CIA. online e-issn Int Arch Allergy Immunol 172(3) (2017) print ISSN

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1 Int Arch Allergy Immunol 172(3) (2017) print ISSN online e-issn /iaa Official Journal of the Collegium Internationale Allergologicum COLLEGIUM CIA INTERNATIONALE ALLERGOLOGICUM Review 129 Multiple Drug Hypersensitivity Pichler, W.J. (Bern); Srinoulprasert, Y. (Bangkok); Yun, J. (Sydney, NSW); Hausmann, O. (Bern/Luzern) Molecules and Cells in Allergy Original Paper 139 Serological Reactivity and Identification of Immunoglobulin E-Binding Polypeptides of Ganoderma applanatum Crude Spore Cytoplasmic Extract in Puerto Rican Subjects Vilá-Héreter, F. (San Juan, PR); Rivera-Mariani, F.E. (Miami, FL); Bolaños-Rosero, B. (San Juan, PR) Clinical Allergology Original Papers 150 Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features Takejima, P.; Agondi, R.C.; Rodrigues, H.; Aun, M.V.; Kalil, J.; Giavina-Bianchi, P. (São Paulo) 161 Effectiveness of Autologous Whole-Blood Injections in Patients with Refractory Chronic Spontaneous Urticaria Kitsioulis, N.A. (Athens/Larissa); Xepapadaki, P. (Athens); Roussaki-Schulze, A.-V. (Larissa); Papadopoulos, N. (Athens/ Manchester); Zafiriou, E. (Larissa) 167 Long-Term Follow-Up of Children after Venom Immunotherapy: Low Adherence to Anaphylaxis Guidelines Fiedler, C.; Miehe, U.; Treudler, R.; Kiess, W.; Prenzel, F. (Leipzig) 173 Risk Factors for Severe Reactions during Double-Blind Placebo-Controlled Food Challenges Yanagida, N.; Sato, S.; Asaumi, T.; Ogura, K.; Ebisawa, M. (Sagamihara) Clinical Allergology Short Communication 183 Accelerated Up-Dosing of Subcutaneous Immunotherapy with a Registered Allergoid Birch Pollen Preparation Buczyłko, K. (Łódź); van der Werf, J.F.; Boot, D. (Leiden); van Ree, R. (Amsterdam) S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney

2 A valuable tool for clinical practice Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 52 Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases J. Serup W. Bäumler Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases Jørgen Serup Wolfgang Bäumler Diagnosis and Therapy of Tattoo Complications With Atlas of Illustrative Cases : Serup, J. (Copenhagen); Bäumler, W. (Regensburg) VIII p., 242 fig., 239 in color, 8 tab., 2017 CHF / EUR / USD Hard cover or online prices for personal customers Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN e-isbn Current Problems in Dermatology, Vol. 52 Series Editor: Itin, P. (Basel); Jemec, G.B.E. (Roskilde) ISSN / e-issn Listed in MEDLINE/Pubmed, Thomson Reuters indices Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: Tattooing breaches the skin and can, therefore, cause a variety of complications. This book covers the full spectrum of issues clinical practitioners may encounter when treating affected patients. Introductory chapters include educational information on methods for tattooing, types of tattoos, tattoo inks, and tattoo ink toxicology. The focus is on the diagnosis and classification of tattoo complications. In this regard, a comprehensive atlas of acute and chronic complications serves as a valuable tool. Further chapters summarize available therapies, their rationale, and indication. This includes various medical and surgical treatments with a review of dermatome shaving. Lastly, tattoo removal by gold standard YAG lasers and the more recent pico-second lasers is discussed with the optimal therapeutic outcome in mind. Dermatologists, plastic surgeons, general practitioners, laser surgeons, and other specialists treating tattoo complications will find this book to be an indispensable resource. It also includes information relevant for a broad range of stakeholders in the tattoo business, including authorities and regulators. Contents Preface: Serup, J.; Bäumler, W. From Technique of Tattooing to Biokinetics and Toxicology of Injected Tattoo Ink Particles and Chemicals: