Exhibition New raw materials and actives for the SEPAWA Congress Visit us in Berlin at Booth A ;

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1 Exhibition New raw materials and actives for the SEPAWA Congress Visit us in Berlin at Booth A ; IN FOCUS Focus: body curves New strategies for smoother skin Focus: skin microflora Eye care Radiant skin Biodegradable scrub particles Instant solution for thickening Preservatives from nature Natural silica-based texturizers Visible naturalness with petals and leaves

2 SVELTINE S T Focus: body curves SVELTINE ST is extracted from purple loosestrife (Lythrum salicaria), a flowering plant that has been used for medicinal purposes since ancient times. The natural slimming ingredient Vescalagin is the primary substance as stated in the specification. The active ingredient inhibits the maturation of fat cells (adipocytes) and thus reduces the accumulation of lipids in the hypodermis. A 3D hypodermis model clearly demonstrated that SVELTINE ST significantly reduces the thickness of the adipose layer while also reducing the quantity and surface area of fat droplets. These effects are seen especially clearly in two body areas: SVELTINE ST pushes up the bottom and tightens the thighs. SVELTINE ST INCI: Maltodextrin (and) Lythrum Salicaria Extract Description: Hydroalcoholic extract of the Purple Loosestrife; aerial parts of the plant Appearance: Off-white to dark beige powder Recommended dosage: 0.25% Solubility: -soluble Biomarkers/specification: Vescalagin and Castalagin/product specification: % eq. Vescalagin Certification: : Complies to Cosmos standards SVELTINE is a trademark of BASF COLLALIFT 18 The beauty secret from Africa COLLALIFT 18, an extract from the bark of African mahogany (Khaya senegalensis), successfully transfers the structuring properties of mahogany bark to the skin. COLLALIFT 18 stimulates the synthesis of collagen XVIII, which envelops many of the components within all three dermal layers. This sheathing of the tissue manifests as greater elasticity and firmness of skin. Clinical studies show that COLLALIFT 18 increases skin elasticity by 12% and reduces skin irregularities ( 38%) and wrinkles ( 16%) compared to placebo. COLLALIFT 18 INCI: Glycerin (and) Aqua (and) Khaya Senegalensis Bark Extract (and) Maltodextrin Phytochemical profile: Procyanidolic oligomers (OPC) Appearance: Clear to opalescent, amber to red-brown syrupy liquid Recommended dosage: 1% Solubility: -soluble Certification: Complies to Cosmos standards COLLALIFT is a trademark of BASF Skin surface Dermo-epidermal junction Pores Firmness and elasticity Skin homogeneity Capillaries (dermis) Collagen XVIII Nutrition and drainage Anti-wrinkle Skin elasticity and firmness Adipocytes (hypodermis) Sheathing and tightening Fig 1: COLLALIFT 18 creates a sheathing effect for the entire skin structure from dermis to hypodermis 2

