicle used to simplify the process of compounding oral non-soluble suspensions. It is buffered to an acidic ph providing a uniform, consistent and stable vehicle. Flavor-free, white liquid suspension ph 3.5 ph.0 Recommended use hydrophilic, acid-stable hydrophobic actives Ideal for diabetic preparations oz $ gal $ oz $ gal $62.00 FLAVOR SWEET-SF SUGAR-FREE SYRUP VEHICLE Flavor Sweet SF is a sugar-free and alcohol-free cherry flavored syrup. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension s physical stability. Flavor Sweet SF contains suitable preservatives and is buffered to a slightly acidic ph to provide a dependable and consistent vehicle. Pink colored, cherry flavored, sugar-free syrup ph.5 ph 5.0 Recommended use hydrophilic, acid-stable hydrophobic actives Ideal for diabetic preparations FLAVOR BLEND ALL-IN-ONE SYRUP/SUSPENDING VEHICLE Flavor Blend is a uniquely formulated flavored oral suspending vehicle designed to simplify the extemporaneous compounding process of oral suspensions. It combines the flavoring agents of Flavor Sweet and the suspending agents of Flavor Plus, along with preservatives and an anti-foam agent to provide an easy preparation of smooth, elegant oral suspensions. Easy to use Light pink liquid blend with a cherry flavor ph.5 ph 5.0 Recommended use hydrophilic, acid-stable hydrophobic actives Incorporate virtually all medicated powders or crushed tablets Ideal for pediatric geriatric preparations oz $ gal $62.00 VERSA FREE VERSA PLUS DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SYRUP VEHICLE DYE-FREE, CHEMICAL-FREE, AND SUGAR-FREE SUSPENSION VEHICLE oz $ gal $75.00 Versa Free is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free syrup vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste. Flavor-free clear liquid syrup ph.5 ph 5.0 Natural ingredients natural preservatives Recommended use hydrophilic, acid-stable hydrophobic actives Ideal for diabetic allergy-sensitive patients Soy gluten-free Versa Plus is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free suspension vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste. Flavor-free white liquid suspension ph 3.5 ph.0 Natural ingredients natural preservatives Recommended use hydrophilic, acid-stable hydrophobic actives Ideal for diabetic allergy-sensitive patients Soy gluten-free oz $ gal $75.00 HUMCO +1 (855) (855) HUMCO 5

24 Oral Vehicles ADDITIONAL ORAL VEHICLES ADDITIONAL CMPDG INGREDIENTS Miscellaneous Ingredients Product Ingredients Ordering Information Almond Oil Sweet, NF Cherry Syrup Recommended Use: Ionic Hydrophilic Actives Sucrose 82% w/v, purified water, artificial cherry flavors, citric acid, FDC Red #0, sodium benzoate as a preservative, inert ingredients and natural preservatives oz $ gal $56.00 Arnica Tincture Barium Sulfate Powder USP oz $ oz $ oz $ lb $53.5 Raspberry Syrup Recommended Use: Ionic Hydrophilic Actives Sucrose 82% w/v, purified water, artificial raspberry flavors, citric acid, FDC Red #0, FDC Blue #1, sodium benzoate as a preservative, inert ingredients and natural preservatives oz $9.83 Benzoin Compound Tincture USP Bismuth Bicarbonate Powder oz $ oz $ lb $ Simple Syrup Recommended Use: Ionic Hydrophilic Actives Sorbitol Solution 70%, USP Recommended Use: Ionic Hydrophilic Actives, Diabetic Additives Sucrose 85% w/v, citric acid, purified water, methyl paraben as a preservative along with natural preservatives. Natural ingredients and preservatives 70% solution of sorbitol and purified water oz $ gal $ oz $.96 Coal Tar Topical Solution USP Glycerin USP Iodine Tincture, Mild 2% USP Mineral Oil Light oz $ oz $ gal $ gal $ oz $ oz $ gal $ Syrpalta (red) Recommended Use: Ionic Hydrophilic Actives Syrpalta (without color) Recommended Use: Ionic Hydrophilic Actives Sucrose 83% w/v, purified water, glycerin, artificial flavors, 0.2% alcohol, 0.1% sodium benzoate, 0.001% benzalkonium chloride as a preservative and inert ingredients. Sucrose 83% w/v, purified water, artificial flavors, 0.2% alcohol, 0.1% sodium benzoate, 0.001% benzalkonium chloride as a preservative, inert ingredients and natural preservatives oz $ oz $12.6 Olive Oil Peruvian Balsam Polyethylene Glycol 300 Propylene Glycol oz $ gal $ oz $ gal $ gal $36.8 Salicylic Acid Powder USP Strong Iodine Solution (Lugol's) * oz $ lb $ oz $56.20 * To purchase this item you must have a DEA license on file 6 HUMCO +1 (855) (855) HUMCO 7

25 HUMCO GLOBAL HEADQUARTERS 201 West 5th Street Floor 12 Austin, TX (855)