Serup, J. Individual Risk and Prevention of Complications: Doctors Advice to Persons Wishing a New Tattoo: Serup, J. Tattoo Infections, Personal Resistance, and Contagious Exposure through Tattooing: Serup, J. Diagnostic Tools for Doctors Evaluation of Tattoo Complications: Serup, J. How to Diagnose and Classify Tattoo Complications in the Clinic: A System of Distinctive Patterns: Serup, J. Medical Treatment of Tattoo Complications: Serup, J. Surgical Treatment of Tattoo Complications: Sepehri, M.; Jørgensen, B. Laser Treatment of Tattoos: Basic Principles: Bäumler, W. Removal of Tattoos by Q-Switched Nanosecond Lasers: Karsai, S. New and Advanced Picosecond Lasers for Tattoo Removals: Adatto, M.A.; Amir, R.; Bhawalkar, J.; Sierra, R.; Bankowski, R.; Rozen D.; Dierickx, C.; Lapidoth, M. Laser Surgeon, Client Education, and Satisfaction with Tattoo Removal: Hutton Carlsen, K.; Esmann, J.; Serup, J. Guide to Treatment of Tattoo Complications and Tattoo Removal: Serup, J.; Bäumler, W. Atlas of Illustrative Cases Index of Cases Author Index/Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger representative. The easiest way to order: /cupde Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI17256

3 Official Journal of the Collegium Internationale Allergologicum COLLEGIUM INTERNATIONALE CIA ALLERGOLOGICUM Founded 1950 by D. Harley, P. Kallós, W. Löffler and F.W. Wittich Continued by E.A. Brown ( ), W. Kaufman ( ), F. Hahn ( ), H.C. Goodman ( ), R.R.A. Coombs ( ), Z. Trnka ( ), P. Kallós ( ), G.B. West ( ), J. Bienenstock ( ), L.Å. Hanson ( ), K. Kano ( ), F. Milgrom ( ), K. Rother ( ), G. Wick ( ), B. Grubeck-Loebenstein ( ), D. Kraft ( ) -in-chief Editorial Board R. Valenta, Vienna B. Bohle, Vienna Associate F. Annunziato, Florence K. Blaser, Meikirch J. Bousquet, Montpellier A.W. Burks, Chapel Hill, N.C. D. Dombrowicz, Lille M. Ebisawa, Kanagawa H. Garn, Marburg P. Gevaert, Ghent J. Gutermuth, Brussels T. Jakob, Giessen V. Niederberger-Leppin, Vienna M. Ollert, Esch-sur-Alzette E. Padovan, Basel R. Pawankar, Tokyo W.F. Pickl, Vienna A. Radbruch, Berlin H. Saito, Tokyo C.B. Schmidt-Weber, Munich T. Schwarz, Kiel W. Thomas, Perth, W.A. M. Triggiani, Naples R. van Ree, Amsterdam Consulting Editor for Biostatistics M. Kundi, Vienna W. Aberer, Graz M. Akdis, Davos I.J. Ansotegui, Erandio L.K. Arruda, Ribeirão Preto T. Biedermann, Munich S.C. Bischoff, Stuttgart H. Breiteneder, Vienna G.W. Canonica, Genoa M. Capron, Lille M.D. Chapman, Charlottesville, Va. E. Fernández-Caldas, Seefeld F. Ferreira, Salzburg V. Garib, Vienna H. Grönlund, Stockholm K.T. HayGlass, Winnipeg, Man. K. Hoffmann-Sommergruber, Vienna P.G. Holt, Perth, W.A. F. Horak, Vienna E. Jensen-Jarolim, Vienna M. Jutel, Wroclaw D. Kabelitz, Kiel A. Kapp, Hannover A. Karaulov, Moscow D. Kraft, Vienna M. Larché, Hamilton, Ont. E. Maggi, Florence R.N. Maini, London A. Mari, Latina S.F. Martin, Freiburg M. Maurer, Berlin F. Melchers, Berlin I. Melero, Pamplona N.G. Papadopoulos, Athens O. Pérez, Havana City W.J. Pichler, Bern T.A.E. Platts-Mills, Charlottesville, Va. H. Renz, Marburg/Lahn N. Rezaei, Tehran M. Röllinghoff, Erlangen L.J. Rosenwasser, Overland Park, Kans. K. Roux, Tallahassee, Fla. J.-M. Saint-Rémy, Leuven H.A. Sampson, New York, N.Y. R. Sepiashvili, Moscow Y. Shoenfeld, Tel Hashomer H.-U. Simon, Bern J. Smolen, Vienna Z. Szépfalusi, Vienna E. Toubi, Haifa P. Valent, Vienna M. van Hage, Stockholm D.V. Wallace, Fort Lauderdale, Fla. H. Wekerle, Martinsried T. Werfel, Hannover G. Wick, Innsbruck U. Wiedermann, Vienna S. Wöhrl, Vienna H. Yssel, Montpellier C. Zielinski, Vienna Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