3 TIGHTENYL AND REVIVYL Novel strategies for effective skin smoothing The skin is a complex organ consisting of several layers, each with its own distinct architecture comprising different cell types. Young skin is kept plump by a well-organised extracellular matrix. This scaffold consists of not only collagen and elastin, but also polysaccharides. With age, the degree of organization decreases and the result is wrinkles. Another important process for upholding the structure of skin is the constant renewal of cells. Old and damaged cells are being continually replenished in an ongoing process. With advancing age and the compounded effects of environmental factors such as pollution and UV light, this replenishment slows down. The skin dries out, becomes rough and more sensitive, and wrinkles start to appear. TIGHTENYL supports the organization and function of the skin s complex network structure while REVIVYL reactivates the skin renewal process. TIGHTENYL TIGHTENYL has an effective anti-aging function that delivers impressive results already within 8 days. TIGHTENYL provides important components for restoring S-GAG synthesis. Specifically, these are N-acetylglucosamine-6-phosphate (NAG 6P), glucuronic acid as a precursor of S-GAG, and magnesium sulfate, which serves as a sulfate source in the sulfation of S-GAG. In a placebo-controlled study, application of a cream containing 2% TIGHTENYL achieved the following improvements in biometric properties: +75% firmness, +129% tone, +117% viscoelasticity, and +83% plasticity. Echographic analysis reveal that, after three months of application, skin matrix organization had improved and the structure was restored to that of very young skin. Extraordinary effects were also achieved when used for smoothing crow s feet, yielding a more uniform and visibly smoother skin with a more organized structure (see Fig. 2). REVIVYL REVIVYL possesses a unique potential: it restarts the whole skin renewal cycle from scratch and thus helps to restore a youthful, healthy looking skin. It achieves this by protecting and activating the skin stem cells, reactivating cell metabolism and improving cell differentiation. It also reinforces the skin barrier and increases shedding of dead skin cells. REVIVYL has furthermore been shown to actively protect the natural skin microbiota. REVIVYL is extracted from greater boomrape (Orobanche rapum). In extensive in-vitro and ex-vivo studies, REVIVYL was shown to activate stem cells, protect them against UV damage, and delay their cell death. It stimulated epidermal cell metabolism at the dermoepidermal junction (ex-vivo testing). Furthermore, REVIVYL increased the count of ceramides in the skin and improved shedding of the uppermost skin layer. Volunteers in placebo-controlled double-blind studies applied 0.5% REVIVYL twice daily over a total of 28 days. The skin barrier was demonstrably reinforced compared to placebo. This had a positive effect on the lipid, protein and water content of the skin. The structure of the skin was improved and skin shedding and surface regeneration were increased. REVIVYL maintains balance in the skin s microflora and even reduces the number of harmful pathogens. After four weeks, a 30% decrease in the number of wrinkles and 12% reduction of the wrinkle area were observed (see Fig. 3 and 4). Day 0 Day 28 Fig 3: Silicone replica of crow s feet placebo Day 0 Day 84 Fig 2: Application of a cream containing 2% TIGHTENYL led to a visible reduction of crow s feet after 84 days Day 0 Day 28 Fig 4: Silicone replica of crow s feet with 0.5% REVIVYL TIGHTENYL INCI: Glycerin,, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate Appearance: Clear, beige to brown liquid Recommended dosage: 0.6 2% TIGHTENYL is a trademark of Induchem/Givaudan REVIVYL INCI: Propanediol (and) Orobanche Rapum Extract Appearance: Clear, dark-yellow/orange liquid Recommended dosage: % Certification: Ecocert/Cosmos pending REVIVYL is a trademark of Induchem/Givaudan 3

4 IBR-DORMIN Regeneration consumes a lot of energy during our beauty sleep Dormins are inhibitors of cell proliferation. IBR-DORMIN is obtained from the bulb of the Chinese sacred lily (Narcissus tazetta). The active ingredient is isolated from parts of the plant that are in a dormant state. By being able to downregulate cell proliferation, dormins allow the skin to regenerate like in a beauty sleep and therefore remain in a youthful state for much longer. The latest studies on human keratinocytes have shown that IBR-DORMIN increases the cellular ATP level by 80% after 24 hours and by as much as 119% after 48 hours of incubation. IBR-DORMIN maintains cellular youth by repurposing the cell energy normally used for cell proliferation to other vital cellular processes. Volunteer trials with IBR-DORMIN show an increase in skin elasticity, a decrease in wrinkle depth, and a prolongation of artificial skin tan by 17 days. Another in-vivo study has also confirmed an improved skin complexion with reduced flaking, oiliness and gloss in acne patients. IBR-DORMIN ALL NATURAL 305 INCI: Glycerin,, Narcissus Tazetta Bulb Extract Appearance: Pale yellow, slightly viscous liquid Odour: Characteristic Recommended dosage: 0.5 2% IBR-DORMIN ALL NATURAL 305 is a trademark of IBR IBR-TCLC 701 Versatile colourless carotenoids IBR-TCLC is an oil-soluble extract obtained from the tomato, containing the colourless carotenoid precursors phytoene and phytofluene, known collectively as Phyto(flu)ene. Plants produce these substances to protect themselves against external stress, especially against excessive UV exposure and free radicals. The colourless carotenoids exhibit outstanding effects in the skin and hair care segment. The most recent studies on IBR-TCLC in body care, for example, demonstrated a smoothing out of stretch marks and cellulite. The effect was seen in a clinical double-blind study of 24 women aged 18 to 60. These women had stage 2 or 3 cellulite (on the Nürnberger-Müller scale) and visible stretch marks ICSS > = 2 (individual clinical stretch marks score, where 2 = visible stretch marks). In this study, the volunteers applied a cream containing 1.5% IBR-TCLC twice daily to the abdomen, hip and thigh area on one side of the body and a placebo to the same areas on the other side of the body. After 28 days of treatment, a significant reduction of stretch marks (see Fig. 5) and cellulite on the hips and thighs were observed. IBR-TCLC 701 INCI: Hydrogenated Polydecene, Solanum Lycopersicum (Tomato) Fruit Extract Appearance: Yellowish liquid Odour: Odourless Recommended dosage: 0.1 2% IBR-TCLC 701 is a trademark of IBR Results of the fringe projection before (Day 0) and after 4 weeks of treatment with IBR-TCLC Day 0 Day 28 Fig 5: 1.5% IBR-TCLC cream shows a significant reduction of stretch marks 4

5 COBIOPHYTONIC Botanical mixture for targeted eye care COBIOPHYTONIC is a power cocktail consisting of six different plant extracts, each with special properties: Hamamelis virginiana: improves blood circulatio Arnica montana: anti-inflammatory and venotonic Aesculus hippocastanum (horse chestnut): anti-inflammatory Malva silvestris (mallow): calming, decongestive and soothing Ruscus aculeatus: acts against oedema Hesperidin methyl chalcone: antioxidative, decongestive and anti-inflammatory This effective mixture of plant extracts helps to improve the skin s appearance. In particular, COBIOPHYTONIC acts targetedly on eye bags, dark circles and wrinkles around the eyes. COBIOPHYTONIC has been tested in a clinical trial on 15 female volunteers aged between 42 and 79. The subjects initially had a tired appearance, characterized by dark rings around the eyes, puffiness and pronounced crow s feet. A cream containing 3% COBIOPHYTONIC was applied twice daily to the eye area. Already after 28 days of treatment, a 49% reduction in the volume of eye bags was observed (see Fig. 6). Furthermore, a reduction of the dark circles and skin roughness around the eyes was observed % COBIOPHYTONIC Placebo * 49% Day 0 Day 28 Fig 6: Reduction of eye bags by 3% COBIOPHYTONIC after 28 days of treatment Score COBIOPHYTONIC INCI: Propylene Glycol,, Hesperidin Methyl Chalcone, Malva Sylvestris (Mallow) Extract, Aesculus Hippocastanum, (Horse Chestnut) Seed Extract, Hamamelis Virginiana (Whitch Hazel) Extract, Ruscus Aculeatus Root Extract, Arnica Montana Flower Extract Appearance: Yellow liquid Odour: Characteristic Recommended dosage: 2 5% COBIOPHYTONIC is a Cobiosa product COBIOWHITE For radiant, healthy skin COBIOWHITE is a plant extract from witch-hazel that has a skin lightening and antioxidative effect. The plant extract inhibits both melanogenesis and tyrosinase activity (by 55.34%) in human melanocytes. COBIOWHITE also prevents collagen degradation by inhibiting matrix metalloproteinases MMP-9 and MMP-2. Armed with this combination of actions, COBIOWHITE is an ideal raw material for treating liver spots in elderly skin. In an in-vivo study of 1% COBIOWHITE in an emulsion, the following results were observed during an application period of 56 days (see Fig. 7): Skin melanin decreased by 21% The colour difference between dark liver spots and skin colour diminished by 25% Hyperpigmented areas diminished in 80% of the volunteers The size and irregularity of dark spots decreased in 75% of the volunteers Figure 7 shows the treatments in strongly pigmented cheek areas of the subjects before treatment (Day 0) and after 56 days of treatment with 1% COBIOWHITE. A lightening can be clearly discerned. Day 0 Day 56 Fig 7: Visioface pictures before treatment with 1% COBIOWHITE (Day 0) and after 56 days of treatment COBIOWHITE INCI: Aqua, Glycerin, Polysorbate 20, Hamamelis Virginiana Leaf Extract, Coriandrum Sativum Fruit Extract, Olea Europaea Fruit Extract Appearance: Clear liquid Odour: Characteristic Recommended dosage: 0.5 2% COBIOWHITE is a Cobiosa product 5