4 Guidelines for Authors International Archives of Allergy and Immunology appears monthly and provides a forum for publication of work from all aspects of modern allergology and immunology. Papers considered of special interest will be treated as hot topics and every attempt will be made to publish these especially fast. The Editor-in-Chief, the Managing Editor and a team of internationally established Associate competently covering all fields of allergology and immunology are responsible for the scientific quality of this international core journal. International Archives publishes original work in the fields of allergy, immunopathology and transplantation, cellular immunology, immunogenetics, immunopharmacology and immunoendocrinology, mucosal immunity, immunology of infectious diseases and immunology of connective tissue diseases. In addition, reviews, minireviews, commentaries and opinions on controversial subjects are published regularly. 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6 General Information ISSN Print Edition: ISSN Online Edition: Journal Homepage: /iaa Publication Data: International Archives of Allergy and Immunology is published 12 times a year. Volumes , each with 4 issues, appear in Copyright: 2017 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.com. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: kargerusa@karger.com France Enter & Read Albertine Luginbuhl 23, rue du Départ, boite Paris France t: +33 (0) e: albertineluginbuhl@orange.fr South East Asia, China and Taiwan Karger Regional Office (Malaysia) Level A, PJ Exchange No. 16A, Persiaran Barat Petaling Jaya Selangor Darul Ehsan Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 51F Raffles City Centre 268 Xi Zang Middle Road Huang Pu District Shanghai P.R. China t: f: e: service@karger.cn r.chew@karger.cn w: India, Bangladesh, Sri Lanka Karger India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: r.kumar@kargerindia.com w: Change of Address: Both old and new address should be sent to the subscription source S. Karger AG, Basel karger@karger.com The Journal Home Page is available at: /iaa

7 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

8 The complex endocrine-neuro-immune network condensed into one comprehensive volume Frontiers of Hormone Research Editor: E. Ghigo Vol. 48 Endocrine Immunology W. Savino F. Guaraldi Endocrine Immunology Wilson Savino Federica Guaraldi Endocrine Immunology : Savino, W. (Rio de Janeiro); Guaraldi, F. (Turin) VIII p., 19 fig., 12 in color, 11 tab., 2017 CHF / EUR / USD Hard cover or online prices for personal customers Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN e-isbn Frontiers of Hormone Research, Vol. 48 Series : Ghigo, E. (Turin); Guaraldi, F. (Turin) Listed in MEDLINE/PubMEd, Thomson Reuters indices Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: In the last decades, several in vitro and in vivo studies have revealed the existence of a very complex network between the neuroendocrine and immune system. Important molecular mechanisms underlying these interactions, in both physiological and pathological conditions, have also been described. Indeed, hormones play a pivotal role in the development and functional regulation of the immune system both innate and acquired responses. Immune system cells present specific hormone receptors and themselves produce some hormones, thus influencing hormone secretion. More recently, the modulation of hormone secretion has been attempted for treating associated autoimmune disorders, further supporting the strong interplay between the endocrine and immune system. Distinguished experts, who have published extensively in their fields, have contributed comprehensive chapters to this volume. The focus is on the various aspects of endocrine-neuro-immune connections, providing an updated panorama from basics to clinical applications of current knowledge and still debated issues. Contents Preface: Savino, W.; Guaraldi, F.; Ghigo, E. Immune-Neuro-Endocrine Reflexes, Circuits, and Networks Physiologic and Evolutionary Implications: del Rey, A.; Besedovsky, H.O. Inflammation and Thymus Ageing: Lepletier, A.; lsharif, A.; Chidgey, A.P. Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs: Renner, U.; Sapochnik, M.; Lucia, K.; Stalla, G.K.; Arzt, E. Pituitary Autoimmunity: Guaraldi, F.; Giordano, R.; Grottoli, S.; Ghizzoni, L.; Arvat, E.; Ghigo, E. Prolactin: An Immunomodulator in Health and Disease: Savino, W. A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome: Iguchi, G.; Bando, H.; Takahashi, Y. Leptin, Neuroinflammation and Obesity: Dragano, N.R.V.; Haddad-Tovolli, R.; Velloso, L.A. Thyroid Autoimmunity and Cancer: Felicetti, F.; Catalano, M.G.; Fortunati, N. Role of Cortistatin in the Stressed Immune System: Delgado, M.; Gonzalez-Rey, E. Steroids and Autoimmunity: Trombetta, A.C.; Meroni, M.; Cutolo, M. Endocrine Autoimmunity in Down s Syndrome: Guaraldi, F.; Rossetto Giaccherino, R.; Lanfranco, F.; Motta, G.; Gori, D.; Arvat, E.; Ghigo, E.; Giordano, R. The Somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/ Insulin-Like Growth Factor-1 Axis in Immunoregulation and Immunosenescence: Bodart, G.; Farhat, K.; Charlet-Renard, C.; Salvatori, R.; Geenen, V.; Martens, H. Endocrine Immunology of Chagas Disease: Savino, W. Author Index / Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger representative. The easiest way to order: /fhore Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI17245

9 Book Award 2016 highly commended in Internal Medicine Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 48 Tattooed Skin and Health J. Serup N. Kluger W. Bäumler An interdisciplinary update Tattooed Skin and Health Jørgen Serup Nicolas Kluger Wolfgang Bäumler Tattooed Skin and Health sets a new benchmark. This interdisciplinary volume has been written by academics and professionals who are experts in their fields and convincingly present research-based solutions to the medical, chemical and technical questions which arise if one engages with health- and skin-related aspects of tattooing. Dr. Igor Eberhard, University of Vienna Tattooed Skin and Health : Serup, J. (Copenhagen); Kluger, N. (Helsinki); Bäumler, W. (Regensburg) X p., 110 fig., 85 in color, 25 tab., 2015 CHF / EUR / USD (hard cover) CHF / EUR / USD (online) Online version for institutional purchase Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN (hard cover) e-isbn Current Problems in Dermatology, Vol. 48 Series : Itin, P. (Basel); Jemec, G.B.E. (Roskilde) ISSN / e-issn Listed in bibliographic services, including PubMed/MEDLINE Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: With about 10 20% of the adult population in Europe being tattooed, there is a strong demand for publications discussing the various issues related to tattooed skin and health. Until now, only a few scientific studies on tattooing have been published. This book discusses different aspects of the various medical risks associated with tattoos, such as allergic reactions from red tattoos, papulo-nodular reactions from black tattoos as well as technical and psycho-social complications, in addition to bacterial and viral infections. Further sections are dedicated to the composition of tattoo inks, and a case is made for the urgent introduction of national and international regulations. Distinguished authors, all specialists in their particular fields, have contributed to this publication which provides a comprehensive view of the health implications associated with tattooing. The book covers a broad range of topics that will be of interest to clinicians and nursing staff, toxicologists and regulators as well as laser surgeons who often face the challenge of having to remove tattoos, professional tattooists and producers of tattoo ink. Contents Preface: Serup, J.; Kluger, N.; Bäumler, W. The Tattooed and the Social Environment The Cultural Heritage of Tattooing: A Brief History: Krutak, L. Epidemiology of Tattoos in Industrialized Countries: Kluger, N. The Practise of Tattooing Tattoo Machines, Needles and Utilities: Rosenkilde, F. The Technique and