6 SUNSIL-OLEO Functionality and naturalness in one raw material As its name suggests, SUNSIL-OLEO is a product line of silica-based texturizers that have been made to be hydrophobic and are therefore suitable for water-free formulations or for working into the oil-phase of emulsions. Silica in its uncoated form is hydrophilic due to the silanol groups (Si-OH) on the surface of each particle. The surface structure (porosity) and size of the particles characterize this product, making it an ideal additive for improving the touch, transparency and stability of cosmetic textures. Lipophilic fillers based on polymers like PMMA or silane-coated silica are not compliant for natural cosmetics, and therefore not universally applicable. With the SUNSIL-OLEO line, our South Korean partner SUNJIN Beauty Science has developed a COSMOS certified product line that combines mineral silica beads with cetyl alcohol and makes them hydrophobic. In a comparative test with other texturizers, these naturally coated, spherical silica beads exhibit excellent absorptivity and selective sebum absorption. Fig 8: Serum with porous PMMA (4%) SUNPMMA P20 (2 μm) Fig 9: Serum with hydrophobized silica (4%) SUNSIL- OLEO20 (2 μm) Immediately after application 15 seconds after application SUNSIL-OLEO comes in three different particle sizes: Product INCI Particle size SUNSIL-OLEO20 Silica & Cetyl Alcohol 2 µm SUNSIL-OLEO130 Silica & Cetyl Alcohol 7 µm SUNSIL-OLEO150H Silica & Cetyl Alcohol 13 µm SUNSIL-OLEO20 INCI: Silica & Cetyl Alcohol Appearance: White powder Recommended dosage: 2 10% Formulation: Work into the cooled emulsion at the end of production, and mix until homogeneously dispersed. ph range: No limitations Incompatibilities with other raw materials: None known SUNSIL-OLEO20 is a product of Sunjin Beauty Science Co., Ltd NATURESCRUB Effective, biodegradable exfoliating particles based on natural waxes New in the NATURESCRUB line by Micro Powders are the exfoliating particles based on hydrogenated castor oil, available in three sizes. Given their irregular shape, their feel and their relatively high melting point (82 87 C), these white particles exhibit excellent scrub performance without irritating the skin. The products are COSMOS and China compliant (IECIC listed). Product INCI Particle size NATURESCRUB H14 Hydrogenated Castor 1410 µm NATURESCRUB H20 Hydrogenated Castor 840 µm NATURESCRUB H50 Hydrogenated Castor 297 µm The average degradation rate of NATURESCRUB-H over 28 days is higher than 60%, therefore the product can be considered inherently biodegradable according to OECD 302C (Zahn-Wellens/EMPA Test). The oxygen requirements in the toxicity control show that the test substance does not influence the activity of microbes in the concentrations used. NATURESCRUB H14 / H20 / H50 INCI: Hydrogenated Castor Appearance: White powder Recommended dosage: 0.5 2% Application: Surfactant and emulsion-based exfoliating products, face and body scrubs NATURESCRUB is a product of Micro Powders Inc. 6

7 PERLASTAN Rheo2Green1 Instant solution for thickening rinse-off products This blend of disodium cocoyl glutamate (anionic surfactant) and lauryl glucoside (hydrophobic additive) greatly simplifies the thickening of surfactant-containing formulations. Immediately after diluting with water and adjusting the ph with organic acids, a high-viscosity, viscoelastic product develops that leaves behind an excellent skin feel and can even be used in natural cosmetics lines. By lowering the ph, PERLASTAN Rheo2Green1 can be thickened in a cold process in order to obtain high viscosity. Because the rheological properties are based on micellar thickening, polymer additives are no longer required. PERLASTAN Rheo2Green1 has the following properties: Outstanding foaming properties (a more voluminous, finely bubbled foam) Excellent micellar thickening in the ph range 4.8 Cold processability Capacity to buffer the ph on the skin Mildness to skin and hair Good cleansing power Applicable in certified cosmetic formulations Environmentally friendly thanks to biodegradability Free of preservatives, solvents and perfumes Sulfate-free Fig 10: Micellar thickening Example formula: shampoo containing PERLASTAN Rheo2Green1 Phase INCI Product name (supplier) Weight % A Aqua B Disodium Cocoyl Glutamate, Lauryl Glucoside PERLASTAN Rheo2Green1 (Schill+Seilacher GmbH) Panthenol 2.50 Chamomilla Recutita Extract 2.50 C Hydrolyzed Wheat Protein 0.50 D Citric Acid qs to ph E Preservatives*), perfumes etc. qs Add phase B to phase A and mix until the formulation appears homogeneous 2. Add phase C while stirring and homogenize 3. Adjust ph with phase D 4. Add in phase E *) Preservatives based on potassium sorbate and sodium benzoate can be used PERLASTAN Rheo2Green1 INCI: Aqua, Disodium Cocoyl Glutamate, Lauryl Glucoside Appearance: Cloudy, colourless to pale-yellow, viscous liquid Recommended dosage: 45% ph (10%): NaCl content: < 4.0% Viscosity: mpaxs Certification: The product is NaTrue, COSMOS, ECOCERT, BDIH and ECO-Label compliant PERLASTAN Rheo2Green1 is a Schill+Seilacher product EVERGUARD LAE-20 The preservative from nature EVERGUARD LAE-20 (INCI: Ethyl Lauroyl Arginate HCl, Glycerin) is an ECOCERT certified preservative obtained from naturally occurring substances. With its components lauric acid, L-arginine and ethanol, EVERGUARD LAE-20 combines high antimicrobial action with non-sensitizing properties and an irritation-free action. Due to its cationic nature, the preservative lends suppleness to skin and hair and can be used as an antimicrobial against gram-positive and gram-negative bacteria, fungi and yeasts. The action of EVERGUARD LAE-20 can be increased by combining it with other preservatives such as caprylyl glycol. EVERGUARD LAE-20 INCI: Ethyl Lauroyl Arginate HCl, Glycerin Chemical name: N-lauroyl-L-arginine ethyl ester monohydrochloride Appearance: Clear, colourless to pale-yellow, sticky liquid Recommended dosage: 1 4% Certification: ECOCERT certified EVERGUARD LAE-20 is a Sino Lion product 7

8 PIECE OF NATURE Discover the diversity of nature! Flowers, leaves and fruit: we encounter plants not only in nature but also on the packaging of ever more beauty products on the shelves. The market for green cosmetics is growing and thriving in fact, it is positively blooming. The new latest trend is to use plants not only as active ingredients, but also as eye catchers. The visual attractiveness of the product is its own advertisement, showing consumers what will help to make their skin more beautiful. Based on a carefully selected choice of flowers and leaves, the new Nature line of our supply partner Lessonia responds to the desire for visible naturalness in cosmetics. In order to guarantee best quality and optimal application pleasure while also respecting the person and the environment, the plants are hand-picked according to strict regulations in close cooperation with the local growers. The applications are diverse: from massage and body oils to creams and lotions, from shampoos and shower gels to cleansing products. Beautiful visual effects can be achieved already at low application concentrations of around 0.1%. Thanks to the colour diversity and different flower shapes, there are no limits to your creativity. The violet blooms of lavender, whose unmistakable fragrance is reminiscent of Provence, lend your product a touch of nostalgia and harmony. The bright orange of calendula, known for its healing and soothing effects, embodies joie de vivre and captures the rays of sunlight. A hint of elegance and youthfulness arises from the pink of the Damask Rose, which has been long cherished in cosmetics for its skin-soothing and moisturizing characteristics. Let the intricate beauty of the Nature petals enchant you and make the Nature in your product visible at first sight! Nature product range Name Calendula (G) * Camomilla Head Cornflower Helichrysum (G) * Jasmine Lavender Bloom Prosopis (G) * Rosa Damascena Saffron INCI Calendula Officinalis Flower Anthemis Nobilis Flower Powder Centaurea Cyanus (Flower) Extract Helichrysum Bracteatum Flower Extract Jasminum Officinale (Jasmine) Flower Lavandula Angustifolia (Lavender) Flower Prosopis Juliflora Leaves Rosa Damascena Flower Crocus Sativus Flower Extract Appearance Orange Beige flower heads Blue-yellow Pink: Pink to white White: Pearly white Slightly yellow Violet blooms Green leaves Pink Violet, partially orange flowers Growing region France (Anjou) France Albania Netherlands China France (Provence) India Iran Iran Stable in Pink: White: * Also available in a heat treated Green version Distributed by IMPAG Import GmbH Fritz-Remy-Straße Offenbach am Main Phone: Fax: kosmetik@impag.de Web: IMPAG Group Country Offices Switzerland/Zurich Germany/Offenbach France/Nancy Poland/Warsaw Austria/Vienna 10/ 2017

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