Craftsmanship of Tattooing in the Professional Tattoo Parlour: Kristensen, L. Tattoo as Art, the Drivers Behind the Fascination and the Decision to Become Tattooed: Kierstein, L.; Kjelskau, K.C. Personal Records from My Tattoo Parlour: Deep Emotions Drawn as Life-Long Pictures on the Skin s Canvas: Kierstein, L. Tattooist-Customer Relationships in a Diversified Environment of Professional Tattooists and Scratchers : Wedel Kristensen, M. Tattoos and Adverse Events Tattoo Complaints and Complications: Diagnosis and Clinical Spectrum: Serup, J.; Hutton Carlsen, K.; Sepehri, M. Complications of Cosmetic Tattoos: De Cuyper, C. Chronic Tattoo Reactions Cause Reduced Quality of Life Equaling Cumbersome Skin Diseases: Hutton Carlsen, K.; Serup, J. Contraindications for Tattooing: Kluger, N. Laser Tattoo Removal, Precautions, and Unwanted Effects: Eklund, Y.; Troilius Rubin, A. Nano-Scale Observations of Tattoo Pigments in Skin by Atomic Force Microscopy: Grant, C.A.; Twigg, P.C.; Tobin, D.J. Manufacturing, Materials and Properties of Marketed Tattoo Ink Stock Products Manufacturing of Tattoo Ink Products Today and in Future: Europe: Michel, R. The Realistic Variables Underlying True Safety in Tattoo Pigment Manufacturing: Barth, M. Making Innovative Tattoo Ink Products with Improved Safety: Possible and Impossible Ingredients in Practical Usage: Dirks, M. Tailored Surface Engineering of Pigments by Layer-by-Layer Coating: Dähne, L.; Schneider, J.; Lewe, D.; Petersen, H. Ingredients, Chemical Analysis and Safety of Marketed Tattoo Ink Stock Products Chemical Purity and Toxicology of Pigments Used in Tattoo Inks: Petersen, H.; Lewe, D. Survey on European Studies of the Chemical Characterisation of Tattoo Ink Products and the Measurement of Potentially Harmful Ingredients: Agnello, M.; Fontana, M. Tattoo Inks: Legislation, Pigments, Metals and Chemical Analysis: Prior, G. The Challenges and Limitations of Chemical Analysis of Particulate Pigments of Very Low Solubility: Olsen, O. Photostability and Breakdown Products of Pigments Currently Used in Tattoo Inks: Hauri, U.; Hohl, C. Carbon Black Nanoparticles and Other Problematic Constituents of Black Ink and Their Potential to Harm Tattooed Humans: Jacobsen, N.R.; Clausen, P.A. Absorption, Distribution, Metabolism and Excretion of Tattoo Colorants and Ingredients in Mouse and Man: The Known and the Unknown: Bäumler, W. Towards the Limiting of Health Risks Associated with Tattooing: Whitelists for Tattoo Pigments and Preservatives: Blume, A.; Platzek, T.; Vieth, B.; Hutzler, C.; Luch, A. Survey of Studies on Microbial Contamination of Marketed Tattoo Inks: Bonadonna, L. Regulation of and Intervention in the Tattoo Business The European Landscape of National Regulations of Tattoo Inks and Businesses: Laux, P.; Luch, A. Implementation of European Council Resolution ResAP(2008)1 in Italy. National and Regional Regulation of Tattoo Practices: Diversity and Challenges: Renzoni, A.; Pirrera, A.; Novello, F.; Diamante, M.S.; Guarino, C. EU Actions to Ensure the Safety of Tattoos and the Protection of Consumers: Blass Rico, A.M. Surveillance of Tattoo-Related Adverse Events by the EU RAPEX System and by National Monitoring: Verdier, C. The Amsterdam Model for Control of Tattoo Parlours and Businesses: Veenstra, T. Hygiene Standards for Tattooists: Schmidt, A. Hygiene Standards in the Tattoo Parlour and Practices for Prevention of Infection: Bergström, J; Bodlund, M. Seamless Prevention of Adverse Events from Tattooing: Integrated Strategy Emphasising the Customer-Tattooist Interaction: Serup, J. Regulation of Tattoo Ink Production and the Tattoo Business in the US: Haugh, I.M.; Laumann, S.L.; Laumann, A.E. Author Index/Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger distributor. The easiest way to order: /cupde Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: KI15218_BMA

10 PD Innovative coverage of recent advances in basic and translational medical research Exploring the Basis of Disease Exploring the Basis of Disease GM AG AG AG Days in culture Editor-in-Chief B. Borisch, Geneva Regional Editor: Far East W. Yasui, Hiroshima AG09602 (PD 19) AG11513 (PD 20) Free access after 1 year Pathobiology offers a valuable platform for the publication of highquality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, Pathobiology features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic. Pathobiology Founded: 1938 Category: Basic and Clinical Research Field of Interest: Pathology Listed in bibliographic services, including: PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase Selected contributions Absence of Microsatellite Instability In Soft Tissue Sarcomas: Campanella, N.C.; Penna, V.; Ribeiro, G.; Abrahão-Machado, L.F.; Scapulatempo-Neto, C. (Barretos); Reis, R.M. (Barretos/Braga/Guimara es) Fibroblast Growth Factor Receptor 1 Gene Copy Number and mrna Expression in Primary Colorectal Cancer and Its Clinicopathologic Correlation: Kwak, Y. (Seoul/Seongnam); Nam, S.K. (Seongnam); Seo, A.N. (Daegu); Kim, D.-W.; Kang, S.-B. (Seongnam); Kim, W.H. (Seoul); Lee, H.S. (Seongnam) Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations: Abe, H. (Tokyo); Kaneda, A. (Chiba/Saitama); Fukayama, M. (Tokyo/Saitama) Cancer Therapeutic Effects of Titanium Dioxide Nanoparticles Are Associated with Oxidative Stress and Cytokine Induction: Fujiwara, R.; Luo, Y. (Kashihara); Sasaki, T. (Fukuoka); Fujii, K.; Ohmori, H.; Kuniyasu, H. (Kashihara) Role of the Tumor Microenvironment in Breast Cancer: Soysal, S.D.; Tzankov, A.; Muenst, S.E. (Basel) Metabolomics Biomarkers for Breast Cancer: Günther, U.L. (Birmingham) International Clinical Guidelines for the Adoption of Digital Pathology: A Review of Technical Aspects: García-Rojo, M. (Jerez de la Frontera) International Telepathology: Promises and Pitfalls: Farahani, N. (Pittsburgh, Pa.); Riben, M. (Houston, Tex.); Evans, A.J. (Toronto, Ont.); Pantanowitz L. (Pittsburgh, Pa.) 2017: Volume 84 6 issues per volume Language: English ISSN e-issn Impact Factor: More information at /pat KF17085

11 Three BMA awards for Karger Publishers We are delighted to announce that three Karger titles received Highly Commended awards by the British Medical Association in their prestigious 2016 Medical Book Competition: In the category Internal Medicine In the category Oncology Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 48 Tattooed Skin and Health J. Serup N. Kluger W. Bäumler Developments in Ophthalmology Editor: F. Bandello Vol. 55 Retinal Pharmacotherapeutics Quan Dong Nguyen Eduardo B. Rodrigues Michel Eid Farah William F. Mieler Diana V. Do Progress in Tumor Research (formerly Progress in Experimental Tumor Research) : R.A. Stahel, S. Peters Vol. 42 Immuno-Oncology O. Michielin G. Coukos Tattooed Skin and Health : Serup, J. (Copenhagen); Kluger, N. (Helsinki); Bäumler, W. (Regensburg) X p., 110 fig., 85 in color, 25 tab., hard cover, 2015 ISBN e-isbn Retinal Pharmacotherapeutics : Nguyen, Q.D. (Omaha, Nebr.); Rodrigues, E.B. (São Paulo); Farah, M.E. (São Paulo); Mieler, W.F. (Chicago, Ill.); Do, D.V. (Omaha, Nebr.) XVI p., 83 fig., 71 in color, 33 tab., hard cover, 2016 ISBN e-isbn /deoph Immuno-Oncology : Michielin, O.; Coukos, G. (Lausanne) VI p., 8 fig., 5 in color, 11 tab., hard cover, 2015 ISBN e-isbn /pritr Karger titles which received awards in previous BMA Medical Book Competitions Olszewski and Baxter s Cytoarchitecture of the Human Brainstem J.A. Büttner-Ennever A.K.E. Horn 3rd, revised and extended edition Progress in Respiratory Research Editor: C.T. Bolliger Vol. 38 Paediatric Bronchoscopy K.N. Priftis M.B. Anthracopoulos E. Eber A.C. Koumbourlis R.E. Wood Developments in Ophthalmology : F. Bandello, W. Behrens-Baumann Vol. 47 Macular Edema A Practical Approach Editor Gabriel Coscas Co- José Cunha-Vaz Anat Loewenstein Gisèle Soubrane KI 16175